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Aliases for ADAM33 Gene

Aliases for ADAM33 Gene

  • ADAM Metallopeptidase Domain 33 2 3
  • A Disintegrin And Metalloproteinase Domain 33 2 3
  • C20orf153 3 4
  • ADAM 33 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 33 3
  • Disintegrin And Reprolysin Metalloproteinase Family Protein 3
  • Chromosome 20 Open Reading Frame 153 2
  • A Disintegrin And Metalloprotease 33 3
  • EC 3.4.24.- 4
  • DJ964F7.1 3

External Ids for ADAM33 Gene

Previous HGNC Symbols for ADAM33 Gene

  • C20orf153

Previous GeneCards Identifiers for ADAM33 Gene

  • GC20M003637
  • GC20M003643

Summaries for ADAM33 Gene

Entrez Gene Summary for ADAM33 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

GeneCards Summary for ADAM33 Gene

ADAM33 (ADAM Metallopeptidase Domain 33) is a Protein Coding gene. Diseases associated with ADAM33 include asthma. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM21.

Gene Wiki entry for ADAM33 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM33 Gene

Genomics for ADAM33 Gene

Regulatory Elements for ADAM33 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAM33 Gene

Start:
3,667,965 bp from pter
End:
3,682,246 bp from pter
Size:
14,282 bases
Orientation:
Minus strand

Genomic View for ADAM33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM33 Gene

Proteins for ADAM33 Gene

  • Protein details for ADAM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ11-ADA33_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 33
    Protein Accession:
    Q9BZ11
    Secondary Accessions:
    • A0A1K6
    • Q5JT75
    • Q5JT76
    • Q8N0W6

    Protein attributes for ADAM33 Gene

    Size:
    813 amino acids
    Molecular mass:
    87739 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADAM33 Gene

    Alternative splice isoforms for ADAM33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM33 Gene

Proteomics data for ADAM33 Gene at MOPED

Post-translational modifications for ADAM33 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn109, Asn145, Asn231, Asn276, and Asn448
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM33 Gene

No data available for DME Specific Peptides for ADAM33 Gene

Domains for ADAM33 Gene

Gene Families for ADAM33 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q9BZ11

UniProtKB/Swiss-Prot:

ADA33_HUMAN :
  • Q9BZ11
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM33: view

Function for ADAM33 Gene

Enzyme Numbers (IUBMB) for ADAM33 Gene

Gene Ontology (GO) - Molecular Function for ADAM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity NAS 11814695
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding NAS 11814695
genes like me logo Genes that share ontologies with ADAM33: view

Phenotypes for ADAM33 Gene

genes like me logo Genes that share phenotypes with ADAM33: view

Animal Models for ADAM33 Gene

MGI Knock Outs for ADAM33:

Animal Model Products

CRISPR Products

miRNA for ADAM33 Gene

miRTarBase miRNAs that target ADAM33

No data available for Molecular function , Transcription Factor Targeting and HOMER Transcription for ADAM33 Gene

Localization for ADAM33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM33 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM33 Gene COMPARTMENTS Subcellular localization image for ADAM33 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADAM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 11814695
genes like me logo Genes that share ontologies with ADAM33: view

Pathways for ADAM33 Gene

SuperPathways for ADAM33 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADAM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 11814695
genes like me logo Genes that share ontologies with ADAM33: view

No data available for Pathways by source for ADAM33 Gene

Compounds for ADAM33 Gene

(1) Drugbank Compounds for ADAM33 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
genes like me logo Genes that share compounds with ADAM33: view

Transcripts for ADAM33 Gene

Unigene Clusters for ADAM33 Gene

ADAM metallopeptidase domain 33:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM33

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADAM33

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM33 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: - - - - - - - - - - -
SP6:
SP7: - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - - - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13:
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: -
SP17:
SP18: -
SP19:

ExUns: 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15: - - - - -
SP16:
SP17: -
SP18:
SP19:

Relevant External Links for ADAM33 Gene

GeneLoc Exon Structure for
ADAM33
ECgene alternative splicing isoforms for
ADAM33

