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Aliases for YEATS4 Gene

Aliases for YEATS4 Gene

  • YEATS Domain Containing 4 2 3
  • GAS41 3 4 6
  • Glioma-Amplified Sequence 41 3 4
  • NuMA-Binding Protein 1 3 4
  • NUBI-1 3 4
  • NuBI1 3 4
  • YEATS Domain-Containing Protein 4 3
  • Glioma-Amplified Sequence-41 3
  • NuMA Binding Protein 1 3
  • 4930573H17Rik 3
  • B230215M10Rik 3
  • YAF9 3

External Ids for YEATS4 Gene

Summaries for YEATS4 Gene

Entrez Gene Summary for YEATS4 Gene

  • The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for YEATS4 Gene

YEATS4 (YEATS Domain Containing 4) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and structural constituent of cytoskeleton. An important paralog of this gene is YEATS2.

UniProtKB/Swiss-Prot for YEATS4 Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YEATS4 Gene

Genomics for YEATS4 Gene

Genomic Location for YEATS4 Gene

Start:
69,359,703 bp from pter
End:
69,390,796 bp from pter
Size:
31,094 bases
Orientation:
Plus strand

Genomic View for YEATS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YEATS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YEATS4 Gene

Regulatory Elements for YEATS4 Gene

Proteins for YEATS4 Gene

  • Protein details for YEATS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95619-YETS4_HUMAN
    Recommended name:
    YEATS domain-containing protein 4
    Protein Accession:
    O95619
    Secondary Accessions:
    • Q9NQD0

    Protein attributes for YEATS4 Gene

    Size:
    227 amino acids
    Molecular mass:
    26499 Da
    Quaternary structure:
    • Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.
    SequenceCaution:
    • Sequence=CAC01935.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for YEATS4 Gene

Proteomics data for YEATS4 Gene at MOPED

Post-translational modifications for YEATS4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys17 and Lys198

Other Protein References for YEATS4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for YEATS4 Gene

Domains for YEATS4 Gene

Protein Domains for YEATS4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YEATS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95619

UniProtKB/Swiss-Prot:

YETS4_HUMAN
Domain:
  • Contains 1 YEATS domain.:
    • O95619
genes like me logo Genes that share domains with YEATS4: view

No data available for Gene Families for YEATS4 Gene

Function for YEATS4 Gene

Molecular function for YEATS4 Gene

UniProtKB/Swiss-Prot Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Gene Ontology (GO) - Molecular Function for YEATS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9302258
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9302258
GO:0005200 structural constituent of cytoskeleton NAS 10913114
GO:0005515 protein binding IPI 11903063
GO:0008022 protein C-terminus binding IPI 10913114
genes like me logo Genes that share ontologies with YEATS4: view

Phenotypes for YEATS4 Gene

genes like me logo Genes that share phenotypes with YEATS4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for YEATS4 Gene

Localization for YEATS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YEATS4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YEATS4 Gene COMPARTMENTS Subcellular localization image for YEATS4 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for YEATS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0016363 nuclear matrix NAS 10913114
genes like me logo Genes that share ontologies with YEATS4: view

Pathways for YEATS4 Gene

genes like me logo Genes that share pathways with YEATS4: view

Pathways by source for YEATS4 Gene

1 BioSystems pathway for YEATS4 Gene

Gene Ontology (GO) - Biological Process for YEATS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007067 mitotic nuclear division NAS 10913114
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with YEATS4: view

Compounds for YEATS4 Gene

(1) PharmGKB related drug/compound annotations for YEATS4 Gene

Drug/compound Annotation
hydrochlorothiazide CA
genes like me logo Genes that share compounds with YEATS4: view

Transcripts for YEATS4 Gene

mRNA/cDNA for YEATS4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YEATS4 Gene

YEATS domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YEATS4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: -
SP3: -
SP4: - - - -
SP5: - - -

Relevant External Links for YEATS4 Gene

GeneLoc Exon Structure for
YEATS4
ECgene alternative splicing isoforms for
YEATS4

Expression for YEATS4 Gene

mRNA expression in normal human tissues for YEATS4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YEATS4 Gene

