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Aliases for HIST1H2BE Gene

Aliases for HIST1H2BE Gene

  • Histone Cluster 1, H2be 2 3
  • H2B Histone Family, Member H 2 3
  • Histone H2B.1 A 3 4
  • Histone 1, H2be 2 3
  • Histone H2B.H 3 4
  • H2B/H 3 4
  • H2BFH 3 4
  • HIST1H2BC HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BI 4
  • Histone H2B.A 4
  • Histone H2B.G 4
  • Histone H2B.K 4
  • Histone H2B.L 4
  • DJ221C16.8 3
  • H2BFK 4
  • H2B/K 4
  • H2B/A 4
  • H2B/G 4
  • H2B/L 4
  • H2BFA 4
  • H2BFG 4
  • H2BFL 4
  • H2B.H 3

External Ids for HIST1H2BE Gene

Previous HGNC Symbols for HIST1H2BE Gene

  • H2BFH

Previous GeneCards Identifiers for HIST1H2BE Gene

  • GC06P026241
  • GC06P026292
  • GC06P026127

Summaries for HIST1H2BE Gene

Entrez Gene Summary for HIST1H2BE Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2BE Gene

HIST1H2BE (Histone Cluster 1, H2be) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity.

UniProtKB/Swiss-Prot for HIST1H2BE Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST1H2BE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BE Gene

Genomics for HIST1H2BE Gene

Regulatory Elements for HIST1H2BE Gene

Genomic Location for HIST1H2BE Gene

Chromosome:
6
Start:
26,183,795 bp from pter
End:
26,184,230 bp from pter
Size:
436 bases
Orientation:
Plus strand

Genomic View for HIST1H2BE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2BE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BE Gene

Proteins for HIST1H2BE Gene

  • Protein details for HIST1H2BE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62807-H2B1C_HUMAN
    Recommended name:
    Histone H2B type 1-C/E/F/G/I
    Protein Accession:
    P62807
    Secondary Accessions:
    • P02278
    • Q3B872
    • Q4VB69
    • Q93078
    • Q93080

    Protein attributes for HIST1H2BE Gene

    Size:
    126 amino acids
    Molecular mass:
    13906 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

neXtProt entry for HIST1H2BE Gene

Proteomics data for HIST1H2BE Gene at MOPED

Post-translational modifications for HIST1H2BE Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys 121
  • Glycosylation at Ser 113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BE Gene

Domains & Families for HIST1H2BE Gene

Gene Families for HIST1H2BE Gene

HGNC:

Protein Domains for HIST1H2BE Gene

Graphical View of Domain Structure for InterPro Entry

P62807

UniProtKB/Swiss-Prot:

H2B1C_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BE: view

No data available for Suggested Antigen Peptide Sequences for HIST1H2BE Gene

Function for HIST1H2BE Gene

Molecular function for HIST1H2BE Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
UniProtKB/Swiss-Prot Function:
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Ontology (GO) - Molecular Function for HIST1H2BE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 422550
GO:0005515 protein binding IPI 25416956
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BE: view

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST1H2BE
    • Block miRNA regulation of HIST1H2BE using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BE

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BE Gene

    Localization for HIST1H2BE Gene

    Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BE Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for HIST1H2BE Gene COMPARTMENTS Subcellular localization image for HIST1H2BE gene
    Compartment Confidence
    extracellular 5
    nucleus 5

    Gene Ontology (GO) - Cellular Components for HIST1H2BE Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0000786 nucleosome NAS 422550
    GO:0000788 nuclear nucleosome IBA --
    GO:0005615 extracellular space IDA 12860195
    GO:0005634 nucleus IDA 21630459
    GO:0005654 nucleoplasm TAS --
    genes like me logo Genes that share ontologies with HIST1H2BE: view

    Pathways & Interactions for HIST1H2BE Gene

    SuperPathways for HIST1H2BE Gene

    Superpath Contained pathways
    1 RNA Polymerase I Promoter Opening
    2 RNA Polymerase I Transcription
    3 G2/M DNA damage checkpoint
    4 DNA Double-Strand Break Repair
    5 Cellular Senescence
    genes like me logo Genes that share pathways with HIST1H2BE: view

    Pathways by source for HIST1H2BE Gene

    1 GeneGo (Thomson Reuters) pathway for HIST1H2BE Gene

    Gene Ontology (GO) - Biological Process for HIST1H2BE Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0002227 innate immune response in mucosa IDA 12860195
    GO:0006325 chromatin organization TAS --
    GO:0006334 nucleosome assembly NAS 422550
    GO:0019731 antibacterial humoral response IDA 12860195
    GO:0050830 defense response to Gram-positive bacterium IDA 12860195
    genes like me logo Genes that share ontologies with HIST1H2BE: view

