Aliases for HIST1H2AM Gene
Aliases for HIST1H2AM Gene
External Ids for HIST1H2AM Gene
- HGNC: 4735
- Entrez Gene: 8336
- Ensembl: ENSG00000278677
- OMIM: 602796
- UniProtKB: P0C0S8
Previous HGNC Symbols for HIST1H2AM Gene
- H2AFN
Previous GeneCards Identifiers for HIST1H2AM Gene
- GC06M027919
- GC06M027968
- GC06M027867
- GC06M027668
- GC06M027869
- GC06M027880
- GC06M027896
- GC06M027921
- GC06M027944
- GC06M027964
- GC06M027988
- GC06M028005
- GC06M028016
- GC06M028035
- GC06M028060
- GC06M028080
Summaries for HIST1H2AM Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H2AM Gene
HIST1H2AM (Histone Cluster 1 H2A Family Member M) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is HIST1H2AL.
UniProtKB/Swiss-Prot for HIST1H2AM Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Additional gene information for HIST1H2AM Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AM Gene
Genomics for HIST1H2AM Gene
GeneHancer (GH) Regulatory Elements for HIST1H2AM Gene
Promoters and enhancers for HIST1H2AM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HIST1H2AM on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for HIST1H2AM Gene
Genomic Locations for HIST1H2AM Gene
- chr6:27,892,699-27,893,185
- (GRCh38/hg38)
- Size:
- 487 bases
- Orientation:
- Minus strand
- chr6:27,860,477-27,860,963
- (GRCh37/hg19)
Genomic View for HIST1H2AM Gene
Genes around HIST1H2AM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by Ensembl
- 6p22.1 by Entrez Gene
- 6p22.1 by HGNC
HIST1H2AM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H2AM Gene
Proteins for HIST1H2AM Gene
-
Protein details for HIST1H2AM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C0S8-H2A1_HUMAN
- Recommended name:
- Histone H2A type 1
- Protein Accession:
- P0C0S8
- P02261
- Q2M1R2
- Q76PA6
Protein attributes for HIST1H2AM Gene
- Size:
- 130 amino acids
- Molecular mass:
- 14091 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST1H2AM Gene
Post-translational modifications for HIST1H2AM Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Deiminated on Arg-4 in granulocytes upon calcium entry.
- Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
- Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
- Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
- Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Ubiquitination at isoforms=14 and isoforms=16
Other Protein References for HIST1H2AM Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Cloud-Clone Corp. Antibodies for HIST1H2AM
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Protein Products
-
OriGene Purified Proteins for HIST1H2AM
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-
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- Search GeneTex for Proteins for HIST1H2AM
Assay Products
No data available for DME Specific Peptides for HIST1H2AM Gene
Domains & Families for HIST1H2AM Gene
Gene Families for HIST1H2AM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for HIST1H2AM Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H2AM Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0C0S8- Family:
-
- Belongs to the histone H2A family.
