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Aliases for CANX Gene

Aliases for CANX Gene

  • Calnexin 2 3
  • Major Histocompatibility Complex Class I Antigen-Binding Protein P88 2 3 4
  • IP90 3 4
  • P90 3 4
  • CNX 3

External Ids for CANX Gene

Previous GeneCards Identifiers for CANX Gene

  • GC05P179238
  • GC05P180070
  • GC05P179190
  • GC05P179235
  • GC05P179058
  • GC05P179105
  • GC05P173852

Summaries for CANX Gene

Entrez Gene Summary for CANX Gene

  • This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CANX Gene

CANX (Calnexin) is a Protein Coding gene. Diseases associated with CANX include orbital melanoma. Among its related pathways are Disease and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include calcium ion binding and apolipoprotein binding. An important paralog of this gene is CALR.

UniProtKB/Swiss-Prot for CANX Gene

  • Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse

Gene Wiki entry for CANX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CANX Gene

Genomics for CANX Gene

Regulatory Elements for CANX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CANX Gene

Start:
179,678,628 bp from pter
End:
179,731,641 bp from pter
Size:
53,014 bases
Orientation:
Plus strand

Genomic View for CANX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CANX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CANX Gene

Proteins for CANX Gene

  • Protein details for CANX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27824-CALX_HUMAN
    Recommended name:
    Calnexin
    Protein Accession:
    P27824
    Secondary Accessions:
    • B2R5V8
    • B4DGP8
    • B4E2T8
    • D3DWQ3
    • D6R9K3

    Protein attributes for CANX Gene

    Size:
    592 amino acids
    Molecular mass:
    67568 Da
    Quaternary structure:
    • Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins. Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP. Interacts with PPIB.

    Alternative splice isoforms for CANX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CANX Gene

Proteomics data for CANX Gene at MOPED

Post-translational modifications for CANX Gene

  • Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.
  • Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
  • Ubiquitination at Lys103, Lys118, Lys137, Lys170, Lys182, Lys227, Lys398, Lys401, and Lys515
  • Glycosylation at Thr59, Thr66, and Thr79
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CANX (Calnexin)

No data available for DME Specific Peptides for CANX Gene

Domains for CANX Gene

Protein Domains for CANX Gene

Suggested Antigen Peptide Sequences for CANX Gene

Graphical View of Domain Structure for InterPro Entry

P27824

UniProtKB/Swiss-Prot:

CALX_HUMAN :
  • P27824
Family:
  • Belongs to the calreticulin family.
genes like me logo Genes that share domains with CANX: view

No data available for Gene Families for CANX Gene

Function for CANX Gene

Molecular function for CANX Gene

GENATLAS Biochemistry: calnexin,90kDa,integral membrane,calcium binding protein,chaperone,interacting with an ER-located peptide transporter for peptide translocation into microsomes
UniProtKB/Swiss-Prot Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse

Gene Ontology (GO) - Molecular Function for CANX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16361248
GO:0030246 carbohydrate binding IEA --
GO:0034185 apolipoprotein binding IEA --
genes like me logo Genes that share ontologies with CANX: view
genes like me logo Genes that share phenotypes with CANX: view

Animal Models for CANX Gene

MGI Knock Outs for CANX:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CANX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CANX Gene

Localization for CANX Gene

Subcellular locations from UniProtKB/Swiss-Prot for CANX Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form preferentially localizes to the perinuclear rough ER.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CANX Gene COMPARTMENTS Subcellular localization image for CANX gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
golgi apparatus 2
plasma membrane 2
vacuole 2
cytoskeleton 1
endosome 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CANX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum IDA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IDA 19723497
GO:0005790 smooth endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with CANX: view

Pathways for CANX Gene

genes like me logo Genes that share pathways with CANX: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CANX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006457 protein folding TAS --
GO:0007568 aging IEA --
GO:0009306 protein secretion TAS 8055875
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with CANX: view

Compounds for CANX Gene

(1) HMDB Compounds for CANX Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Drugbank Compounds for CANX Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Antihemophilic Factor
  • AHF
target chaperone
Tenecteplase
  • t- PA
191588-94-0 target

(36) Novoseek inferred chemical compound relationships for CANX Gene

Compound -log(P) Hits PubMed IDs
castanospermine 91.6 29
dolichyl diphosphate 80.5 1
man9(glcnac)2 70.8 1
tunicamycin 70.7 13
polysaccharide 66.9 36
genes like me logo Genes that share compounds with CANX: view

Transcripts for CANX Gene

Unigene Clusters for CANX Gene

Calnexin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CANX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CANX Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - -
SP6:
SP7: - - -
SP8: -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CANX Gene

