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Aliases for PLA2G12A Gene

Aliases for PLA2G12A Gene

  • Phospholipase A2, Group XIIA 2 3
  • Phosphatidylcholine 2-Acylhydrolase 12A 3 4
  • Phospholipase A2, Group XII 2 3
  • GXII SPLA2 3 4
  • SPLA2-XII 3 4
  • PLA2G12 3 4
  • ROSSY 3 6
  • GXII 3 6
  • Group XIIA Secretory Phospholipase A2 3
  • Group XIIA Secreted Phospholipase A2 3
  • Group XII Secreted Phospholipase A2 3
  • EC 3.1.1.4 4

External Ids for PLA2G12A Gene

Previous HGNC Symbols for PLA2G12A Gene

  • PLA2G12

Previous GeneCards Identifiers for PLA2G12A Gene

  • GC04M111093
  • GC04M110992
  • GC04M110854
  • GC04M110631
  • GC04M106364

Summaries for PLA2G12A Gene

Entrez Gene Summary for PLA2G12A Gene

  • Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PLA2G12A Gene

PLA2G12A (Phospholipase A2, Group XIIA) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and PAK Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G12B.

UniProtKB/Swiss-Prot for PLA2G12A Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

Tocris Summary for PLA2G12A Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G12A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G12A Gene

Genomics for PLA2G12A Gene

Regulatory Elements for PLA2G12A Gene

Genomic Location for PLA2G12A Gene

Start:
109,709,989 bp from pter
End:
109,730,086 bp from pter
Size:
20,098 bases
Orientation:
Minus strand

Genomic View for PLA2G12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G12A Gene

Proteins for PLA2G12A Gene

  • Protein details for PLA2G12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM1-PG12A_HUMAN
    Recommended name:
    Group XIIA secretory phospholipase A2
    Protein Accession:
    Q9BZM1
    Secondary Accessions:
    • Q9BZ89

    Protein attributes for PLA2G12A Gene

    Size:
    189 amino acids
    Molecular mass:
    21067 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for PLA2G12A Gene

Proteomics data for PLA2G12A Gene at MOPED

Post-translational modifications for PLA2G12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G12A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G12A Gene

Domains for PLA2G12A Gene

Gene Families for PLA2G12A Gene

Protein Domains for PLA2G12A Gene

Suggested Antigen Peptide Sequences for PLA2G12A Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZM1

UniProtKB/Swiss-Prot:

PG12A_HUMAN :
  • Q9BZM1
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G12A: view

Function for PLA2G12A Gene

Molecular function for PLA2G12A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

Enzyme Numbers (IUBMB) for PLA2G12A Gene

Gene Ontology (GO) - Molecular Function for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity --
GO:0005509 calcium ion binding IEA --
GO:0047498 calcium-dependent phospholipase A2 activity NAS 11031251
genes like me logo Genes that share ontologies with PLA2G12A: view

miRNA for PLA2G12A Gene

miRTarBase miRNAs that target PLA2G12A

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PLA2G12A Gene

Localization for PLA2G12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G12A Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G12A Gene COMPARTMENTS Subcellular localization image for PLA2G12A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with PLA2G12A: view

Pathways for PLA2G12A Gene

genes like me logo Genes that share pathways with PLA2G12A: view

Interacting Proteins for PLA2G12A Gene

Gene Ontology (GO) - Biological Process for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0016042 lipid catabolic process IEA --
GO:0036148 phosphatidylglycerol acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLA2G12A: view

Compounds for PLA2G12A Gene

(5) Tocris Compounds for PLA2G12A Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]
VU 0155069 Potent and selective PLD1 inhibitor [1130067-06-9]
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor [1244640-48-9]

(2140) HMDB Compounds for PLA2G12A Gene

Compound Synonyms Cas Number PubMed IDs
Alpha-Linolenic acid
  • (9,12,15)-linolenate
463-40-1
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Calcium
  • Ca
7440-70-2
Heptadecanoic acid
  • Heptadecanoate
506-12-7
genes like me logo Genes that share compounds with PLA2G12A: view

