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Aliases for EPX Gene

Aliases for EPX Gene

  • Eosinophil Peroxidase 2 3
  • EC 1.11.1.7 4 63
  • EPO 3 4
  • EPP 3 4
  • EC 1.11.1 63
  • EPX-PEN 3
  • EPER 4

External Ids for EPX Gene

Previous GeneCards Identifiers for EPX Gene

  • GC17P056014
  • GC17P058751
  • GC17P056612
  • GC17P056744
  • GC17P053625
  • GC17P056270
  • GC17P051630

Summaries for EPX Gene

Entrez Gene Summary for EPX Gene

  • This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Sep 2009]

GeneCards Summary for EPX Gene

EPX (Eosinophil Peroxidase) is a Protein Coding gene. Diseases associated with EPX include eosinophil peroxidase deficiency and urinary schistosomiasis. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include heme binding and peroxidase activity. An important paralog of this gene is MPO.

UniProtKB/Swiss-Prot for EPX Gene

  • Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

Gene Wiki entry for EPX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPX Gene

Genomics for EPX Gene

Regulatory Elements for EPX Gene

Genomic Location for EPX Gene

Start:
58,192,728 bp from pter
End:
58,205,378 bp from pter
Size:
12,651 bases
Orientation:
Plus strand

Genomic View for EPX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPX Gene

Proteins for EPX Gene

  • Protein details for EPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11678-PERE_HUMAN
    Recommended name:
    Eosinophil peroxidase
    Protein Accession:
    P11678
    Secondary Accessions:
    • Q4TVP3

    Protein attributes for EPX Gene

    Size:
    715 amino acids
    Molecular mass:
    81040 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per heterodimer.;
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) covalently through ester linkages to hydroxylated methyl groups formed auto-catalytically with hydrogen peroxide at the heme C-1 and C-5 positions. The ester linkage to Asp-232 was observed in 30% of the chains.;
    Quaternary structure:
    • Tetramer of two light chains and two heavy chains

neXtProt entry for EPX Gene

Proteomics data for EPX Gene at MOPED

Selected DME Specific Peptides for EPX Gene

Post-translational modifications for EPX Gene

  • Glycosylation at Asn52, Asn113, Asn327, Asn363, Asn700, and Asn708
  • Modification sites at PhosphoSitePlus

Other Protein References for EPX Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for EPX Gene

Suggested Antigen Peptide Sequences for EPX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11678

UniProtKB/Swiss-Prot:

PERE_HUMAN :
  • P11678
Family:
  • Belongs to the peroxidase family. XPO subfamily.
genes like me logo Genes that share domains with EPX: view

No data available for Gene Families for EPX Gene

Function for EPX Gene

Molecular function for EPX Gene

GENATLAS Biochemistry: eosinophil peroxidase
UniProtKB/Swiss-Prot CatalyticActivity: 2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O
UniProtKB/Swiss-Prot Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

Enzyme Numbers (IUBMB) for EPX Gene

Gene Ontology (GO) - Molecular Function for EPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0020037 heme binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with EPX: view

Phenotypes for EPX Gene

genes like me logo Genes that share phenotypes with EPX: view

Animal Models for EPX Gene

MGI Knock Outs for EPX:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for EPX Gene

Localization for EPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPX Gene

Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPX Gene COMPARTMENTS Subcellular localization image for EPX gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2
lysosome 2
plasma membrane 2
vacuole 2
nucleus 1

Gene Ontology (GO) - Cellular Components for EPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with EPX: view

Pathways for EPX Gene

genes like me logo Genes that share pathways with EPX: view

PCR Array Products

Gene Ontology (GO) - Biological Process for EPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002215 defense response to nematode IEA --
GO:0006979 response to oxidative stress IEA --
GO:0032693 negative regulation of interleukin-10 production IEA --
GO:0032714 negative regulation of interleukin-5 production IEA --
GO:0032753 positive regulation of interleukin-4 production IEA --
genes like me logo Genes that share ontologies with EPX: view

Compounds for EPX Gene

(11) HMDB Compounds for EPX Gene

Compound Synonyms Cas Number PubMed IDs
2-Phenylacetamide
  • Benzeneacetamide
103-81-1
4-Coumaryl alcohol
  • 3-(4-Hydroxyphenyl)-1-propane
1076-38-6
Calcium
  • Ca
7440-70-2
Cyanosulfurous acid anion
  • CNSu
Not Available
Formaldehyde
  • Aldeide formica
50-00-0

(1) Drugbank Compounds for EPX Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Melatonin
  • MEL
73-31-4 target inhibitor

(64) Novoseek inferred chemical compound relationships for EPX Gene

Compound -log(P) Hits PubMed IDs
hobr 88.2 15
lte4 72.7 16
fml 72.5 4
hocl 66 5
bromide 65.1 14
genes like me logo Genes that share compounds with EPX: view

Transcripts for EPX Gene

mRNA/cDNA for EPX Gene

(16) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPX Gene

Eosinophil peroxidase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPX

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EPX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPX Gene

No ASD Table

Relevant External Links for EPX Gene

GeneLoc Exon Structure for
EPX
ECgene alternative splicing isoforms for
EPX

Expression for EPX Gene

mRNA expression in normal human tissues for EPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPX Gene

This gene is overexpressed in Whole Blood (28.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EPX Gene

SOURCE GeneReport for Unigene cluster for EPX Gene Hs.279259

genes like me logo Genes that share expressions with EPX: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EPX Gene

Orthologs for EPX Gene

This gene was present in the common ancestor of animals.