SOURCE GeneReport for Unigene cluster for YEATS4 Gene Hs.4029

mRNA Expression by UniProt/SwissProt for YEATS4 Gene

O95619-YETS4_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
genes like me logo Genes that share expressions with YEATS4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for YEATS4 Gene

Orthologs for YEATS4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for YEATS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YEATS4 35
  • 99.85 (n)
  • 100 (a)
YEATS4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YEATS4 35
  • 95.45 (n)
  • 99.12 (a)
YEATS4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YEATS4 35
  • 95.59 (n)
  • 99.12 (a)
YEATS4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yeats4 35
  • 88.55 (n)
  • 99.56 (a)
Yeats4 16
Yeats4 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia YEATS4 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YEATS4 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yeats4 35
  • 91.48 (n)
  • 98.68 (a)
chicken
(Gallus gallus)
Aves GAS41 36
  • 97 (a)
OneToOne
YEATS4 35
  • 80.32 (n)
  • 97.36 (a)
lizard
(Anolis carolinensis)
Reptilia YEATS4 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8404 35
yeats4 35
  • 82.23 (n)
  • 96.48 (a)
zebrafish
(Danio rerio)
Actinopterygii yeats4 35
  • 73.78 (n)
  • 91.56 (a)
yeats4 36
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009650 35
  • 59.39 (n)
  • 64.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gas41 35
  • 59.22 (n)
  • 62.33 (a)
Gas41 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gfl-1 35
  • 52.68 (n)
  • 49.27 (a)
gfl-1 36
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL227C 35
  • 45.7 (n)
  • 38.66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAF9 35
  • 48.92 (n)
  • 35.82 (a)
YAF9 36
  • 27 (a)
OneToMany
YAF9 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23584g 35
  • 48.81 (n)
  • 38.27 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00359 35
  • 46.58 (n)
  • 41.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes yaf9 35
  • 45.96 (n)
  • 32.32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5263 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for YEATS4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YEATS4 Gene

ENSEMBL:
Gene Tree for YEATS4 (if available)
TreeFam:
Gene Tree for YEATS4 (if available)

Paralogs for YEATS4 Gene

Paralogs for YEATS4 Gene

Selected SIMAP similar genes for YEATS4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with YEATS4: view

Variants for YEATS4 Gene

Sequence variations from dbSNP and Humsavar for YEATS4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs160827 -- 69,376,367(-) ttatt(C/T)tgaga intron-variant
rs160828 -- 69,375,782(-) tggga(C/T)tgcag intron-variant
rs160829 -- 69,375,758(-) cgcct(C/G)accag intron-variant
rs160830 -- 69,375,526(-) gtgcc(A/G)agatt intron-variant
rs160831 -- 69,375,354(-) ctctg(A/C/G/T)ccggc intron-variant

Relevant External Links for YEATS4 Gene

HapMap Linkage Disequilibrium report
YEATS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for YEATS4 Gene

Disorders for YEATS4 Gene

(1) University of Copenhagen DISEASES for YEATS4 Gene

(2) Novoseek inferred disease relationships for YEATS4 Gene

Disease -log(P) Hits PubMed IDs
glioma 40.2 2
tumors 0 6

Relevant External Links for YEATS4

Genetic Association Database (GAD)
YEATS4
Human Genome Epidemiology (HuGE) Navigator
YEATS4
genes like me logo Genes that share disorders with YEATS4: view

No data available for UniProtKB/Swiss-Prot for YEATS4 Gene

Publications for YEATS4 Gene

  1. Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I. (PMID: 9302258) Fischer U. … Meese E. (Hum. Mol. Genet. 1997) 2 3 4 23
  2. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PMID: 11903063) Lauffart B. … Still I.H. (Biochem. J. 2002) 2 3 4 23
  3. GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. (PMID: 10913114) Harborth J. … Osborn M. (J. Biol. Chem. 2000) 3 4
  4. GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation. (PMID: 16705155) Park J.H. … Roeder R.G. (Mol. Cell. Biol. 2006) 3 23
  5. HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. (PMID: 18214854) Italiano A. … Pedeutour F. (Int. J. Cancer 2008) 3 23

Products for YEATS4 Gene

Sources for YEATS4 Gene

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