Transcripts for PLA2G12A Gene

mRNA/cDNA for PLA2G12A Gene

Unigene Clusters for PLA2G12A Gene

Phospholipase A2, group XIIA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6: - - -

Relevant External Links for PLA2G12A Gene

GeneLoc Exon Structure for
PLA2G12A
ECgene alternative splicing isoforms for
PLA2G12A

Expression for PLA2G12A Gene

mRNA expression in normal human tissues for PLA2G12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLA2G12A Gene

SOURCE GeneReport for Unigene cluster for PLA2G12A Gene Hs.389452

mRNA Expression by UniProt/SwissProt for PLA2G12A Gene

Q9BZM1-PG12A_HUMAN
Tissue specificity: Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas
genes like me logo Genes that share expressions with PLA2G12A: view

No data available for mRNA differential expression in normal tissues for PLA2G12A Gene

Orthologs for PLA2G12A Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G12A 35
  • 99.65 (n)
  • 99.47 (a)
PLA2G12A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLA2G12A 35
  • 90.53 (n)
  • 97.04 (a)
PLA2G12A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G12A 35
  • 93.65 (n)
  • 98.21 (a)
mouse
(Mus musculus)
Mammalia Pla2g12a 35
  • 83.91 (n)
  • 93.1 (a)
Pla2g12a 16
Pla2g12a 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA2G12A 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G12A 35
  • 77.19 (n)
  • 81.29 (a)
PLA2G12A 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G12A 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.31928 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g12a 35
  • 73.96 (n)
  • 78.11 (a)
Str.4030 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10570 35
zebrafish
(Danio rerio)
Actinopterygii Dr.20271 35
pla2g12a 35
  • 65.46 (n)
  • 65.06 (a)
pla2g12a 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta GXIVsPLA2 36
  • 22 (a)
OneToMany
Species with no ortholog for PLA2G12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G12A Gene

ENSEMBL:
Gene Tree for PLA2G12A (if available)
TreeFam:
Gene Tree for PLA2G12A (if available)

Paralogs for PLA2G12A Gene

Paralogs for PLA2G12A Gene

Selected SIMAP similar genes for PLA2G12A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PLA2G12A Gene

genes like me logo Genes that share paralogs with PLA2G12A: view

Variants for PLA2G12A Gene

Sequence variations from dbSNP and Humsavar for PLA2G12A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2498 -- 109,714,332(+) AAAGG(G/T)TATGT utr-variant-3-prime
rs3266 -- 109,726,548(-) TAAAA(A/G)TGGAA intron-variant
rs2040716 -- 109,715,588(+) tcaag(C/T)gattc intron-variant
rs2107047 -- 109,726,619(+) CATAC(A/G)TCACT intron-variant
rs2285713 -- 109,713,735(+) CCCTA(C/T)GAGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PLA2G12A Gene

Variant ID Type Subtype PubMed ID
nsv4463 CNV Loss 18451855

Relevant External Links for PLA2G12A Gene

HapMap Linkage Disequilibrium report
PLA2G12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G12A Gene

Disorders for PLA2G12A Gene

Relevant External Links for PLA2G12A

Genetic Association Database (GAD)
PLA2G12A
Human Genome Epidemiology (HuGE) Navigator
PLA2G12A
genes like me logo Genes that share disorders with PLA2G12A: view

No data available for UniProtKB/Swiss-Prot for PLA2G12A Gene

Publications for PLA2G12A Gene

  1. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. (PMID: 11031251) Gelb M.H. … Lambeau G. (J. Biol. Chem. 2000) 2 3 4
  2. Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII). (PMID: 12522102) Murakami M. … Kudo I. (J. Biol. Chem. 2003) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48

Products for PLA2G12A Gene

Sources for PLA2G12A Gene

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