Orthologs for EPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPX 35
  • 99.44 (n)
  • 99.58 (a)
EPX 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPX 35
  • 86.15 (n)
  • 85.5 (a)
mouse
(Mus musculus)
Mammalia Epx 35
  • 85.71 (n)
  • 89.5 (a)
Epx 16
Epx 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPX 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPX 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epx 35
  • 85.01 (n)
  • 88.66 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia PMR-1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12335 35
zebrafish
(Danio rerio)
Actinopterygii CU184832.2 36
  • 41 (a)
ManyToMany
mpx 35
  • 53.6 (n)
  • 51.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pxt 36
  • 24 (a)
ManyToMany
CG8913 37
  • 25 (a)
CG6879 37
  • 35 (a)
CG6969 37
  • 34 (a)
CG10211 37
  • 37 (a)
CG5873 37
  • 34 (a)
pxt 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea K10B4.1 36
  • 17 (a)
ManyToMany
F09F3.5 37
  • 31 (a)
K10B4.1 37
  • 33 (a)
R08F11.7 37
  • 30 (a)
ZK430.8 37
  • 35 (a)
C46A5.4 37
  • 34 (a)
F32A5.2a 37
  • 38 (a)
F32A5.2b 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
Species with no ortholog for EPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPX Gene

ENSEMBL:
Gene Tree for EPX (if available)
TreeFam:
Gene Tree for EPX (if available)

Paralogs for EPX Gene

Paralogs for EPX Gene

Selected SIMAP similar genes for EPX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EPX: view

Variants for EPX Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for EPX Gene

P11678-PERE_HUMAN
Allelic variant in EPX is associated with Japanese cedar pollinosis which is a type I allergic disease with ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These symptoms, which occur seasonally each year, are typical features of allergic rhinitis, such as sneezing, excessive nasal secretion, nasal congestion, and conjunctival itching

Sequence variations from dbSNP and Humsavar for EPX Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2240815 -- 58,195,029(+) GGCCG(A/G)GCCCT reference, synonymous-codon
rs2302311 - 58,203,086(+) GGTAC(A/T)ATGCT reference, missense
rs2333143 -- 58,197,450(+) TGTGG(C/G)CAGAG intron-variant
rs3760170 -- 58,192,513(-) CTACC(A/G)AGCCC upstream-variant-2KB
rs3785495 -- 58,201,759(-) tgaaa(C/T)gttcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPX Gene

Variant ID Type Subtype PubMed ID
nsv517229 CNV Gain+Loss 19592680
nsv457858 CNV Loss 19166990

Relevant External Links for EPX Gene

HapMap Linkage Disequilibrium report
EPX
Human Gene Mutation Database (HGMD)
EPX

Disorders for EPX Gene

(1) OMIM Diseases for EPX Gene (131399)

UniProtKB/Swiss-Prot

PERE_HUMAN
  • Eosinophil peroxidase deficiency (EPXD) [MIM:261500]: A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils. {ECO:0000269 PubMed:7809065}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for EPX Gene

(40) Novoseek inferred disease relationships for EPX Gene

Disease -log(P) Hits PubMed IDs
asthma 69.2 47
eosinophilia 66.7 5
asthma childhood 57.1 5
inflammation 56.7 31
hypereosinophilic syndrome 53.8 1

Relevant External Links for EPX

Genetic Association Database (GAD)
EPX
Human Genome Epidemiology (HuGE) Navigator
EPX
genes like me logo Genes that share disorders with EPX: view

Publications for EPX Gene

  1. Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect. (PMID: 7809065) Romano M. … Dri P. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  2. Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase. The ester with Asp-93 is only partially formed in vivo. (PMID: 10358043) Oxvig C. … Sottrup-Jensen L. (J. Biol. Chem. 1999) 3 4 23
  3. Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis. (PMID: 12540536) Borelli V. … Zabucchi G. (Infect. Immun. 2003) 3 4 23
  4. High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis. (PMID: 14657871) Nakamura H. … Eboshida A. (J. Allergy Clin. Immunol. 2003) 3 4 23
  5. Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. (PMID: 18694936) Ulrich M. … Doering G. (J. Biol. Chem. 2008) 3 4 23

Products for EPX Gene

Sources for EPX Gene

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