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Aliases for AKAP17A Gene

Aliases for AKAP17A Gene

  • A Kinase (PRKA) Anchor Protein 17A 2 3
  • Splicing Factor, Arginine/Serine-Rich 17A 2 3 4
  • Protein Kinase A-Anchoring Protein 17A 3 4
  • AKAP-17A 3 4
  • DXYS155E 3 4
  • CXYorf3 3 4
  • SFRS17A 3 4
  • PRKA17A 3 4
  • 721P 3 4
  • XE7 3 4
  • Chromosome X And Y Open Reading Frame 3 2
  • B-Lymphocyte Surface Antigen 3
  • Pseudoautosomal Gene XE7 3
  • B-Lymphocyte Antigen 4
  • Protein XE7 4
  • CCDC133 3
  • XE7Y 3

External Ids for AKAP17A Gene

Previous HGNC Symbols for AKAP17A Gene

  • CXYorf3
  • SFRS17A

Previous GeneCards Identifiers for AKAP17A Gene

  • GC0XP001710

Summaries for AKAP17A Gene

Entrez Gene Summary for AKAP17A Gene

  • This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]

GeneCards Summary for AKAP17A Gene

AKAP17A (A Kinase (PRKA) Anchor Protein 17A) is a Protein Coding gene. Diseases associated with AKAP17A include null-cell leukemia and chronic tic disorder. GO annotations related to this gene include poly(A) RNA binding and protein kinase A binding.

UniProtKB/Swiss-Prot for AKAP17A Gene

  • Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.

Gene Wiki entry for AKAP17A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKAP17A Gene

Genomics for AKAP17A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AKAP17A Gene

Chromosome:
X
Start:
1,591,593 bp from pter
End:
1,602,520 bp from pter
Size:
10,928 bases
Orientation:
Plus strand

Genomic View for AKAP17A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKAP17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKAP17A Gene

No data available for Regulatory Elements for AKAP17A Gene

Proteins for AKAP17A Gene

  • Protein details for AKAP17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02040-AK17A_HUMAN
    Recommended name:
    A-kinase anchor protein 17A
    Protein Accession:
    Q02040
    Secondary Accessions:
    • Q02832
    • Q2TB98
    • Q5JQ74
    • Q5JQ76
    • Q8N6U9

    Protein attributes for AKAP17A Gene

    Size:
    695 amino acids
    Molecular mass:
    80735 Da
    Quaternary structure:
    • Monomer. Component of the spliceosome. Interacts with ZRANB2 and SFRS1/ASF through its Arg/Ser-rich domain. Interacts with RI and RII subunits of PKA.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes
    SequenceCaution:
    • Sequence=AAA36187.1; Type=Frameshift; Positions=461; Evidence={ECO:0000305};

    Alternative splice isoforms for AKAP17A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKAP17A Gene

Proteomics data for AKAP17A Gene at MOPED

Post-translational modifications for AKAP17A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKAP17A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AKAP17A Gene

Domains & Families for AKAP17A Gene

Protein Domains for AKAP17A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKAP17A Gene

Graphical View of Domain Structure for InterPro Entry

Q02040

UniProtKB/Swiss-Prot:

AK17A_HUMAN :
  • RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Domain:
  • RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with AKAP17A: view

Function for AKAP17A Gene

Molecular function for AKAP17A Gene

UniProtKB/Swiss-Prot Function:
Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.

Gene Ontology (GO) - Molecular Function for AKAP17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 16982639
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0051018 protein kinase A binding IDA 19840947
genes like me logo Genes that share ontologies with AKAP17A: view

Phenotypes for AKAP17A Gene

GenomeRNAi human phenotypes for AKAP17A:
genes like me logo Genes that share phenotypes with AKAP17A: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP17A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for AKAP17A Gene

Localization for AKAP17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKAP17A Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKAP17A Gene COMPARTMENTS Subcellular localization image for AKAP17A gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for AKAP17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19840947
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IDA --
GO:0016607 nuclear speck IDA 16982639
genes like me logo Genes that share ontologies with AKAP17A: view

Pathways & Interactions for AKAP17A Gene

SuperPathways for AKAP17A Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKAP17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 1438229
GO:0006397 mRNA processing IEA --
GO:0007165 signal transduction NAS 1438229
GO:0008380 RNA splicing IEA --
GO:0042113 B cell activation NAS 1438229
genes like me logo Genes that share ontologies with AKAP17A: view

