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Aliases for PLA2G12A Gene

Aliases for PLA2G12A Gene

  • Phospholipase A2 Group XIIA 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 12A 3 4
  • Phospholipase A2, Group XIIA 2 3
  • Phospholipase A2, Group XII 2 3
  • GXII SPLA2 3 4
  • SPLA2-XII 3 4
  • PLA2G12 3 4
  • Group XIIA Secreted Phospholipase A2 3
  • Group XII Secreted Phospholipase A2 3
  • EC 4
  • ROSSY 3
  • GXII 3

External Ids for PLA2G12A Gene

Previous HGNC Symbols for PLA2G12A Gene

  • PLA2G12

Previous GeneCards Identifiers for PLA2G12A Gene

  • GC04M111093
  • GC04M110992
  • GC04M110854
  • GC04M110631
  • GC04M106364

Summaries for PLA2G12A Gene

Entrez Gene Summary for PLA2G12A Gene

  • Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PLA2G12A Gene

PLA2G12A (Phospholipase A2 Group XIIA) is a Protein Coding gene. Diseases associated with PLA2G12A include Macular Degeneration, Age-Related, 1. Among its related pathways are Linoleic acid metabolism and Pancreatic secretion. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G12B.

UniProtKB/Swiss-Prot for PLA2G12A Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

Tocris Summary for PLA2G12A Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G12A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G12A Gene

Genomics for PLA2G12A Gene

Regulatory Elements for PLA2G12A Gene

Enhancers for PLA2G12A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA2G12A on UCSC Golden Path with GeneCards custom track

Promoters for PLA2G12A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLA2G12A on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G12A Gene

109,709,989 bp from pter
109,730,086 bp from pter
20,098 bases
Minus strand

Genomic View for PLA2G12A Gene

Genes around PLA2G12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G12A Gene

Proteins for PLA2G12A Gene

  • Protein details for PLA2G12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Group XIIA secretory phospholipase A2
    Protein Accession:
    Secondary Accessions:
    • Q9BZ89

    Protein attributes for PLA2G12A Gene

    189 amino acids
    Molecular mass:
    21067 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLA2G12A Gene

Proteomics data for PLA2G12A Gene at MOPED

Post-translational modifications for PLA2G12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G12A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G12A Gene

Domains & Families for PLA2G12A Gene

Gene Families for PLA2G12A Gene

Protein Domains for PLA2G12A Gene

Suggested Antigen Peptide Sequences for PLA2G12A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase A2 family.
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G12A: view

Function for PLA2G12A Gene

Molecular function for PLA2G12A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

Enzyme Numbers (IUBMB) for PLA2G12A Gene

Phenotypes for PLA2G12A Gene

genes like me logo Genes that share phenotypes with PLA2G12A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G12A

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G12A Gene

Localization for PLA2G12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G12A Gene

Secreted. Cytoplasm.

Subcellular locations from

Jensen Localization Image for PLA2G12A Gene COMPARTMENTS Subcellular localization image for PLA2G12A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for PLA2G12A Gene

Pathways & Interactions for PLA2G12A Gene

genes like me logo Genes that share pathways with PLA2G12A: view

Interacting Proteins for PLA2G12A Gene

Gene Ontology (GO) - Biological Process for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA --
GO:0008150 biological_process ND --
GO:0016042 lipid catabolic process IEA --
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
GO:0036150 phosphatidylserine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLA2G12A: view

No data available for SIGNOR curated interactions for PLA2G12A Gene

Drugs & Compounds for PLA2G12A Gene

(9) Drugs for PLA2G12A Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(13) Additional Compounds for PLA2G12A Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate

(5) Tocris Compounds for PLA2G12A Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G12A: view

Transcripts for PLA2G12A Gene

Unigene Clusters for PLA2G12A Gene

Phospholipase A2, group XIIA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP6: - - -

Relevant External Links for PLA2G12A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLA2G12A Gene

mRNA expression in normal human tissues for PLA2G12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLA2G12A Gene

This gene is overexpressed in Liver (38.7), Peripheral blood mononuclear cells (12.6), and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLA2G12A Gene

SOURCE GeneReport for Unigene cluster for PLA2G12A Gene Hs.389452

mRNA Expression by UniProt/SwissProt for PLA2G12A Gene

Tissue specificity: Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.
genes like me logo Genes that share expression patterns with PLA2G12A: view

Protein tissue co-expression partners for PLA2G12A Gene

Primer Products

No data available for mRNA differential expression in normal tissues for PLA2G12A Gene

Orthologs for PLA2G12A Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLA2G12A 35
  • 90.53 (n)
  • 97.04 (a)
PLA2G12A 36
  • 91 (a)
(Canis familiaris)
Mammalia PLA2G12A 35
  • 93.65 (n)
  • 98.21 (a)
(Mus musculus)
Mammalia Pla2g12a 35
  • 83.91 (n)
  • 93.1 (a)
Pla2g12a 16
Pla2g12a 36
  • 89 (a)
(Pan troglodytes)
Mammalia PLA2G12A 35
  • 99.65 (n)
  • 99.47 (a)
PLA2G12A 36
  • 99 (a)
(Monodelphis domestica)
Mammalia PLA2G12A 36
  • 69 (a)
(Gallus gallus)
Aves PLA2G12A 35
  • 77.19 (n)
  • 81.29 (a)
PLA2G12A 36
  • 74 (a)
(Anolis carolinensis)
Reptilia PLA2G12A 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g12a 35
  • 73.96 (n)
  • 78.11 (a)
Str.4030 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.31928 35
(Danio rerio)
Actinopterygii Dr.20271 35
pla2g12a 35
  • 65.46 (n)
  • 65.06 (a)
pla2g12a 36
  • 45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10570 35
fruit fly
(Drosophila melanogaster)
Insecta GXIVsPLA2 36
  • 22 (a)
Species with no ortholog for PLA2G12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G12A Gene

Gene Tree for PLA2G12A (if available)
Gene Tree for PLA2G12A (if available)

Paralogs for PLA2G12A Gene

Paralogs for PLA2G12A Gene

(1) SIMAP similar genes for PLA2G12A Gene using alignment to 3 proteins: Pseudogenes for PLA2G12A Gene

genes like me logo Genes that share paralogs with PLA2G12A: view

Variants for PLA2G12A Gene

Sequence variations from dbSNP and Humsavar for PLA2G12A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3266 -- 109,726,548(-) TAAAA(A/G)TGGAA intron-variant
rs2107047 -- 109,726,619(+) CATAC(A/G)TCACT intron-variant
rs2285714 -- 109,717,654(+) CAGGT(C/T)TCATA reference, synonymous-codon
rs2285715 -- 109,717,887(+) CTTAC(C/T)CATAC intron-variant
rs4557260 -- 109,730,495(-) GCACA(A/C/G)GGGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLA2G12A Gene

Variant ID Type Subtype PubMed ID
nsv4463 CNV Loss 18451855

Variation tolerance for PLA2G12A Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLA2G12A Gene

Disorders for PLA2G12A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLA2G12A Gene - From: DISEASES

Disorder Aliases PubMed IDs
macular degeneration, age-related, 1
  • macular degeneration, age-related, 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G12A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PLA2G12A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G12A Gene

Publications for PLA2G12A Gene

  1. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. (PMID: 11031251) Gelb M.H. … Lambeau G. (J. Biol. Chem. 2000) 2 3 4 67
  2. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3
  5. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. (PMID: 20385819) Chen W. … Swaroop A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for PLA2G12A Gene

Sources for PLA2G12A Gene