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Aliases for CAMK4 Gene

Aliases for CAMK4 Gene

  • Calcium/Calmodulin-Dependent Protein Kinase IV 2 3 5
  • Calcium/Calmodulin-Dependent Protein Kinase Type IV Catalytic Chain 2 3
  • Brain Ca++-Calmodulin-Dependent Protein Kinase Type IV 2 3
  • CAM Kinase- GR 2 3
  • CAM Kinase IV 2 3
  • CaMK IV 3 4
  • CaMK-GR 3 4
  • CAMK 3 4
  • Brain Ca(2+)-Calmodulin-Dependent Protein Kinase Type IV 3
  • CaM Kinase-GR 4
  • EC 2.7.11.17 4
  • EC 2.7.11 63
  • CAMKIV 4

External Ids for CAMK4 Gene

Previous GeneCards Identifiers for CAMK4 Gene

  • GC05P110183
  • GC05P111005
  • GC05P110590
  • GC05P110636
  • GC05P110587
  • GC05P105739

Summaries for CAMK4 Gene

Entrez Gene Summary for CAMK4 Gene

  • The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK4 Gene

CAMK4 (Calcium/Calmodulin-Dependent Protein Kinase IV) is a Protein Coding gene. Diseases associated with CAMK4 include gingival fibromatosis and cerebral hypoxia. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Insulin secretion. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK2D.

UniProtKB/Swiss-Prot for CAMK4 Gene

  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Gene Wiki entry for CAMK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK4 Gene

Genomics for CAMK4 Gene

Regulatory Elements for CAMK4 Gene

Enhancers for CAMK4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAMK4 on UCSC Golden Path with GeneCards custom track

Promoters for CAMK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAMK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAMK4 Gene

Chromosome:
5
Start:
111,223,653 bp from pter
End:
111,494,886 bp from pter
Size:
271,234 bases
Orientation:
Plus strand

Genomic View for CAMK4 Gene

Genes around CAMK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK4 Gene

Proteins for CAMK4 Gene

  • Protein details for CAMK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16566-KCC4_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type IV
    Protein Accession:
    Q16566
    Secondary Accessions:
    • D3DSZ7

    Protein attributes for CAMK4 Gene

    Size:
    473 amino acids
    Molecular mass:
    51926 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.
    SequenceCaution:
    • Sequence=AAH16695.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK4 Gene

neXtProt entry for CAMK4 Gene

Proteomics data for CAMK4 Gene at MOPED

Selected DME Specific Peptides for CAMK4 Gene

Post-translational modifications for CAMK4 Gene

  • Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.
  • Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
  • Ubiquitination at Lys 190 and Lys 303
  • Glycosylation at Thr 57, Ser 58, Ser 137, Ser 189, Ser 344, Ser 345, and Ser 356
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAMK4 (CAMK4)

Domains & Families for CAMK4 Gene

Gene Families for CAMK4 Gene

Suggested Antigen Peptide Sequences for CAMK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16566

UniProtKB/Swiss-Prot:

KCC4_HUMAN :
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK4: view

Function for CAMK4 Gene

Molecular function for CAMK4 Gene

GENATLAS Biochemistry:
protein kinase,type IV,calcium/calmodulin dependent,brain
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Enzyme Numbers (IUBMB) for CAMK4 Gene

genes like me logo Genes that share phenotypes with CAMK4: view

Animal Models for CAMK4 Gene

MGI Knock Outs for CAMK4:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK4 Gene

Localization for CAMK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK4 Gene

Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK4 Gene COMPARTMENTS Subcellular localization image for CAMK4 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CAMK4: view

Pathways & Interactions for CAMK4 Gene

SuperPathways for CAMK4 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 DAG and IP3 signaling
3 Post NMDA receptor activation events
4 Activation of cAMP-Dependent PKA
5 CREB Pathway
genes like me logo Genes that share pathways with CAMK4: view

SIGNOR curated interactions for CAMK4 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002372 NOT myeloid dendritic cell cytokine production IMP 17909078
GO:0006468 protein phosphorylation IEA,TAS 8089075
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 8089075
genes like me logo Genes that share ontologies with CAMK4: view

Drugs & Compounds for CAMK4 Gene

(13) Drugs for CAMK4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one Experimental Pharma Target 0
5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE Experimental Pharma Target 0
calcium Nutra 0

(4) Additional Compounds for CAMK4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CAMK4: view

Transcripts for CAMK4 Gene

Unigene Clusters for CAMK4 Gene

Calcium/calmodulin-dependent protein kinase IV:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2:
SP3:

