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Aliases for CDK2AP1 Gene

Aliases for CDK2AP1 Gene

  • Cyclin-Dependent Kinase 2 Associated Protein 1 2 3
  • CDK2-Associated Protein 1 2 3 4
  • DOC1 3 4 6
  • Putative Oral Cancer Suppressor 3 4
  • Deleted In Oral Cancer 1 3 4
  • Doc-1 3 4
  • Cyclin-Dependent Kinase 2-Associated Protein 1 3
  • Deleted In Oral Cancer-1 3
  • P12DOC-1 3
  • CDKAP1 4
  • DORC1 3
  • ST19 3

External Ids for CDK2AP1 Gene

Previous GeneCards Identifiers for CDK2AP1 Gene

  • GC12P122351
  • GC12M123446
  • GC12M123553
  • GC12M122183
  • GC12M122270
  • GC12M123745
  • GC12M120706

Summaries for CDK2AP1 Gene

Entrez Gene Summary for CDK2AP1 Gene

  • The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CDK2AP1 Gene

CDK2AP1 (Cyclin-Dependent Kinase 2 Associated Protein 1) is a Protein Coding gene. Diseases associated with CDK2AP1 include oral cancer. An important paralog of this gene is CDK2AP2.

UniProtKB/Swiss-Prot for CDK2AP1 Gene

  • specific inhibitor of the cell-cycle kinase CDK2.

Gene Wiki entry for CDK2AP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK2AP1 Gene

Genomics for CDK2AP1 Gene

Regulatory Elements for CDK2AP1 Gene

Genomic Location for CDK2AP1 Gene

123,260,970 bp from pter
123,272,334 bp from pter
11,365 bases
Minus strand

Genomic View for CDK2AP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK2AP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK2AP1 Gene

Proteins for CDK2AP1 Gene

  • Protein details for CDK2AP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 2-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • F5GYA4

    Protein attributes for CDK2AP1 Gene

    115 amino acids
    Molecular mass:
    12365 Da
    Quaternary structure:
    • Homodimer. Interacts with monomeric unphosphorylated CDK2.

    Three dimensional structures from OCA and Proteopedia for CDK2AP1 Gene

    Alternative splice isoforms for CDK2AP1 Gene


neXtProt entry for CDK2AP1 Gene

Proteomics data for CDK2AP1 Gene at MOPED

Post-translational modifications for CDK2AP1 Gene

Antibody Products

No data available for DME Specific Peptides for CDK2AP1 Gene

Domains for CDK2AP1 Gene

Protein Domains for CDK2AP1 Gene

Suggested Antigen Peptide Sequences for CDK2AP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDK2AP family.
  • Belongs to the CDK2AP family.
genes like me logo Genes that share domains with CDK2AP1: view

No data available for Gene Families for CDK2AP1 Gene

Function for CDK2AP1 Gene

Molecular function for CDK2AP1 Gene

UniProtKB/Swiss-Prot Function:
specific inhibitor of the cell-cycle kinase CDK2.

Gene Ontology (GO) - Molecular Function for CDK2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0070182 DNA polymerase binding IPI 9506968
genes like me logo Genes that share ontologies with CDK2AP1: view
genes like me logo Genes that share phenotypes with CDK2AP1: view

Animal Models for CDK2AP1 Gene

MGI Knock Outs for CDK2AP1:

Animal Model Products

CRISPR Products

miRNA for CDK2AP1 Gene

miRTarBase miRNAs that target CDK2AP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDK2AP1 Gene

Localization for CDK2AP1 Gene

Subcellular locations from

Jensen Localization Image for CDK2AP1 Gene COMPARTMENTS Subcellular localization image for CDK2AP1 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 1

Gene Ontology (GO) - Cellular Components for CDK2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9506968
GO:0048471 perinuclear region of cytoplasm IDA 9506968
genes like me logo Genes that share ontologies with CDK2AP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK2AP1 Gene

Pathways for CDK2AP1 Gene

SuperPathways for CDK2AP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDK2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 9506968
GO:0006261 DNA-dependent DNA replication NAS 9506968
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CDK2AP1: view

No data available for Pathways by source for CDK2AP1 Gene

Transcripts for CDK2AP1 Gene

Unigene Clusters for CDK2AP1 Gene

Cyclin-dependent kinase 2 associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK2AP1 Gene

