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Aliases for CAMK2B Gene

Aliases for CAMK2B Gene

  • Calcium/Calmodulin Dependent Protein Kinase II Beta 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase II Beta 3 5
  • Proline Rich Calmodulin-Dependent Protein Kinase 2 3
  • CaM Kinase II Beta Subunit 2 3
  • CaM-Kinase II Beta Chain 2 3
  • CaMK-II Subunit Beta 3 4
  • EC 2.7.11.17 4 63
  • CAMKB 3 4
  • CAMK2 3 4
  • CAM2 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Beta 2
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Beta Chain 2
  • CaM Kinase II Subunit Beta 4
  • EC 2.7.11 63

External Ids for CAMK2B Gene

Previous HGNC Symbols for CAMK2B Gene

  • CAMKB

Previous GeneCards Identifiers for CAMK2B Gene

  • GC07M043905
  • GC07M043999
  • GC07M044032
  • GC07M044225
  • GC07M044142

Summaries for CAMK2B Gene

Entrez Gene Summary for CAMK2B Gene

  • The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for CAMK2B Gene

CAMK2B (Calcium/Calmodulin Dependent Protein Kinase II Beta) is a Protein Coding gene. Diseases associated with CAMK2B include Phencyclidine Abuse. Among its related pathways are Axon guidance and Trafficking of AMPA receptors. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2D.

UniProtKB/Swiss-Prot for CAMK2B Gene

  • Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Tocris Summary for CAMK2B Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Gene Wiki entry for CAMK2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2B Gene

Genomics for CAMK2B Gene

Regulatory Elements for CAMK2B Gene

Enhancers for CAMK2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAMK2B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CAMK2B gene promoter:

Genomic Location for CAMK2B Gene

Chromosome:
7
Start:
44,217,150 bp from pter
End:
44,334,577 bp from pter
Size:
117,428 bases
Orientation:
Minus strand

Genomic View for CAMK2B Gene

Genes around CAMK2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2B Gene

Proteins for CAMK2B Gene

  • Protein details for CAMK2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13554-KCC2B_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit beta
    Protein Accession:
    Q13554
    Secondary Accessions:
    • A4D2K0
    • A4D2K1
    • A4D2K2
    • A4D2K3
    • A4D2K4
    • A4D2K5
    • A4D2K6
    • O95437
    • O95438
    • O95599
    • Q9UGH7
    • Q9UGH8
    • Q9UGH9
    • Q9UNX0
    • Q9UNX7
    • Q9UP00
    • Q9Y5N4
    • Q9Y6F4

    Protein attributes for CAMK2B Gene

    Size:
    666 amino acids
    Molecular mass:
    72678 Da
    Quaternary structure:
    • CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.
    SequenceCaution:
    • Sequence=AAC99802.1; Type=Frameshift; Positions=426, 433, 511, 516; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK2B Gene

    Alternative splice isoforms for CAMK2B Gene

neXtProt entry for CAMK2B Gene

Proteomics data for CAMK2B Gene at MOPED

Post-translational modifications for CAMK2B Gene

  • Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAMK2B (CAMK2B)

Domains & Families for CAMK2B Gene

Graphical View of Domain Structure for InterPro Entry

Q13554

UniProtKB/Swiss-Prot:

KCC2B_HUMAN :
  • The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK2B: view

Function for CAMK2B Gene

Molecular function for CAMK2B Gene

GENATLAS Biochemistry:
protein kinase,type II,calcium/calmodulin dependent,beta isoform
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
UniProtKB/Swiss-Prot Induction:
Activity is induced in skeletal muscle during exercise.

Enzyme Numbers (IUBMB) for CAMK2B Gene

Gene Ontology (GO) - Molecular Function for CAMK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0043274 phospholipase binding IEA --
genes like me logo Genes that share ontologies with CAMK2B: view
genes like me logo Genes that share phenotypes with CAMK2B: view

Animal Models for CAMK2B Gene

MGI Knock Outs for CAMK2B:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAMK2B

miRNA for CAMK2B Gene

miRTarBase miRNAs that target CAMK2B

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK2B Gene

Localization for CAMK2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2B Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK2B Gene COMPARTMENTS Subcellular localization image for CAMK2B gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 3
endoplasmic reticulum 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAMK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with CAMK2B: view

Pathways & Interactions for CAMK2B Gene

SuperPathways for CAMK2B Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Post NMDA receptor activation events
3 Development Angiotensin activation of ERK
4 Development Endothelin-1/EDNRA signaling
5 Cardiac conduction
genes like me logo Genes that share pathways with CAMK2B: view

Pathways by source for CAMK2B Gene

SIGNOR curated interactions for CAMK2B Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for CAMK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0006468 protein phosphorylation IEA,TAS 9060999
GO:0007165 signal transduction TAS 9060999
GO:0007265 Ras protein signal transduction TAS --
genes like me logo Genes that share ontologies with CAMK2B: view

