Aliases for HMGA2 Gene
External Ids for HMGA2 Gene
Previous HGNC Symbols for HMGA2 Gene
Previous GeneCards Identifiers for HMGA2 Gene
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for HMGA2 Gene
HMGA2 (High Mobility Group AT-Hook 2) is a Protein Coding gene. Diseases associated with HMGA2 include Adenomas, Salivary Gland Pleomorphic, Somatic and Silver-Russell Syndrome. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Mesodermal Commitment Pathway. GO annotations related to this gene include enzyme binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding.
UniProtKB/Swiss-Prot for HMGA2 Gene
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity).