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Aliases for SLC14A2 Gene

Aliases for SLC14A2 Gene

  • Solute Carrier Family 14 (Urea Transporter), Member 2 2 3
  • UT2 3 4 6
  • Solute Carrier Family 14 Member 2 3 4
  • Urea Transporter, Kidney 3 4
  • HUT2 3 4
  • UTR 3 6
  • Urea Transporter 2 3
  • Urea Transporter-2 3
  • HUT-A6 3
  • UT-A2 3
  • UTA 3

External Ids for SLC14A2 Gene

Previous GeneCards Identifiers for SLC14A2 Gene

  • GC18P043517
  • GC18P042991
  • GC18P041456
  • GC18P041446
  • GC18P041448
  • GC18P043194
  • GC18P040052
  • GC18P042747
  • GC18P042792

Summaries for SLC14A2 Gene

Entrez Gene Summary for SLC14A2 Gene

  • The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for SLC14A2 Gene

SLC14A2 (Solute Carrier Family 14 (Urea Transporter), Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include urea transmembrane transporter activity. An important paralog of this gene is SLC14A1.

UniProtKB/Swiss-Prot for SLC14A2 Gene

  • Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.

Gene Wiki entry for SLC14A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC14A2 Gene

Genomics for SLC14A2 Gene

Regulatory Elements for SLC14A2 Gene

Genomic Location for SLC14A2 Gene

Start:
45,212,982 bp from pter
End:
45,683,686 bp from pter
Size:
470,705 bases
Orientation:
Plus strand

Genomic View for SLC14A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC14A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC14A2 Gene

Proteins for SLC14A2 Gene

  • Protein details for SLC14A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15849-UT2_HUMAN
    Recommended name:
    Urea transporter 2
    Protein Accession:
    Q15849
    Secondary Accessions:
    • A8K8Q7
    • Q2TBD6
    • Q96PH5

    Protein attributes for SLC14A2 Gene

    Size:
    920 amino acids
    Molecular mass:
    101209 Da
    Quaternary structure:
    • Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane.

    Alternative splice isoforms for SLC14A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC14A2 Gene

Proteomics data for SLC14A2 Gene at MOPED

Post-translational modifications for SLC14A2 Gene

  • Glycosylation at Asn733
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC14A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC14A2 Gene

Domains for SLC14A2 Gene

Gene Families for SLC14A2 Gene

Protein Domains for SLC14A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15849

UniProtKB/Swiss-Prot:

UT2_HUMAN :
  • Q15849
Family:
  • Belongs to the urea transporter family.
genes like me logo Genes that share domains with SLC14A2: view

Function for SLC14A2 Gene

Molecular function for SLC14A2 Gene

GENATLAS Biochemistry: solute carrier family (urea transport),member 2,expressed in kidney
UniProtKB/Swiss-Prot Function: Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.
UniProtKB/Swiss-Prot Induction: Isoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration

Gene Ontology (GO) - Molecular Function for SLC14A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17702749
GO:0015204 urea transmembrane transporter activity IEA --
GO:0050839 cell adhesion molecule binding IDA 23620790
genes like me logo Genes that share ontologies with SLC14A2: view
genes like me logo Genes that share phenotypes with SLC14A2: view

Animal Models for SLC14A2 Gene

MGI Knock Outs for SLC14A2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC14A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC14A2 Gene

Localization for SLC14A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC14A2 Gene

Apical cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC14A2 Gene COMPARTMENTS Subcellular localization image for SLC14A2 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC14A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 8647271
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC14A2: view

Pathways for SLC14A2 Gene

genes like me logo Genes that share pathways with SLC14A2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC14A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000255226%0d%0a9606.ENSP00000357674%0d%0a
Selected Interacting proteins: ENSP00000255226 Q15849-UT2_HUMAN for SLC14A2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SLC14A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015840 urea transport TAS 8647271
GO:0055085 transmembrane transport TAS --
GO:0071918 urea transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC14A2: view

Compounds for SLC14A2 Gene

(1) HMDB Compounds for SLC14A2 Gene

Compound Synonyms Cas Number PubMed IDs
Urea
  • Carbonyl diamine
57-13-6

(1) Novoseek inferred chemical compound relationships for SLC14A2 Gene

Compound -log(P) Hits PubMed IDs
urea 76.1 17

(1) PharmGKB related drug/compound annotations for SLC14A2 Gene

Drug/compound Annotation
nifedipine CA
genes like me logo Genes that share compounds with SLC14A2: view

Transcripts for SLC14A2 Gene

mRNA/cDNA for SLC14A2 Gene

(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC14A2 Gene

Solute carrier family 14 (urea transporter), member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC14A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC14A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3:

Relevant External Links for SLC14A2 Gene

GeneLoc Exon Structure for
SLC14A2
ECgene alternative splicing isoforms for
SLC14A2

Expression for SLC14A2 Gene

mRNA expression in normal human tissues for SLC14A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC14A2 Gene

