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Aliases for C1orf21 Gene

Aliases for C1orf21 Gene

  • Chromosome 1 Open Reading Frame 21 2 3 5
  • Cell Proliferation-Inducing Gene 13 Protein 3 4
  • Proliferation-Inducing Protein 13 2 3
  • PIG13 3

External Ids for C1orf21 Gene

Previous GeneCards Identifiers for C1orf21 Gene

  • GC01P181882
  • GC01P179784
  • GC01P180876
  • GC01P181595
  • GC01P181087
  • GC01P182622
  • GC01P155591

Summaries for C1orf21 Gene

GeneCards Summary for C1orf21 Gene

C1orf21 (Chromosome 1 Open Reading Frame 21) is a Protein Coding gene.

Gene Wiki entry for C1orf21 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf21 Gene

Genomics for C1orf21 Gene

Regulatory Elements for C1orf21 Gene

Promoters for C1orf21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C1orf21 on UCSC Golden Path with GeneCards custom track

Genomic Location for C1orf21 Gene

184,387,016 bp from pter
184,629,021 bp from pter
242,006 bases
Plus strand

Genomic View for C1orf21 Gene

Genes around C1orf21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf21 Gene

Proteins for C1orf21 Gene

  • Protein details for C1orf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C1orf21
    Protein Accession:
    Secondary Accessions:
    • B2R551

    Protein attributes for C1orf21 Gene

    121 amino acids
    Molecular mass:
    13865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf21 Gene

Proteomics data for C1orf21 Gene at MOPED

Post-translational modifications for C1orf21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf21 Gene

Domains & Families for C1orf21 Gene

Protein Domains for C1orf21 Gene


Suggested Antigen Peptide Sequences for C1orf21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf21: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C1orf21 Gene

Function for C1orf21 Gene

genes like me logo Genes that share phenotypes with C1orf21: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf21 Gene

Localization for C1orf21 Gene

Subcellular locations from

Jensen Localization Image for C1orf21 Gene COMPARTMENTS Subcellular localization image for C1orf21 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf21 Gene

Pathways & Interactions for C1orf21 Gene

SuperPathways for C1orf21 Gene

No Data Available

Interacting Proteins for C1orf21 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9H246-CA021_HUMAN ENSP00000235307 for C1orf21 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for C1orf21 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf21 Gene

Drugs & Compounds for C1orf21 Gene

No Compound Related Data Available

Transcripts for C1orf21 Gene

Unigene Clusters for C1orf21 Gene

Chromosome 1 open reading frame 21:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf21 Gene

No ASD Table

Relevant External Links for C1orf21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf21 Gene

mRNA expression in normal human tissues for C1orf21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf21 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for C1orf21 Gene

This gene is overexpressed in Frontal cortex (35.0), Oral epithelium (11.7), Urinary Bladder (6.7), and Prostate (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C1orf21 Gene

SOURCE GeneReport for Unigene cluster for C1orf21 Gene Hs.497159

mRNA Expression by UniProt/SwissProt for C1orf21 Gene

Tissue specificity: Expressed in spleen, prostate, testis and uterus.
genes like me logo Genes that share expression patterns with C1orf21: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for C1orf21 Gene

Orthologs for C1orf21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C16H1orf21 35
  • 96.69 (n)
  • 99.17 (a)
-- 36
  • 95 (a)
C16H1ORF21 36
  • 99 (a)
(Canis familiaris)
Mammalia C7H1orf21 35
  • 96.97 (n)
  • 99.17 (a)
C1orf21 36
  • 99 (a)
(Mus musculus)
Mammalia 1700025G04Rik 35
  • 93.94 (n)
  • 96.69 (a)
1700025G04Rik 16
1700025G04Rik 36
  • 97 (a)
(Pan troglodytes)
Mammalia C1H1orf21 35
  • 99.72 (n)
  • 100 (a)
C1H1ORF21 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1309104 35
  • 93.11 (n)
  • 96.69 (a)
(Monodelphis domestica)
Mammalia C1orf21 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia C1orf21 36
  • 92 (a)
(Gallus gallus)
Aves C8H1ORF21 35
  • 92.84 (n)
  • 93.39 (a)
C1orf21 36
  • 93 (a)
(Anolis carolinensis)
Reptilia C1orf21 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf21 35
  • 75.21 (n)
  • 76.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69115 35
(Danio rerio)
Actinopterygii Dr.20974 35
zgc:92140 35
  • 64.64 (n)
  • 66.96 (a)
C2H1orf21 36
  • 59 (a)
Species with no ortholog for C1orf21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf21 Gene

Gene Tree for C1orf21 (if available)
Gene Tree for C1orf21 (if available)

Paralogs for C1orf21 Gene

No data available for Paralogs for C1orf21 Gene

Variants for C1orf21 Gene

Sequence variations from dbSNP and Humsavar for C1orf21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs8972 -- 184,628,865(+) TTTGA(C/T)TTGAC utr-variant-3-prime
rs10030 -- 184,620,294(+) TTTTT(C/T)TAAGA utr-variant-3-prime
rs10228 -- 184,619,935(-) AGAAG(A/G)GAAGT utr-variant-3-prime
rs12652 -- 184,628,732(+) CTCTC(C/T)GGGTC utr-variant-3-prime
rs749214 -- 184,567,037(+) AACAT(C/T)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf21 Gene

Variant ID Type Subtype PubMed ID
nsv3821 CNV Loss 18451855
esv2674731 CNV Deletion 23128226
esv2668015 CNV Deletion 23128226
esv2720162 CNV Deletion 23290073
nsv832037 CNV Gain 17160897
dgv20n21 CNV Loss 19592680

Variation tolerance for C1orf21 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C1orf21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf21 Gene

Disorders for C1orf21 Gene

Relevant External Links for C1orf21

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C1orf21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf21 Gene

Publications for C1orf21 Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for C1orf21 Gene

Sources for C1orf21 Gene

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