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Aliases for TRRAP Gene

Aliases for TRRAP Gene

  • Transformation/Transcription Domain-Associated Protein 2 3
  • 350/400 KDa PCAF-Associated Factor 3 4
  • Tra1 Homolog 3 4
  • PAF350/400 3 4
  • PAF400 3 4
  • STAF40 3 4
  • TR-AP 3
  • Tra1 3

External Ids for TRRAP Gene

Summaries for TRRAP Gene

Entrez Gene Summary for TRRAP Gene

  • This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for TRRAP Gene

TRRAP (Transformation/Transcription Domain-Associated Protein) is a Protein Coding gene. Diseases associated with TRRAP include glioblastoma multiforme and glioblastoma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Cell Cycle / Checkpoint Control. GO annotations related to this gene include transcription coactivator activity and phosphotransferase activity, alcohol group as acceptor.

UniProtKB/Swiss-Prot for TRRAP Gene

  • Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Wiki entry for TRRAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRRAP Gene

Genomics for TRRAP Gene

Genomic Location for TRRAP Gene

Start:
98,877,933 bp from pter
End:
99,013,243 bp from pter
Size:
135,311 bases
Orientation:
Plus strand

Genomic View for TRRAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRRAP Gene

Regulatory Elements for TRRAP Gene

Proteins for TRRAP Gene

  • Protein details for TRRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4A5-TRRAP_HUMAN
    Recommended name:
    Transformation/transcription domain-associated protein
    Protein Accession:
    Q9Y4A5
    Secondary Accessions:
    • A4D265
    • O75218
    • Q9Y631
    • Q9Y6H4

    Protein attributes for TRRAP Gene

    Size:
    3859 amino acids
    Molecular mass:
    437600 Da
    Quaternary structure:
    • Interacts with MYC, E2F1 and E2F4 transcription factors. Interacts directly with p53/TP53. Interacts with GCN5L2. Component of various HAT complexes. Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Interacts with NPAT. Interaction with TELO2 AND TTI1. Component of a SWR1-like complex.
    SequenceCaution:
    • Sequence=AAC62433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TRRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRRAP Gene

Proteomics data for TRRAP Gene at MOPED

Post-translational modifications for TRRAP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys2059, Lys2638, Lys3050, Lys3508, Lys3598, and Lys3834

Other Protein References for TRRAP Gene

No data available for DME Specific Peptides for TRRAP Gene

Domains for TRRAP Gene

Suggested Antigen Peptide Sequences for TRRAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4A5

UniProtKB/Swiss-Prot:

TRRAP_HUMAN
Domain:
  • The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity.:
    • Q9Y4A5
  • Contains 1 FAT domain.:
    • Q9Y4A5
  • Contains 1 FATC domain.:
    • Q9Y4A5
  • Contains 1 PI3K/PI4K domain.:
    • Q9Y4A5
Family:
  • Belongs to the PI3/PI4-kinase family. TRA1 subfamily.:
    • Q9Y4A5
genes like me logo Genes that share domains with TRRAP: view

Function for TRRAP Gene

Molecular function for TRRAP Gene

GENATLAS Biochemistry: transformation/transcription domain associated protein,434kDa,essential cofactor for the c-Myc and E2F oncoproteins
UniProtKB/Swiss-Prot Function: Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Ontology (GO) - Molecular Function for TRRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IDA 11418595
GO:0003713 transcription coactivator activity IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 11415895
GO:0016301 kinase activity IBA --
genes like me logo Genes that share ontologies with TRRAP: view
genes like me logo Genes that share phenotypes with TRRAP: view

Animal Models for TRRAP Gene

MGI Knock Outs for TRRAP:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRRAP Gene

Localization for TRRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRRAP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRRAP Gene COMPARTMENTS Subcellular localization image for TRRAP gene
Compartment Confidence
nucleus 5
plasma membrane 3
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TRRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex NAS 9885574
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IDA 9708738
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex --
genes like me logo Genes that share ontologies with TRRAP: view

Pathways for TRRAP Gene

genes like me logo Genes that share pathways with TRRAP: view

Gene Ontology (GO) - Biological Process for TRRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IBA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007093 mitotic cell cycle checkpoint IEA --
genes like me logo Genes that share ontologies with TRRAP: view

Compounds for TRRAP Gene

(1) Novoseek inferred chemical compound relationships for TRRAP Gene

Compound -log(P) Hits PubMed IDs
polypropylene glycol 73.2 2
genes like me logo Genes that share compounds with TRRAP: view

Transcripts for TRRAP Gene

Unigene Clusters for TRRAP Gene

Transformation/transcription domain-associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRRAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^
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ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b · 32c ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^
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ExUns: 38a · 38b ^ 39a · 39b · 39c ^ 40 ^ 41a · 41b ^ 42a · 42b ^ 43 ^ 44a · 44b ^ 45 ^ 46 ^ 47a · 47b · 47c ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^
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ExUns: 56 ^ 57 ^ 58 ^ 59 ^
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Relevant External Links for TRRAP Gene