Drugs & Compounds for CAMK2B Gene

(4) Drugs for CAMK2B Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile Experimental Pharma Target 0
calcium Nutra 0
KN-62 Pharma CaM kinase II inhibitor, Non-competitive P2X7 antagonist 0

(5) Additional Compounds for CAMK2B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Arcyriaflavin A
118458-54-1
Autocamtide-2-related inhibitory peptide
167114-91-2
KN 93
139298-40-1
STO-609 acetate
1173022-21-3

(5) Tocris Compounds for CAMK2B Gene

Compound Action Cas Number
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) 118458-54-1
Autocamtide-2-related inhibitory peptide Selective CaM kinase II inhibitor 167114-91-2
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) 139298-40-1
KN-62 Non-competitive P2X7 antagonist 127191-97-3
STO-609 acetate Selective CaM kinase kinase inhibitor 1173022-21-3
genes like me logo Genes that share compounds with CAMK2B: view

Transcripts for CAMK2B Gene

Unigene Clusters for CAMK2B Gene

Calcium/calmodulin-dependent protein kinase II beta:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:
SP15:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14: -
SP15:

Relevant External Links for CAMK2B Gene

GeneLoc Exon Structure for
CAMK2B
ECgene alternative splicing isoforms for
CAMK2B

Expression for CAMK2B Gene

mRNA expression in normal human tissues for CAMK2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK2B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.6), Brain - Cerebellum (x5.5), Brain - Putamen (basal ganglia) (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for CAMK2B Gene

This gene is overexpressed in Brain (40.1) and Frontal cortex (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK2B Gene



SOURCE GeneReport for Unigene cluster for CAMK2B Gene Hs.351887

mRNA Expression by UniProt/SwissProt for CAMK2B Gene

Q13554-KCC2B_HUMAN
Tissue specificity: Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with CAMK2B: view

Protein tissue co-expression partners for CAMK2B Gene

- Elite partner

Primer Products

Orthologs for CAMK2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAMK2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMK2B 35
  • 90.18 (n)
  • 94.45 (a)
CAMK2B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk2b 35
  • 91.5 (n)
  • 97.98 (a)
Camk2b 16
Camk2b 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk2b 35
  • 91.96 (n)
  • 97.79 (a)
dog
(Canis familiaris)
Mammalia CAMK2B 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMK2B 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK2B 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMK2B 35
  • 84.46 (n)
  • 91.65 (a)
lizard
(Anolis carolinensis)
Reptilia CAMK2B 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk2b 35
  • 78.23 (n)
  • 90.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.987 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12561 35
LOC798222 35
  • 79.26 (n)
  • 86.64 (a)
camk2b1 36
  • 82 (a)
OneToMany
camk2b2 36
  • 91 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CaMKII 36
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-43 36
  • 49 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.1824 35
Species with no ortholog for CAMK2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK2B Gene

ENSEMBL:
Gene Tree for CAMK2B (if available)
TreeFam:
Gene Tree for CAMK2B (if available)

Paralogs for CAMK2B Gene

genes like me logo Genes that share paralogs with CAMK2B: view

Variants for CAMK2B Gene

Sequence variations from dbSNP and Humsavar for CAMK2B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_045581 A colorectal adenocarcinoma sample
rs35452727 - 44,226,585(+) GCCCT(A/C/G/T)GGCTT intron-variant, reference, missense
rs917791 -- 44,229,186(-) CACTT(C/T)CCTGC intron-variant
rs917792 -- 44,226,380(-) CCCAG(A/G)GAATT intron-variant
rs1003573 -- 44,223,857(-) AAGGG(A/G)GGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK2B Gene

Variant ID Type Subtype PubMed ID
nsv509195 CNV Insertion 20534489
nsv887998 CNV Loss 21882294
esv24646 CNV Gain 19812545
esv2734322 CNV Deletion 23290073
esv9227 CNV Loss 19470904
esv2629662 CNV Insertion 19546169
nsv830984 CNV Gain 17160897
esv22639 CNV Loss 19812545

Variation tolerance for CAMK2B Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMK2B Gene

Human Gene Mutation Database (HGMD)
CAMK2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2B Gene

Disorders for CAMK2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAMK2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
phencyclidine abuse
  • pcp abuse
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAMK2B

Genetic Association Database (GAD)
CAMK2B
Human Genome Epidemiology (HuGE) Navigator
CAMK2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK2B
genes like me logo Genes that share disorders with CAMK2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK2B Gene

Publications for CAMK2B Gene

  1. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. (PMID: 22399527) Kristiansson K. … Salomaa V. (Circ Cardiovasc Genet 2012) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. Possible inhibitor from traditional Chinese medicine for the I^ form of calcium-dependent protein kinase type II in the treatment of major depressive disorder. (PMID: 25045698) Hung T.C. … Chen C.Y. (Biomed Res Int 2014) 3

Products for CAMK2B Gene

Sources for CAMK2B Gene

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