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Aliases for SLC10A3 Gene

Aliases for SLC10A3 Gene

  • Solute Carrier Family 10 Member 3 2 3 4 5
  • Solute Carrier Family 10, Member 3 2 3
  • DXS253E 3 4
  • P3 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 3 3
  • Protein P3 3

External Ids for SLC10A3 Gene

Previous GeneCards Identifiers for SLC10A3 Gene

  • GC0XM151301
  • GC0XM152183
  • GC0XM153279
  • GC0XM153368
  • GC0XM153715
  • GC0XM142292

Summaries for SLC10A3 Gene

Entrez Gene Summary for SLC10A3 Gene

  • This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It is thought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2008]

GeneCards Summary for SLC10A3 Gene

SLC10A3 (Solute Carrier Family 10 Member 3) is a Protein Coding gene. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A6.

UniProtKB/Swiss-Prot for SLC10A3 Gene

  • The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

Gene Wiki entry for SLC10A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A3 Gene

Genomics for SLC10A3 Gene

Regulatory Elements for SLC10A3 Gene

Promoters for SLC10A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC10A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC10A3 Gene

Chromosome:
X
Start:
154,487,306 bp from pter
End:
154,490,690 bp from pter
Size:
3,385 bases
Orientation:
Minus strand

Genomic View for SLC10A3 Gene

Genes around SLC10A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A3 Gene

Proteins for SLC10A3 Gene

  • Protein details for SLC10A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09131-P3_HUMAN
    Recommended name:
    P3 protein
    Protein Accession:
    P09131
    Secondary Accessions:
    • Q5HY79
    • Q9BSL2

    Protein attributes for SLC10A3 Gene

    Size:
    477 amino acids
    Molecular mass:
    50333 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC10A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC10A3 Gene

Proteomics data for SLC10A3 Gene at MOPED

Post-translational modifications for SLC10A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC10A3 Gene

No data available for DME Specific Peptides for SLC10A3 Gene

Domains & Families for SLC10A3 Gene

Gene Families for SLC10A3 Gene

Protein Domains for SLC10A3 Gene

Suggested Antigen Peptide Sequences for SLC10A3 Gene

Graphical View of Domain Structure for InterPro Entry

P09131

UniProtKB/Swiss-Prot:

P3_HUMAN :
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A3: view

Function for SLC10A3 Gene

Molecular function for SLC10A3 Gene

UniProtKB/Swiss-Prot Function:
The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
genes like me logo Genes that share phenotypes with SLC10A3: view

Human Phenotype Ontology for SLC10A3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A3 Gene

Localization for SLC10A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC10A3 Gene COMPARTMENTS Subcellular localization image for SLC10A3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC10A3: view

Pathways & Interactions for SLC10A3 Gene

SuperPathways for SLC10A3 Gene

No Data Available

Interacting Proteins for SLC10A3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263512%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000254940%0d%0a9606.ENSP00000355136%0d%0a
Selected Interacting proteins: ENSP00000263512 for SLC10A3 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032526 response to retinoic acid IEA --
genes like me logo Genes that share ontologies with SLC10A3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC10A3 Gene

Drugs & Compounds for SLC10A3 Gene

(1) Additional Compounds for SLC10A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC10A3: view

Transcripts for SLC10A3 Gene

Unigene Clusters for SLC10A3 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A3 Gene

No ASD Table

Relevant External Links for SLC10A3 Gene

GeneLoc Exon Structure for
SLC10A3
ECgene alternative splicing isoforms for
SLC10A3

Expression for SLC10A3 Gene

mRNA expression in normal human tissues for SLC10A3 Gene

SOURCE GeneReport for Unigene cluster for SLC10A3 Gene Hs.522826

genes like me logo Genes that share expression patterns with SLC10A3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC10A3 Gene

Orthologs for SLC10A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC10A3 35
  • 86.65 (n)
  • 86.37 (a)
SLC10A3 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC10A3 35
  • 89.1 (n)
  • 88.47 (a)
SLC10A3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a3 35
  • 83.44 (n)
  • 85.84 (a)
Slc10a3 16
Slc10a3 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC10A3 35
  • 98.95 (n)
  • 98.95 (a)
rat
(Rattus norvegicus)
Mammalia Slc10a3 35
  • 84.07 (n)
  • 85.84 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC10A3 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC10A3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC10A3 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a3 35
  • 59.27 (n)
  • 59.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9703 35
zebrafish
(Danio rerio)
Actinopterygii slc10a3 35
  • 66.35 (n)
  • 60.71 (a)
slc10a3 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11655 36
  • 22 (a)
ManyToMany
CG9903 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for SLC10A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC10A3 Gene

ENSEMBL:
Gene Tree for SLC10A3 (if available)
TreeFam:
Gene Tree for SLC10A3 (if available)

Paralogs for SLC10A3 Gene

Paralogs for SLC10A3 Gene

(1) SIMAP similar genes for SLC10A3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC10A3: view

Variants for SLC10A3 Gene

Sequence variations from dbSNP and Humsavar for SLC10A3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_050229 -
rs5986983 -- 154,489,674(+) CCTGC(C/T)AGAAC intron-variant, utr-variant-5-prime
rs5987268 -- 154,490,637(+) CTGGC(A/C)GGCAG upstream-variant-2KB, utr-variant-5-prime
rs5945435 -- 154,489,490(+) TTTGA(C/G)CTCCC intron-variant, utr-variant-5-prime
rs6655248 -- 154,490,171(+) CCAGA(A/T)CCCAC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC10A3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680

Variation tolerance for SLC10A3 Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC10A3 Gene

HapMap Linkage Disequilibrium report
SLC10A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A3 Gene

Disorders for SLC10A3 Gene

Relevant External Links for SLC10A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC10A3

No disorders were found for SLC10A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A3 Gene

Publications for SLC10A3 Gene

  1. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen E.Y. … D'Urso M. (Hum. Mol. Genet. 1996) 2 3 4 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F. … Reymond A. (Genome Res. 2007) 3
  5. NKCC1 does not accumulate chloride in developing retinal neurons. (PMID: 17493914) Zhang L.L. … Vardi N. (J. Neurophysiol. 2007) 23

Products for SLC10A3 Gene

Sources for SLC10A3 Gene

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