This gene is overexpressed in Adrenal Gland (11.3), Kidney - Cortex (5.6), and Adipose - Visceral (Omentum) (4.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC14A2 Gene

SOURCE GeneReport for Unigene cluster for SLC14A2 Gene Hs.710927

mRNA Expression by UniProt/SwissProt for SLC14A2 Gene

Q15849-UT2_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.
genes like me logo Genes that share expressions with SLC14A2: view

In Situ Assay Products

Orthologs for SLC14A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC14A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC14A2 35
  • 98.98 (n)
  • 98.8 (a)
SLC14A2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC14A2 35
  • 87.25 (n)
  • 86.85 (a)
SLC14A2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC14A2 35
  • 87.9 (n)
  • 88.48 (a)
SLC14A2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc14a2 35
  • 85.33 (n)
  • 85.43 (a)
Slc14a2 16
Slc14a2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC14A2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC14A2 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc14a2 35
  • 85.33 (n)
  • 85.98 (a)
chicken
(Gallus gallus)
Aves SLC14A2 35
  • 66 (n)
  • 65.05 (a)
SLC14A2 36
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc14a2 35
  • 63.79 (n)
  • 63.23 (a)
slc14a2 36
  • 46 (a)
OneToMany
wufe01a06 35
Species with no ortholog for SLC14A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC14A2 Gene

ENSEMBL:
Gene Tree for SLC14A2 (if available)
TreeFam:
Gene Tree for SLC14A2 (if available)

Paralogs for SLC14A2 Gene

Paralogs for SLC14A2 Gene

Selected SIMAP similar genes for SLC14A2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC14A2: view

Variants for SLC14A2 Gene

Sequence variations from dbSNP and Humsavar for SLC14A2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs269958 -- 45,214,893(+) TTTTA(G/T)TATCT intron-variant
rs376142 -- 45,211,474(-) TCTCC(C/G)TAAAA upstream-variant-2KB
rs416808 -- 45,211,271(-) AAAGG(C/T)AAACA upstream-variant-2KB
rs722383 -- 45,601,065(-) GGTAA(A/G)GATGA intron-variant
rs723007 -- 45,356,703(+) CAAAC(A/C)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC14A2 Gene

Variant ID Type Subtype PubMed ID
nsv525268 CNV Gain 19592680
nsv512530 CNV Loss 21212237
esv2457646 CNV Deletion 19546169
esv2717022 CNV Deletion 23290073
esv1664752 CNV Deletion 17803354
nsv523238 CNV Gain 19592680
esv2593617 CNV Deletion 19546169
esv2393030 CNV Deletion 18987734
nsv828221 CNV Loss 20364138
esv2717023 CNV Deletion 23290073
esv2660868 CNV Deletion 23128226
nsv132183 CNV Loss 16902084
esv28429 CNV Loss 19812545
esv2717024 CNV Deletion 23290073
esv2661309 CNV Deletion 23128226
nsv833638 CNV Gain 17160897
esv26245 CNV Loss 19812545
esv275024 CNV Gain+Loss 21479260
nsv2275 CNV Loss 18451855
nsv518479 CNV Loss 19592680
nsv909586 CNV Gain 21882294
esv991584 CNV Deletion 20482838
esv2508453 CNV Deletion 19546169
esv2073991 CNV Deletion 18987734
esv3150 CNV Deletion 18987735
esv988746 CNV Deletion 20482838
esv2717025 CNV Deletion 23290073
esv1524268 CNV Deletion 17803354
esv8679 CNV Loss 19470904

Relevant External Links for SLC14A2 Gene

HapMap Linkage Disequilibrium report
SLC14A2
Human Gene Mutation Database (HGMD)
SLC14A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC14A2 Gene

Disorders for SLC14A2 Gene

Relevant External Links for SLC14A2

Genetic Association Database (GAD)
SLC14A2
Human Genome Epidemiology (HuGE) Navigator
SLC14A2
genes like me logo Genes that share disorders with SLC14A2: view

No data available for UniProtKB/Swiss-Prot for SLC14A2 Gene

Publications for SLC14A2 Gene

  1. Genetic variation in the human urea transporter-2 is associated with variation in blood pressure. (PMID: 11590132) Ranade K. … Botstein D. (Hum. Mol. Genet. 2001) 3 23 48
  2. Molecular characterization of a new urea transporter in the human kidney. (PMID: 8647271) Olives B. … Bailly P. (FEBS Lett. 1996) 2 3 4
  3. Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. (PMID: 11502588) Bagnasco S.M. … Sands J.M. (Am. J. Physiol. 2001) 3 4
  4. Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6. (PMID: 15189812) Smith C.P. … Stewart G.S. (Am. J. Physiol. Cell Physiol. 2004) 3 23
  5. Cloning and functional expression of a urea transporter from human bone marrow cells. (PMID: 7989337) Olives B. … Ripoche P. (J. Biol. Chem. 1994) 3 23

Products for SLC14A2 Gene

Sources for SLC14A2 Gene

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