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Aliases for USP11 Gene

Aliases for USP11 Gene

  • Ubiquitin Specific Peptidase 11 2 3
  • UHX1 3 4 6
  • Ubiquitin-Specific-Processing Protease 11 3 4
  • Deubiquitinating Enzyme 11 3 4
  • Ubiquitin Thioesterase 11 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase, X-Linked 3
  • Ubiquitin-Specific Processing Protease 11 3
  • Ubiquitin Carboxyl-Terminal Hydrolase 11 3
  • Ubiquitin Specific Protease 11 2
  • Ubiquitin Thiolesterase 11 3
  • EC 4
  • EC 63

External Ids for USP11 Gene

Previous GeneCards Identifiers for USP11 Gene

  • GC0XP045895
  • GC0XP045352
  • GC0XP045918
  • GC0XP046138
  • GC0XP046848
  • GC0XP046977
  • GC0XP047093
  • GC0XP044802

Summaries for USP11 Gene

Entrez Gene Summary for USP11 Gene

  • Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]

GeneCards Summary for USP11 Gene

USP11 (Ubiquitin Specific Peptidase 11) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include ubiquitin thiolesterase activity and ubiquitin-specific protease activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP11 Gene

  • Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.

Gene Wiki entry for USP11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP11 Gene

Genomics for USP11 Gene

Regulatory Elements for USP11 Gene

Genomic Location for USP11 Gene

47,232,690 bp from pter
47,248,328 bp from pter
15,639 bases
Plus strand

Genomic View for USP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP11 Gene

Proteins for USP11 Gene

  • Protein details for USP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 11
    Protein Accession:
    Secondary Accessions:
    • B2RTX1
    • Q8IUG6
    • Q9BWE1

    Protein attributes for USP11 Gene

    963 amino acids
    Molecular mass:
    109817 Da
    Quaternary structure:
    • Interacts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA. Interacts with papilloma virus protein 16E7.
    • Sequence=AAC50450.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC50450.1; Type=Frameshift; Positions=65, 117, 134, 146; Evidence={ECO:0000305}; Sequence=BAC20463.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD20056.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP11 Gene

neXtProt entry for USP11 Gene

Proteomics data for USP11 Gene at MOPED

Selected DME Specific Peptides for USP11 Gene

Post-translational modifications for USP11 Gene

  • Ubiquitination at Lys107, Lys191, Lys245, Lys355, Lys367, Lys447, Lys493, Lys531, Lys714, Lys766, Lys835, Lys840, Lys896, and Lys920
  • Modification sites at PhosphoSitePlus

Other Protein References for USP11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for USP11 Gene

Gene Families for USP11 Gene

  • USP :Ubiquitin-specific peptidases

Graphical View of Domain Structure for InterPro Entry



  • P51784
  • Contains 1 DUSP domain.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP11: view

Function for USP11 Gene

Molecular function for USP11 Gene

GENATLAS Biochemistry: ubiquitin specific protease 11,highly expressed in the retina,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.

Enzyme Numbers (IUBMB) for USP11 Gene

Gene Ontology (GO) - Molecular Function for USP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 9827704
GO:0004843 ubiquitin-specific protease activity IDA 15314155
GO:0005515 protein binding IPI 15314155
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP11: view
genes like me logo Genes that share phenotypes with USP11: view

miRNA for USP11 Gene

miRTarBase miRNAs that target USP11

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP11 Gene

Localization for USP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP11 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin.

Subcellular locations from

Jensen Localization Image for USP11 Gene COMPARTMENTS Subcellular localization image for USP11 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for USP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15314155
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with USP11: view

Pathways for USP11 Gene

genes like me logo Genes that share pathways with USP11: view

Pathways by source for USP11 Gene

Gene Ontology (GO) - Biological Process for USP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IDA 15314155
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP11: view

Compounds for USP11 Gene

(1) HMDB Compounds for USP11 Gene

Compound Synonyms Cas Number PubMed IDs
  • Dihydrogen oxide
genes like me logo Genes that share compounds with USP11: view

Transcripts for USP11 Gene

Unigene Clusters for USP11 Gene

Ubiquitin specific peptidase 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ·
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - -
SP8: -
SP9: - - - - - - - - - - -

ExUns: 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3: -

Relevant External Links for USP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP11 Gene

mRNA expression in normal human tissues for USP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP11 Gene

SOURCE GeneReport for Unigene cluster for USP11 Gene Hs.171501

genes like me logo Genes that share expressions with USP11: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for USP11 Gene

Orthologs for USP11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP11 35
  • 85.33 (n)
  • 83.78 (a)
USP11 36
  • 83 (a)
(Canis familiaris)
Mammalia USP11 35
  • 86.13 (n)
  • 85.64 (a)
USP11 36
  • 85 (a)
(Mus musculus)
Mammalia Usp11 35
  • 83.86 (n)
  • 82.55 (a)
Usp11 16
Usp11 36
  • 82 (a)
(Monodelphis domestica)
Mammalia USP11 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia USP11 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Usp11 35
  • 83.93 (n)
  • 83 (a)
(Anolis carolinensis)
Reptilia USP11 36
  • 64 (a)
(Danio rerio)
Actinopterygii usp11 35
  • 63.3 (n)
  • 62.25 (a)
usp11 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30421 37
  • 37 (a)
(Caenorhabditis elegans)
Secernentea H34C03.2 36
  • 29 (a)
H34C03.2 37
  • 54 (a)
F07A11.4 37
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP12 36
  • 20 (a)
(Glycine max)
eudicotyledons Gma.15565 35
(Oryza sativa)
Liliopsida Os.45946 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2770 36
  • 37 (a)
Species with no ortholog for USP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP11 Gene

Gene Tree for USP11 (if available)
Gene Tree for USP11 (if available)

Paralogs for USP11 Gene

Paralogs for USP11 Gene

Selected SIMAP similar genes for USP11 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with USP11: view

Variants for USP11 Gene

Sequence variations from dbSNP and Humsavar for USP11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1319 -- 47,247,837(+) GTGGC(A/G)CGACG synonymous-codon, reference
rs3747465 -- 47,244,577(-) AGCCC(A/C)CGCCC intron-variant
rs3747466 -- 47,240,487(-) TCTGC(C/T)AGTCC intron-variant
rs4824602 -- 47,241,951(+) CTGTG(C/T)ATCCC intron-variant
rs5906359 -- 47,242,071(+) ATGAC(A/T)CTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP11 Gene

Variant ID Type Subtype PubMed ID
esv2740137 CNV Deletion 23290073
esv2740138 CNV Deletion 23290073
esv988260 CNV Deletion 20482838
esv1746874 CNV Deletion 17803354

Relevant External Links for USP11 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP11 Gene

Disorders for USP11 Gene

No disorders were found for USP11 Gene.

No data available for UniProtKB/Swiss-Prot for USP11 Gene

Publications for USP11 Gene

  1. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. (PMID: 12084015) Ideguchi H. … Ishigatsubo Y. (Biochem. J. 2002) 3 4 23
  2. USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha. (PMID: 19874889) Sun W. … Yang J. (Cell. Signal. 2010) 3 4 23
  3. Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. (PMID: 20233726) Wiltshire T.D. … Cortez D. (J. Biol. Chem. 2010) 4 23
  4. A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders. (PMID: 8845848) Swanson D.A. … Valle D. (Hum. Mol. Genet. 1996) 3 4
  5. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3

Products for USP11 Gene

  • Addgene plasmids for USP11

Sources for USP11 Gene

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