GeneLoc Exon Structure for
TRRAP
ECgene alternative splicing isoforms for
TRRAP

Expression for TRRAP Gene

mRNA expression in normal human tissues for TRRAP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRRAP Gene

SOURCE GeneReport for Unigene cluster for TRRAP Gene Hs.203952

genes like me logo Genes that share expressions with TRRAP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRRAP Gene

Orthologs for TRRAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRRAP 35
  • 99.6 (n)
  • 99.95 (a)
TRRAP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRRAP 35
  • 88.79 (n)
  • 99.06 (a)
TRRAP 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRRAP 35
  • 90.02 (n)
  • 99.35 (a)
TRRAP 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trrap 35
  • 87.81 (n)
  • 98.77 (a)
Trrap 16
Trrap 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRRAP 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRRAP 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trrap 35
  • 87.72 (n)
  • 98.61 (a)
chicken
(Gallus gallus)
Aves TRRAP 35
  • 81.43 (n)
  • 96.88 (a)
TRRAP 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRRAP 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6856 35
trrap 35
  • 79.77 (n)
  • 94.87 (a)
zebrafish
(Danio rerio)
Actinopterygii trrap 35
  • 79.17 (n)
  • 92.84 (a)
trrap 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005533 35
  • 59.73 (n)
  • 57.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nipped-A 35
  • 54.71 (n)
  • 54.65 (a)
Nipped-A 36
  • 50 (a)
OneToOne
Tra1 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea trr-1 35
  • 42.69 (n)
  • 29.64 (a)
trr-1 36
  • 24 (a)
OneToOne
C47D12.1 37
  • 23 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER393C 35
  • 43.91 (n)
  • 31.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRA1 35
  • 43.3 (n)
  • 31.31 (a)
TRA1 36
  • 27 (a)
OneToOne
TRA1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22066g 35
  • 42.65 (n)
  • 30.73 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G17930 35
  • 44.91 (n)
  • 32.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01379 35
  • 45.84 (n)
  • 31.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tra1 35
  • 41.84 (n)
  • 31.01 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13901 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 77 (a)
OneToMany
CSA.2888 36
  • 73 (a)
OneToMany
Species with no ortholog for TRRAP:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRRAP Gene

ENSEMBL:
Gene Tree for TRRAP (if available)
TreeFam:
Gene Tree for TRRAP (if available)

Paralogs for TRRAP Gene

Pseudogenes.org Pseudogenes for TRRAP Gene

genes like me logo Genes that share paralogs with TRRAP: view

No data available for Paralogs for TRRAP Gene

Variants for TRRAP Gene

Sequence variations from dbSNP and Humsavar for TRRAP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs41633 -- 98,959,339(+) GAATT(C/T)CTAGG intron-variant
rs41634 -- 98,960,019(+) TACAC(A/G)TAGGA intron-variant
rs41635 -- 98,962,590(+) CCGTC(C/T)CCTGT intron-variant
rs41636 -- 98,962,604(+) CTGCA(C/T)CCCCC intron-variant
rs41637 -- 98,963,008(+) TTATT(A/G)CATAT intron-variant

Relevant External Links for TRRAP Gene

HapMap Linkage Disequilibrium report
TRRAP
Human Gene Mutation Database (HGMD)
TRRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRRAP Gene

Disorders for TRRAP Gene

UniProtKB/Swiss-Prot

TRRAP_HUMAN
  • Note=TRRAP mutation Phe-722 has been frequently found in cutaneous malignant melanoma, suggesting that TRRAP may play a role in the pathogenesis of melanoma. {ECO:0000269 PubMed:21499247}.

(2) Novoseek inferred disease relationships for TRRAP Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 24 1
cancer 0 1

Relevant External Links for TRRAP

Genetic Association Database (GAD)
TRRAP
Human Genome Epidemiology (HuGE) Navigator
TRRAP
genes like me logo Genes that share disorders with TRRAP: view

Publications for TRRAP Gene

  1. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. (PMID: 9708738) McMahon S.B. … Cole M.D. (Cell 1998) 2 3 4 23
  2. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. (PMID: 10611234) McMahon S.B. … Cole M.D. (Mol. Cell. Biol. 2000) 3 4 23
  3. E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PMID: 11418595) Lang S.E. … Hearing P. (J. Biol. Chem. 2001) 3 4 23
  4. The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. (PMID: 11445536) Park J. … Cole M.D. (Genes Dev. 2001) 3 4 23
  5. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. (PMID: 12660246) Liu X. … Martinez E. (J. Biol. Chem. 2003) 3 4 23

Products for TRRAP Gene

Sources for TRRAP Gene

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