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Aliases for TCL1A Gene

Aliases for TCL1A Gene

  • T-Cell Leukemia/Lymphoma 1A 2 3 5
  • Protein P14 TCL1 3 4
  • Oncogene TCL-1 3 4
  • Oncogene TCL1 3 4
  • TCL1 3 4
  • T-Cell Lymphoma-1 3

External Ids for TCL1A Gene

Previous GeneCards Identifiers for TCL1A Gene

  • GC14M093687
  • GC14M089992
  • GC14M094166
  • GC14M095246
  • GC14M096177
  • GC14M076361

Summaries for TCL1A Gene

Entrez Gene Summary for TCL1A Gene

  • Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

GeneCards Summary for TCL1A Gene

TCL1A (T-Cell Leukemia/Lymphoma 1A) is a Protein Coding gene. Diseases associated with TCL1A include precursor t-cell acute lymphoblastic leukemia and t-cell leukemia. Among its related pathways are PI3K-Akt signaling pathway and PI3K / Akt Signaling. An important paralog of this gene is MTCP1.

UniProtKB/Swiss-Prot for TCL1A Gene

  • Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

Gene Wiki entry for TCL1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCL1A Gene

Genomics for TCL1A Gene

Regulatory Elements for TCL1A Gene

Enhancers for TCL1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCL1A on UCSC Golden Path with GeneCards custom track

Promoters for TCL1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCL1A on UCSC Golden Path with GeneCards custom track

Genomic Location for TCL1A Gene

Chromosome:
14
Start:
95,709,967 bp from pter
End:
95,714,196 bp from pter
Size:
4,230 bases
Orientation:
Minus strand

Genomic View for TCL1A Gene

Genes around TCL1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCL1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCL1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCL1A Gene

Proteins for TCL1A Gene

  • Protein details for TCL1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56279-TCL1A_HUMAN
    Recommended name:
    T-cell leukemia/lymphoma protein 1A
    Protein Accession:
    P56279
    Secondary Accessions:
    • Q6IBK7

    Protein attributes for TCL1A Gene

    Size:
    114 amino acids
    Molecular mass:
    13460 Da
    Quaternary structure:
    • Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.

    Three dimensional structures from OCA and Proteopedia for TCL1A Gene

neXtProt entry for TCL1A Gene

Proteomics data for TCL1A Gene at MOPED

Post-translational modifications for TCL1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TCL1A (TCL1A)
  • Cloud-Clone Corp. Antibodies for TCL1A

No data available for DME Specific Peptides for TCL1A Gene

Domains & Families for TCL1A Gene

Protein Domains for TCL1A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TCL1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56279

UniProtKB/Swiss-Prot:

TCL1A_HUMAN :
  • Belongs to the TCL1 family.
Family:
  • Belongs to the TCL1 family.
genes like me logo Genes that share domains with TCL1A: view

No data available for Gene Families for TCL1A Gene

Function for TCL1A Gene

Molecular function for TCL1A Gene

GENATLAS Biochemistry:
T cell leukemia,transcript 1a,14kDa,normally expressed in pre-B cells and immature IgM expressing B cells and in early T cell progenitors with very low levels in bone marrow and peripheral lymphocytes activated in T cell leukemia and lymphoma by rearrangements of the 14q32.1 region
UniProtKB/Swiss-Prot Function:
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
genes like me logo Genes that share phenotypes with TCL1A: view

Human Phenotype Ontology for TCL1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TCL1A Gene

MGI Knock Outs for TCL1A:

Animal Model Products

CRISPR Products

miRNA for TCL1A Gene

miRTarBase miRNAs that target TCL1A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TCL1A Gene

Localization for TCL1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCL1A Gene

Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCL1A Gene COMPARTMENTS Subcellular localization image for TCL1A gene
Compartment Confidence
endoplasmic reticulum 3
nucleus 3
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TCL1A Gene

Pathways & Interactions for TCL1A Gene

genes like me logo Genes that share pathways with TCL1A: view

Pathways by source for TCL1A Gene

1 Cell Signaling Technology pathway for TCL1A Gene
1 KEGG pathway for TCL1A Gene

SIGNOR curated interactions for TCL1A Gene

Activates:

Gene Ontology (GO) - Biological Process for TCL1A Gene

None

Drugs & Compounds for TCL1A Gene

(2) Drugs for TCL1A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TCL1A: view