GeneLoc Exon Structure for
CANX
ECgene alternative splicing isoforms for
CANX

Expression for CANX Gene

mRNA expression in normal human tissues for CANX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CANX Gene

SOURCE GeneReport for Unigene cluster for CANX Gene Hs.567968

genes like me logo Genes that share expressions with CANX: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CANX Gene

Orthologs for CANX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CANX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CANX 35
  • 99.38 (n)
  • 99.32 (a)
CANX 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CANX 35
  • 90.69 (n)
  • 94.75 (a)
CANX 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CANX 35
  • 91.6 (n)
  • 95.43 (a)
CANX 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Canx 35
  • 88.31 (n)
  • 92.2 (a)
Canx 16
Canx 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CANX 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Canx 35
  • 89.47 (n)
  • 93.04 (a)
chicken
(Gallus gallus)
Aves CANX 35
  • 79.44 (n)
  • 84.58 (a)
CANX 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CANX 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia canx 35
  • 73.42 (n)
  • 79.05 (a)
zebrafish
(Danio rerio)
Actinopterygii canx 35
  • 69.78 (n)
  • 70.29 (a)
canx 36
  • 71 (a)
OneToOne
wufc27b06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005032 35
  • 57.81 (n)
  • 57.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1924 36
  • 44 (a)
ManyToMany
Cnx14D 35
  • 57.23 (n)
  • 54.72 (a)
Cnx14D 36
  • 45 (a)
ManyToMany
Cnx99A 36
  • 44 (a)
ManyToMany
CG1924 37
  • 49 (a)
Cnx99A 37
  • 61 (a)
CG9906 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea cnx-1 35
  • 55.9 (n)
  • 47.79 (a)
cnx-1 36
  • 40 (a)
OneToMany
cnx-1 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNE1 36
  • 29 (a)
OneToMany
CNE1 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2586 35
soybean
(Glycine max)
eudicotyledons Gma.6427 35
thale cress
(Arabidopsis thaliana)
eudicotyledons CNX1 35
  • 58.25 (n)
  • 52.83 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3581 35
corn
(Zea mays)
Liliopsida Zm.2862 35
rice
(Oryza sativa)
Liliopsida Os.11092 35
Os04g0402100 35
  • 57.68 (n)
  • 51.79 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2538 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14852 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for CANX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CANX Gene

ENSEMBL:
Gene Tree for CANX (if available)
TreeFam:
Gene Tree for CANX (if available)

Paralogs for CANX Gene

Paralogs for CANX Gene

genes like me logo Genes that share paralogs with CANX: view

Variants for CANX Gene

Sequence variations from dbSNP and Humsavar for CANX Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6639 -- 179,729,781(+) GACTT(G/T)AGAAG utr-variant-3-prime
rs7566 -- 179,729,448(+) AGGAA(C/T)GCTAG utr-variant-3-prime
rs10387 -- 179,730,153(+) TTCTT(C/T)AGAGG utr-variant-3-prime
rs14539 -- 179,729,192(+) CTAAG(A/G)AAATT utr-variant-3-prime
rs1134924 -- 179,699,089(+) GGTCC(C/T)CGGGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CANX Gene

Variant ID Type Subtype PubMed ID
nsv883270 CNV Loss 21882294
nsv830560 CNV Loss 17160897
nsv5160 CNV Insertion 18451855

Relevant External Links for CANX Gene

HapMap Linkage Disequilibrium report
CANX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CANX Gene

Disorders for CANX Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CANX Gene including...

Search for CANX Gene in MalaCards »

(1) University of Copenhagen DISEASES for CANX Gene

(16) Novoseek inferred disease relationships for CANX Gene

Disease -log(P) Hits PubMed IDs
cystic fibrosis 40 3
albinism 37.1 1
shock 17.5 6
mastocytoma 15.2 1
influenza 14.4 4

Relevant External Links for CANX

Genetic Association Database (GAD)
CANX
genes like me logo Genes that share disorders with CANX: view

No data available for UniProtKB/Swiss-Prot for CANX Gene

Publications for CANX Gene

  1. The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. (PMID: 1326756) Galvin K. … Ozturk M. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23
  2. Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. (PMID: 8136357) Tjoelker L.W. … Gray P.W. (Biochemistry 1994) 2 3 4 23
  3. The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin. (PMID: 8055875) Honore B. … Celis J.E. (Electrophoresis 1994) 3 4 23
  4. The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly. (PMID: 8163531) Lenter M. … Vestweber D. (J. Biol. Chem. 1994) 3 23
  5. Retention of unassembled components of integral membrane proteins by calnexin. (PMID: 8278814) Rajagopalan S. … Brenner M.B. (Science 1994) 3 23

Products for CANX Gene

Sources for CANX Gene

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