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Aliases for ADAMTS12 Gene

Aliases for ADAMTS12 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 12 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 12 2 3
  • ADAM-TS 12 3 4
  • ADAM-TS12 3 4
  • ADAMTS-12 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 12 3
  • EC 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • PRO4389 3

External Ids for ADAMTS12 Gene

Previous GeneCards Identifiers for ADAMTS12 Gene

  • GC05M033471
  • GC05M033973
  • GC05M033572
  • GC05M033563

Summaries for ADAMTS12 Gene

Entrez Gene Summary for ADAMTS12 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS12 Gene

ADAMTS12 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 12) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTSL1.

UniProtKB/Swiss-Prot for ADAMTS12 Gene

  • Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.

Gene Wiki entry for ADAMTS12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS12 Gene

Genomics for ADAMTS12 Gene

Regulatory Elements for ADAMTS12 Gene

Genomic Location for ADAMTS12 Gene

33,523,535 bp from pter
33,892,192 bp from pter
368,658 bases
Minus strand

Genomic View for ADAMTS12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS12 Gene

Proteins for ADAMTS12 Gene

  • Protein details for ADAMTS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 12
    Protein Accession:
    Secondary Accessions:
    • A2RRN9
    • A5D6V6
    • Q6UWL3

    Protein attributes for ADAMTS12 Gene

    1594 amino acids
    Molecular mass:
    177676 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with COMP.

    Alternative splice isoforms for ADAMTS12 Gene


neXtProt entry for ADAMTS12 Gene

Proteomics data for ADAMTS12 Gene at MOPED

Selected DME Specific Peptides for ADAMTS12 Gene

Post-translational modifications for ADAMTS12 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • Subjected to an intracellular maturation process yielding a 120 kDa N-terminal fragment containing the metalloproteinase, disintegrin, one TSP type-1 and the Cys-rich domains and a 83 kDa C-terminal fragment containing the spacer 2 and four TSP type-1 domains
  • The precursor is cleaved by a furin endopeptidase
  • Glycosylation at Asn105, Asn125, Asn215, Asn485, Asn685, Asn790, Asn952, Asn1105, Asn1276, Asn1301, Asn1321, Asn1372, Asn1379, and Asn1504
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ADAMTS12 Gene

Gene Families for ADAMTS12 Gene

Suggested Antigen Peptide Sequences for ADAMTS12 Gene

Graphical View of Domain Structure for InterPro Entry



  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The C-terminal four TSP1-like repeats are necessary and sufficient for binding COMP
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 1 PLAC domain.
  • Contains 8 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS12: view

Function for ADAMTS12 Gene

Molecular function for ADAMTS12 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is between 7.5 and 9.5 with COMP for substrate. {ECO:0000269 PubMed:16611630};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by alpha-2 macroglobulin.
UniProtKB/Swiss-Prot Function:
Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.
UniProtKB/Swiss-Prot Induction:
By IFN-alpha and by IL1B/interleukin-1 beta. Up-regulated in articular cartilage and synovium from arthritis patients. Up-regulared in chondrocytes.

Enzyme Numbers (IUBMB) for ADAMTS12 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IDA 16611630
GO:0005515 protein binding IPI 16611630
GO:0008233 peptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS12: view

Phenotypes for ADAMTS12 Gene

genes like me logo Genes that share phenotypes with ADAMTS12: view

Animal Models for ADAMTS12 Gene

MGI Knock Outs for ADAMTS12:

Animal Model Products

miRNA for ADAMTS12 Gene

miRTarBase miRNAs that target ADAMTS12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS12

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ADAMTS12 Gene

Localization for ADAMTS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS12 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for ADAMTS12 Gene COMPARTMENTS Subcellular localization image for ADAMTS12 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 extracellular matrix IDA 11279086
genes like me logo Genes that share ontologies with ADAMTS12: view

Pathways for ADAMTS12 Gene

SuperPathways for ADAMTS12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADAMTS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0007160 cell-matrix adhesion IMP 21494557
GO:0016477 cell migration IMP 21494557
GO:0030167 proteoglycan catabolic process IDA 17895370
GO:0032331 negative regulation of chondrocyte differentiation IDA 22247065
genes like me logo Genes that share ontologies with ADAMTS12: view

No data available for Pathways by source for ADAMTS12 Gene

Transcripts for ADAMTS12 Gene

Unigene Clusters for ADAMTS12 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS12 Gene

No ASD Table

Relevant External Links for ADAMTS12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS12 Gene

mRNA expression in normal human tissues for ADAMTS12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS12 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.3).