    No data available for SIGNOR curated interactions for HIST1H2BE Gene

    Drugs & Compounds for HIST1H2BE Gene

    No Compound Related Data Available

    Transcripts for HIST1H2BE Gene

    mRNA/cDNA for HIST1H2BE Gene

    (1) REFSEQ mRNAs :
    (2) Additional mRNA sequences :
    (2) Selected AceView cDNA sequences:
    (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for HIST1H2BE Gene

    Histone cluster 1, H2be:
    Representative Sequences:

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST1H2BE
      • Block miRNA regulation of HIST1H2BE using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BE

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BE Gene

      No ASD Table

      Relevant External Links for HIST1H2BE Gene

      GeneLoc Exon Structure for
      HIST1H2BE
      ECgene alternative splicing isoforms for
      HIST1H2BE

      Expression for HIST1H2BE Gene

      mRNA expression in normal human tissues for HIST1H2BE Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for HIST1H2BE Gene

      This gene is overexpressed in Whole Blood (x6.3) and Cervix - Ectocervix (x5.8).

      Protein differential expression in normal tissues from HIPED for HIST1H2BE Gene

      This gene is overexpressed in Tlymphocyte (13.3), Ovary (12.8), Monocytes (11.3), Blymphocyte (6.7), Liver, secretome (6.5), and Neutrophil (6.4).

      Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HIST1H2BE Gene



      SOURCE GeneReport for Unigene cluster for HIST1H2BE Gene Hs.534369

      genes like me logo Genes that share expression patterns with HIST1H2BE: view

      Protein tissue co-expression partners for HIST1H2BE Gene

      - Elite partner

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      In Situ Assay Products

      No data available for mRNA Expression by UniProt/SwissProt for HIST1H2BE Gene

      Orthologs for HIST1H2BE Gene

      This gene was present in the common ancestor of mammals.

      Orthologs for HIST1H2BE Gene

      Organism Taxonomy Gene Similarity Type Details
      cow
      (Bos Taurus)
      Mammalia HIST1H2BL 35
      • 89.95 (n)
      • 100 (a)
      dog
      (Canis familiaris)
      Mammalia LOC100856116 35
      • 92.86 (n)
      • 100 (a)
      mouse
      (Mus musculus)
      Mammalia Hist1h2bl 35
      • 93.12 (n)
      • 99.21 (a)
      Hist1h2be 16
      chimpanzee
      (Pan troglodytes)
      Mammalia LOC471883 35
      • 89.68 (n)
      • 100 (a)
      Species with no ortholog for HIST1H2BE:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for HIST1H2BE Gene

      ENSEMBL:
      Gene Tree for HIST1H2BE (if available)
      TreeFam:
      Gene Tree for HIST1H2BE (if available)

      Paralogs for HIST1H2BE Gene

      genes like me logo Genes that share paralogs with HIST1H2BE: view

      No data available for Paralogs for HIST1H2BE Gene

      Variants for HIST1H2BE Gene

      Sequence variations from dbSNP and Humsavar for HIST1H2BE Gene

      SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
      rs4331976 -- 26,184,190(+) CTGCA(A/T)CTGCC utr-variant-3-prime
      rs4496782 -- 26,184,389(+) GATAG(C/T)ACCTA downstream-variant-500B
      rs4593350 -- 26,184,572(+) TTTTT(C/T)CCTTT downstream-variant-500B
      rs7766641 -- 26,183,874(+) AGGAC(A/G)GCAAG missense, reference
      rs11753084 -- 26,181,833(+) TCCCA(A/G)GTAGC upstream-variant-2KB

      Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BE Gene

      Variant ID Type Subtype PubMed ID
      nsv428137 CNV Loss 18775914
      dgv375n21 CNV Loss 19592680
      nsv883490 CNV Loss 21882294

      Variation tolerance for HIST1H2BE Gene

      Residual Variation Intolerance Score: 58.05% of all genes are more intolerant (likely to be disease-causing)
      Gene Damage Index Score: 9.80; 89.52% of all genes are more intolerant (likely to be disease-causing)

      Relevant External Links for HIST1H2BE Gene

      HapMap Linkage Disequilibrium report
      HIST1H2BE
      Human Gene Mutation Database (HGMD)
      HIST1H2BE

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BE Gene

      Disorders for HIST1H2BE Gene

      Relevant External Links for HIST1H2BE

      Atlas of Genetics and Cytogenetics in Oncology and Haematology:
      HIST1H2BE
      genes like me logo Genes that share disorders with HIST1H2BE: view

      No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BE Gene

      Publications for HIST1H2BE Gene

      1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 67
      2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 67
      3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
      4. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PMID: 23463506) Perez-Hernandez D. … YA!A+ez-MA^ M. (J. Biol. Chem. 2013) 67
      5. The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-I^1 production and FcRL4 expression. (PMID: 24162774) Jelicic K. … Fauci A.S. (Nat. Immunol. 2013) 67

      Products for HIST1H2BE Gene

      Sources for HIST1H2BE Gene

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