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Aliases for CAMP Gene

Aliases for CAMP Gene

  • Cathelicidin Antimicrobial Peptide 2 3 5
  • 18 KDa Cationic Antimicrobial Protein 3 4
  • CAP-18 3 4
  • FALL39 3 4
  • CAP18 3 4
  • FALL-39 3
  • HCAP-18 4
  • CRAMP 3
  • HSD26 3
  • LL37 3

External Ids for CAMP Gene

Previous GeneCards Identifiers for CAMP Gene

  • GC03P048066
  • GC03P047547
  • GC03P048225
  • GC03P048240
  • GC03P048264

Summaries for CAMP Gene

Entrez Gene Summary for CAMP Gene

  • This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CAMP Gene

CAMP (Cathelicidin Antimicrobial Peptide) is a Protein Coding gene. Diseases associated with CAMP include Rosacea and Mycobacterium Marinum. Among its related pathways are Tuberculosis and Innate Immune System.

UniProtKB/Swiss-Prot for CAMP Gene

  • Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.

Gene Wiki entry for CAMP Gene

Additional gene information for CAMP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMP Gene

Genomics for CAMP Gene

Regulatory Elements for CAMP Gene

Enhancers for CAMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H048267 0.9 Ensembl ENCODE 11 +45.3 45335 3.2 PAF1 MNT ELF1 PAX8 ZFHX2 POLR2A BCL11A IKZF1 NBN KLF9 ZNF589 WDR6 FBXW12 PLXNB1 CDC25A NME6 SPINK8 CAMP ENSG00000244380 ATRIP
GH03H048247 0.8 Ensembl ENCODE 11.2 +24.7 24695 2.1 SOX6 IKZF1 MLLT1 NFE2 SPI1 CAMP NME6 CDC25A FBXW12 CCDC51 TMA7 ATRIP SPINK8 RNU7-128P NDUFB1P1
GH03H048412 0.5 dbSUPER 10.1 +191.2 191235 4.2 POLR2A FOS RAD21 TMA7 ATRIP ZNF589 FBXW12 CCDC51 ENSG00000244380 NME6 SPINK8 CAMP CDC25A
GH03H048221 1.1 Ensembl ENCODE 0.7 -0.3 -326 2.4 CTCF NFIB ZNF133 MAX CEBPG ZFHX2 ZNF766 CTBP1 POLR2A EED CDC25A NDUFB1P1 RNU7-128P NME6 SPINK8 ZNF589 PIR41492 CAMP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAMP on UCSC Golden Path with GeneCards custom track

Genomic Locations for CAMP Gene

Genomic Locations for CAMP Gene
2,145 bases
Plus strand

Genomic View for CAMP Gene

Genes around CAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMP Gene

Proteins for CAMP Gene

  • Protein details for CAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathelicidin antimicrobial peptide
    Protein Accession:
    Secondary Accessions:
    • Q71SN9

    Protein attributes for CAMP Gene

    170 amino acids
    Molecular mass:
    19301 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAMP Gene

neXtProt entry for CAMP Gene

Post-translational modifications for CAMP Gene

Other Protein References for CAMP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CAMP (CAMP/LL37/FALL39)

Assay Products

No data available for DME Specific Peptides for CAMP Gene

Domains & Families for CAMP Gene

Gene Families for CAMP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CAMP Gene

Suggested Antigen Peptide Sequences for CAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cathelicidin family.
  • Belongs to the cathelicidin family.
genes like me logo Genes that share domains with CAMP: view

Function for CAMP Gene

Molecular function for CAMP Gene

GENATLAS Biochemistry:
cathelicidin cationic antimicrobial peptide,cathelin family,expressed in the specific granules of neutrophils,also expressed in bone marrow and testis
UniProtKB/Swiss-Prot Function:
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
genes like me logo Genes that share phenotypes with CAMP: view

Animal Models for CAMP Gene

MGI Knock Outs for CAMP:

Animal Model Products

miRNA for CAMP Gene

miRTarBase miRNAs that target CAMP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMP Gene

Localization for CAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMP gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IDA,IEA 12759353
GO:0005737 cytoplasm IEA --
GO:0035580 specific granule lumen TAS --
GO:0042581 specific granule IEA,IDA 12759353
genes like me logo Genes that share ontologies with CAMP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CAMP Gene

Pathways & Interactions for CAMP Gene

genes like me logo Genes that share pathways with CAMP: view

Pathways by source for CAMP Gene

Interacting Proteins for CAMP Gene

SIGNOR curated interactions for CAMP Gene


Gene Ontology (GO) - Biological Process for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006952 defense response IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0019730 antimicrobial humoral response TAS --
GO:0019731 antibacterial humoral response IDA 12860195
genes like me logo Genes that share ontologies with CAMP: view

Drugs & Compounds for CAMP Gene

(50) Drugs for CAMP Gene - From: DrugBank, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitoxantrone Approved, Investigational Pharma 276
Prednisone Approved, Vet_approved Pharma 1436
Selenocysteine Experimental Pharma Target 0
Analgesics Pharma 12159
Anti-Inflammatory Agents Pharma 11061

