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Aliases for CALML3 Gene

Aliases for CALML3 Gene

  • Calmodulin Like 3 2 3 5
  • Calmodulin-Related Protein NB-1 3 4
  • Calmodulin-Like 3 2 3
  • CaM-Like Protein 3 4
  • CLP 3 4

External Ids for CALML3 Gene

Previous GeneCards Identifiers for CALML3 Gene

  • GC10M005445
  • GC10P005525
  • GC10P005666
  • GC10P005520

Summaries for CALML3 Gene

GeneCards Summary for CALML3 Gene

CALML3 (Calmodulin Like 3) is a Protein Coding gene. Diseases associated with CALML3 include cardiomyopathy, dilated, 1m and cardiomyopathy, hypertrophic, 12. Among its related pathways are cAMP signaling pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CABP2.

UniProtKB/Swiss-Prot for CALML3 Gene

  • May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.

Gene Wiki entry for CALML3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALML3 Gene

Genomics for CALML3 Gene

Regulatory Elements for CALML3 Gene

Genomic Location for CALML3 Gene

Chromosome:
10
Start:
5,524,009 bp from pter
End:
5,526,771 bp from pter
Size:
2,763 bases
Orientation:
Plus strand

Genomic View for CALML3 Gene

Genes around CALML3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALML3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML3 Gene

Proteins for CALML3 Gene

  • Protein details for CALML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27482-CALL3_HUMAN
    Recommended name:
    Calmodulin-like protein 3
    Protein Accession:
    P27482
    Secondary Accessions:
    • B2R9V6
    • Q5SQI4

    Protein attributes for CALML3 Gene

    Size:
    149 amino acids
    Molecular mass:
    16891 Da
    Quaternary structure:
    • Interacts with MYO10, the interaction is calcium-dependent and essential for MYO10 function in filopodial extension.
    Miscellaneous:
    • Binds four calcium ions.

    Three dimensional structures from OCA and Proteopedia for CALML3 Gene

neXtProt entry for CALML3 Gene

Proteomics data for CALML3 Gene at MOPED

Post-translational modifications for CALML3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALML3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CALML3 Gene

Domains & Families for CALML3 Gene

Gene Families for CALML3 Gene

Protein Domains for CALML3 Gene

Suggested Antigen Peptide Sequences for CALML3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27482

UniProtKB/Swiss-Prot:

CALL3_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the calmodulin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the calmodulin family.
genes like me logo Genes that share domains with CALML3: view

Function for CALML3 Gene

Molecular function for CALML3 Gene

GENATLAS Biochemistry:
calmodulin-like 1,calcium modulated protein
UniProtKB/Swiss-Prot Function:
May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.
UniProtKB/Swiss-Prot Induction:
By TGFB1.

Gene Ontology (GO) - Molecular Function for CALML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CALML3: view
genes like me logo Genes that share phenotypes with CALML3: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALML3 Gene

Localization for CALML3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALML3 Gene COMPARTMENTS Subcellular localization image for CALML3 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CALML3 Gene

Pathways & Interactions for CALML3 Gene

genes like me logo Genes that share pathways with CALML3: view

Pathways by source for CALML3 Gene

Gene Ontology (GO) - Biological Process for CALML3 Gene

None

No data available for SIGNOR curated interactions for CALML3 Gene

Drugs & Compounds for CALML3 Gene

(1) Drugs for CALML3 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CALML3: view

Transcripts for CALML3 Gene

mRNA/cDNA for CALML3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(55) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALML3 Gene

Calmodulin-like 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALML3 Gene

No ASD Table

Relevant External Links for CALML3 Gene

GeneLoc Exon Structure for
CALML3
ECgene alternative splicing isoforms for
CALML3

Expression for CALML3 Gene

mRNA expression in normal human tissues for CALML3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALML3 Gene

This gene is overexpressed in Esophagus - Mucosa (x18.6), Skin - Not Sun Exposed (Suprapubic) (x9.4), Vagina (x7.5), Skin - Sun Exposed (Lower leg) (x5.7), Cervix - Ectocervix (x5.1), and Minor Salivary Gland (x5.0).

