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Aliases for CANX Gene

Aliases for CANX Gene

  • Calnexin 2 3 5
  • Major Histocompatibility Complex Class I Antigen-Binding Protein P88 2 3 4
  • IP90 3 4
  • P90 3 4
  • CNX 3

External Ids for CANX Gene

Previous GeneCards Identifiers for CANX Gene

  • GC05P179238
  • GC05P180070
  • GC05P179190
  • GC05P179235
  • GC05P179058
  • GC05P179105
  • GC05P173852

Summaries for CANX Gene

Entrez Gene Summary for CANX Gene

  • This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CANX Gene

CANX (Calnexin) is a Protein Coding gene. Diseases associated with CANX include cystic fibrosis and granulocytopenia. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include poly(A) RNA binding and carbohydrate binding. An important paralog of this gene is CALR.

UniProtKB/Swiss-Prot for CANX Gene

  • Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

Gene Wiki entry for CANX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CANX Gene

Genomics for CANX Gene

Regulatory Elements for CANX Gene

Promoters for CANX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CANX on UCSC Golden Path with GeneCards custom track

Genomic Location for CANX Gene

Chromosome:
5
Start:
179,678,628 bp from pter
End:
179,731,641 bp from pter
Size:
53,014 bases
Orientation:
Plus strand

Genomic View for CANX Gene

Genes around CANX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CANX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CANX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CANX Gene

Proteins for CANX Gene

  • Protein details for CANX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27824-CALX_HUMAN
    Recommended name:
    Calnexin
    Protein Accession:
    P27824
    Secondary Accessions:
    • B2R5V8
    • B4DGP8
    • B4E2T8
    • D3DWQ3
    • D6R9K3

    Protein attributes for CANX Gene

    Size:
    592 amino acids
    Molecular mass:
    67568 Da
    Quaternary structure:
    • Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (PubMed:16361248). Associates with ribosomes (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (PubMed:22314232). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (PubMed:23826168). Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP (PubMed:22016385). Interacts with PPIB (PubMed:20801878). Interacts with ZNRF4 (PubMed:21205830).

    Alternative splice isoforms for CANX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CANX Gene

Proteomics data for CANX Gene at MOPED

Post-translational modifications for CANX Gene

  • Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.
  • Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
  • Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.
  • Ubiquitination at Lys 103, Lys 118, Lys 137, Lys 170, Lys 182, Lys 227, Lys 398, Lys 401, and Lys 515
  • Glycosylation at Thr 59, Thr 66, and Thr 79
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CANX (Calnexin)

No data available for DME Specific Peptides for CANX Gene

Domains & Families for CANX Gene

Protein Domains for CANX Gene

Suggested Antigen Peptide Sequences for CANX Gene

Graphical View of Domain Structure for InterPro Entry

P27824

UniProtKB/Swiss-Prot:

CALX_HUMAN :
  • Belongs to the calreticulin family.
Family:
  • Belongs to the calreticulin family.
genes like me logo Genes that share domains with CANX: view

No data available for Gene Families for CANX Gene

Function for CANX Gene

Molecular function for CANX Gene

GENATLAS Biochemistry:
calnexin,90kDa,integral membrane,calcium binding protein,chaperone,interacting with an ER-located peptide transporter for peptide translocation into microsomes
UniProtKB/Swiss-Prot Function:
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

Gene Ontology (GO) - Molecular Function for CANX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034185 apolipoprotein binding IEA --
genes like me logo Genes that share ontologies with CANX: view
genes like me logo Genes that share phenotypes with CANX: view

Animal Models for CANX Gene

MGI Knock Outs for CANX:

Animal Model Products

miRNA for CANX Gene

miRTarBase miRNAs that target CANX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CANX Gene

Localization for CANX Gene

Subcellular locations from UniProtKB/Swiss-Prot for CANX Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232). {ECO:0000269 PubMed:12643545, ECO:0000269 PubMed:17081065, ECO:0000269 PubMed:22314232}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CANX Gene COMPARTMENTS Subcellular localization image for CANX gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
cytosol 2
endosome 2
golgi apparatus 2
lysosome 2
plasma membrane 2
vacuole 2
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CANX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IDA 19723497
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with CANX: view

Pathways & Interactions for CANX Gene

genes like me logo Genes that share pathways with CANX: view

Gene Ontology (GO) - Biological Process for CANX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0034975 protein folding in endoplasmic reticulum TAS 22013210
GO:0072583 clathrin-mediated endocytosis ISS --
genes like me logo Genes that share ontologies with CANX: view

No data available for SIGNOR curated interactions for CANX Gene

Drugs & Compounds for CANX Gene

(16) Drugs for CANX Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antihemophilic Factor Approved, Investigational Pharma Target, chaperone 0
Tenecteplase Approved Pharma Target 39
calcium Nutra 0

(22) Additional Compounds for CANX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CANX: view

Transcripts for CANX Gene

Unigene Clusters for CANX Gene

Calnexin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CANX Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - -
SP6:
SP7: - - -
SP8: -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CANX Gene

GeneLoc Exon Structure for
CANX
ECgene alternative splicing isoforms for
CANX

Expression for CANX Gene

mRNA expression in normal human tissues for CANX Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CANX Gene