Transcripts for TCL1A Gene

Unigene Clusters for TCL1A Gene

T-cell leukemia/lymphoma 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCL1A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP2:
SP3: - - - -
SP4: - - - - - -
SP5: - -
SP6: - - -
SP7:

Relevant External Links for TCL1A Gene

GeneLoc Exon Structure for
TCL1A
ECgene alternative splicing isoforms for
TCL1A

Expression for TCL1A Gene

mRNA expression in normal human tissues for TCL1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCL1A Gene

This gene is overexpressed in Spleen (x7.9) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for TCL1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.5) and Blymphocyte (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCL1A Gene



SOURCE GeneReport for Unigene cluster for TCL1A Gene Hs.2484

mRNA Expression by UniProt/SwissProt for TCL1A Gene

P56279-TCL1A_HUMAN
Tissue specificity: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
genes like me logo Genes that share expression patterns with TCL1A: view

Protein tissue co-expression partners for TCL1A Gene

Primer Products

In Situ Assay Products

Orthologs for TCL1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCL1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCL1A 35
  • 77.18 (n)
  • 64.86 (a)
TCL1A 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcl1 35
  • 69.1 (n)
  • 59.37 (a)
Tcl1 16
Tcl1 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCL1A 35
  • 99.12 (n)
  • 99.12 (a)
TCL1A 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcl1a 35
  • 69.44 (n)
  • 61.46 (a)
dog
(Canis familiaris)
Mammalia TCL1A 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
Species with no ortholog for TCL1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCL1A Gene

ENSEMBL:
Gene Tree for TCL1A (if available)
TreeFam:
Gene Tree for TCL1A (if available)

Paralogs for TCL1A Gene

Paralogs for TCL1A Gene

(2) SIMAP similar genes for TCL1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCL1A: view

Variants for TCL1A Gene

Sequence variations from dbSNP and Humsavar for TCL1A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17093294 - 95,712,351(+) GACGA(C/T)GTCTT nc-transcript-variant, reference, missense
rs728739 -- 95,715,725(-) TATTC(C/T)CAGAA upstream-variant-2KB
rs2887399 -- 95,714,358(+) GGAAC(G/T)CAGAC upstream-variant-2KB
rs1951989 -- 95,715,937(+) TGAAC(A/G)TTCCA upstream-variant-2KB
rs3831076 -- 95,710,371(+) TTTAC(C/G)GGCAG nc-transcript-variant, utr-variant-3-prime

Variation tolerance for TCL1A Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCL1A Gene

HapMap Linkage Disequilibrium report
TCL1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCL1A Gene

Disorders for TCL1A Gene

MalaCards: The human disease database

(10) MalaCards diseases for TCL1A Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
t-cell leukemia
  • leukemia t-cell
leukemia
lymphoma
  • lymphoid cancer
t-cell prolymphocytic leukemia
  • leukemia, t-cell, chronic
- elite association - COSMIC cancer census association via MalaCards
Search TCL1A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TCL1A_HUMAN
  • Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.

Genatlas disease for TCL1A Gene

chronic lymphocytic leukemia (T-CLL) associated breakpoint 1,with inversion inv(14) (q11;q32) and translocations t(14;14)(q11;q32),t(7;14)(q35;q32)

Relevant External Links for TCL1A

Genetic Association Database (GAD)
TCL1A
Human Genome Epidemiology (HuGE) Navigator
TCL1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCL1A
genes like me logo Genes that share disorders with TCL1A: view

Publications for TCL1A Gene

  1. Identification of the TCL1 gene involved in T-cell malignancies. (PMID: 7809072) Virgilio L. … Russo G. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23 67
  2. TCL1 protein expression in testicular germ cell tumors. (PMID: 20395523) Lau S.K. … Chu P.G. (Am. J. Clin. Pathol. 2010) 3 23
  3. CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. (PMID: 20357824) Efanov A. … Pekarsky Y. (Leukemia 2010) 3 23
  4. miR-34b/miR-34c: a regulator of TCL1 expression in 11q- chronic lymphocytic leukaemia? (PMID: 19536169) Cardinaud B. … Barbry P. (Leukemia 2009) 3 23
  5. High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia. (PMID: 17890451) Herling M. … Jones D. (Blood 2008) 3 23

Products for TCL1A Gene

Sources for TCL1A Gene

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