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Aliases for EOMES Gene

Aliases for EOMES Gene

  • Eomesodermin 2 3
  • T-Box Brain Protein 2 3 4
  • TBR2 3 4
  • Eomesodermin (Xenopus Laevis) Homolog 2
  • T-Box Brain2 2
  • T-Brain-2 4
  • TBR-2 4

External Ids for EOMES Gene

Previous GeneCards Identifiers for EOMES Gene

  • GC03M027209
  • GC03M027607
  • GC03M027732
  • GC03M027757
  • GC03M027700

Summaries for EOMES Gene

Entrez Gene Summary for EOMES Gene

  • This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for EOMES Gene

EOMES (Eomesodermin) is a Protein Coding gene. Diseases associated with EOMES include microcephaly with polymicrogyria and microcephaly - polymicrogyria - corpus callosum agenesis. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Downstream signaling in naive CD8+ T cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is MGA.

UniProtKB/Swiss-Prot for EOMES Gene

  • Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

Gene Wiki entry for EOMES Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EOMES Gene

Genomics for EOMES Gene

Regulatory Elements for EOMES Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EOMES Gene

Chromosome:
3
Start:
27,715,949 bp from pter
End:
27,722,715 bp from pter
Size:
6,767 bases
Orientation:
Minus strand

Genomic View for EOMES Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EOMES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EOMES Gene

Proteins for EOMES Gene

  • Protein details for EOMES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95936-EOMES_HUMAN
    Recommended name:
    Eomesodermin homolog
    Protein Accession:
    O95936
    Secondary Accessions:
    • B7Z4I2
    • B7ZA51
    • G3XAI5
    • Q8TAZ2
    • Q9UPM7

    Protein attributes for EOMES Gene

    Size:
    686 amino acids
    Molecular mass:
    72732 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EOMES Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EOMES Gene

Proteomics data for EOMES Gene at MOPED

Post-translational modifications for EOMES Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EOMES Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EOMES (Eomes)

No data available for DME Specific Peptides for EOMES Gene

Domains & Families for EOMES Gene

Gene Families for EOMES Gene

Protein Domains for EOMES Gene

Suggested Antigen Peptide Sequences for EOMES Gene

Graphical View of Domain Structure for InterPro Entry

O95936

UniProtKB/Swiss-Prot:

EOMES_HUMAN :
  • Contains 1 T-box DNA-binding domain.
Domain:
  • Contains 1 T-box DNA-binding domain.
genes like me logo Genes that share domains with EOMES: view

Function for EOMES Gene

Molecular function for EOMES Gene

GENATLAS Biochemistry:
eomesodermin,expressed in forebrain and T lymphocyte (T,brachyury,TBR1 subfamily),involved in developmental regulation
UniProtKB/Swiss-Prot Function:
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4.

Gene Ontology (GO) - Molecular Function for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001102 RNA polymerase II activating transcription factor binding ISS --
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding ISS --
GO:0003677 DNA binding ISS --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with EOMES: view
genes like me logo Genes that share phenotypes with EOMES: view

Animal Models for EOMES Gene

MGI Knock Outs for EOMES:

Animal Model Products

miRNA for EOMES Gene

miRTarBase miRNAs that target EOMES
Targeted motifs for EOMES Gene
HOMER Transcription Factor Regulatory Elements motif EOMES
  • Consensus sequence: ATTAACACCT Submotif: canonical Cell Type: H9 GEO ID: GSE26097

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EOMES

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for EOMES Gene

Localization for EOMES Gene

Subcellular locations from UniProtKB/Swiss-Prot for EOMES Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EOMES Gene COMPARTMENTS Subcellular localization image for EOMES gene
Compartment Confidence
nucleus 3
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EOMES: view

Pathways & Interactions for EOMES Gene

genes like me logo Genes that share pathways with EOMES: view

Pathways by source for EOMES Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • T-Cell Anergy & Immune Tolerance in human,mouse,rat
    • T Helper Cell Differentiation in human,mouse,rat

Gene Ontology (GO) - Biological Process for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001706 endoderm formation ISS --
GO:0001707 mesoderm formation ISS --
GO:0001714 endodermal cell fate specification IEA --
GO:0001824 blastocyst development --
genes like me logo Genes that share ontologies with EOMES: view

No data available for SIGNOR curated interactions for EOMES Gene

Drugs & Compounds for EOMES Gene

No Compound Related Data Available

Transcripts for EOMES Gene

Unigene Clusters for EOMES Gene

Eomesodermin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EOMES

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EOMES Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: -

Relevant External Links for EOMES Gene

GeneLoc Exon Structure for
EOMES
ECgene alternative splicing isoforms for
EOMES

Expression for EOMES Gene

mRNA expression in normal human tissues for EOMES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EOMES Gene

This gene is overexpressed in Whole Blood (x12.8), Brain - Cerebellar Hemisphere (x11.7), Brain - Cerebellum (x11.4), and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for EOMES Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EOMES Gene



SOURCE GeneReport for Unigene cluster for EOMES Gene Hs.591663

mRNA Expression by UniProt/SwissProt for EOMES Gene

O95936-EOMES_HUMAN
Tissue specificity: Expressed in CD8+ T-cells.
genes like me logo Genes that share expression patterns with EOMES: view

Protein tissue co-expression partners for EOMES Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for EOMES Gene

This gene was present in the common ancestor of animals.

