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Aliases for FCRL4 Gene

Aliases for FCRL4 Gene

  • Fc Receptor Like 4 2 3 5
  • Immune Receptor Translocation-Associated Protein 1 3 4
  • Fc Receptor Homolog 4 3 4
  • IFGP Family Protein 2 3 4
  • FcR-Like Protein 4 3 4
  • HIFGP2 3 4
  • FCRH4 3 4
  • IRTA1 3 4
  • Immunoglobulin Superfamily Receptor Translocation Associated 1 3
  • Immunoglobulin Superfamily Fc Receptor, Gp42 3
  • Fc Receptor-Like Protein 4 3
  • Fc Receptor-Like 4 2
  • CD307d Antigen 4
  • CD307d 3
  • IGFP2 3
  • FcRL4 4
  • IFGP2 4

External Ids for FCRL4 Gene

Previous GeneCards Identifiers for FCRL4 Gene

  • GC01M154357
  • GC01M155811
  • GC01M128901

Summaries for FCRL4 Gene

Entrez Gene Summary for FCRL4 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCRL4 Gene

FCRL4 (Fc Receptor Like 4) is a Protein Coding gene. Diseases associated with FCRL4 include Hodgkin Lymphoma and Multiple Myeloma. An important paralog of this gene is FCRL3.

UniProtKB/Swiss-Prot for FCRL4 Gene

  • May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.

Gene Wiki entry for FCRL4 Gene

Additional gene information for FCRL4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL4 Gene

Genomics for FCRL4 Gene

Regulatory Elements for FCRL4 Gene

Enhancers for FCRL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H157595 0.8 ENCODE 0.7 +2.5 2545 0.1 TBL1XR1 BMI1 BATF POLR2A EED ATF7 ETV6 RUNX3 IKZF2 CREM FCRL5 ENSG00000227217 FCRL3 FCRL2 FCRL1 FCRL4
GH01H157562 0.7 FANTOM5 0.3 +35.4 35406 0.3 PKNOX1 MAZ TBL1XR1 DPF2 ZNF217 IKZF1 NBN CUX1 ATF7 RUNX3 FCRL5 FCRL4
GH01H157566 0.7 ENCODE 0.3 +31.1 31125 1.7 MAZ MAFG ELF1 RELA ZNF217 IKZF1 NFE2 MLLT1 ATF7 IKZF2 FCRL5 ENSG00000227217 FCRL3 FCRL4
GH01H157552 0.7 ENCODE 0.2 +45.5 45515 1 PKNOX1 CBFB NR2F1 DPF2 RELA ZNF217 POLR2A IKZF1 ZNF24 MLLT1 FCRL5 FCRL4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCRL4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FCRL4 Gene

Genomic Locations for FCRL4 Gene
24,332 bases
Minus strand

Genomic View for FCRL4 Gene

Genes around FCRL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL4 Gene

Proteins for FCRL4 Gene

  • Protein details for FCRL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fc receptor-like protein 4
    Protein Accession:
    Secondary Accessions:
    • Q96PJ3
    • Q96RE0

    Protein attributes for FCRL4 Gene

    515 amino acids
    Molecular mass:
    57224 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCRL4 Gene


neXtProt entry for FCRL4 Gene

Post-translational modifications for FCRL4 Gene

Other Protein References for FCRL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FCRL4 Gene

Domains & Families for FCRL4 Gene

Gene Families for FCRL4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Predicted membrane proteins

Protein Domains for FCRL4 Gene

Suggested Antigen Peptide Sequences for FCRL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCRL4: view

No data available for UniProtKB/Swiss-Prot for FCRL4 Gene

Function for FCRL4 Gene

Molecular function for FCRL4 Gene

UniProtKB/Swiss-Prot Function:
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.

