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Aliases for CAMP Gene

Aliases for CAMP Gene

  • Cathelicidin Antimicrobial Peptide 2 3
  • 18 KDa Cationic Antimicrobial Protein 3 4
  • CAP-18 3 4
  • FALL39 3 4
  • CAP18 3 4
  • FALL-39 3
  • HCAP-18 4
  • CRAMP 3
  • HSD26 3
  • LL37 3

External Ids for CAMP Gene

Previous GeneCards Identifiers for CAMP Gene

  • GC03P048066
  • GC03P047547
  • GC03P048225
  • GC03P048240
  • GC03P048264

Summaries for CAMP Gene

Entrez Gene Summary for CAMP Gene

  • This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CAMP Gene

CAMP (Cathelicidin Antimicrobial Peptide) is a Protein Coding gene. Diseases associated with CAMP include mycobacterium marinum and guttate psoriasis. Among its related pathways are Immune System and Integrated Pancreatic Cancer Pathway.

UniProtKB/Swiss-Prot for CAMP Gene

  • Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.

Gene Wiki entry for CAMP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMP Gene

Genomics for CAMP Gene

Regulatory Elements for CAMP Gene

Genomic Location for CAMP Gene

Chromosome:
3
Start:
48,223,347 bp from pter
End:
48,225,491 bp from pter
Size:
2,145 bases
Orientation:
Plus strand

Genomic View for CAMP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMP Gene

Proteins for CAMP Gene

  • Protein details for CAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49913-CAMP_HUMAN
    Recommended name:
    Cathelicidin antimicrobial peptide
    Protein Accession:
    P49913
    Secondary Accessions:
    • Q71SN9

    Protein attributes for CAMP Gene

    Size:
    170 amino acids
    Molecular mass:
    19301 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAMP Gene

neXtProt entry for CAMP Gene

Proteomics data for CAMP Gene at MOPED

Post-translational modifications for CAMP Gene

Other Protein References for CAMP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CAMP (CAMP/LL37/FALL39)

No data available for DME Specific Peptides for CAMP Gene

Domains & Families for CAMP Gene

Gene Families for CAMP Gene

Protein Domains for CAMP Gene

Suggested Antigen Peptide Sequences for CAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49913

UniProtKB/Swiss-Prot:

CAMP_HUMAN :
  • Belongs to the cathelicidin family.
Family:
  • Belongs to the cathelicidin family.
genes like me logo Genes that share domains with CAMP: view

Function for CAMP Gene

Molecular function for CAMP Gene

GENATLAS Biochemistry:
cathelicidin cationic antimicrobial peptide,cathelin family,expressed in the specific granules of neutrophils,also expressed in bone marrow and testis
UniProtKB/Swiss-Prot Function:
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.

Gene Ontology (GO) - Molecular Function for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21685939
genes like me logo Genes that share ontologies with CAMP: view
genes like me logo Genes that share phenotypes with CAMP: view

Animal Models for CAMP Gene

MGI Knock Outs for CAMP:

Animal Model Products

miRNA for CAMP Gene

miRTarBase miRNAs that target CAMP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CAMP Gene

Localization for CAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMP Gene

Secreted.

Gene Ontology (GO) - Cellular Components for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 12759353
GO:0005618 cell wall TAS --
GO:0005622 intracellular IDA 9182550
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with CAMP: view

No data available for Subcellular locations from COMPARTMENTS for CAMP Gene

Pathways & Interactions for CAMP Gene

genes like me logo Genes that share pathways with CAMP: view

Pathways by source for CAMP Gene

2 BioSystems pathways for CAMP Gene
2 Reactome pathways for CAMP Gene
2 KEGG pathways for CAMP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat

Interacting Proteins for CAMP Gene

SIGNOR curated interactions for CAMP Gene

Activates:

Gene Ontology (GO) - Biological Process for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IDA 14978112
GO:0001934 positive regulation of protein phosphorylation --
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0002544 chronic inflammatory response IMP 9182550
GO:0006952 defense response --
genes like me logo Genes that share ontologies with CAMP: view

Drugs & Compounds for CAMP Gene

(32) Drugs for CAMP Gene - From: NovoSeek, DrugBank, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitoxantrone Approved, Investigational Pharma 246
Prednisone Approved Pharma 1208
Dexamethasone Approved, Investigational Pharma Agonist 1806
Estradiol Approved, Investigational Pharma Sex hormone 1057
Heparin Approved, Investigational Pharma Antagonist 672,226

(38) Additional Compounds for CAMP Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-pgf2-alpha
1,25 DIHYDROXY VITAMIN D3
25-hydroxyvitamin d
8-bromo-cyclic amp
Actinomycin D
genes like me logo Genes that share compounds with CAMP: view

Transcripts for CAMP Gene

mRNA/cDNA for CAMP Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMP Gene

Cathelicidin antimicrobial peptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMP Gene

No ASD Table

Relevant External Links for CAMP Gene

GeneLoc Exon Structure for
CAMP
ECgene alternative splicing isoforms for
CAMP

Expression for CAMP Gene

mRNA expression in normal human tissues for CAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMP Gene

This gene is overexpressed in Whole Blood (x45.6).