(34) Additional Compounds for CAMP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) ApexBio Compounds for CAMP Gene

Compound Action Cas Number
6-Bnz-cAMP sodium salt cAMP analog,PKA activator 1135306-29-4
8-Bromo-cAMP, sodium salt cAMP-analogue 76939-46-3
cAMPS-Rp, triethylammonium salt 151837-09-1
cAMPS-Sp, triethylammonium salt
Dibutyryl-cAMP, sodium salt 16980-89-5
genes like me logo Genes that share compounds with CAMP: view

Drug Products

Transcripts for CAMP Gene

mRNA/cDNA for CAMP Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMP Gene

Cathelicidin antimicrobial peptide:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMP Gene

No ASD Table

Relevant External Links for CAMP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMP Gene

This gene is overexpressed in Whole Blood (x45.6).

Protein differential expression in normal tissues from HIPED for CAMP Gene

This gene is overexpressed in Nasal epithelium (25.5), Neutrophil (12.7), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAMP Gene

Protein tissue co-expression partners for CAMP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMP Gene:


SOURCE GeneReport for Unigene cluster for CAMP Gene:


mRNA Expression by UniProt/SwissProt for CAMP Gene:

Tissue specificity: Expressed in bone marrow and testis and neutrophils.

Evidence on tissue expression from TISSUES for CAMP Gene

  • Bone marrow(4.7)
  • Blood(3.4)
  • Lung(3.1)
  • Muscle(2.8)
  • Skin(2.5)
  • Spleen(2.5)
  • Nervous system(2.4)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with CAMP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMP Gene

Orthologs for CAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAMP 33 34
  • 99.41 (n)
(Bos Taurus)
Mammalia CATHL5 33 34
  • 78.12 (n)
-- 34
  • 60 (a)
  • 59 (a)
-- 34
  • 58 (a)
  • 57 (a)
  • 56 (a)
CATHL1 34 34
  • 54 (a)
  • 49 (a)
-- 34
  • 46 (a)
  • 45 (a)
(Canis familiaris)
Mammalia CAMP 33 34
  • 76.39 (n)
(Rattus norvegicus)
Mammalia Camp 33
  • 72.62 (n)
(Mus musculus)
Mammalia Camp 33 16 34
  • 70.48 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 35 (a)
-- 34
  • 34 (a)
-- 34
  • 28 (a)
-- 34
  • 26 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 32 (a)
-- 34
  • 32 (a)
-- 34
  • 23 (a)
-- 34
  • 22 (a)
-- 34
  • 20 (a)
-- 34
  • 9 (a)
(Anolis carolinensis)
Reptilia CAMP 34
  • 25 (a)
Species where no ortholog for CAMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CAMP Gene

Gene Tree for CAMP (if available)
Gene Tree for CAMP (if available)

Paralogs for CAMP Gene

No data available for Paralogs for CAMP Gene

Variants for CAMP Gene

Sequence variations from dbSNP and Humsavar for CAMP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000630674 -- 48,225,763(+) GAGGT(A/G)ACATT downstream-variant-500B
rs1001795751 -- 48,223,252(+) TGGCT(A/C)TGACA upstream-variant-2KB
rs1002905688 -- 48,225,711(+) TACTC(-/TG)TGTGT downstream-variant-500B
rs1003641539 -- 48,224,236(+) AGCCC(A/G)GCACC intron-variant
rs1004600702 -- 48,222,736(+) CCCTT(G/T)CAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAMP Gene

Variant ID Type Subtype PubMed ID
nsv834682 CNV gain 17160897

Variation tolerance for CAMP Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMP Gene

Disorders for CAMP Gene

MalaCards: The human disease database

(46) MalaCards diseases for CAMP Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • acne roscea
mycobacterium marinum
  • fish tank granuloma
anal spasm
guttate psoriasis
  • psoriasis guttate
- elite association - COSMIC cancer census association via MalaCards
Search CAMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAMP

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CAMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMP Gene

Publications for CAMP Gene

  1. Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. (PMID: 7890387) Larrick JW … Wright SC (Infection and immunity 1995) 3 4 22 60
  2. Injury downregulates the expression of the human cathelicidin protein hCAP18/LL-37 in atopic dermatitis. (PMID: 19645825) Mallbris L … Ståhle M (Experimental dermatology 2010) 3 22 60
  3. LL-37 promotes rapid sensing of CpG oligodeoxynucleotides by B lymphocytes and plasmacytoid dendritic cells. (PMID: 20042575) Hurtado P … Peh CA (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 22 60
  4. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. (PMID: 20190140) Niyonsaba F … Okumura K (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 22 60
  5. Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis. (PMID: 19133797) Gombart AF … Thadhani R (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009) 3 22 60

Products for CAMP Gene

Sources for CAMP Gene

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