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Aliases for CALM2 Gene

Aliases for CALM2 Gene

  • Calmodulin 2 (Phosphorylase Kinase, Delta) 2 3
  • Prepro-Calmodulin 2 2 3
  • CAM 3 4
  • Phosphorylase Kinase Delta 3
  • LP7057 Protein 3
  • Calmodulin 3
  • CALML2 4
  • CAMIII 4
  • CAMII 3
  • LQT15 3
  • PHKD2 3
  • PHKD 3
  • CALM 4
  • CAM1 4
  • CAM2 4
  • CAM3 4
  • CAMB 4
  • CAMC 4

External Ids for CALM2 Gene

Summaries for CALM2 Gene

Entrez Gene Summary for CALM2 Gene

  • This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

GeneCards Summary for CALM2 Gene

CALM2 (Calmodulin 2 (Phosphorylase Kinase, Delta)) is a Protein Coding gene. Diseases associated with CALM2 include phencyclidine abuse and otomycosis. Among its related pathways are PI-3K cascade and Signaling by FGFR. An important paralog of this gene is CABP2.

UniProtKB/Swiss-Prot for CALM2 Gene

  • Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

Gene Wiki entry for CALM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALM2 Gene

Genomics for CALM2 Gene

Genomic Location for CALM2 Gene

47,160,082 bp from pter
47,176,601 bp from pter
16,520 bases
Minus strand

Genomic View for CALM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALM2 Gene

Regulatory Elements for CALM2 Gene

Proteins for CALM2 Gene

  • Protein details for CALM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • P02593
    • P70667
    • P99014
    • Q13942
    • Q53S29
    • Q61379
    • Q61380
    • Q96HK3

    Protein attributes for CALM2 Gene

    149 amino acids
    Molecular mass:
    16838 Da
    Quaternary structure:
    • Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport.
    • This protein has four functional calcium-binding sites
    • Sequence=CAA36839.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CALM2 Gene

neXtProt entry for CALM2 Gene

Proteomics data for CALM2 Gene at MOPED

Post-translational modifications for CALM2 Gene

Other Protein References for CALM2 Gene

No data available for DME Specific Peptides for CALM2 Gene

Domains for CALM2 Gene

Gene Families for CALM2 Gene


Protein Domains for CALM2 Gene


  • Contains 4 EF-hand domains.:
    • P62158
  • Belongs to the calmodulin family.:
    • P62158
genes like me logo Genes that share domains with CALM2: view

Function for CALM2 Gene

Molecular function for CALM2 Gene

GENATLAS Biochemistry: calmodulin 2,calcium modulated protein
UniProtKB/Swiss-Prot Function: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

Gene Ontology (GO) - Molecular Function for CALM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IPI 10692436
GO:0008179 adenylate cyclase binding IEA --
GO:0016301 kinase activity --
GO:0019901 protein kinase binding IPI 20668654
genes like me logo Genes that share ontologies with CALM2: view

Phenotypes for CALM2 Gene

GenomeRNAi human phenotypes for CALM2:
genes like me logo Genes that share phenotypes with CALM2: view

miRNA for CALM2 Gene

miRTarBase miRNAs that target CALM2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CALM2 Gene

Localization for CALM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALM2 Gene

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Subcellular locations from

Jensen Localization Image for CALM2 Gene COMPARTMENTS Subcellular localization image for CALM2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
extracellular 4
nucleus 4
endoplasmic reticulum 3
golgi apparatus 2
mitochondrion 2
vacuole 2
chloroplast 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CALM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 16760425
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 10899953
genes like me logo Genes that share ontologies with CALM2: view

Pathways for CALM2 Gene

SuperPathways for CALM2 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Post NMDA receptor activation events
4 Development Angiotensin activation of ERK
5 Development Endothelin-1/EDNRA signaling
genes like me logo Genes that share pathways with CALM2: view

Gene Ontology (GO) - Biological Process for CALM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0002027 regulation of heart rate IMP 23040497
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002576 platelet degranulation TAS --
GO:0005513 detection of calcium ion IMP 23040497
genes like me logo Genes that share ontologies with CALM2: view

Transcripts for CALM2 Gene

Unigene Clusters for CALM2 Gene

Calmodulin 2 (phosphorylase kinase, delta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALM2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: -
SP3: - -