Protein differential expression in normal tissues from HIPED for CAMP Gene

This gene is overexpressed in Nasal epithelium (25.5), Neutrophil (12.7), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAMP Gene



SOURCE GeneReport for Unigene cluster for CAMP Gene Hs.51120

mRNA Expression by UniProt/SwissProt for CAMP Gene

P49913-CAMP_HUMAN
Tissue specificity: Expressed in bone marrow and testis and neutrophils
genes like me logo Genes that share expression patterns with CAMP: view

Protein tissue co-expression partners for CAMP Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMP 36
  • 99 (a)
OneToOne
CAMP 35
  • 99.41 (n)
  • 99.41 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Camp 36
  • 55 (a)
OneToOne
Camp 16
Camp 35
  • 70.48 (n)
  • 54.82 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
-- 36
  • 9 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CAMP 36
  • 58 (a)
OneToOne
CAMP 35
  • 76.39 (n)
  • 58.93 (a)
cow
(Bos Taurus)
Mammalia CATHL7 36
  • 59 (a)
OneToMany
CATHL6 36
  • 56 (a)
OneToMany
CATHL5 36
  • 56 (a)
OneToMany
CATHL4 36
  • 57 (a)
OneToMany
CATHL3 36
  • 45 (a)
OneToMany
CATHL2 36
  • 49 (a)
OneToMany
CATHL1 36
  • 54 (a)
OneToMany
CATHL1 36
  • 54 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
CATHL5 35
  • 78.12 (n)
  • 68.75 (a)
rat
(Rattus norvegicus)
Mammalia Camp 35
  • 72.62 (n)
  • 58.33 (a)
lizard
(Anolis carolinensis)
Reptilia CAMP 36
  • 25 (a)
OneToOne
Species with no ortholog for CAMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CAMP Gene

ENSEMBL:
Gene Tree for CAMP (if available)
TreeFam:
Gene Tree for CAMP (if available)

Paralogs for CAMP Gene

No data available for Paralogs for CAMP Gene

Variants for CAMP Gene

Sequence variations from dbSNP and Humsavar for CAMP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6796498 -- 48,225,715(+) CTGTG(G/T)GTGGT downstream-variant-500B
rs7645101 -- 48,224,479(+) GCTGG(G/T)GGTGT intron-variant
rs9844566 -- 48,223,299(+) GAAAC(C/G)ACTTC upstream-variant-2KB
rs9844812 -- 48,223,232(+) TTAAC(A/G)CTCTT upstream-variant-2KB
rs34721542 -- 48,224,089(+) CCCCA(-/G)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMP Gene

Variant ID Type Subtype PubMed ID
nsv834682 CNV Gain 17160897

Variation tolerance for CAMP Gene

Residual Variation Intolerance Score: 76.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMP Gene

HapMap Linkage Disequilibrium report
CAMP
Human Gene Mutation Database (HGMD)
CAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMP Gene

Disorders for CAMP Gene

MalaCards: The human disease database

(7) MalaCards diseases for CAMP Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
mycobacterium marinum
  • fish tank granuloma
guttate psoriasis
  • psoriasis guttate
cellulitis
eczema herpeticum
  • herpes simplex dermatitis
coffin-lowry syndrome
  • cls
- elite association
Search CAMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAMP

Human Genome Epidemiology (HuGE) Navigator
CAMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMP
genes like me logo Genes that share disorders with CAMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMP Gene

Publications for CAMP Gene

  1. Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skin in vivo. (PMID: 19878298) Heilborn J.D. … StAYhle M. (Exp. Dermatol. 2010) 23 67
  2. Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. (PMID: 19948723) Wang T.T. … White J.H. (J. Biol. Chem. 2010) 23 67
  3. Effect of nicotine on advanced glycation end product-induced immune response in human monocytes. (PMID: 19955489) Takahashi H.K. … Nishibori M. (J. Pharmacol. Exp. Ther. 2010) 23 67
  4. CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP. (PMID: 20360387) Carascossa S. … Picard D. (Genes Dev. 2010) 23 67
  5. Injury downregulates the expression of the human cathelicidin protein hCAP18/LL-37 in atopic dermatitis. (PMID: 19645825) Mallbris L. … StAYhle M. (Exp. Dermatol. 2010) 23 67

Products for CAMP Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CAMP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CAMP
    • Block miRNA regulation of CAMP using miScript Target Protectors

    Sources for CAMP Gene

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