Aliases for EPX Gene
External Ids for EPX Gene
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Sep 2009]
GeneCards Summary for EPX Gene
EPX (Eosinophil Peroxidase) is a Protein Coding gene. Diseases associated with EPX include eosinophil peroxidase deficiency and urinary schistosomiasis. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include heme binding and peroxidase activity. An important paralog of this gene is MPO.
UniProtKB/Swiss-Prot for EPX Gene
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.