Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C6orf25 Gene

Aliases for C6orf25 Gene

  • Chromosome 6 Open Reading Frame 25 2 3 5
  • G6b 3 4
  • Immunoglobulin Receptor 3
  • NG31 3

External Ids for C6orf25 Gene

Previous GeneCards Identifiers for C6orf25 Gene

  • GC06P031754
  • GC06P031461
  • GC06P031795
  • GC06P031799
  • GC06P031686
  • GC06P031477
  • GC06P031721
  • GC06P031733

Summaries for C6orf25 Gene

Entrez Gene Summary for C6orf25 Gene

  • This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for C6orf25 Gene

C6orf25 (Chromosome 6 Open Reading Frame 25) is a Protein Coding gene. Diseases associated with C6orf25 include gray platelet syndrome and paraneoplastic pemphigus. Among its related pathways are Platelet activation, signaling and aggregation and G beta-gamma signalling through PI3Kgamma. GO annotations related to this gene include heparin binding.

UniProtKB/Swiss-Prot for C6orf25 Gene

  • Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart.

Gene Wiki entry for C6orf25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf25 Gene

Genomics for C6orf25 Gene

Regulatory Elements for C6orf25 Gene

Transcription factor binding sites by QIAGEN in the C6orf25 gene promoter:

Genomic Location for C6orf25 Gene

Chromosome:
6
Start:
31,718,594 bp from pter
End:
31,726,714 bp from pter
Size:
8,121 bases
Orientation:
Plus strand

Genomic View for C6orf25 Gene

Genes around C6orf25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for C6orf25 Gene

  • Protein details for C6orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95866-G6B_HUMAN
    Recommended name:
    Protein G6b
    Protein Accession:
    O95866
    Secondary Accessions:
    • A2BEZ1
    • A2BEZ2
    • A2BEZ3
    • A2BEZ4
    • A2BEZ5
    • B0UXC4
    • B0UXC7
    • B0UXC8
    • B0V024
    • B0V026
    • Q14CK2
    • Q96A86
    • Q96A87
    • Q96A88
    • Q96A89
    • Q96A90
    • Q96A91

    Protein attributes for C6orf25 Gene

    Size:
    241 amino acids
    Molecular mass:
    26163 Da
    Quaternary structure:
    • Interacts with PTPN6 and PTPN11. Binds to heparin.

    Alternative splice isoforms for C6orf25 Gene

neXtProt entry for C6orf25 Gene

Proteomics data for C6orf25 Gene at MOPED

Post-translational modifications for C6orf25 Gene

No data available for DME Specific Peptides for C6orf25 Gene

Domains & Families for C6orf25 Gene

Protein Domains for C6orf25 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for C6orf25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf25: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C6orf25 Gene

Function for C6orf25 Gene

Molecular function for C6orf25 Gene

UniProtKB/Swiss-Prot Function:
Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart.
genes like me logo Genes that share phenotypes with C6orf25: view

Animal Models for C6orf25 Gene

MGI Knock Outs for C6orf25:
  • G6b tm1.1Arte

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C6orf25 Gene

Localization for C6orf25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C6orf25 Gene

Isoform E: Endoplasmic reticulum. Golgi apparatus.
Isoform D: Endoplasmic reticulum. Golgi apparatus.
Isoform B: Cell membrane; Single-pass type I membrane protein.
Isoform A: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C6orf25 Gene COMPARTMENTS Subcellular localization image for C6orf25 gene
Compartment Confidence
extracellular 3
plasma membrane 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for C6orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,TAS --
genes like me logo Genes that share ontologies with C6orf25: view

Pathways & Interactions for C6orf25 Gene

genes like me logo Genes that share pathways with C6orf25: view

Pathways by source for C6orf25 Gene

Interacting Proteins for C6orf25 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364964%0d%0a9606.ENSP00000340944%0d%0a9606.ENSP00000391592%0d%0a
Selected Interacting proteins: O95866-G6B_HUMAN ENSP00000364964 for C6orf25 Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for C6orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation IEA,IBA --
GO:0030220 platelet formation IEA,IBA --
genes like me logo Genes that share ontologies with C6orf25: view

