Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIST1H2BN Gene

Aliases for HIST1H2BN Gene

  • Histone Cluster 1, H2bn 2 3 5
  • H2B Histone Family, Member D 2 3
  • Histone 1, H2bn 2 3
  • Histone H2B.D 3 4
  • H2BFD 3 4
  • H2B/D 3 4

External Ids for HIST1H2BN Gene

Previous HGNC Symbols for HIST1H2BN Gene

  • H2BFD

Previous GeneCards Identifiers for HIST1H2BN Gene

  • GC06P027864
  • GC06P027914
  • GC06P027913
  • GC06P027805
  • GC06P027614

Summaries for HIST1H2BN Gene

Entrez Gene Summary for HIST1H2BN Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2BN Gene

HIST1H2BN (Histone Cluster 1, H2bn) is a Protein Coding gene. Among its related pathways are Chromatin organization and Packaging Of Telomere Ends. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BH.

UniProtKB/Swiss-Prot for HIST1H2BN Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2BN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BN Gene

Genomics for HIST1H2BN Gene

Regulatory Elements for HIST1H2BN Gene

Enhancers for HIST1H2BN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIST1H2BN on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H2BN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H2BN on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H2BN Gene

Chromosome:
6
Start:
27,837,760 bp from pter
End:
27,865,798 bp from pter
Size:
28,039 bases
Orientation:
Plus strand

Genomic View for HIST1H2BN Gene

Genes around HIST1H2BN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2BN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2BN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BN Gene

Proteins for HIST1H2BN Gene

  • Protein details for HIST1H2BN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99877-H2B1N_HUMAN
    Recommended name:
    Histone H2B type 1-N
    Protein Accession:
    Q99877
    Secondary Accessions:
    • B2R5L4
    • Q494S8
    • Q96FB7

    Protein attributes for HIST1H2BN Gene

    Size:
    126 amino acids
    Molecular mass:
    13922 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

neXtProt entry for HIST1H2BN Gene

Proteomics data for HIST1H2BN Gene at MOPED

Post-translational modifications for HIST1H2BN Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys 121
  • Glycosylation at Ser 113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BN Gene

No data available for DME Specific Peptides for HIST1H2BN Gene

Domains & Families for HIST1H2BN Gene

Gene Families for HIST1H2BN Gene

Protein Domains for HIST1H2BN Gene

Suggested Antigen Peptide Sequences for HIST1H2BN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99877

UniProtKB/Swiss-Prot:

H2B1N_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BN: view

Function for HIST1H2BN Gene

Molecular function for HIST1H2BN Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
genes like me logo Genes that share phenotypes with HIST1H2BN: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BN Gene

Localization for HIST1H2BN Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BN Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2BN Gene COMPARTMENTS Subcellular localization image for HIST1H2BN gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2BN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HIST1H2BN: view

Pathways & Interactions for HIST1H2BN Gene

SuperPathways for HIST1H2BN Gene

Superpath Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Packaging Of Telomere Ends
genes like me logo Genes that share pathways with HIST1H2BN: view

Gene Ontology (GO) - Biological Process for HIST1H2BN Gene

None

No data available for SIGNOR curated interactions for HIST1H2BN Gene

Drugs & Compounds for HIST1H2BN Gene

No Compound Related Data Available

Transcripts for HIST1H2BN Gene

mRNA/cDNA for HIST1H2BN Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BN Gene

No ASD Table

Relevant External Links for HIST1H2BN Gene

GeneLoc Exon Structure for
HIST1H2BN
ECgene alternative splicing isoforms for
HIST1H2BN

Expression for HIST1H2BN Gene

mRNA expression in normal human tissues for HIST1H2BN Gene

Protein differential expression in normal tissues from HIPED for HIST1H2BN Gene

This gene is overexpressed in Saliva (57.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H2BN Gene



SOURCE GeneReport for Unigene cluster for HIST1H2BN Gene Hs.673851

genes like me logo Genes that share expression patterns with HIST1H2BN: view

Protein tissue co-expression partners for HIST1H2BN Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST1H2BN Gene

Orthologs for HIST1H2BN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H2BN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC787269 35
  • 91.53 (n)
  • 99.21 (a)
H2B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC478743 35
  • 93.65 (n)
  • 99.21 (a)
-- 36
  • 92 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hist1h2bm 35
  • 93.39 (n)
  • 99.21 (a)
Hist1h2bm 16
chimpanzee
(Pan troglodytes)
Mammalia LOC462508 35
  • 99.47 (n)
  • 100 (a)
HIST1H2BN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hist1h2bd 35
  • 90.48 (n)
  • 98.41 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.12831 35
Species with no ortholog for HIST1H2BN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2BN Gene

ENSEMBL:
Gene Tree for HIST1H2BN (if available)
TreeFam:
Gene Tree for HIST1H2BN (if available)

Paralogs for HIST1H2BN Gene

genes like me logo Genes that share paralogs with HIST1H2BN: view

Variants for HIST1H2BN Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs201004 -- 27,837,156(-) ctccc(A/G)ccccc upstream-variant-2KB
rs71546575 -- 27,837,244(+) GTGTG(-/TA)TGTTT upstream-variant-2KB
rs73386609 -- 27,837,005(+) GGTCC(C/T)TCCGC upstream-variant-2KB
rs143710027 -- 27,836,712(+) ATCTC(C/T)GGAAC upstream-variant-2KB
rs191487041 -- 27,836,836(+) CTGCA(A/G)TGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BN Gene

Variant ID Type Subtype PubMed ID
nsv883512 CNV Gain 21882294

Variation tolerance for HIST1H2BN Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HIST1H2BN Gene

Disorders for HIST1H2BN Gene

Relevant External Links for HIST1H2BN

Genetic Association Database (GAD)
HIST1H2BN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2BN

No disorders were found for HIST1H2BN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BN Gene

Publications for HIST1H2BN Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for HIST1H2BN Gene

Sources for HIST1H2BN Gene

Content