Aliases for ELL Gene
External Ids for ELL Gene
Previous Symbols for ELL Gene
GeneCards Summary for ELL Gene
ELL (Elongation Factor RNA Polymerase II) is a Protein Coding gene. Diseases associated with ELL include leukemia. Among its related pathways are Disease and Gene Expression. GO annotations related to this gene include phosphatase binding. An important paralog of this gene is ELL3.
UniProtKB/Swiss-Prot for ELL Gene
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.