No data available for SIGNOR curated interactions for C6orf25 Gene

Drugs & Compounds for C6orf25 Gene

(3) Drugs for C6orf25 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for C6orf25 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with C6orf25: view

Transcripts for C6orf25 Gene

Unigene Clusters for C6orf25 Gene

Chromosome 6 open reading frame 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf25 Gene

No ASD Table

Relevant External Links for C6orf25 Gene

GeneLoc Exon Structure for
C6orf25
ECgene alternative splicing isoforms for
C6orf25

Expression for C6orf25 Gene

mRNA expression in normal human tissues for C6orf25 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf25 Gene

This gene is overexpressed in Whole Blood (x22.3), Skin - Sun Exposed (Lower leg) (x6.0), and Skin - Not Sun Exposed (Suprapubic) (x5.0).

Protein differential expression in normal tissues from HIPED for C6orf25 Gene

This gene is overexpressed in Platelet (40.9), Peripheral blood mononuclear cells (13.4), and Monocytes (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf25 Gene



SOURCE GeneReport for Unigene cluster for C6orf25 Gene Hs.247879

mRNA Expression by UniProt/SwissProt for C6orf25 Gene

O95866-G6B_HUMAN
Tissue specificity: Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. Expressed in platelets.
genes like me logo Genes that share expression patterns with C6orf25: view

Protein tissue co-expression partners for C6orf25 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C6orf25 Gene

Orthologs for C6orf25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf25 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C12H6orf25 35
  • 81.68 (n)
  • 80.2 (a)
C6orf25 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia G6b 35
  • 77.92 (n)
  • 73.84 (a)
G6b 16
AU023871 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf25 35
  • 99.59 (n)
  • 99.17 (a)
C6orf25 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia G6b 35
  • 77.87 (n)
  • 73.71 (a)
cow
(Bos Taurus)
Mammalia C6ORF25 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C6orf25 36
  • 56 (a)
OneToOne
Species with no ortholog for C6orf25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf25 Gene

ENSEMBL:
Gene Tree for C6orf25 (if available)
TreeFam:
Gene Tree for C6orf25 (if available)

Paralogs for C6orf25 Gene

(1) SIMAP similar genes for C6orf25 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with C6orf25: view

No data available for Paralogs for C6orf25 Gene

Variants for C6orf25 Gene

Sequence variations from dbSNP and Humsavar for C6orf25 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs407283 -- 31,725,193(-) CCAGT(C/T)TAGCA utr-variant-3-prime
rs453098 -- 31,723,880(-) GAGTC(C/T)CCCGC reference, synonymous-codon
rs805306 -- 31,724,386(-) ACCAG(C/T)CAGCG intron-variant
rs4947252 -- 31,723,889(+) TCGGG(A/C)ACTTT reference, synonymous-codon
rs11575845 -- 31,724,609(+) CGATT(C/G)GACCA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for C6orf25 Gene

Variant ID Type Subtype PubMed ID
nsv884418 CNV Gain 21882294
nsv884425 CNV Loss 21882294

Variation tolerance for C6orf25 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf25 Gene

HapMap Linkage Disequilibrium report
C6orf25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf25 Gene

Disorders for C6orf25 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C6orf25 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gray platelet syndrome
  • gps
paraneoplastic pemphigus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C6orf25

Human Genome Epidemiology (HuGE) Navigator
C6orf25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf25
genes like me logo Genes that share disorders with C6orf25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C6orf25 Gene

Publications for C6orf25 Gene

  1. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. (PMID: 11544253) de Vet E.C.M. … Campbell R.D. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PMID: 10384126) Ribas G. … Campbell R.D. (J. Immunol. 1999) 2 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  4. Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a phase 1/2 Study. (PMID: 20032102) Mease P.J. … Heald A.E. (J. Rheumatol. 2010) 23
  5. Gene expression profiling and network analysis reveals lipid and steroid metabolism to be the most favored by TNFalpha in HepG2 cells. (PMID: 20140224) Pandey A.K. … Datta M. (PLoS ONE 2010) 23

Products for C6orf25 Gene

Sources for C6orf25 Gene

Back to Top

Content