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Aliases for GTPBP6 Gene

Aliases for GTPBP6 Gene

  • GTP Binding Protein 6 (Putative) 2 3 5
  • PGPL 3 4
  • Pseudoautosomal GTP Binding Protein-Like 2
  • Pseudoautosomal GTP-Binding Protein-Like 4

External Ids for GTPBP6 Gene

Previous GeneCards Identifiers for GTPBP6 Gene

  • GC0YM000160
  • GC0XM000161
  • GC00U931416

Summaries for GTPBP6 Gene

Entrez Gene Summary for GTPBP6 Gene

  • This gene encodes a GTP binding protein and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. [provided by RefSeq, Nov 2011]

GeneCards Summary for GTPBP6 Gene

GTPBP6 (GTP Binding Protein 6 (Putative)) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

Gene Wiki entry for GTPBP6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP6 Gene

Genomics for GTPBP6 Gene

Regulatory Elements for GTPBP6 Gene

Genomic Location for GTPBP6 Gene

Chromosome:
X
Start:
303,357 bp from pter
End:
318,819 bp from pter
Size:
15,463 bases
Orientation:
Minus strand

Genomic View for GTPBP6 Gene

Genes around GTPBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTPBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTPBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP6 Gene

Proteins for GTPBP6 Gene

  • Protein details for GTPBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43824-GTPB6_HUMAN
    Recommended name:
    Putative GTP-binding protein 6
    Protein Accession:
    O43824
    Secondary Accessions:
    • Q53F77
    • Q5HYX8

    Protein attributes for GTPBP6 Gene

    Size:
    516 amino acids
    Molecular mass:
    56883 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    SequenceCaution:
    • Sequence=AAH14636.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP36024.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD97132.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA74749.2; Type=Miscellaneous discrepancy; Note=Has an upstream in-frame stop codon because of a region of poor sequence quality.; Evidence={ECO:0000305};

neXtProt entry for GTPBP6 Gene

Proteomics data for GTPBP6 Gene at MOPED

Post-translational modifications for GTPBP6 Gene

  • Ubiquitination at Lys 155 and Lys 509
  • Modification sites at PhosphoSitePlus

Other Protein References for GTPBP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GTPBP6 Gene

Domains & Families for GTPBP6 Gene

Gene Families for GTPBP6 Gene

Suggested Antigen Peptide Sequences for GTPBP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43824

UniProtKB/Swiss-Prot:

GTPB6_HUMAN :
  • Contains 1 Hflx-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
Domain:
  • Contains 1 Hflx-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
genes like me logo Genes that share domains with GTPBP6: view

Function for GTPBP6 Gene

Gene Ontology (GO) - Molecular Function for GTPBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
GO:0043022 ribosome binding IBA --
genes like me logo Genes that share ontologies with GTPBP6: view

Phenotypes for GTPBP6 Gene

GenomeRNAi human phenotypes for GTPBP6:
genes like me logo Genes that share phenotypes with GTPBP6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GTPBP6 Gene

Localization for GTPBP6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GTPBP6 Gene COMPARTMENTS Subcellular localization image for GTPBP6 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1
golgi apparatus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GTPBP6 Gene

Pathways & Interactions for GTPBP6 Gene

SuperPathways for GTPBP6 Gene

No Data Available

Interacting Proteins for GTPBP6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000316598%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000316598 O43824-GTPB6_HUMAN for GTPBP6 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for GTPBP6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GTPBP6 Gene

Drugs & Compounds for GTPBP6 Gene

(1) Drugs for GTPBP6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GTPBP6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GTPBP6: view

Transcripts for GTPBP6 Gene

Unigene Clusters for GTPBP6 Gene

GTP binding protein 6 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP6 Gene

No ASD Table

Relevant External Links for GTPBP6 Gene

GeneLoc Exon Structure for
GTPBP6
ECgene alternative splicing isoforms for
GTPBP6

Expression for GTPBP6 Gene

mRNA expression in normal human tissues for GTPBP6 Gene

Protein differential expression in normal tissues from HIPED for GTPBP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.6), Blymphocyte (10.6), Pancreas (9.6), and Ovary (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GTPBP6 Gene



SOURCE GeneReport for Unigene cluster for GTPBP6 Gene Hs.437145

mRNA Expression by UniProt/SwissProt for GTPBP6 Gene

O43824-GTPB6_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with GTPBP6: view

Protein tissue co-expression partners for GTPBP6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GTPBP6 Gene

Orthologs for GTPBP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTPBP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GTPBP6 35
  • 77.69 (n)
  • 75.15 (a)
dog
(Canis familiaris)
Mammalia GTPBP6 35
  • 78.71 (n)
  • 73.98 (a)
GTPBP6 36
  • 43 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gtpbp6 35
  • 68.26 (n)
  • 63.94 (a)
Gtpbp6 16
Gtpbp6 36
  • 37 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTPBP6 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves GTPBP6 35
  • 64.97 (n)
  • 70.14 (a)
GTPBP6 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTPBP6 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp6 35
  • 62.19 (n)
  • 66.98 (a)
zebrafish
(Danio rerio)
Actinopterygii wu:fc56b07 35
  • 62.05 (n)
  • 63.85 (a)
wufl82e09 35
gtpbp6 36
  • 35 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13061 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003969 35
  • 53.28 (n)
  • 42.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5116 35
  • 50.4 (n)
  • 42.03 (a)
CG5116 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F46B6.4 35
  • 45.89 (n)
  • 38.4 (a)
F46B6.4 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5044 36
  • 28 (a)
OneToOne
Species with no ortholog for GTPBP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP6 Gene

ENSEMBL:
Gene Tree for GTPBP6 (if available)
TreeFam:
Gene Tree for GTPBP6 (if available)

Paralogs for GTPBP6 Gene

No data available for Paralogs for GTPBP6 Gene

Variants for GTPBP6 Gene

Structural Variations from Database of Genomic Variants (DGV) for GTPBP6 Gene

Variant ID Type Subtype PubMed ID
esv27600 CNV Gain+Loss 19812545
esv2673995 CNV Deletion 23128226
esv2352842 CNV Deletion 18987734

Variation tolerance for GTPBP6 Gene

Gene Damage Index Score: 5.28; 70.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTPBP6 Gene

HapMap Linkage Disequilibrium report
GTPBP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GTPBP6 Gene

Disorders for GTPBP6 Gene

Relevant External Links for GTPBP6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTPBP6

No disorders were found for GTPBP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTPBP6 Gene

Publications for GTPBP6 Gene

  1. A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere. (PMID: 9466997) Gianfrancesco F. … Forabosco A. (Hum. Mol. Genet. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition. (PMID: 17347996) Vawter M.P. … DeLisi L.E. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GTPBP6 Gene

Sources for GTPBP6 Gene

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