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Aliases for CAPZB Gene

Aliases for CAPZB Gene

  • Capping Actin Protein Of Muscle Z-Line Beta Subunit 2 3
  • Capping Protein (Actin Filament) Muscle Z-Line, Beta 2 3 5
  • CapZ Beta 3 4
  • CAPPB 3
  • CAPZ 3
  • CAPB 3

External Ids for CAPZB Gene

Previous GeneCards Identifiers for CAPZB Gene

  • GC01M019225
  • GC01M018690
  • GC01M018811
  • GC01M019135
  • GC01M019134
  • GC01M019410
  • GC01M019537
  • GC01M019665
  • GC01M017911

Summaries for CAPZB Gene

Entrez Gene Summary for CAPZB Gene

  • This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

GeneCards Summary for CAPZB Gene

CAPZB (Capping Actin Protein Of Muscle Z-Line Beta Subunit) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include actin binding and beta-tubulin binding.

UniProtKB/Swiss-Prot for CAPZB Gene

  • F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Wiki entry for CAPZB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPZB Gene

Genomics for CAPZB Gene

Regulatory Elements for CAPZB Gene

Promoters for CAPZB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAPZB on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPZB Gene

Chromosome:
1
Start:
19,338,773 bp from pter
End:
19,485,641 bp from pter
Size:
146,869 bases
Orientation:
Minus strand

Genomic View for CAPZB Gene

Genes around CAPZB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPZB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPZB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPZB Gene

Proteins for CAPZB Gene

  • Protein details for CAPZB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47756-CAPZB_HUMAN
    Recommended name:
    F-actin-capping protein subunit beta
    Protein Accession:
    P47756
    Secondary Accessions:
    • Q32Q68
    • Q5U0L4
    • Q8TB49
    • Q9NUC4

    Protein attributes for CAPZB Gene

    Size:
    277 amino acids
    Molecular mass:
    31350 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with ARHGAP17 and RCSD1/CAPZIP. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53.

    Alternative splice isoforms for CAPZB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPZB Gene

Proteomics data for CAPZB Gene at MOPED

Post-translational modifications for CAPZB Gene

  • Ubiquitination at Lys 57, Lys 78, Lys 95, Lys 223, Lys 235, and Lys 254
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CAPZB Gene

Domains & Families for CAPZB Gene

Protein Domains for CAPZB Gene

Graphical View of Domain Structure for InterPro Entry

P47756

UniProtKB/Swiss-Prot:

CAPZB_HUMAN :
  • Belongs to the F-actin-capping protein beta subunit family.
Family:
  • Belongs to the F-actin-capping protein beta subunit family.
genes like me logo Genes that share domains with CAPZB: view

No data available for Gene Families for CAPZB Gene

Function for CAPZB Gene

Molecular function for CAPZB Gene

GENATLAS Biochemistry:
actin-capping protein Z,beta subunit 1
UniProtKB/Swiss-Prot Function:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for CAPZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CAPZB: view
genes like me logo Genes that share phenotypes with CAPZB: view

Animal Models for CAPZB Gene

MGI Knock Outs for CAPZB:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPZB Gene

Localization for CAPZB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPZB Gene

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPZB Gene COMPARTMENTS Subcellular localization image for CAPZB gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 3
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CAPZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005903 brush border IEA --
GO:0014704 intercalated disc IEA --
GO:0015629 actin cytoskeleton TAS 7665558
GO:0030863 cortical cytoskeleton IEA --
genes like me logo Genes that share ontologies with CAPZB: view

Pathways & Interactions for CAPZB Gene

genes like me logo Genes that share pathways with CAPZB: view

Pathways by source for CAPZB Gene

1 KEGG pathway for CAPZB Gene

Gene Ontology (GO) - Biological Process for CAPZB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010591 regulation of lamellipodium assembly IBA --
GO:0030032 lamellipodium assembly IEA --
GO:0051016 barbed-end actin filament capping IEA,IBA --
genes like me logo Genes that share ontologies with CAPZB: view

No data available for SIGNOR curated interactions for CAPZB Gene

Drugs & Compounds for CAPZB Gene

No Compound Related Data Available

Transcripts for CAPZB Gene

Unigene Clusters for CAPZB Gene

Capping protein (actin filament) muscle Z-line, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPZB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4:
SP5: - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: -
SP11: - -

ExUns: 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CAPZB Gene

GeneLoc Exon Structure for
CAPZB
ECgene alternative splicing isoforms for
CAPZB

Expression for CAPZB Gene

mRNA expression in normal human tissues for CAPZB Gene

mRNA differential expression in normal tissues according to GTEx for CAPZB Gene

This gene is overexpressed in Whole Blood (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPZB Gene



