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Aliases for LAS1L Gene

Aliases for LAS1L Gene

  • LAS1-Like (S. Cerevisiae) 2 3
  • Protein LAS1 Homolog 3 4
  • Ribosomal Biogenesis Protein LAS1L 3
  • Las1-Like 3
  • DJ475B7.2 3

External Ids for LAS1L Gene

Summaries for LAS1L Gene

GeneCards Summary for LAS1L Gene

LAS1L (LAS1-Like (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with LAS1L include spinal muscular atrophy with respiratory distress type 2.

UniProtKB/Swiss-Prot for LAS1L Gene

  • Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Wiki entry for LAS1L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAS1L Gene

Genomics for LAS1L Gene

Genomic Location for LAS1L Gene

Start:
65,512,582 bp from pter
End:
65,534,806 bp from pter
Size:
22,225 bases
Orientation:
Minus strand

Genomic View for LAS1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAS1L Gene

Regulatory Elements for LAS1L Gene

Proteins for LAS1L Gene

  • Protein details for LAS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4W2-LAS1L_HUMAN
    Recommended name:
    Ribosomal biogenesis protein LAS1L
    Protein Accession:
    Q9Y4W2
    Secondary Accessions:
    • A9X410
    • Q5JXQ0
    • Q8TEN5
    • Q9H9V5

    Protein attributes for LAS1L Gene

    Size:
    734 amino acids
    Molecular mass:
    83065 Da
    Quaternary structure:
    • Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.
    SequenceCaution:
    • Sequence=BAB84913.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for LAS1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAS1L Gene

Proteomics data for LAS1L Gene at MOPED

Post-translational modifications for LAS1L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys31, Lys64, Lys98, Lys139, Lys263, Lys286, Lys295, Lys312, Lys365, Lys376, Lys486, Lys499, Lys540, and Lys691

Other Protein References for LAS1L Gene

No data available for DME Specific Peptides for LAS1L Gene

Domains for LAS1L Gene

Protein Domains for LAS1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAS1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4W2

UniProtKB/Swiss-Prot:

LAS1L_HUMAN
Family:
  • Belongs to the LAS1 family.:
    • Q9Y4W2
genes like me logo Genes that share domains with LAS1L: view

No data available for Gene Families for LAS1L Gene

Function for LAS1L Gene

Molecular function for LAS1L Gene

UniProtKB/Swiss-Prot Function: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Ontology (GO) - Molecular Function for LAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with LAS1L: view

Phenotypes for LAS1L Gene

genes like me logo Genes that share phenotypes with LAS1L: view

miRNA for LAS1L Gene

miRTarBase miRNAs that target LAS1L

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LAS1L Gene

Localization for LAS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAS1L Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAS1L Gene COMPARTMENTS Subcellular localization image for LAS1L gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for LAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with LAS1L: view

Pathways for LAS1L Gene

SuperPathways for LAS1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for LAS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with LAS1L: view

No data available for Pathways by source for LAS1L Gene

Transcripts for LAS1L Gene

Unigene Clusters for LAS1L Gene

LAS1-like (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAS1L Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ·
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6: - -
SP7: - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - -
SP11: - -
SP12:
SP13:
SP14: - - - -
SP15:
SP16:
SP17:

ExUns: 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:
SP12: -
SP13: -
SP14: -
SP15:
SP16:
SP17:

Relevant External Links for LAS1L Gene

GeneLoc Exon Structure for
LAS1L
ECgene alternative splicing isoforms for
LAS1L

Expression for LAS1L Gene

mRNA expression in normal human tissues for LAS1L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAS1L Gene

SOURCE GeneReport for Unigene cluster for LAS1L Gene Hs.522675

genes like me logo Genes that share expressions with LAS1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LAS1L Gene

Orthologs for LAS1L Gene

This gene was present in the common ancestor of animals.

Orthologs for LAS1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAS1L 35
  • 91.33 (n)
  • 89.39 (a)
LAS1L 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LAS1L 35
  • 87.71 (n)
  • 82.49 (a)
LAS1L 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAS1L 35
  • 87.63 (n)
  • 85.27 (a)
LAS1L 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Las1l 35
  • 78.94 (n)
  • 73.33 (a)
Las1l 16
Las1l 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia LAS1L 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Las1l 35
  • 79.19 (n)
  • 71.15 (a)
chicken
(Gallus gallus)
Aves LAS1L 35
  • 54.08 (n)
  • 42.07 (a)
LAS1L 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAS1L 36
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.28968 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.751 35
zebrafish
(Danio rerio)
Actinopterygii las1l 36
  • 37 (a)
OneToOne
LOC561321 35
  • 51.73 (n)
  • 41.8 (a)
worm
(Caenorhabditis elegans)
Secernentea Y6B3B.9 36
  • 21 (a)
OneToOne
Species with no ortholog for LAS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LAS1L Gene

ENSEMBL:
Gene Tree for LAS1L (if available)
TreeFam:
Gene Tree for LAS1L (if available)

Paralogs for LAS1L Gene

No data available for Paralogs for LAS1L Gene

Variants for LAS1L Gene

Sequence variations from dbSNP and Humsavar for LAS1L Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs926806 -- 65,532,283(+) gcagg(C/T)gctgt intron-variant
rs1051802 -- 65,512,649(-) TGTCC(A/C)CCACA utr-variant-3-prime, nc-transcript-variant
rs2747381 -- 65,519,577(+) GATGA(A/C)ACTGT intron-variant
rs2747382 -- 65,519,597(+) AGACG(A/G)CGCCA intron-variant
rs3192187 -- 65,512,646(-) CCACC(A/C)CAGGG utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for LAS1L Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354

Relevant External Links for LAS1L Gene

HapMap Linkage Disequilibrium report
LAS1L
Human Gene Mutation Database (HGMD)
LAS1L
Locus Specific Mutation Databases (LSDB)
LAS1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAS1L Gene

Disorders for LAS1L Gene

genes like me logo Genes that share disorders with LAS1L: view

No data available for UniProtKB/Swiss-Prot for LAS1L Gene

Publications for LAS1L Gene

  1. Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis. (PMID: 20647540) Castle C.D. … Denicourt C. (Mol. Cell. Biol. 2010) 3 4
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for LAS1L Gene

Sources for LAS1L Gene

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