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Aliases for HIST1H2AB Gene

Aliases for HIST1H2AB Gene

  • Histone Cluster 1, H2ab 2 3
  • H2AFM 3 4 6
  • H2A Histone Family, Member M 2 3
  • Histone 1, H2ab 2 3
  • Histone H2A/M 3 4
  • Histone H2A Type 1-B/E 3
  • HIST1H2AB HIST1H2AE 4
  • Histone H2A.2 4
  • Histone H2A/A 4
  • H2AFA 4
  • H2A/M 3

External Ids for HIST1H2AB Gene

Previous HGNC Symbols for HIST1H2AB Gene

  • H2AFM

Previous GeneCards Identifiers for HIST1H2AB Gene

  • GC06M026090
  • GC06M026141
  • GC06M025976

Summaries for HIST1H2AB Gene

Entrez Gene Summary for HIST1H2AB Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2AB Gene

HIST1H2AB (Histone Cluster 1, H2ab) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for HIST1H2AB Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AB Gene

Genomics for HIST1H2AB Gene

Regulatory Elements for HIST1H2AB Gene

Genomic Location for HIST1H2AB Gene

Start:
26,033,092 bp from pter
End:
26,033,568 bp from pter
Size:
477 bases
Orientation:
Minus strand

Genomic View for HIST1H2AB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2AB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AB Gene

Proteins for HIST1H2AB Gene

  • Protein details for HIST1H2AB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04908-H2A1B_HUMAN
    Recommended name:
    Histone H2A type 1-B/E
    Protein Accession:
    P04908
    Secondary Accessions:
    • P28001
    • Q76P63

    Protein attributes for HIST1H2AB Gene

    Size:
    130 amino acids
    Molecular mass:
    14135 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

    Three dimensional structures from OCA and Proteopedia for HIST1H2AB Gene

neXtProt entry for HIST1H2AB Gene

Proteomics data for HIST1H2AB Gene at MOPED

Post-translational modifications for HIST1H2AB Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys14, Lys16, Lys96, and Lys119
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2AB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AB Gene

Domains for HIST1H2AB Gene

Gene Families for HIST1H2AB Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2AB Gene

Suggested Antigen Peptide Sequences for HIST1H2AB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04908

UniProtKB/Swiss-Prot:

H2A1B_HUMAN :
  • P04908
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AB: view

Function for HIST1H2AB Gene

Molecular function for HIST1H2AB Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 6647026
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2AB: view

Phenotypes for HIST1H2AB Gene

GenomeRNAi human phenotypes for HIST1H2AB:
genes like me logo Genes that share phenotypes with HIST1H2AB: view

miRNA for HIST1H2AB Gene

miRTarBase miRNAs that target HIST1H2AB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2AB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H2AB Gene

Localization for HIST1H2AB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AB Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2AB Gene COMPARTMENTS Subcellular localization image for HIST1H2AB gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with HIST1H2AB: view

Pathways for HIST1H2AB Gene

genes like me logo Genes that share pathways with HIST1H2AB: view

Pathways by source for HIST1H2AB Gene

1 BioSystems pathway for HIST1H2AB Gene
29 Reactome pathways for HIST1H2AB Gene
2 KEGG pathways for HIST1H2AB Gene

Gene Ontology (GO) - Biological Process for HIST1H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process --
GO:0008285 negative regulation of cell proliferation IMP 23956221
genes like me logo Genes that share ontologies with HIST1H2AB: view

Compounds for HIST1H2AB Gene

(1) HMDB Compounds for HIST1H2AB Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with HIST1H2AB: view

Transcripts for HIST1H2AB Gene

mRNA/cDNA for HIST1H2AB Gene

(9) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AB Gene

Histone cluster 1, H2ab:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2AB

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIST1H2AB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AB Gene

No ASD Table

Relevant External Links for HIST1H2AB Gene

GeneLoc Exon Structure for
HIST1H2AB
ECgene alternative splicing isoforms for
HIST1H2AB

Expression for HIST1H2AB Gene

mRNA expression in normal human tissues for HIST1H2AB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2AB Gene

This gene is overexpressed in Testis (10.1) and Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HIST1H2AB Gene

SOURCE GeneReport for Unigene cluster for HIST1H2AB Gene Hs.248174

genes like me logo Genes that share expressions with HIST1H2AB: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H2AB Gene

Orthologs for HIST1H2AB Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2AB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471884 35
  • 83.08 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia LOC524236 35
  • 84.87 (n)
  • 97.69 (a)
mouse
(Mus musculus)
Mammalia Hist1h2ab 16
Hist1h2ag 35
  • 85.9 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Hist1h2ak 35
  • 82.82 (n)
  • 99.23 (a)
Species with no ortholog for HIST1H2AB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2AB Gene

ENSEMBL:
Gene Tree for HIST1H2AB (if available)
TreeFam:
Gene Tree for HIST1H2AB (if available)

Paralogs for HIST1H2AB Gene

genes like me logo Genes that share paralogs with HIST1H2AB: view

No data available for Paralogs for HIST1H2AB Gene

Variants for HIST1H2AB Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4401650 -- 26,034,980(+) taaaa(A/G)tatta upstream-variant-2KB
rs12194421 -- 26,035,512(+) GGTAT(C/T)TACTA upstream-variant-2KB
rs28432210 -- 26,035,503(+) AATTT(A/C)TGAGG upstream-variant-2KB
rs73736523 -- 26,034,988(+) TTACT(C/G)TAACC upstream-variant-2KB
rs75435421 -- 26,034,144(+) AAAAA(A/G)CCGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AB Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914
nsv509122 CNV Insertion 20534489

Relevant External Links for HIST1H2AB Gene

HapMap Linkage Disequilibrium report
HIST1H2AB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AB Gene

Disorders for HIST1H2AB Gene

Relevant External Links for HIST1H2AB

Genetic Association Database (GAD)
HIST1H2AB
Human Genome Epidemiology (HuGE) Navigator
HIST1H2AB
genes like me logo Genes that share disorders with HIST1H2AB: view

No data available for UniProtKB/Swiss-Prot for HIST1H2AB Gene

Publications for HIST1H2AB Gene

  1. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  3. The primary structure and expression of four cloned human histone genes. (PMID: 6647026) Zhong R. … Heintz N. (Nucleic Acids Res. 1983) 3 4
  4. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3
  5. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PMID: 16359901) Cao R. … Zhang Y. (Mol. Cell 2005) 3 4

Products for HIST1H2AB Gene

Sources for HIST1H2AB Gene

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