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Aliases for ZNF34 Gene

Aliases for ZNF34 Gene

  • Zinc Finger Protein 34 2 3 5
  • Zinc Finger Protein 34 (KOX 32) 2 3
  • Zinc Finger Protein KOX32 3 4
  • KOX32 3 4

External Ids for ZNF34 Gene

Previous GeneCards Identifiers for ZNF34 Gene

  • GC08U990067
  • GC08M146003
  • GC08M146002
  • GC08M145969
  • GC08M141115

Summaries for ZNF34 Gene

GeneCards Summary for ZNF34 Gene

ZNF34 (Zinc Finger Protein 34) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF485.

UniProtKB/Swiss-Prot for ZNF34 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF34 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF34 Gene

Genomics for ZNF34 Gene

Regulatory Elements for ZNF34 Gene

Promoters for ZNF34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF34 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF34 Gene

Chromosome:
8
Start:
144,772,224 bp from pter
End:
144,787,359 bp from pter
Size:
15,136 bases
Orientation:
Minus strand

Genomic View for ZNF34 Gene

Genes around ZNF34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF34 Gene

Proteins for ZNF34 Gene

  • Protein details for ZNF34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ26-ZNF34_HUMAN
    Recommended name:
    Zinc finger protein 34
    Protein Accession:
    Q8IZ26
    Secondary Accessions:
    • D3DWN1
    • Q9BSZ0

    Protein attributes for ZNF34 Gene

    Size:
    560 amino acids
    Molecular mass:
    64038 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH04480.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH28136.1; Type=Miscellaneous discrepancy; Note=Codon in position 67 corresponds to a stop codon in genome.; Evidence={ECO:0000305};

neXtProt entry for ZNF34 Gene

Proteomics data for ZNF34 Gene at MOPED

Post-translational modifications for ZNF34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF34 Gene

No data available for DME Specific Peptides for ZNF34 Gene

Domains & Families for ZNF34 Gene

Gene Families for ZNF34 Gene

Suggested Antigen Peptide Sequences for ZNF34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZ26

UniProtKB/Swiss-Prot:

ZNF34_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF34: view

Function for ZNF34 Gene

Molecular function for ZNF34 Gene

GENATLAS Biochemistry:
zinc finger protein 34 (KOX32) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF34: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF34 Gene

Localization for ZNF34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF34 Gene COMPARTMENTS Subcellular localization image for ZNF34 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF34 Gene

Pathways & Interactions for ZNF34 Gene

SuperPathways for ZNF34 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF34: view

Pathways by source for ZNF34 Gene

2 Reactome pathways for ZNF34 Gene

Gene Ontology (GO) - Biological Process for ZNF34 Gene

None

No data available for SIGNOR curated interactions for ZNF34 Gene

Drugs & Compounds for ZNF34 Gene

No Compound Related Data Available

Transcripts for ZNF34 Gene

Unigene Clusters for ZNF34 Gene

Zinc finger protein 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF34 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1:
SP2:
SP3: - -
SP4: - -
SP5: - -
SP6: - -

Relevant External Links for ZNF34 Gene

GeneLoc Exon Structure for
ZNF34
ECgene alternative splicing isoforms for
ZNF34

Expression for ZNF34 Gene

mRNA expression in normal human tissues for ZNF34 Gene

Protein differential expression in normal tissues from HIPED for ZNF34 Gene

This gene is overexpressed in Stomach (60.1) and Uterus (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF34 Gene



SOURCE GeneReport for Unigene cluster for ZNF34 Gene Hs.631854

genes like me logo Genes that share expression patterns with ZNF34: view

Protein tissue co-expression partners for ZNF34 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF34 Gene

Orthologs for ZNF34 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF34 35
  • 99.69 (n)
  • 99.44 (a)
ZNF34 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF34 36
  • 82 (a)
OneToOne
ZNF34 35
  • 84.3 (n)
  • 84.11 (a)
dog
(Canis familiaris)
Mammalia ZNF34 35
  • 87.24 (n)
  • 86.25 (a)
ZNF34 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf180 35
  • 52.22 (n)
  • 44.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 36
  • 22 (a)
OneToMany
Species with no ortholog for ZNF34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF34 Gene

ENSEMBL:
Gene Tree for ZNF34 (if available)
TreeFam:
Gene Tree for ZNF34 (if available)

Paralogs for ZNF34 Gene

(515) SIMAP similar genes for ZNF34 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF34 Gene

genes like me logo Genes that share paralogs with ZNF34: view

Variants for ZNF34 Gene

Sequence variations from dbSNP and Humsavar for ZNF34 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2958497 -- 144,785,785(-) CCATA(A/G)AGTAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs2958498 -- 144,785,432(-) tcccc(G/T)gatgt intron-variant, upstream-variant-2KB
rs2958507 -- 144,782,876(-) CTTTT(C/T)TTTTT intron-variant, upstream-variant-2KB
rs2958512 -- 144,787,825(+) CTGGA(A/G)CAAAC upstream-variant-2KB
rs2979092 -- 144,779,798(-) GCTTA(C/G)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF34 Gene

Variant ID Type Subtype PubMed ID
nsv891807 CNV Loss 21882294
nsv891897 CNV Loss 21882294
nsv522459 CNV Loss 19592680
nsv891925 CNV Loss 21882294
nsv891926 CNV Gain 21882294
dgv7985n71 CNV Loss 21882294
nsv891929 CNV Loss 21882294

Variation tolerance for ZNF34 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF34 Gene

HapMap Linkage Disequilibrium report
ZNF34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF34 Gene

Disorders for ZNF34 Gene

Relevant External Links for ZNF34

Genetic Association Database (GAD)
ZNF34
Human Genome Epidemiology (HuGE) Navigator
ZNF34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF34

No disorders were found for ZNF34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF34 Gene

Publications for ZNF34 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A BanII RFLP in the ZNF34 zinc finger gene on chromosome 8. (PMID: 8104631) La Pillo B. … Horsthemke B. (Hum. Mol. Genet. 1993) 2 3
  3. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K. … Thiesen H.J. (Am. J. Hum. Genet. 1991) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for ZNF34 Gene

Sources for ZNF34 Gene

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