SOURCE GeneReport for Unigene cluster for CANX Gene Hs.567968

genes like me logo Genes that share expression patterns with CANX: view

Protein tissue co-expression partners for CANX Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CANX Gene

Orthologs for CANX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CANX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CANX 35
  • 99.38 (n)
  • 99.32 (a)
CANX 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CANX 36
  • 94 (a)
OneToOne
CANX 35
  • 90.69 (n)
  • 94.75 (a)
dog
(Canis familiaris)
Mammalia CANX 35
  • 91.6 (n)
  • 95.43 (a)
CANX 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Canx 16
Canx 35
  • 88.31 (n)
  • 92.2 (a)
Canx 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CANX 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Canx 35
  • 89.47 (n)
  • 93.04 (a)
chicken
(Gallus gallus)
Aves CANX 36
  • 83 (a)
OneToOne
CANX 35
  • 79.44 (n)
  • 84.58 (a)
lizard
(Anolis carolinensis)
Reptilia CANX 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia canx 35
  • 73.42 (n)
  • 79.05 (a)
zebrafish
(Danio rerio)
Actinopterygii canx 35
  • 69.78 (n)
  • 70.29 (a)
wufc27b06 35
canx 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005032 35
  • 57.81 (n)
  • 57.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1924 36
  • 44 (a)
ManyToMany
Cnx14D 36
  • 45 (a)
ManyToMany
Cnx99A 36
  • 44 (a)
ManyToMany
CG1924 37
  • 49 (a)
CG9906 37
  • 47 (a)
Cnx99A 37
  • 61 (a)
Cnx14D 35
  • 57.23 (n)
  • 54.72 (a)
worm
(Caenorhabditis elegans)
Secernentea cnx-1 37
  • 47 (a)
cnx-1 36
  • 40 (a)
OneToMany
cnx-1 35
  • 55.9 (n)
  • 47.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNE1 36
  • 29 (a)
OneToMany
CNE1 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2586 35
soybean
(Glycine max)
eudicotyledons Gma.6427 35
thale cress
(Arabidopsis thaliana)
eudicotyledons CNX1 35
  • 58.25 (n)
  • 52.83 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3581 35
corn
(Zea mays)
Liliopsida Zm.2862 35
rice
(Oryza sativa)
Liliopsida Os.11092 35
Os04g0402100 35
  • 57.68 (n)
  • 51.79 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2538 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14852 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for CANX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CANX Gene

ENSEMBL:
Gene Tree for CANX (if available)
TreeFam:
Gene Tree for CANX (if available)

Paralogs for CANX Gene

Paralogs for CANX Gene

genes like me logo Genes that share paralogs with CANX: view

Variants for CANX Gene

Sequence variations from dbSNP and Humsavar for CANX Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs7566 -- 179,729,448(+) AGGAA(C/T)GCTAG utr-variant-3-prime
rs10387 -- 179,730,153(+) TTCTT(C/T)AGAGG utr-variant-3-prime
rs14539 -- 179,729,192(+) CTAAG(A/G)AAATT utr-variant-3-prime
rs1134924 -- 179,699,089(+) GGTCC(C/T)CGGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1135895 -- 179,730,818(+) TGCCC(A/C)CTCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CANX Gene

Variant ID Type Subtype PubMed ID
nsv883270 CNV Loss 21882294
nsv830560 CNV Loss 17160897
nsv5160 CNV Insertion 18451855

Variation tolerance for CANX Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CANX Gene

HapMap Linkage Disequilibrium report
CANX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CANX Gene

Disorders for CANX Gene

MalaCards: The human disease database

(6) MalaCards diseases for CANX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
granulocytopenia
  • agranulocytosis
lateral medullary syndrome
  • vertebral artery syndrome
glossopharyngeal neuralgia
  • glossovasopharyngeal neuralgia
charcot-marie-tooth disease
  • charcot marie tooth muscular atrophy
- elite association - COSMIC cancer census association via MalaCards
Search CANX in MalaCards View complete list of genes associated with diseases

Relevant External Links for CANX

Genetic Association Database (GAD)
CANX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CANX
genes like me logo Genes that share disorders with CANX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CANX Gene

Publications for CANX Gene

  1. Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. (PMID: 8136357) Tjoelker L.W. … Gray P.W. (Biochemistry 1994) 2 3 4 23 67
  2. The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. (PMID: 1326756) Galvin K. … Ozturk M. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 23
  3. Mapping of domains on HIV envelope protein mediating association with calnexin and protein-disulfide isomerase. (PMID: 20202930) PapandrAcou M.J. … Fenouillet E. (J. Biol. Chem. 2010) 3 23
  4. Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinal. (PMID: 19801547) Noorwez S.M. … Kaushal S. (J. Biol. Chem. 2009) 3 23
  5. Calnexin phosphorylation attenuates the release of partially misfolded alpha1-antitrypsin to the secretory pathway. (PMID: 19815548) Cameron P.H. … Bergeron J.J. (J. Biol. Chem. 2009) 3 23

Products for CANX Gene

Sources for CANX Gene

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