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Aliases for CAMK4 Gene

Aliases for CAMK4 Gene

  • Calcium/Calmodulin-Dependent Protein Kinase IV 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type IV Catalytic Chain 2 3
  • Brain Ca++-Calmodulin-Dependent Protein Kinase Type IV 2 3
  • CAM Kinase- GR 2 3
  • CAM Kinase IV 2 3
  • CaM Kinase-GR 3 4
  • CaMK IV 3 4
  • CaMK-GR 3 4
  • CaMK 3 4
  • Brain Ca(2+)-Calmodulin-Dependent Protein Kinase Type IV 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type IV 3
  • EC 2.7.11.17 4
  • EC 2.7.11 64
  • CAMKIV 4
  • IV 3

External Ids for CAMK4 Gene

Summaries for CAMK4 Gene

Entrez Gene Summary for CAMK4 Gene

  • The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK4 Gene

CAMK4 (Calcium/Calmodulin-Dependent Protein Kinase IV) is a Protein Coding gene. Diseases associated with CAMK4 include cerebral hypoxia and allan-herndon-dudley syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for CAMK4 Gene

  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Gene Wiki entry for CAMK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK4 Gene

Genomics for CAMK4 Gene

Genomic Location for CAMK4 Gene

Start:
111,223,653 bp from pter
End:
111,494,886 bp from pter
Size:
271,234 bases
Orientation:
Plus strand

Genomic View for CAMK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK4 Gene

Regulatory Elements for CAMK4 Gene

Proteins for CAMK4 Gene

  • Protein details for CAMK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16566-KCC4_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type IV
    Protein Accession:
    Q16566
    Secondary Accessions:
    • D3DSZ7

    Protein attributes for CAMK4 Gene

    Size:
    473 amino acids
    Molecular mass:
    51926 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.
    SequenceCaution:
    • Sequence=AAH16695.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK4 Gene

neXtProt entry for CAMK4 Gene

Proteomics data for CAMK4 Gene at MOPED

Selected DME Specific Peptides for CAMK4 Gene

Post-translational modifications for CAMK4 Gene

  • Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.
  • Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys190 and Lys303
  • Glycosylation at Thr57, Ser58, Ser137, Ser189, Ser344, Ser345, and Ser356

Other Protein References for CAMK4 Gene

Domains for CAMK4 Gene

Gene Families for CAMK4 Gene

UniProtKB/Swiss-Prot:

KCC4_HUMAN
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.:
    • Q16566
  • Contains 1 protein kinase domain.:
    • Q16566
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.:
    • Q16566
genes like me logo Genes that share domains with CAMK4: view

Function for CAMK4 Gene

Molecular function for CAMK4 Gene

GENATLAS Biochemistry: protein kinase,type IV,calcium/calmodulin dependent,brain
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.
UniProtKB/Swiss-Prot Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Enzyme Numbers (IUBMB) for CAMK4 Gene

Gene Ontology (GO) - Molecular Function for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004683 calmodulin-dependent protein kinase activity IDA 8107230
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with CAMK4: view
genes like me logo Genes that share phenotypes with CAMK4: view

Animal Models for CAMK4 Gene

MGI Knock Outs for CAMK4:

miRNA for CAMK4 Gene

miRTarBase miRNAs that target CAMK4

No data available for Transcription Factor Targeting and HOMER Transcription for CAMK4 Gene

Localization for CAMK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK4 Gene

Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK4 Gene COMPARTMENTS Subcellular localization image for CAMK4 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CAMK4: view

Pathways for CAMK4 Gene

genes like me logo Genes that share pathways with CAMK4: view

Gene Ontology (GO) - Biological Process for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002372 NOT myeloid dendritic cell cytokine production IMP 17909078
GO:0006468 protein phosphorylation TAS 8089075
GO:0006913 nucleocytoplasmic transport IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with CAMK4: view

Compounds for CAMK4 Gene

(3) HMDB Compounds for CAMK4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2

(13) Novoseek inferred chemical compound relationships for CAMK4 Gene

Compound -log(P) Hits PubMed IDs
syntide-2 86.4 1
calcium 53.5 36
threonine 45.8 4
serine 42.6 6
cyclic amp 41.8 2
genes like me logo Genes that share compounds with CAMK4: view

Transcripts for CAMK4 Gene

Unigene Clusters for CAMK4 Gene

Calcium/calmodulin-dependent protein kinase IV:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2:
SP3:

Relevant External Links for CAMK4 Gene

GeneLoc Exon Structure for
CAMK4
ECgene alternative splicing isoforms for
CAMK4

Expression for CAMK4 Gene

mRNA expression in normal human tissues for CAMK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (12.4), Brain - Cerebellum (11.3), Brain - Nucleus accumbens (basal ganglia) (5.0), and Brain - Putamen (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK4 Gene

