Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CALM3 Gene

Aliases for CALM3 Gene

  • Calmodulin 3 (Phosphorylase Kinase, Delta) 2 3
  • Prepro-Calmodulin 3 2 3
  • CAM 3 4
  • Epididymis Secretory Protein Li 72 3
  • CALM1 CALM2 CALM3 4
  • Calmodulin 3
  • HEL-S-72 3
  • CALML2 4
  • CAMIII 4
  • PHKD3 3
  • PHKD 3
  • CALM 4
  • CAM1 4
  • CAM2 4
  • CAM3 4
  • CAMB 4
  • CAMC 4

External Ids for CALM3 Gene

Summaries for CALM3 Gene

GeneCards Summary for CALM3 Gene

CALM3 (Calmodulin 3 (Phosphorylase Kinase, Delta)) is a Protein Coding gene. Diseases associated with CALM3 include otomycosis and pseudoachondroplasia. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include calcium ion binding and ion channel binding. An important paralog of this gene is CABP2.

UniProtKB/Swiss-Prot for CALM3 Gene

  • Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

Gene Wiki entry for CALM3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALM3 Gene

Genomics for CALM3 Gene

Genomic Location for CALM3 Gene

Start:
46,601,074 bp from pter
End:
46,610,793 bp from pter
Size:
9,720 bases
Orientation:
Plus strand

Genomic View for CALM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALM3 Gene

Regulatory Elements for CALM3 Gene

Proteins for CALM3 Gene

  • Protein details for CALM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62158-CALM_HUMAN
    Recommended name:
    Calmodulin
    Protein Accession:
    P62158
    Secondary Accessions:
    • P02593
    • P70667
    • P99014
    • Q13942
    • Q53S29
    • Q61379
    • Q61380
    • Q96HK3

    Protein attributes for CALM3 Gene

    Size:
    149 amino acids
    Molecular mass:
    16838 Da
    Quaternary structure:
    • Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport.
    Miscellaneous:
    • This protein has four functional calcium-binding sites
    SequenceCaution:
    • Sequence=CAA36839.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CALM3 Gene

neXtProt entry for CALM3 Gene

Proteomics data for CALM3 Gene at MOPED

Post-translational modifications for CALM3 Gene

Other Protein References for CALM3 Gene

No data available for DME Specific Peptides for CALM3 Gene

Domains for CALM3 Gene

Gene Families for CALM3 Gene

HGNC:

Protein Domains for CALM3 Gene

UniProtKB/Swiss-Prot:

CALM_HUMAN
Domain:
  • Contains 4 EF-hand domains.:
    • P62158
Family:
  • Belongs to the calmodulin family.:
    • P62158
genes like me logo Genes that share domains with CALM3: view

Function for CALM3 Gene

Molecular function for CALM3 Gene

GENATLAS Biochemistry: calmodulin 3,calcium modulated protein
UniProtKB/Swiss-Prot Function: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

Gene Ontology (GO) - Molecular Function for CALM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IPI 10692436
GO:0008179 adenylate cyclase binding IEA --
GO:0016301 kinase activity --
GO:0019901 protein kinase binding IPI 20668654
genes like me logo Genes that share ontologies with CALM3: view
genes like me logo Genes that share phenotypes with CALM3: view

miRNA for CALM3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CALM3 Gene

Localization for CALM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALM3 Gene

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALM3 Gene COMPARTMENTS Subcellular localization image for CALM3 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
extracellular 4
nucleus 4
endoplasmic reticulum 3
golgi apparatus 2
mitochondrion 2
vacuole 2
chloroplast 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CALM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 16760425
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 10899953
genes like me logo Genes that share ontologies with CALM3: view

Pathways for CALM3 Gene

SuperPathways for CALM3 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Post NMDA receptor activation events
4 Development Angiotensin activation of ERK
5 Development Endothelin-1/EDNRA signaling
genes like me logo Genes that share pathways with CALM3: view

Gene Ontology (GO) - Biological Process for CALM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0002027 regulation of heart rate IMP 23040497
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002576 platelet degranulation TAS --
GO:0005513 detection of calcium ion IMP 23040497
genes like me logo Genes that share ontologies with CALM3: view

Transcripts for CALM3 Gene

Unigene Clusters for CALM3 Gene

Calmodulin 3 (phosphorylase kinase, delta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALM3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CALM3 Gene