Orthologs for EOMES Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EOMES 35
  • 91.54 (n)
  • 95.75 (a)
EOMES 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EOMES 35
  • 93.24 (n)
  • 96.74 (a)
EOMES 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eomes 35
  • 86.99 (n)
  • 91.54 (a)
Eomes 16
Eomes 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EOMES 35
  • 99.75 (n)
  • 99.81 (a)
EOMES 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eomes 35
  • 88.37 (n)
  • 95.37 (a)
oppossum
(Monodelphis domestica)
Mammalia EOMES 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EOMES 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves EOMES 35
  • 77.26 (n)
  • 81.33 (a)
EOMES 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EOMES 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eomes 35
  • 70.42 (n)
  • 72.11 (a)
Str.14985 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398065 35
zebrafish
(Danio rerio)
Actinopterygii eomes 35
eomesa 35
  • 64.37 (n)
  • 66.35 (a)
eomesa 36
  • 62 (a)
OneToMany
eomesb 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbx-8 37
  • 38 (a)
tbx-9 37
  • 41 (a)
tbx-11 36
  • 23 (a)
ManyToMany
tbx-30 36
  • 17 (a)
ManyToMany
tbx-34 36
  • 20 (a)
ManyToMany
tbx-35 36
  • 20 (a)
ManyToMany
tbx-37 36
  • 26 (a)
ManyToMany
tbx-38 36
  • 24 (a)
ManyToMany
tbx-39 36
  • 15 (a)
ManyToMany
tbx-40 36
  • 16 (a)
ManyToMany
tbx-42 36
  • 17 (a)
ManyToMany
tbx-43 36
  • 24 (a)
ManyToMany
tbx-8 36
  • 27 (a)
ManyToMany
tbx-9 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7001 36
  • 16 (a)
OneToMany
Species with no ortholog for EOMES:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EOMES Gene

ENSEMBL:
Gene Tree for EOMES (if available)
TreeFam:
Gene Tree for EOMES (if available)

Paralogs for EOMES Gene

Paralogs for EOMES Gene

(6) SIMAP similar genes for EOMES Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EOMES: view

Variants for EOMES Gene

Sequence variations from dbSNP and Humsavar for EOMES Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs751718 -- 27,723,804(+) GGAGA(A/T)GCCTG upstream-variant-2KB
rs1078848 -- 27,715,901(-) TTAAA(G/T)ATCTC downstream-variant-500B
rs1874198 Benign 27,721,936(+) CGGCG(C/G)CTGCA reference, missense, intron-variant
rs2371108 -- 27,715,527(+) GATGG(G/T)TGGCC downstream-variant-500B
rs2371109 -- 27,716,783(+) TTGAA(G/T)GGTTA utr-variant-3-prime

Variation tolerance for EOMES Gene

Residual Variation Intolerance Score: 20.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EOMES Gene

HapMap Linkage Disequilibrium report
EOMES
Human Gene Mutation Database (HGMD)
EOMES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EOMES Gene

Disorders for EOMES Gene

MalaCards: The human disease database

(4) MalaCards diseases for EOMES Gene - From: GeneTests, Orphanet, DISEASES, and GeneCards

UniProtKB/Swiss-Prot

EOMES_HUMAN
  • Note=A translocation t(3;10)(p24;q23) located 215 kb 3 to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.

Relevant External Links for EOMES

Genetic Association Database (GAD)
EOMES
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EOMES
genes like me logo Genes that share disorders with EOMES: view

No data available for Genatlas for EOMES Gene

Publications for EOMES Gene

  1. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PMID: 9888994) Yi C.-H. … Brook J.D. (Genomics 1999) 2 23 67
  2. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. (PMID: 20060330) Rao R.R. … Shrikant P.A. (Immunity 2010) 23 67
  3. ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta. (PMID: 20354077) Hemberger M. … Burton G.J. (Hum. Mol. Genet. 2010) 23 67
  4. The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. (PMID: 20399120) Yagi R. … Zhu J. (Immunity 2010) 23 67
  5. Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. (PMID: 20498708) Narayanan S. … Borrego F. (PLoS ONE 2010) 23 67

Products for EOMES Gene

Sources for EOMES Gene

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