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Aliases for GTPBP6 Gene

Aliases for GTPBP6 Gene

  • GTP Binding Protein 6 (Putative) 2 3
  • PGPL 3 4 6
  • Pseudoautosomal GTP Binding Protein-Like 2
  • Pseudoautosomal GTP-Binding Protein-Like 4
  • Putative GTP-Binding Protein 6 3

External Ids for GTPBP6 Gene

Previous GeneCards Identifiers for GTPBP6 Gene

  • GC0YM000160
  • GC0XM000161
  • GC00U931416

Summaries for GTPBP6 Gene

Entrez Gene Summary for GTPBP6 Gene

  • This gene encodes a GTP binding protein and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. [provided by RefSeq, Nov 2011]

GeneCards Summary for GTPBP6 Gene

GTPBP6 (GTP Binding Protein 6 (Putative)) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

Gene Wiki entry for GTPBP6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP6 Gene

Genomics for GTPBP6 Gene

Regulatory Elements for GTPBP6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GTPBP6 Gene

304,529 bp from pter
318,819 bp from pter
14,291 bases
Minus strand

Genomic View for GTPBP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GTPBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP6 Gene

Proteins for GTPBP6 Gene

  • Protein details for GTPBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative GTP-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • Q53F77
    • Q5HYX8

    Protein attributes for GTPBP6 Gene

    516 amino acids
    Molecular mass:
    56883 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes
    • Sequence=AAH14636.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP36024.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD97132.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA74749.2; Type=Miscellaneous discrepancy; Note=Has an upstream in-frame stop codon because of a region of poor sequence quality.; Evidence={ECO:0000305};

neXtProt entry for GTPBP6 Gene

Proteomics data for GTPBP6 Gene at MOPED

Post-translational modifications for GTPBP6 Gene

  • Ubiquitination at Lys155 and Lys509
  • Modification sites at PhosphoSitePlus

Other Protein References for GTPBP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GTPBP6 Gene

Domains for GTPBP6 Gene

Gene Families for GTPBP6 Gene

  • PAR1 :Pseudoautosomal regions / PAR1

Suggested Antigen Peptide Sequences for GTPBP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O43824
  • Contains 1 Hflx-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
genes like me logo Genes that share domains with GTPBP6: view

Function for GTPBP6 Gene

Gene Ontology (GO) - Molecular Function for GTPBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GTPBP6: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTPBP6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GTPBP6 Gene

Localization for GTPBP6 Gene

Subcellular locations from

Jensen Localization Image for GTPBP6 Gene COMPARTMENTS Subcellular localization image for GTPBP6 gene
Compartment Confidence
nucleus 2
cytosol 1
endosome 1
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GTPBP6 Gene

Pathways for GTPBP6 Gene

SuperPathways for GTPBP6 Gene

No Data Available

Interacting Proteins for GTPBP6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000316598 O43824-GTPB6_HUMAN for GTPBP6 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for GTPBP6 Gene


No data available for Pathways by source for GTPBP6 Gene

Compounds for GTPBP6 Gene

(1) HMDB Compounds for GTPBP6 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP

(1) Novoseek inferred chemical compound relationships for GTPBP6 Gene

Compound -log(P) Hits PubMed IDs
gtp 56.3 4
genes like me logo Genes that share compounds with GTPBP6: view

Transcripts for GTPBP6 Gene

Unigene Clusters for GTPBP6 Gene

GTP binding protein 6 (putative):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GTPBP6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP6 Gene

No ASD Table

Relevant External Links for GTPBP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTPBP6 Gene

mRNA expression in normal human tissues for GTPBP6 Gene

Protein differential expression in normal tissues for GTPBP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.6), Blymphocyte (10.6), Pancreas (9.6), and Ovary (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GTPBP6 Gene

SOURCE GeneReport for Unigene cluster for GTPBP6 Gene Hs.437145

mRNA Expression by UniProt/SwissProt for GTPBP6 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with GTPBP6: view

Expression partners for GTPBP6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GTPBP6 Gene

Orthologs for GTPBP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTPBP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GTPBP6 35
  • 77.69 (n)
  • 75.15 (a)
(Canis familiaris)
Mammalia GTPBP6 35
  • 78.71 (n)
  • 73.98 (a)
  • 43 (a)
(Mus musculus)
Mammalia Gtpbp6 35
  • 68.26 (n)
  • 63.94 (a)
107999 16
Gtpbp6 36
  • 37 (a)
(Monodelphis domestica)
Mammalia GTPBP6 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
-- 36
  • 68 (a)
(Gallus gallus)
Aves GTPBP6 35
  • 64.97 (n)
  • 70.14 (a)
  • 39 (a)
(Anolis carolinensis)
Reptilia GTPBP6 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp6 35
  • 62.19 (n)
  • 66.98 (a)
(Danio rerio)
Actinopterygii wu:fc56b07 35
  • 62.05 (n)
  • 63.85 (a)
wufl82e09 35
gtpbp6 36
  • 35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13061 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003969 35
  • 53.28 (n)
  • 42.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5116 35
  • 50.4 (n)
  • 42.03 (a)
CG5116 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea F46B6.4 35
  • 45.89 (n)
  • 38.4 (a)
F46B6.4 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5044 36
  • 28 (a)
Species with no ortholog for GTPBP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP6 Gene

Gene Tree for GTPBP6 (if available)
Gene Tree for GTPBP6 (if available)

Paralogs for GTPBP6 Gene

No data available for Paralogs for GTPBP6 Gene

Variants for GTPBP6 Gene

Structural Variations from Database of Genomic Variants (DGV) for GTPBP6 Gene

Variant ID Type Subtype PubMed ID
esv27600 CNV Gain+Loss 19812545
esv2673995 CNV Deletion 23128226
esv2352842 CNV Deletion 18987734

Relevant External Links for GTPBP6 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GTPBP6 Gene

Disorders for GTPBP6 Gene

No disorders were found for GTPBP6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GTPBP6 Gene

Publications for GTPBP6 Gene

  1. A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere. (PMID: 9466997) Gianfrancesco F. … Forabosco A. (Hum. Mol. Genet. 1998) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for GTPBP6 Gene

Sources for GTPBP6 Gene

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