GeneLoc Exon Structure for
CALM3
ECgene alternative splicing isoforms for
CALM3

Expression for CALM3 Gene

mRNA expression in normal human tissues for CALM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALM3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.4) and Brain - Anterior cingulate cortex (BA24) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CALM3 Gene

SOURCE GeneReport for Unigene cluster for CALM3 Gene Hs.515487

genes like me logo Genes that share expressions with CALM3: view

Orthologs for CALM3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALM3 36
  • 100 (n)
  • 100 (a)
CALM3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALM 36
  • 81.88 (n)
  • 98.66 (a)
CALM 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALM3 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calm3 16
Calm3 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 100 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CALM1 36
  • 82.55 (n)
  • 99.33 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 99 (a)
ManyToMany
-- 37
  • 100 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii -- 36
calm1a 37
  • 100 (a)
ManyToMany
calm1b 37
  • 100 (a)
ManyToMany
calm2a 37
  • 100 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cam 37
  • 98 (a)
OneToMany
And 38
  • 65 (a)
Cam 38
  • 96 (a)
Mlc-c 38
  • 45 (a)
CG11165 38
  • 52 (a)
TpnC41C 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea cal-6 37
  • 76 (a)
ManyToMany
cmd-1 37
  • 98 (a)
ManyToMany
cal-4 38
  • 58 (a)
cal-1 38
  • 66 (a)
cmd-1 38
  • 96 (a)
cal-3 38
  • 57 (a)
Y73B3A.12 38
  • 74 (a)
cal-2 38
  • 63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMD1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons CAM7 36
  • 78.08 (n)
  • 89.93 (a)
corn
(Zea mays)
Liliopsida Zm.176 36
rice
(Oryza sativa)
Liliopsida Os.10290 36
Os01g0267900 36
  • 79.42 (n)
  • 90.6 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04120 36
  • 76.06 (n)
  • 85.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cam1 36
  • 67.59 (n)
  • 76.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10340 37
  • 97 (a)
OneToMany
Species with no ortholog for CALM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CALM3 Gene

ENSEMBL:
Gene Tree for CALM3 (if available)
TreeFam:
Gene Tree for CALM3 (if available)

Paralogs for CALM3 Gene

genes like me logo Genes that share paralogs with CALM3: view

Variants for CALM3 Gene

Sequence variations from dbSNP and Humsavar for CALM3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10113 -- 46,609,391(+) ATCCA(C/T)GTCTT utr-variant-3-prime
rs710889 -- 46,609,483(-) AAATG(A/G)AGGAG utr-variant-3-prime
rs1056342 -- 46,610,533(+) TTTCC(C/T)GGGAC utr-variant-3-prime
rs1391260 -- 46,603,548(-) GACAA(A/G)AAAAA intron-variant
rs1803240 -- 46,610,020(+) GTCGC(C/T)TTGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CALM3 Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV Loss 17160897
dgv3961n71 CNV Loss 21882294

Relevant External Links for CALM3 Gene

HapMap Linkage Disequilibrium report
CALM3
Human Gene Mutation Database (HGMD)
CALM3

Disorders for CALM3 Gene

UniProtKB/Swiss-Prot

CALM_HUMAN
  • Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM:614916]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. {ECO:0000269 PubMed:23040497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CALM3

Genetic Association Database (GAD)
CALM3
Human Genome Epidemiology (HuGE) Navigator
CALM3
genes like me logo Genes that share disorders with CALM3: view

Publications for CALM3 Gene

  1. Drug binding by calmodulin: crystal structure of a calmodulin- trifluoperazine complex. (PMID: 7803388) Cook W.J. … Walter M.R. (Biochemistry 1994) 3 4
  2. Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2. (PMID: 7925473) Rhyner J.A. … Strehler E.E. (Eur. J. Biochem. 1994) 3 4
  3. Alpha-helix nucleation by a calcium-binding peptide loop. (PMID: 9927666) Siedlecka M. … Bierzyski A. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4
  4. Calmodulin structure refined at 1.7 A resolution. (PMID: 1474585) Chattopadhyaya R. … Quiocho F.A. (J. Mol. Biol. 1992) 3 4
  5. Structural organization of the human CaMIII calmodulin gene. (PMID: 2223880) Koller M. … Strehler E.E. (Biochim. Biophys. Acta 1990) 3 4

Products for CALM3 Gene

Sources for CALM3 Gene

Back to Top

Content