Relevant External Links for CALM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALM2 Gene

mRNA expression in normal human tissues for CALM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CALM2 Gene

SOURCE GeneReport for Unigene cluster for CALM2 Gene Hs.468442

genes like me logo Genes that share expressions with CALM2: view

Orthologs for CALM2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CALM2 36
  • 100 (n)
  • 100 (a)
CALM3 37
  • 100 (a)
(Bos Taurus)
Mammalia -- 37
  • 99 (a)
  • 97.09 (n)
  • 98.66 (a)
  • 99 (a)
(Canis familiaris)
Mammalia CALM2 37
  • 89 (a)
(Mus musculus)
Mammalia Calm2 16
Calm2 37
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 100 (a)
-- 37
  • 97 (a)
-- 37
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia CALM2 37
  • 100 (a)
(Gallus gallus)
Aves CALM 37
  • 100 (a)
CALM1 36
  • 86.58 (n)
  • 99.33 (a)
(Anolis carolinensis)
Reptilia CALM2 37
  • 100 (a)
(Danio rerio)
Actinopterygii calm1a 37
  • 100 (a)
calm2d 36
calm3a 37
  • 100 (a)
calm3b 37
  • 100 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cam 37
  • 98 (a)
And 38
  • 67 (a)
Cam 38
  • 97 (a)
Mlc-c 38
  • 46 (a)
CG11165 38
  • 53 (a)
TpnC41C 38
  • 45 (a)
(Caenorhabditis elegans)
Secernentea cal-6 37
  • 76 (a)
cmd-1 37
  • 98 (a)
cal-4 38
  • 59 (a)
cal-1 38
  • 68 (a)
cmd-1 38
  • 97 (a)
F12A10.5 38
  • 45 (a)
cal-3 38
  • 59 (a)
Y73B3A.12 38
  • 76 (a)
cal-2 38
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMD1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons CAM7 36
  • 75.39 (n)
  • 89.93 (a)
(Oryza sativa)
Liliopsida Os07g0687200 36
  • 75.17 (n)
  • 90.6 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04120 36
  • 68.68 (n)
  • 85.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cam1 36
  • 70.11 (n)
  • 76.55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4990 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10340 37
  • 97 (a)
Species with no ortholog for CALM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CALM2 Gene

Gene Tree for CALM2 (if available)
Gene Tree for CALM2 (if available)

Paralogs for CALM2 Gene

genes like me logo Genes that share paralogs with CALM2: view

Variants for CALM2 Gene

Sequence variations from dbSNP and Humsavar for CALM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9255 -- 47,160,476(+) AAAAA(A/G)GGCAT utr-variant-3-prime
rs9581 -- 47,160,289(-) ATTTT(C/T)TTTTA utr-variant-3-prime
rs11842 -- 47,176,244(+) AGGAA(G/T)CCCCC intron-variant
rs15176 -- 47,160,284(-) CTTTT(A/T)TTGTT utr-variant-3-prime
rs815802 -- 47,164,910(-) TAATA(C/T)GGAAT intron-variant

Relevant External Links for CALM2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Structural Variations from Database of Genomic Variants (DGV) for CALM2 Gene

Disorders for CALM2 Gene


  • Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM:614916]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. {ECO:0000269 PubMed:23040497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CALM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CALM2: view

Publications for CALM2 Gene

  1. Structural organization of the human CaMIII calmodulin gene. (PMID: 2223880) Koller M. … Strehler E.E. (Biochim. Biophys. Acta 1990) 3 4
  2. Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species. (PMID: 2445749) Sengupta B. … Detera-Wadleigh S.D. (J. Biol. Chem. 1987) 3 4
  3. Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3. (PMID: 9681195) Toutenhoofd S.L. … Strehler E.E. (Cell Calcium 1998) 3 4
  4. Crystal structure of a MARCKS peptide containing the calmodulin- binding domain in complex with Ca2+-calmodulin. (PMID: 12577052) Yamauchi E. … Taniguchi H. (Nat. Struct. Biol. 2003) 3 4
  5. Cell type-specific regulation of calmodulin 2 expression by mutant p53. (PMID: 15225611) Knaup K.X. … Roemer K. (FEBS Lett. 2004) 3 23

Products for CALM2 Gene

  • Addgene plasmids for CALM2

Sources for CALM2 Gene

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