Relevant External Links for CAMK4 Gene

GeneLoc Exon Structure for
CAMK4
ECgene alternative splicing isoforms for
CAMK4

Expression for CAMK4 Gene

mRNA expression in normal human tissues for CAMK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.4), Brain - Cerebellum (x11.3), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CAMK4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8), Lymph node (14.7), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK4 Gene



SOURCE GeneReport for Unigene cluster for CAMK4 Gene Hs.591269

mRNA Expression by UniProt/SwissProt for CAMK4 Gene

Q16566-KCC4_HUMAN
Tissue specificity: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
genes like me logo Genes that share expression patterns with CAMK4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CAMK4 Gene

Orthologs for CAMK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMK4 35
  • 85.71 (n)
  • 83.12 (a)
CAMK4 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK4 35
  • 90.17 (n)
  • 90.17 (a)
CAMK4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk4 35
  • 83.26 (n)
  • 81.97 (a)
Camk4 16
Camk4 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMK4 35
  • 99.58 (n)
  • 99.79 (a)
CAMK4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk4 35
  • 82.51 (n)
  • 83.01 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMK4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK4 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMK4 36
  • 83 (a)
OneToOne
CAMK4 35
  • 76.61 (n)
  • 80.39 (a)
lizard
(Anolis carolinensis)
Reptilia CAMK4 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk4 35
  • 76.29 (n)
  • 81.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia camk4-A 35
zebrafish
(Danio rerio)
Actinopterygii camk4 35
  • 72.07 (n)
  • 79.12 (a)
camk4 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CaMKI 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cmk-1 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK2 36
  • 26 (a)
ManyToMany
CMK1 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9956 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for CAMK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK4 Gene

ENSEMBL:
Gene Tree for CAMK4 (if available)
TreeFam:
Gene Tree for CAMK4 (if available)

Paralogs for CAMK4 Gene

genes like me logo Genes that share paralogs with CAMK4: view

Variants for CAMK4 Gene

Sequence variations from dbSNP and Humsavar for CAMK4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_040604 A lung adenocarcinoma sample
rs35548075 - 111,446,758(+) CCCCA(A/G)ATGCA nc-transcript-variant, reference, missense
rs56360861 - 111,484,438(+) TCCAC(A/G)GCAAG nc-transcript-variant, reference, missense
VAR_040607 A lung large cell carcinoma sample
rs712645 -- 111,249,929(-) ATAAT(A/G)TGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK4 Gene

Variant ID Type Subtype PubMed ID
nsv882709 CNV Loss 21882294
esv29054 CNV Loss 19812545
dgv1038e199 CNV Deletion 23128226
esv271918 CNV Insertion 20981092
nsv823173 CNV Loss 20364138
esv269264 CNV Insertion 20981092
esv274515 CNV Insertion 20981092
nsv518727 CNV Gain 19592680
esv2647908 CNV Deletion 19546169
esv2313843 CNV Deletion 18987734
esv4209 CNV Deletion 18987735
esv8952 CNV Loss 19470904
esv2730592 CNV Deletion 23290073
esv1341497 CNV Deletion 17803354
nsv328700 CNV Loss 16902084
nsv830449 CNV Gain+Loss 17160897
nsv823174 CNV Loss 20364138

Variation tolerance for CAMK4 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMK4 Gene

HapMap Linkage Disequilibrium report
CAMK4
Human Gene Mutation Database (HGMD)
CAMK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK4 Gene

Disorders for CAMK4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CAMK4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gingival fibromatosis
  • hereditary gingival fibromatosis
cerebral hypoxia
  • brain hypoxia
- elite association - COSMIC cancer census association via MalaCards
Search CAMK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAMK4

Genetic Association Database (GAD)
CAMK4
Human Genome Epidemiology (HuGE) Navigator
CAMK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK4
genes like me logo Genes that share disorders with CAMK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK4 Gene

Publications for CAMK4 Gene

  1. A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. (PMID: 8107230) Mosialos G. … Chatila T.A. (J. Virol. 1994) 3 4 23 67
  2. PLC/CAMK IV-NF-kappaB involved in the receptor for advanced glycation end products mediated signaling pathway in human endothelial cells. (PMID: 20171262) You J. … Lin J.Y. (Mol. Cell. Endocrinol. 2010) 3 23
  3. The heterogeneous nuclear ribonucleoprotein L is an essential component in the Ca2+/calmodulin-dependent protein kinase IV-regulated alternative splicing through cytidine-adenosine repeats. (PMID: 19017650) Yu J. … Xie J. (J. Biol. Chem. 2009) 3 23
  4. The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex. (PMID: 19538941) Reece K.M. … Wadzinski B.E. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells. (PMID: 19633294) Feliciano D.M. … Edelman A.M. (J. Biol. Chem. 2009) 3 23

Products for CAMK4 Gene

Sources for CAMK4 Gene

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