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Aliases for HIST1H2AM Gene

Aliases for HIST1H2AM Gene

  • Histone Cluster 1, H2am 2 3
  • H2AFN 3 4 6
  • H2A Histone Family, Member N 2 3
  • Histone 1, H2am 2 3
  • H2A.1 3 4
  • HIST1H2AG HIST1H2AI HIST1H2AK HIST1H2AL HIST1H2AM 4
  • Histone H2A Type 1 3
  • Histone H2A/P 4
  • DJ193B12.1 3
  • H2AFP 4
  • H2AFC 4
  • H2AFD 4
  • H2AFI 4
  • H2A/N 3

External Ids for HIST1H2AM Gene

Previous Symbols for HIST1H2AM Gene

  • H2AFN

Summaries for HIST1H2AM Gene

Entrez Gene Summary for HIST1H2AM Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2AM Gene

HIST1H2AM (Histone Cluster 1, H2am) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.

UniProtKB/Swiss-Prot for HIST1H2AM Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AM Gene

Genomics for HIST1H2AM Gene

Genomic Location for HIST1H2AM Gene

Start:
27,892,699 bp from pter
End:
27,893,185 bp from pter
Size:
487 bases
Orientation:
Minus strand

Genomic View for HIST1H2AM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2AM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AM Gene

Regulatory Elements for HIST1H2AM Gene

Proteins for HIST1H2AM Gene

  • Protein details for HIST1H2AM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C0S8-H2A1_HUMAN
    Recommended name:
    Histone H2A type 1
    Protein Accession:
    P0C0S8
    Secondary Accessions:
    • P02261
    • Q2M1R2
    • Q76PA6

    Protein attributes for HIST1H2AM Gene

    Size:
    130 amino acids
    Molecular mass:
    14091 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

    Three dimensional structures from OCA and Proteopedia for HIST1H2AM Gene

neXtProt entry for HIST1H2AM Gene

Proteomics data for HIST1H2AM Gene at MOPED

Post-translational modifications for HIST1H2AM Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14, Lys16, Lys96, Lys100, and Lys119

Other Protein References for HIST1H2AM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AM Gene

Domains for HIST1H2AM Gene

Gene Families for HIST1H2AM Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2AM Gene

UniProtKB/Swiss-Prot:

H2A1_HUMAN
Family:
  • Belongs to the histone H2A family.:
    • P0C0S8
genes like me logo Genes that share domains with HIST1H2AM: view

Function for HIST1H2AM Gene

Molecular function for HIST1H2AM Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H2AM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15161933
GO:0019899 enzyme binding IPI 17980597
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with HIST1H2AM: view

Phenotypes for HIST1H2AM Gene

GenomeRNAi human phenotypes for HIST1H2AM:
genes like me logo Genes that share phenotypes with HIST1H2AM: view

miRNA for HIST1H2AM Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H2AM Gene

Localization for HIST1H2AM Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AM Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2AM Gene COMPARTMENTS Subcellular localization image for HIST1H2AM gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2AM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HIST1H2AM: view

Pathways for HIST1H2AM Gene

genes like me logo Genes that share pathways with HIST1H2AM: view

Pathways by source for HIST1H2AM Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for HIST1H2AM Gene
2 KEGG pathways for HIST1H2AM Gene

Gene Ontology (GO) - Biological Process for HIST1H2AM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HIST1H2AM: view

Transcripts for HIST1H2AM Gene

mRNA/cDNA for HIST1H2AM Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AM Gene

Histone cluster 1, H2am:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AM Gene

No ASD Table

Relevant External Links for HIST1H2AM Gene

GeneLoc Exon Structure for
HIST1H2AM
ECgene alternative splicing isoforms for
HIST1H2AM

Expression for HIST1H2AM Gene

mRNA expression in normal human tissues for HIST1H2AM Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H2AM Gene

SOURCE GeneReport for Unigene cluster for HIST1H2AM Gene Hs.134999

genes like me logo Genes that share expressions with HIST1H2AM: view

Orthologs for HIST1H2AM Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2AM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471905 36
  • 90.26 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia LOC618824 36
  • 86.92 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia LOC488254 36
  • 88.54 (n)
  • 98.44 (a)
mouse
(Mus musculus)
Mammalia Hist1h2ad 36
  • 87.69 (n)
  • 98.46 (a)
rat
(Rattus norvegicus)
Mammalia LOC100910554 36
  • 85.9 (n)
  • 96.15 (a)
Species with no ortholog for HIST1H2AM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2AM Gene

ENSEMBL:
Gene Tree for HIST1H2AM (if available)
TreeFam:
Gene Tree for HIST1H2AM (if available)

Paralogs for HIST1H2AM Gene

genes like me logo Genes that share paralogs with HIST1H2AM: view

No data available for Paralogs for HIST1H2AM Gene

Variants for HIST1H2AM Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AM Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs73386656 -- 27,894,466(+) GTAAC(G/T)TCCCC upstream-variant-2KB
rs114766542 -- 27,894,922(+) GGGGC(G/T)GGGGC upstream-variant-2KB
rs115736640 -- 27,895,057(+) TGCGA(A/G)TACAA upstream-variant-2KB
rs116357049 -- 27,895,071(+) AGTGG(A/G)GACTT upstream-variant-2KB
rs139291354 -- 27,894,797(+) CATTA(A/G)AGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AM Gene

Variant ID Type Subtype PubMed ID
nsv883512 CNV Gain 21882294

Relevant External Links for HIST1H2AM Gene

HapMap Linkage Disequilibrium report
HIST1H2AM

Disorders for HIST1H2AM Gene

No disorders were found for HIST1H2AM Gene.

No data available for UniProtKB/Swiss-Prot for HIST1H2AM Gene

Publications for HIST1H2AM Gene

  1. A novel divergently transcribed human histone H2A/H2B gene pair. (PMID: 1768865) Dobner T. … Lipp M. (DNA Seq. 1991) 2 3 4
  2. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4
  3. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  4. The human H2A and H2B histone gene complement. (PMID: 10064132) Albig W. … Doenecke D. (Biol. Chem. 1999) 3 4
  5. Human spleen histone H2A. Isolation and four variant sequences. (PMID: 7410338) Hayashi T. … Iwai K. (J. Biochem. 1980) 3 4

Products for HIST1H2AM Gene

Sources for HIST1H2AM Gene

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