Function for HIST1H2AM Gene
Molecular function for HIST1H2AM Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phenotypes From GWAS Catalog for HIST1H2AM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 15161933 |
| GO:0019899 | enzyme binding | IPI | 17980597 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H2AM Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2AM gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2AM
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for HIST1H2AM Gene
- miRTarBase miRNAs that target HIST1H2AM
miRNA Products
- Search ViGene Biosciences for HIST1H2AM
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HIST1H2AM
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-
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Clone Products
-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HIST1H2AM gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HIST1H2AM
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H2AM gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AM Gene
Localization for HIST1H2AM Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AM Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000790 | nuclear chromatin | IBA | -- |
| GO:0005634 | nucleus | IDA | 16319397 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0070062 | extracellular exosome | IDA,HDA | 20458337 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST1H2AM Gene
Pathways & Interactions for HIST1H2AM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.34
|
|
| 2 | Chromatin organization | ||
| 3 | Deubiquitination |
.74
|
|
| 4 | Metabolism of proteins | ||
| 5 | Necroptosis | ||
Pathways by source for HIST1H2AM Gene
11 Reactome pathways for HIST1H2AM Gene
3 KEGG pathways for HIST1H2AM Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2AM Gene
Interacting Proteins for HIST1H2AM Gene
Selected Interacting proteins:
P0C0S8-H2A1_HUMAN
ENSP00000352627
for HIST1H2AM Gene via
MINT
UniProtKB
STRING
IID
SIGNOR curated interactions for HIST1H2AM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006342 | chromatin silencing | IBA | -- |
| GO:0008150 | biological_process | ND | -- |
Transcripts for HIST1H2AM Gene
mRNA/cDNA for HIST1H2AM Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (12) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H2AM Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2AM
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2AM
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miRNA Products
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Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HIST1H2AM
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-
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Clone Products
-
OriGene ORF clones in human for HIST1H2AM
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- VectorBuilder custom plasmid, inducible vectors for HIST1H2AM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST1H2AM
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HIST1H2AM gene related products
- orf clones - Search results for available HIST1H2AM gene related products
- Applied Biological Materials Clones for HIST1H2AM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HIST1H2AM Gene
This gene is overexpressed in Saliva (40.4) and Heart (18.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H2AM Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H2AM Gene:
HIST1H2AMSOURCE GeneReport for Unigene cluster for HIST1H2AM Gene:
Hs.134999Evidence on tissue expression from TISSUES for HIST1H2AM Gene
- Intestine(4.3)
- Spleen(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HIST1H2AM
-
OriGene qPCR primer pairs for HIST1H2AM
- genomics-online: primer clones - Search results for available HIST1H2AM gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2AM Gene
Orthologs for HIST1H2AM Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC471905 33 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC488254 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist1h2ad 33 16 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC618824 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100910554 33 |
|
- Species where no ortholog for HIST1H2AM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HIST1H2AM Gene
Paralogs for HIST1H2AM Gene
(23) SIMAP similar genes for HIST1H2AM Gene using alignment to 1 proteins:
Variants for HIST1H2AM Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000538626 | -- | 27,892,660(-) | G/C | downstream_transcript_variant | |
| rs1000653439 | -- | 27,892,474(-) | CC/C | downstream_transcript_variant | |
| rs1001825482 | -- | 27,893,057(-) | C/A/G | coding_sequence_variant, synonymous_variant | |
| rs1002546427 | -- | 27,895,179(-) | A/G | upstream_transcript_variant | |
| rs1003073035 | -- | 27,894,780(-) | C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.24;
5.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HIST1H2AM Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H2AM
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AM Gene
Disorders for HIST1H2AM Gene
Additional Disease Information for HIST1H2AM
No disorders were found for HIST1H2AM Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AM Gene
Publications for HIST1H2AM Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W … Doenecke D (Human genetics 1997) 2 3 4 58
- A novel divergently transcribed human histone H2A/H2B gene pair. (PMID: 1768865) Dobner T … Lipp M (DNA sequence : the journal of DNA sequencing and mapping 1991) 2 3 4 58
- Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PMID: 16457589) Boyne MT … Kelleher NL (Journal of proteome research 2006) 3 4 58
- DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PMID: 16702407) Bergink S … Dantuma NP (Genes & development 2006) 3 4 58
Products for HIST1H2AM Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available HIST1H2AM related products ranked by validation data
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- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for HIST1H2AM siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2AM
- Horizon Cell Lines for HIST1H2AM
- genomics-online: cdna clones - Search results for available HIST1H2AM gene related products
- orf clones - Search results for available HIST1H2AM gene related products
- genomics-online: gRNA clones - Search results for available HIST1H2AM gene related products
- genomics-online: primer clones - Search results for available HIST1H2AM gene related products
- genomics-online: shRNA clones - Search results for available HIST1H2AM gene related products
Sources for HIST1H2AM Gene
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