Expression for ADAM33 Gene

mRNA expression in normal human tissues for ADAM33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ADAM33 Gene Hs.173716

mRNA Expression by UniProt/SwissProt for ADAM33 Gene

Q9BZ11-ADA33_HUMAN
Tissue specificity: Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.
genes like me logo Genes that share expressions with ADAM33: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein expression for ADAM33 Gene

Orthologs for ADAM33 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM33 35
  • 97.95 (n)
  • 96.52 (a)
ADAM33 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAM33 35
  • 81.85 (n)
  • 76.06 (a)
ADAM33 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM33 35
  • 82.96 (n)
  • 77.33 (a)
ADAM33 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam33 35
  • 78.67 (n)
  • 73.35 (a)
Adam33 16
Adam33 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM33 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam33 35
  • 78.62 (n)
  • 73.33 (a)
chicken
(Gallus gallus)
Aves ADAM33 35
  • 66.97 (n)
  • 59.97 (a)
ADAM33 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAM33 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam33 35
  • 60.01 (n)
  • 55.64 (a)
zebrafish
(Danio rerio)
Actinopterygii adam19a 35
  • 60.34 (n)
  • 53.57 (a)
adam19a 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea adm-1 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for ADAM33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM33 Gene

ENSEMBL:
Gene Tree for ADAM33 (if available)
TreeFam:
Gene Tree for ADAM33 (if available)

Paralogs for ADAM33 Gene

genes like me logo Genes that share paralogs with ADAM33: view

Variants for ADAM33 Gene

Sequence variations from dbSNP and Humsavar for ADAM33 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs44707 -- 3,670,579(-) CACCC(A/C)CTTGA intron-variant
rs487377 -- 3,678,284(-) TAGGT(A/G)TCCCC intron-variant
rs511898 -- 3,674,438(+) ATTCC(C/T)GTCTC intron-variant
rs512492 -- 3,667,675(+) TGATA(C/T)AGGCC downstream-variant-500B
rs512625 -- 3,667,731(+) AGGGA(A/G)GCAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ADAM33 Gene

Variant ID Type Subtype PubMed ID
nsv520565 CNV Loss 19592680
dgv4521n71 CNV Loss 21882294
nsv912615 CNV Loss 21882294
nsv912616 CNV Loss 21882294

Relevant External Links for ADAM33 Gene

HapMap Linkage Disequilibrium report
ADAM33
Human Gene Mutation Database (HGMD)
ADAM33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM33 Gene

Disorders for ADAM33 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ADAM33 Gene including...

Search for ADAM33 Gene in MalaCards »

UniProtKB/Swiss-Prot

ADA33_HUMAN
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:12110844, ECO:0000269 PubMed:16773130, ECO:0000269 PubMed:19237393}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ADAM33 Gene

(6) Novoseek inferred disease relationships for ADAM33 Gene

Disease -log(P) Hits PubMed IDs
asthma 71.3 73
asthma childhood 54.1 4
asthma allergic 53.5 3
pulmonary disease chronic obstructive 45.3 2
airway obstruction 36.9 1

Relevant External Links for ADAM33

Genetic Association Database (GAD)
ADAM33
Human Genome Epidemiology (HuGE) Navigator
ADAM33
genes like me logo Genes that share disorders with ADAM33: view

Publications for ADAM33 Gene

  1. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. (PMID: 12110844) Van Eerdewegh P. … Keith T.P. (Nature 2002) 3 4 23 48
  2. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. (PMID: 14564349) Howard T.D. … Meyers D.A. (J. Allergy Clin. Immunol. 2003) 3 23 48
  3. Asthma is associated with single-nucleotide polymorphisms in ADAM33. (PMID: 14720258) Werner M. … Wjst M. (Clin. Exp. Allergy 2004) 3 23 48
  4. ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. (PMID: 15196271) Lee J.H. … Shin H.D. (Clin. Exp. Allergy 2004) 3 23 48
  5. Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function. (PMID: 15805180) Simpson A. … John S.L. (Am. J. Respir. Crit. Care Med. 2005) 3 23 48

Products for ADAM33 Gene

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