SOURCE GeneReport for Unigene cluster for CAMK4 Gene Hs.591269

mRNA Expression by UniProt/SwissProt for CAMK4 Gene

Q16566-KCC4_HUMAN
Tissue specificity: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
genes like me logo Genes that share expressions with CAMK4: view

Orthologs for CAMK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMK4 36
  • 99.58 (n)
  • 99.79 (a)
CAMK4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMK4 36
  • 85.71 (n)
  • 83.12 (a)
CAMK4 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK4 36
  • 90.17 (n)
  • 90.17 (a)
CAMK4 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk4 36
  • 83.26 (n)
  • 81.97 (a)
Camk4 16
Camk4 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMK4 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK4 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk4 36
  • 82.51 (n)
  • 83.01 (a)
chicken
(Gallus gallus)
Aves CAMK4 36
  • 76.61 (n)
  • 80.39 (a)
CAMK4 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMK4 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia camk4-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia camk4 36
  • 76.29 (n)
  • 81.1 (a)
zebrafish
(Danio rerio)
Actinopterygii camk4 36
  • 72.07 (n)
  • 79.12 (a)
camk4 37
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CaMKI 37
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cmk-1 37
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 37
  • 29 (a)
ManyToMany
CMK2 37
  • 26 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9956 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
OneToOne
Species with no ortholog for CAMK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK4 Gene

ENSEMBL:
Gene Tree for CAMK4 (if available)
TreeFam:
Gene Tree for CAMK4 (if available)

Paralogs for CAMK4 Gene

genes like me logo Genes that share paralogs with CAMK4: view

Variants for CAMK4 Gene

Sequence variations from dbSNP and Humsavar for CAMK4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs25917 -- 111,473,151(-) ACTTA(C/T)GTCTA intron-variant
rs25918 -- 111,474,072(-) CTTCC(A/T)TCTCA intron-variant
rs25920 -- 111,457,444(-) TTGTG(C/T)TGTGT intron-variant
rs25921 -- 111,460,748(+) GACTC(A/G)GTCTG intron-variant
rs25922 -- 111,461,220(-) GAGAA(C/G)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK4 Gene

Variant ID Type Subtype PubMed ID
nsv882709 CNV Loss 21882294
esv29054 CNV Loss 19812545
dgv1038e199 CNV Deletion 23128226
esv271918 CNV Insertion 20981092
nsv823173 CNV Loss 20364138
esv269264 CNV Insertion 20981092
esv274515 CNV Insertion 20981092
nsv518727 CNV Gain 19592680
esv2647908 CNV Deletion 19546169
esv2313843 CNV Deletion 18987734
esv4209 CNV Deletion 18987735
esv8952 CNV Loss 19470904
esv2730592 CNV Deletion 23290073
esv1341497 CNV Deletion 17803354
nsv328700 CNV Loss 16902084
nsv830449 CNV Gain+Loss 17160897
nsv823174 CNV Loss 20364138

Relevant External Links for CAMK4 Gene

HapMap Linkage Disequilibrium report
CAMK4
Human Gene Mutation Database (HGMD)
CAMK4

Disorders for CAMK4 Gene

(1) University of Copenhagen DISEASES for CAMK4 Gene

(1) Novoseek inferred disease relationships for CAMK4 Gene

Disease -log(P) Hits PubMed IDs
cerebral hypoxia 51.2 1

Relevant External Links for CAMK4

Genetic Association Database (GAD)
CAMK4
Human Genome Epidemiology (HuGE) Navigator
CAMK4
genes like me logo Genes that share disorders with CAMK4: view

No data available for UniProtKB/Swiss-Prot for CAMK4 Gene

Publications for CAMK4 Gene

  1. cDNA cloning and expression of human calmodulin-dependent protein kinase IV. (PMID: 8089075) Kitani T. … Fujisawa H. (J. Biochem. 1994) 3 4 23
  2. A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. (PMID: 8107230) Mosialos G. … Chatila T.A. (J. Virol. 1994) 3 4 23
  3. The cDNA sequence and characterization of the Ca2+/calmodulin- dependent protein kinase-Gr from human brain and thymus. (PMID: 8194751) Bland M.M. … Ohmstede C.A. (Gene 1994) 3 4 23
  4. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. (PMID: 8855261) Enslen H. … Soderling T.R. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  5. Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. (PMID: 15143065) Anderson K.A. … Means A.R. (J. Biol. Chem. 2004) 3 4 23

Products for CAMK4 Gene

  • Addgene plasmids for CAMK4

Sources for CAMK4 Gene

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