SOURCE GeneReport for Unigene cluster for CAPZB Gene Hs.432760

genes like me logo Genes that share expression patterns with CAPZB: view

Protein tissue co-expression partners for CAPZB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAPZB Gene

Orthologs for CAPZB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAPZB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPZB 36
  • 84 (a)
OneToOne
CAPZB 35
  • 99.38 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CAPZB 36
  • 83 (a)
OneToOne
CAPZB 35
  • 92.36 (n)
  • 98.34 (a)
dog
(Canis familiaris)
Mammalia CAPZB 35
  • 93.91 (n)
  • 99 (a)
CAPZB 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capzb 36
  • 99 (a)
OneToOne
Capzb 35
  • 92.14 (n)
  • 98.67 (a)
Capzb 16
oppossum
(Monodelphis domestica)
Mammalia CAPZB 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPZB 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capzb 35
  • 92.87 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves CAPZB 35
  • 88.02 (n)
  • 99.26 (a)
CAPZB 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPZB 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia capzb-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6774 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11173 35
zebrafish
(Danio rerio)
Actinopterygii capzb 35
  • 79.38 (n)
  • 94.07 (a)
wufk65f06 35
capzb 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007864 35
  • 72.61 (n)
  • 82.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta cpb 35
  • 70.9 (n)
  • 81.72 (a)
cpb 37
  • 81 (a)
cpb 36
  • 76 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cap-2 36
  • 66 (a)
OneToOne
cap-2 37
  • 66 (a)
cap-2 35
  • 62.52 (n)
  • 67.17 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL101C 35
  • 54.05 (n)
  • 48.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAP2 35
  • 51.84 (n)
  • 50.95 (a)
CAP2 36
  • 45 (a)
OneToOne
CAP2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04225g 35
  • 50.32 (n)
  • 47.49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G71790 35
  • 56.84 (n)
  • 54.7 (a)
corn
(Zea mays)
Liliopsida Zm.12180 35
rice
(Oryza sativa)
Liliopsida Os.15764 35
Os03g0381200 35
  • 58.33 (n)
  • 54.24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07471 35
  • 58.49 (n)
  • 56.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes acp2 35
  • 53.17 (n)
  • 54.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6107 36
  • 73 (a)
OneToOne
Species with no ortholog for CAPZB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPZB Gene

ENSEMBL:
Gene Tree for CAPZB (if available)
TreeFam:
Gene Tree for CAPZB (if available)

Paralogs for CAPZB Gene

No data available for Paralogs for CAPZB Gene

Variants for CAPZB Gene

Sequence variations from dbSNP and Humsavar for CAPZB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs214303 -- 19,361,242(-) GATTC(A/G)AAGTG intron-variant
rs214304 -- 19,361,670(-) TTCAT(A/G)TCATT intron-variant
rs214305 -- 19,363,563(-) GTTTT(C/T)CCTTT intron-variant
rs214306 -- 19,363,845(-) AGCCA(C/T)GAATC intron-variant
rs214318 -- 19,370,173(-) TCGTG(A/G)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPZB Gene

Variant ID Type Subtype PubMed ID
nsv871933 CNV Loss 21882294
nsv871934 CNV Loss 21882294
dgv186n71 CNV Loss 21882294
nsv871443 CNV Loss 21882294
esv2744841 CNV Deletion 23290073
nsv834358 CNV Loss 17160897
nsv5409 CNV Insertion 18451855
esv2744852 CNV Deletion 23290073
esv2398290 CNV Deletion 18987734
esv3747 CNV Deletion 18987735
esv2744863 CNV Deletion 23290073
nsv471771 CNV Loss 16327809
esv6224 CNV Loss 19470904
dgv26e199 CNV Deletion 23128226
esv2744874 CNV Deletion 23290073
esv2744885 CNV Deletion 23290073

Variation tolerance for CAPZB Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPZB Gene

HapMap Linkage Disequilibrium report
CAPZB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPZB Gene

Disorders for CAPZB Gene

Relevant External Links for CAPZB

Genetic Association Database (GAD)
CAPZB
Human Genome Epidemiology (HuGE) Navigator
CAPZB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPZB

No disorders were found for CAPZB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPZB Gene

Publications for CAPZB Gene

  1. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. (PMID: 7665558) Barron-Casella E.A. … Casella J.F. (J. Biol. Chem. 1995) 3 4 23 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CAPZB Gene

Sources for CAPZB Gene

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