Protein differential expression in normal tissues from HIPED for CALML3 Gene

This gene is overexpressed in Hair follicle (25.6), Cervix (12.6), Nasal epithelium (11.6), and Urinary Bladder (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALML3 Gene



SOURCE GeneReport for Unigene cluster for CALML3 Gene Hs.239600

mRNA Expression by UniProt/SwissProt for CALML3 Gene

P27482-CALL3_HUMAN
Tissue specificity: Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells.
genes like me logo Genes that share expression patterns with CALML3: view

Protein tissue co-expression partners for CALML3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CALML3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALML3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALML3 36
  • 100 (a)
OneToOne
CALML3 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CALML3 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALML3 36
  • 32 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calml3 16
Calml3 36
  • 89 (a)
OneToOne
Calml3 35
  • 84.34 (n)
  • 89.26 (a)
oppossum
(Monodelphis domestica)
Mammalia CALML3 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calml3 35
  • 85.91 (n)
  • 90.6 (a)
chicken
(Gallus gallus)
Aves CALML3 35
  • 78.97 (n)
  • 78.52 (a)
CALML3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11165 36
  • 45 (a)
ManyToMany
CG31958 36
  • 40 (a)
ManyToMany
CG31960 36
  • 49 (a)
ManyToMany
And 37
  • 63 (a)
Cam 37
  • 85 (a)
CG11165 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea cal-1 36
  • 48 (a)
ManyToMany
cal-2 36
  • 50 (a)
ManyToMany
cal-3 36
  • 33 (a)
ManyToMany
cal-4 36
  • 33 (a)
ManyToMany
cal-1 37
  • 60 (a)
cal-2 37
  • 60 (a)
cal-3 37
  • 54 (a)
cal-4 37
  • 54 (a)
cmd-1 37
  • 85 (a)
Y73B3A.12 37
  • 82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMD1 36
  • 56 (a)
OneToMany
MLC2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CAM1 35
  • 72.93 (n)
  • 80.54 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12866 35
rice
(Oryza sativa)
Liliopsida Os.2226 35
Os05g0491100 35
  • 76.51 (n)
  • 81.88 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1018 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7047 36
  • 47 (a)
ManyToMany
Species with no ortholog for CALML3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • zebrafish (Danio rerio)

Evolution for CALML3 Gene

ENSEMBL:
Gene Tree for CALML3 (if available)
TreeFam:
Gene Tree for CALML3 (if available)

Paralogs for CALML3 Gene

Paralogs for CALML3 Gene

genes like me logo Genes that share paralogs with CALML3: view

Variants for CALML3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CALML3 Gene

Variant ID Type Subtype PubMed ID
nsv831774 CNV Gain 17160897
nsv894798 CNV Loss 21882294
nsv523491 CNV Gain 19592680
dgv215e1 CNV Complex 17122850
dgv216e1 CNV Complex 17122850

Variation tolerance for CALML3 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALML3 Gene

HapMap Linkage Disequilibrium report
CALML3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CALML3 Gene

Disorders for CALML3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CALML3 Gene - From: OMIM

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1m
  • cmd1m
cardiomyopathy, hypertrophic, 12
  • cardiomyopathy, familial hypertrophic, 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CALML3

Genetic Association Database (GAD)
CALML3
Human Genome Epidemiology (HuGE) Navigator
CALML3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALML3
genes like me logo Genes that share disorders with CALML3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALML3 Gene

Publications for CALML3 Gene

  1. The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X. (PMID: 11278607) Rogers M.S. … Strehler E.E. (J. Biol. Chem. 2001) 3 4 23 67
  2. Functional analysis of the promoters of the human CaMIII calmodulin gene and of the intronless gene coding for a calmodulin-like protein. (PMID: 8476923) Koller M. … Strehler E.E. (Biochim. Biophys. Acta 1993) 2 3 23
  3. Calmodulin-like protein upregulates myosin-10 in human keratinocytes and is regulated during epidermal wound healing in vivo. (PMID: 18818677) Bennett R.D. … Strehler E.E. (J. Invest. Dermatol. 2009) 3 23
  4. Human calmodulin-like protein (CLP) expression in oral squamous mucosa and in malignant transformation. (PMID: 19166543) Brooks M.D. … Carr A.B. (J Prosthodont 2009) 3 23
  5. Interaction with the IQ3 motif of myosin-10 is required for calmodulin-like protein-dependent filopodial extension. (PMID: 18570893) Bennett R.D. … Strehler E.E. (FEBS Lett. 2008) 3 23

Products for CALML3 Gene

Sources for CALML3 Gene

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