No ASD Table

Relevant External Links for CDK2AP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDK2AP1 Gene

mRNA expression in normal human tissues for CDK2AP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CDK2AP1 Gene

This gene is overexpressed in Fetal ovary (50.5) and Peripheral blood mononuclear cells (13.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDK2AP1 Gene

SOURCE GeneReport for Unigene cluster for CDK2AP1 Gene Hs.433201

genes like me logo Genes that share expressions with CDK2AP1: view

Expression partners for CDK2AP1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK2AP1 Gene

Orthologs for CDK2AP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK2AP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDK2AP1 35
  • 89.86 (n)
  • 96.52 (a)
CDK2AP1 36
  • 97 (a)
(Canis familiaris)
Mammalia CDK2AP1 35
  • 90.72 (n)
  • 97.39 (a)
CDK2AP1 36
  • 95 (a)
(Mus musculus)
Mammalia Cdk2ap1 35
  • 87.72 (n)
  • 98.25 (a)
Cdk2ap1 16
Cdk2ap1 36
  • 98 (a)
Gm12184 36
  • 98 (a)
(Pan troglodytes)
Mammalia CDK2AP1 35
  • 99.32 (n)
  • 98.98 (a)
CDK2AP1 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Cdk2ap1 35
  • 88.6 (n)
  • 98.25 (a)
(Monodelphis domestica)
Mammalia CDK2AP1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia CDK2AP1 36
  • 87 (a)
(Gallus gallus)
Aves CDK2AP1 35
  • 77.97 (n)
  • 89.57 (a)
CDK2AP1 36
  • 92 (a)
(Anolis carolinensis)
Reptilia CDK2AP1 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk2ap1 35
  • 73.33 (n)
  • 81.74 (a)
Str.6181 35
African clawed frog
(Xenopus laevis)
Amphibia cdk2ap1-prov 35
(Danio rerio)
Actinopterygii LOC100535265 35
  • 71.65 (n)
  • 82.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18292 36
  • 19 (a)
Species with no ortholog for CDK2AP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDK2AP1 Gene

Gene Tree for CDK2AP1 (if available)
Gene Tree for CDK2AP1 (if available)

Paralogs for CDK2AP1 Gene

Paralogs for CDK2AP1 Gene

(2) SIMAP similar genes for CDK2AP1 Gene using alignment to 2 proteins: Pseudogenes for CDK2AP1 Gene

genes like me logo Genes that share paralogs with CDK2AP1: view

Variants for CDK2AP1 Gene

Sequence variations from dbSNP and Humsavar for CDK2AP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs553457906 -- 123,263,545(+) CTACC(A/G)GAGAG intron-variant
rs553544450 -- 123,270,688(+) GAGGA(C/G)TTTCC upstream-variant-2KB, intron-variant
rs554212372 -- 123,262,699(+) GCCTC(C/T)GGAGA intron-variant
rs553409127 -- 123,273,924(+) AAACC(A/G)GGAGG upstream-variant-2KB
rs553216970 -- 123,265,914(+) CGATC(C/T)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK2AP1 Gene

Variant ID Type Subtype PubMed ID
nsv826532 CNV Gain 20364138

Relevant External Links for CDK2AP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK2AP1 Gene

Disorders for CDK2AP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CDK2AP1 Gene in MalaCards »

(1) Disease for CDK2AP1 Gene

(2) Novoseek inferred disease relationships for CDK2AP1 Gene

Disease -log(P) Hits PubMed IDs
oral cancer 63.8 3
tumors 18 5
genes like me logo Genes that share disorders with CDK2AP1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for CDK2AP1 Gene

Publications for CDK2AP1 Gene

  1. Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1. (PMID: 9506968) Tsuji T. … Wong D.T. (J. Biol. Chem. 1998) 2 3 4 23
  2. Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer. (PMID: 9331572) Daigo Y. … Nakamura Y. (Genes Chromosomes Cancer 1997) 2 3 4
  3. Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N- terminal region. (PMID: 22427660) Ertekin A. … Montelione G.T. (J. Biol. Chem. 2012) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer. (PMID: 13679870) Yuan Z. … Weber T.K. (Oncogene 2003) 3 23

Products for CDK2AP1 Gene

Sources for CDK2AP1 Gene

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