Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLR10 Gene

Aliases for TLR10 Gene

  • Toll Like Receptor 10 2 3
  • Toll-Like Receptor 10 2 5
  • CD290 Antigen 4
  • CD290 3

External Ids for TLR10 Gene

Previous GeneCards Identifiers for TLR10 Gene

  • GC04P039119
  • GC04M038938
  • GC04M038609
  • GC04M038671
  • GC04M038597
  • GC04M038450
  • GC04M038098

Summaries for TLR10 Gene

Entrez Gene Summary for TLR10 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for TLR10 Gene

TLR10 (Toll Like Receptor 10) is a Protein Coding gene. Diseases associated with TLR10 include superficial basal cell carcinoma and tonsillitis. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR10 Gene

  • Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Gene Wiki entry for TLR10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR10 Gene

Genomics for TLR10 Gene

Regulatory Elements for TLR10 Gene

Promoters for TLR10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLR10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLR10 Gene

Chromosome:
4
Start:
38,772,238 bp from pter
End:
38,782,990 bp from pter
Size:
10,753 bases
Orientation:
Minus strand

Genomic View for TLR10 Gene

Genes around TLR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR10 Gene

Proteins for TLR10 Gene

  • Protein details for TLR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXR5-TLR10_HUMAN
    Recommended name:
    Toll-like receptor 10
    Protein Accession:
    Q9BXR5
    Secondary Accessions:
    • A8K7L1
    • B3Y668
    • D1CS21
    • D1CS22
    • Q32MI7
    • Q32MI8
    • Q5FWG4
    • Q6UXL3

    Protein attributes for TLR10 Gene

    Size:
    811 amino acids
    Molecular mass:
    94564 Da
    Quaternary structure:
    • Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).

    Three dimensional structures from OCA and Proteopedia for TLR10 Gene

neXtProt entry for TLR10 Gene

Proteomics data for TLR10 Gene at MOPED

Post-translational modifications for TLR10 Gene

  • Glycosylation at Asn 33, Asn 36, Asn 140, Asn 189, Asn 236, Asn 278, Asn 330, Asn 416, and Asn 427
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TLR10 Gene

Domains & Families for TLR10 Gene

Gene Families for TLR10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXR5

UniProtKB/Swiss-Prot:

TLR10_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the Toll-like receptor family.
  • Contains 15 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR10: view

Function for TLR10 Gene

Molecular function for TLR10 Gene

UniProtKB/Swiss-Prot Function:
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Animal Model Products

CRISPR Products

miRNA for TLR10 Gene

miRTarBase miRNAs that target TLR10

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLR10 Gene

Localization for TLR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR10 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR10 Gene COMPARTMENTS Subcellular localization image for TLR10 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
endoplasmic reticulum 2
endosome 2
lysosome 2
mitochondrion 2
nucleus 2
peroxisome 2
vacuole 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TLR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 11267672
genes like me logo Genes that share ontologies with TLR10: view

Pathways & Interactions for TLR10 Gene

genes like me logo Genes that share pathways with TLR10: view

Gene Ontology (GO) - Biological Process for TLR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway IBA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction IEA --
GO:0045087 innate immune response IEA,TAS --
GO:0050729 positive regulation of inflammatory response IEA --
genes like me logo Genes that share ontologies with TLR10: view

No data available for SIGNOR curated interactions for TLR10 Gene

Drugs & Compounds for TLR10 Gene

No Compound Related Data Available

Transcripts for TLR10 Gene

Unigene Clusters for TLR10 Gene

Toll-like receptor 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLR10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - - - - -
SP3: - -
SP4: - - - -
SP5:
SP6:
SP7: - - - - -

Relevant External Links for TLR10 Gene

GeneLoc Exon Structure for
TLR10
ECgene alternative splicing isoforms for
TLR10

Expression for TLR10 Gene

mRNA expression in normal human tissues for TLR10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR10 Gene

This gene is overexpressed in Spleen (x8.0) and Whole Blood (x5.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLR10 Gene



SOURCE GeneReport for Unigene cluster for TLR10 Gene Hs.120551

mRNA Expression by UniProt/SwissProt for TLR10 Gene

Q9BXR5-TLR10_HUMAN
Tissue specificity: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.
genes like me logo Genes that share expression patterns with TLR10: view

Protein tissue co-expression partners for TLR10 Gene

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues for TLR10 Gene

Orthologs for TLR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLR10 35
  • 85.94 (n)
  • 80.64 (a)
TLR10 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLR10 35
  • 87.36 (n)
  • 82.03 (a)
TLR10 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLR10 35
  • 99.22 (n)
  • 99.26 (a)
TLR10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr10 35
  • 77.75 (n)
  • 71.2 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 13 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TLR10 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLR1LA 36
  • 48 (a)
ManyToMany
TLR1LB 36
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii tlr1 36
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Toll-9 36
  • 18 (a)
OneToMany
Species with no ortholog for TLR10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR10 Gene

ENSEMBL:
Gene Tree for TLR10 (if available)
TreeFam:
Gene Tree for TLR10 (if available)

Paralogs for TLR10 Gene

Paralogs for TLR10 Gene

genes like me logo Genes that share paralogs with TLR10: view

Variants for TLR10 Gene

Sequence variations from dbSNP and Humsavar for TLR10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11466649 - 38,775,104(-) AAATT(G/T)CTCAT reference, missense
rs11096957 - 38,774,870(-) TAGAA(A/C)ATGCT reference, missense
rs11466653 - 38,774,614(-) CAAAA(C/T)GGACA reference, missense
rs11096955 - 38,774,486(-) GAACT(A/C/G)TCCAA reference, missense
rs11466655 - 38,774,449(-) GAATG(A/G)CAATA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TLR10 Gene

Variant ID Type Subtype PubMed ID
esv275476 CNV Gain+Loss 21479260

Variation tolerance for TLR10 Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.63; 96.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLR10 Gene

HapMap Linkage Disequilibrium report
TLR10
Human Gene Mutation Database (HGMD)
TLR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLR10 Gene

Disorders for TLR10 Gene

MalaCards: The human disease database

(9) MalaCards diseases for TLR10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
superficial basal cell carcinoma
  • multicentric basal cell carcinoma
tonsillitis
  • chronic tonsillitis
melioidosis
  • acute and fulminating melioidosis
anogenital venereal wart
  • anogenital human papilloma virus infectious disease
irak4 deficiency
  • irak-4 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search TLR10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLR10

Genetic Association Database (GAD)
TLR10
Human Genome Epidemiology (HuGE) Navigator
TLR10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLR10
genes like me logo Genes that share disorders with TLR10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR10 Gene

Publications for TLR10 Gene

  1. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. (PMID: 11267672) Chuang T.-H. … Ulevitch R.J. (Biochim. Biophys. Acta 2001) 2 3 4 67
  2. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. (PMID: 20348427) Guan Y. … Tapping R.I. (J. Immunol. 2010) 3 23
  3. Association of interleukin-13/-4 and toll-like receptor 10 with preterm births. (PMID: 19332998) Heinzmann A. … Krueger M. (Neonatology 2009) 3 23
  4. The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. (PMID: 18332149) Nyman T. … Nordlund P. (J. Biol. Chem. 2008) 3 23
  5. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. (PMID: 18752252) Stevens V.L. … Rodriguez C. (Int. J. Cancer 2008) 3 23

Products for TLR10 Gene

Sources for TLR10 Gene

Back to Top

Content