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Aliases for TMX1 Gene

Aliases for TMX1 Gene

  • TXNDC1 3 4 6
  • TMX 3 4 6
  • Thioredoxin-Related Transmembrane Protein 1 2 3
  • Thioredoxin Domain-Containing Protein 1 3 4
  • Transmembrane Trx-Related Protein 3 4
  • Thioredoxin Domain Containing 1 2 3
  • TXNDC 3 4
  • Protein Disulfide Isomerase Family A, Member 11 3
  • Thioredoxin-Related Transmembrane Protein 2
  • Protein Disulfide Isomerase Family A 2
  • Thioredoxin Domain-Containing 2
  • Thioredoxin Domain Containing 2
  • Member 11 2
  • PDIA11 3

External Ids for TMX1 Gene

Previous HGNC Symbols for TMX1 Gene

  • TXNDC
  • TXNDC1

Previous GeneCards Identifiers for TMX1 Gene

  • GC14P050779
  • GC14P051706
  • GC14P031866

Summaries for TMX1 Gene

Entrez Gene Summary for TMX1 Gene

  • TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al., 2001 [PubMed 11152479]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMX1 Gene

TMX1 is a Protein Coding gene. GO annotations related to this gene include disulfide oxidoreductase activity and arsenate reductase (thioredoxin) activity. An important paralog of this gene is TMX4.

UniProtKB/Swiss-Prot for TMX1 Gene

  • May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions

Gene Wiki entry for TMX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMX1 Gene

Genomics for TMX1 Gene

Regulatory Elements for TMX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMX1 Gene

Start:
51,240,162 bp from pter
End:
51,257,655 bp from pter
Size:
17,494 bases
Orientation:
Plus strand

Genomic View for TMX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMX1 Gene

Proteins for TMX1 Gene

  • Protein details for TMX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3N1-TMX1_HUMAN
    Recommended name:
    Thioredoxin-related transmembrane protein 1
    Protein Accession:
    Q9H3N1
    Secondary Accessions:
    • B2R7A4
    • Q8N487
    • Q8NBN5
    • Q9Y4T6

    Protein attributes for TMX1 Gene

    Size:
    280 amino acids
    Molecular mass:
    31791 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TMX1 Gene

neXtProt entry for TMX1 Gene

Proteomics data for TMX1 Gene at MOPED

Post-translational modifications for TMX1 Gene

  • Ubiquitination at Lys107, Lys121, and Lys130
  • Modification sites at PhosphoSitePlus

Other Protein References for TMX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TMX1 Gene

Domains for TMX1 Gene

Gene Families for TMX1 Gene

HGNC:
  • PDI :Protein disulfide isomerases

Protein Domains for TMX1 Gene

Suggested Antigen Peptide Sequences for TMX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3N1

UniProtKB/Swiss-Prot:

TMX1_HUMAN :
  • Q9H3N1
Domain:
  • Contains 1 thioredoxin domain.
genes like me logo Genes that share domains with TMX1: view

Function for TMX1 Gene

Molecular function for TMX1 Gene

UniProtKB/Swiss-Prot Function:
May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions

Gene Ontology (GO) - Molecular Function for TMX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IBA --
GO:0015036 disulfide oxidoreductase activity IDA 11152479
genes like me logo Genes that share ontologies with TMX1: view

Animal Model Products

miRNA for TMX1 Gene

miRTarBase miRNAs that target TMX1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMX1 Gene

Localization for TMX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMX1 Gene

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. {ECO:0000269 PubMed:11152479}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMX1 Gene COMPARTMENTS Subcellular localization image for TMX1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3

Gene Ontology (GO) - Cellular Components for TMX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IDA 11152479
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMX1: view

Pathways for TMX1 Gene

SuperPathways for TMX1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TMX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0034976 response to endoplasmic reticulum stress IMP 11152479
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TMX1: view

No data available for Pathways by source for TMX1 Gene

Transcripts for TMX1 Gene

mRNA/cDNA for TMX1 Gene

Unigene Clusters for TMX1 Gene

Thioredoxin-related transmembrane protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMX1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMX1 Gene

No ASD Table

Relevant External Links for TMX1 Gene

GeneLoc Exon Structure for
TMX1
ECgene alternative splicing isoforms for
TMX1

Expression for TMX1 Gene

mRNA expression in normal human tissues for TMX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TMX1 Gene

This gene is overexpressed in Nasal epithelium (14.4) and Bone (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMX1 Gene

SOURCE GeneReport for Unigene cluster for TMX1 Gene Hs.125221

mRNA Expression by UniProt/SwissProt for TMX1 Gene

Q9H3N1-TMX1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in kidney, liver, placenta and lung
genes like me logo Genes that share expressions with TMX1: view

Expression partners for TMX1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TMX1 Gene

Orthologs for TMX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMX1 35
  • 90.53 (n)
  • 91.73 (a)
TMX1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMX1 35
  • 91.85 (n)
  • 92.81 (a)
TMX1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmx1 35
  • 82.31 (n)
  • 78.08 (a)
Tmx1 16
Tmx1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMX1 35
  • 99.17 (n)
  • 98.93 (a)
TMX1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmx1 35
  • 82.95 (n)
  • 80.38 (a)
oppossum
(Monodelphis domestica)
Mammalia TMX1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMX1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMX1 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMX1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmx1 35
  • 66.8 (n)
  • 65.56 (a)
zebrafish
(Danio rerio)
Actinopterygii tmx1 35
  • 64.1 (n)
  • 65.64 (a)
tmx1 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001613 35
  • 49.5 (n)
  • 45.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5554 35
  • 50 (n)
  • 46.97 (a)
CG5554 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpy-11 35
  • 53.64 (n)
  • 47.72 (a)
dpy-11 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for TMX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMX1 Gene

ENSEMBL:
Gene Tree for TMX1 (if available)
TreeFam:
Gene Tree for TMX1 (if available)

Paralogs for TMX1 Gene

Paralogs for TMX1 Gene

Selected SIMAP similar genes for TMX1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMX1 Gene

genes like me logo Genes that share paralogs with TMX1: view

Variants for TMX1 Gene

Sequence variations from dbSNP and Humsavar for TMX1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs9918 -- 51,255,972(-) CATCC(A/G)AACTC utr-variant-3-prime
rs13156 -- 51,255,631(-) TAAAA(A/G)TGTTA utr-variant-3-prime
rs1128841 -- 51,255,409(+) TTTTT(C/T)TTTTT utr-variant-3-prime
rs3088089 -- 51,255,964(-) CTCTT(C/T)AATGG utr-variant-3-prime
rs3924306 -- 51,248,848(+) TAATG(A/C)TCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMX1 Gene

Variant ID Type Subtype PubMed ID
esv274183 CNV Insertion 20981092
esv270239 CNV Insertion 20981092

Relevant External Links for TMX1 Gene

HapMap Linkage Disequilibrium report
TMX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMX1 Gene

Disorders for TMX1 Gene

Relevant External Links for TMX1

Genetic Association Database (GAD)
TMX1

No disorders were found for TMX1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMX1 Gene

Publications for TMX1 Gene

  1. Identification of a novel thioredoxin-related transmembrane protein. (PMID: 11152479) Matsuo Y. … Kizaka-Kondoh S. (J. Biol. Chem. 2001) 2 3 4 23
  2. Physical and functional interaction of transmembrane thioredoxin-related protein with major histocompatibility complex class I heavy chain: redox-based protein quality control and its potential relevance to immune responses. (PMID: 19741092) Matsuo Y. … Yodoi J. (Mol. Biol. Cell 2009) 3 23
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMX1 Gene

Sources for TMX1 Gene

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