Aliases for EPX Gene
External Ids for EPX Gene
Previous GeneCards Identifiers for EPX Gene
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]
GeneCards Summary for EPX Gene
EPX (Eosinophil Peroxidase) is a Protein Coding gene. Diseases associated with EPX include eosinophil peroxidase deficiency and proctitis. Among its related pathways are Cellular Senescence and HIF-1-alpha transcription factor network. GO annotations related to this gene include heme binding and peroxidase activity. An important paralog of this gene is PXDN.
UniProtKB/Swiss-Prot for EPX Gene
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.