Gene Ontology (GO) - Molecular Function for FCRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with FCRL4: view
genes like me logo Genes that share phenotypes with FCRL4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCRL4 Gene

Localization for FCRL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRL4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FCRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FCRL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCRL4 Gene

Pathways & Interactions for FCRL4 Gene

SuperPathways for FCRL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCRL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with FCRL4: view

No data available for Pathways by source and SIGNOR curated interactions for FCRL4 Gene

Drugs & Compounds for FCRL4 Gene

No Compound Related Data Available

Transcripts for FCRL4 Gene

mRNA/cDNA for FCRL4 Gene

Unigene Clusters for FCRL4 Gene

Fc receptor-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL4 Gene

No ASD Table

Relevant External Links for FCRL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCRL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRL4 Gene

mRNA differential expression in normal tissues according to GTEx for FCRL4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x14.2) and Spleen (x5.7).

Protein differential expression in normal tissues from HIPED for FCRL4 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL4 Gene

Protein tissue co-expression partners for FCRL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FCRL4 Gene:


SOURCE GeneReport for Unigene cluster for FCRL4 Gene:


mRNA Expression by UniProt/SwissProt for FCRL4 Gene:

Tissue specificity: Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).

Evidence on tissue expression from TISSUES for FCRL4 Gene

  • Lymph node(4.3)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with FCRL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL4 Gene

Orthologs for FCRL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FCRL4 33 34
  • 98.77 (n)
(Bos Taurus)
Mammalia FCRL4 33
  • 76.39 (n)
(Canis familiaris)
Mammalia FCRL4 33 34
  • 76.12 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
-- 34
  • 44 (a)
-- 34
  • 37 (a)
-- 34
  • 36 (a)
-- 34
  • 36 (a)
-- 34
  • 30 (a)
(Gallus gallus)
Aves FCRL2 34
  • 36 (a)
Species where no ortholog for FCRL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL4 Gene

Gene Tree for FCRL4 (if available)
Gene Tree for FCRL4 (if available)

Paralogs for FCRL4 Gene

(4) SIMAP similar genes for FCRL4 Gene using alignment to 1 proteins: Pseudogenes for FCRL4 Gene

genes like me logo Genes that share paralogs with FCRL4: view

Variants for FCRL4 Gene

Sequence variations from dbSNP and Humsavar for FCRL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000125837 -- 157,599,491(+) TGGAT(G/T)AAGAG upstream-variant-2KB
rs1000463315 -- 157,578,446(+) GTTTG(A/C)AGCCA intron-variant
rs1000655940 -- 157,594,124(+) TCTAT(A/C)ATAGG intron-variant
rs1000657728 -- 157,594,918(+) ATTTT(C/T)CAGAT intron-variant
rs1000743145 -- 157,588,698(+) GAAGT(G/T)ACCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL4 Gene

Variant ID Type Subtype PubMed ID
nsv3154 CNV insertion 18451855
esv3587653 CNV loss 21293372
esv2718507 CNV deletion 23290073
esv2661330 CNV deletion 23128226

Variation tolerance for FCRL4 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCRL4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL4 Gene

Disorders for FCRL4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FCRL4 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
hodgkin lymphoma
  • hodgkin's lymphoma
multiple myeloma
  • plasma cell neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search FCRL4 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. {ECO:0000269 PubMed:11290337}.
  • Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). {ECO:0000269 PubMed:12619161}.

Relevant External Links for FCRL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FCRL4: view

No data available for Genatlas for FCRL4 Gene

Publications for FCRL4 Gene

  1. Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). (PMID: 12881317) Falini B … Cattoretti G (Blood 2003) 3 4 22 60
  2. IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. (PMID: 11929751) Miller I … Dalla-Favera R (Blood 2002) 3 4 22 60
  3. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. (PMID: 11290337) Hatzivassiliou G … Dalla-Favera R (Immunity 2001) 2 3 4 60
  4. Identification of a family of Fc receptor homologs with preferential B cell expression. (PMID: 11493702) Davis RS … Cooper MD (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for FCRL4 Gene

Sources for FCRL4 Gene

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