No data available for Pathways by source and SIGNOR curated interactions for AKAP17A Gene

Drugs & Compounds for AKAP17A Gene

No Compound Related Data Available

Transcripts for AKAP17A Gene

mRNA/cDNA for AKAP17A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP17A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKAP17A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2:
SP3: - -

Relevant External Links for AKAP17A Gene

GeneLoc Exon Structure for
AKAP17A
ECgene alternative splicing isoforms for
AKAP17A

Expression for AKAP17A Gene

mRNA expression in normal human tissues for AKAP17A Gene

Protein differential expression in normal tissues from HIPED for AKAP17A Gene

This gene is overexpressed in Colon (20.3), Peripheral blood mononuclear cells (7.4), and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKAP17A Gene



mRNA Expression by UniProt/SwissProt for AKAP17A Gene

Q02040-AK17A_HUMAN
Tissue specificity: Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells.
genes like me logo Genes that share expression patterns with AKAP17A: view

Protein tissue co-expression partners for AKAP17A Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AKAP17A Gene

Orthologs for AKAP17A Gene

This gene was present in the common ancestor of animals.

Orthologs for AKAP17A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKAP17A 35
  • 90.59 (n)
  • 94.23 (a)
AKAP17A 36
  • 22 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKAP17A 35
  • 86.94 (n)
  • 87.61 (a)
-- 36
  • 88 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Akap17b 36
  • 22 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKAP17A 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves AKAP17A 35
  • 67.08 (n)
  • 75.27 (a)
AKAP17A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKAP17A 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia akap17a 35
  • 61.38 (n)
  • 67.99 (a)
Str.10670 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32104 35
zebrafish
(Danio rerio)
Actinopterygii akap17a 35
  • 74.44 (n)
  • 72.65 (a)
zgc65888 35
akap17a 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Xe7 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cux-7 36
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8023 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5814 36
  • 49 (a)
OneToOne
Species with no ortholog for AKAP17A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AKAP17A Gene

ENSEMBL:
Gene Tree for AKAP17A (if available)
TreeFam:
Gene Tree for AKAP17A (if available)

Paralogs for AKAP17A Gene

(1) SIMAP similar genes for AKAP17A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for AKAP17A Gene

genes like me logo Genes that share paralogs with AKAP17A: view

No data available for Paralogs for AKAP17A Gene

Variants for AKAP17A Gene

Sequence variations from dbSNP and Humsavar for AKAP17A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_055353 -

Structural Variations from Database of Genomic Variants (DGV) for AKAP17A Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
nsv510811 CNV Loss 20534489
esv2739739 CNV Deletion 23290073
esv2657890 CNV Deletion 23128226
esv2314773 CNV Deletion 18987734
esv2739741 CNV Deletion 23290073
esv2739742 CNV Deletion 23290073
nsv510871 CNV Loss 20534489

Variation tolerance for AKAP17A Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKAP17A Gene

HapMap Linkage Disequilibrium report
AKAP17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKAP17A Gene

Disorders for AKAP17A Gene

MalaCards: The human disease database

(2) MalaCards diseases for AKAP17A Gene - From: DISEASES

Disorder Aliases PubMed IDs
null-cell leukemia
  • null cell acute lymphoblastic leukemia
chronic tic disorder
  • chronic motor
- elite association

Relevant External Links for AKAP17A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKAP17A
genes like me logo Genes that share disorders with AKAP17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKAP17A Gene

Publications for AKAP17A Gene

  1. Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments. (PMID: 19840947) Jarnaess E. … Tasken K. (J. Biol. Chem. 2009) 2 67
  2. Standardized flow cytometry gating in veterinary medicine. (PMID: 11264953) Byrne K.M. … Hayek M.G. (Methods Cell Sci 2000) 23 67
  3. Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL. (PMID: 9736779) Ried K. … Rappold G.A. (Hum. Mol. Genet. 1998) 2 67
  4. Radiolabeled-antibody therapy of B-cell lymphoma with autologous bone marrow support. (PMID: 7692295) Press O.W. … Porter B. (N. Engl. J. Med. 1993) 23 67
  5. Cloning and sequencing of a trophoblast-endothelial-activated lymphocyte surface protein: cDNA sequence and genomic structure. (PMID: 1438229) Voland J.R. … Dutton R.W. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 67

Products for AKAP17A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate AKAP17A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for AKAP17A
  • Block miRNA regulation of AKAP17A using miScript Target Protectors

Sources for AKAP17A Gene

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