Protein differential expression in normal tissues for ADAMTS12 Gene

This gene is overexpressed in Lung (68.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAMTS12 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS12 Gene Hs.12680

mRNA Expression by UniProt/SwissProt for ADAMTS12 Gene

Tissue specificity: Expressed in skeletal muscle and fat. Detected at significant levels in fetal lung. Widely expressed in gastric carcinomas and in cancer cells of diverse origin.
genes like me logo Genes that share expressions with ADAMTS12: view

Expression partners for ADAMTS12 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for ADAMTS12 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAMTS12 35
  • 86.59 (n)
  • 84.41 (a)
  • 84 (a)
(Canis familiaris)
Mammalia ADAMTS12 35
  • 85.9 (n)
  • 85.12 (a)
  • 67 (a)
(Mus musculus)
Mammalia Adamts12 35
  • 82.53 (n)
  • 81.07 (a)
Adamts12 16
Adamts12 36
  • 80 (a)
(Pan troglodytes)
Mammalia ADAMTS12 35
  • 99.22 (n)
  • 98.92 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Adamts12 35
  • 82.79 (n)
  • 81.37 (a)
(Monodelphis domestica)
Mammalia ADAMTS12 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 87 (a)
-- 36
  • 62 (a)
(Gallus gallus)
Aves ADAMTS12 35
  • 66.42 (n)
  • 62.68 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
-- 36
  • 20 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts12 35
  • 61.89 (n)
  • 59.31 (a)
(Danio rerio)
Actinopterygii LOC100003937 35
  • 57.88 (n)
  • 52.31 (a)
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3622 37
  • 27 (a)
CG4096 37
  • 39 (a)
CG4096 36
  • 35 (a)
stl 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea C37C3.6a 37
  • 35 (a)
C37C3.6b 37
  • 35 (a)
T19D2.1 37
  • 27 (a)
adt-1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for ADAMTS12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS12 Gene

Gene Tree for ADAMTS12 (if available)
Gene Tree for ADAMTS12 (if available)

Paralogs for ADAMTS12 Gene

(11) SIMAP similar genes for ADAMTS12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADAMTS12: view

Variants for ADAMTS12 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS12 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs25754 - 33,534,955(+) GGACA(A/G)TCCTC reference, missense
rs25755 -- 33,535,709(+) ATCTG(G/T)GTCGT intron-variant
rs27404 -- 33,536,511(+) TTTAT(C/G)CCTTC intron-variant
rs27675 -- 33,531,770(+) TTCTT(A/G)GAAAC intron-variant
rs27975 -- 33,533,574(+) AACAC(C/T)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS12 Gene

Variant ID Type Subtype PubMed ID
nsv522715 CNV Gain 19592680
nsv830253 CNV Loss 17160897
nsv818344 CNV Loss 17921354
dgv1793e1 CNV Complex 17122850
nsv525683 CNV Loss 19592680
esv26135 CNV Gain 19812545
nsv4780 CNV Insertion 18451855
esv2659139 CNV Deletion 23128226
nsv509061 CNV Insertion 20534489
esv1004172 CNV Insertion 20482838
esv272783 CNV Insertion 20981092
esv271611 CNV Insertion 20981092
esv1490875 CNV Insertion 17803354
nsv509966 CNV Loss 20534489
esv2730048 CNV Deletion 23290073
esv2306417 CNV Deletion 18987734
esv2730049 CNV Deletion 23290073
esv2623201 CNV Deletion 19546169
nsv327771 CNV Loss 16902084
esv2730050 CNV Deletion 23290073
esv24231 CNV Loss 19812545
esv989506 CNV Deletion 20482838
nsv830254 CNV Loss 17160897
nsv4781 CNV Insertion 18451855
esv268005 CNV Insertion 20981092
esv273639 CNV Insertion 20981092
esv2730052 CNV Deletion 23290073
nsv4782 CNV Insertion 18451855
dgv22e24 CNV Gain 17666407
esv270198 CNV Insertion 20981092
esv33441 CNV Gain 17666407
esv1422494 CNV Insertion 17803354
esv32546 CNV Gain 17666407

Relevant External Links for ADAMTS12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS12 Gene

Disorders for ADAMTS12 Gene

Relevant External Links for ADAMTS12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ADAMTS12 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ADAMTS12 Gene

Publications for ADAMTS12 Gene

  1. Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. (PMID: 11279086) Cal S. … Lopez-Otin C. (J. Biol. Chem. 2001) 2 3 4
  2. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. (PMID: 18485748) Luan Y. … Liu C.-J. (Osteoarthritis Cartilage 2008) 3 4 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity. (PMID: 19151918) Bai X.H. … Liu C.J. (Cell. Mol. Life Sci. 2009) 3 23
  5. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. (PMID: 19098927) Liu C.J. (Nat Clin Pract Rheumatol 2009) 3 23

Products for ADAMTS12 Gene

Sources for ADAMTS12 Gene

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