Aliases for PLA2G12A Gene
External Ids for PLA2G12A Gene
Previous HGNC Symbols for PLA2G12A Gene
Previous GeneCards Identifiers for PLA2G12A Gene
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PLA2G12A Gene
PLA2G12A (Phospholipase A2 Group XIIA) is a Protein Coding gene. Diseases associated with PLA2G12A include Macular Degeneration, Age-Related, 1. Among its related pathways are Linoleic acid metabolism and Vascular smooth muscle contraction. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G12B.
UniProtKB/Swiss-Prot for PLA2G12A Gene
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.