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Aliases for WNT10A Gene

Aliases for WNT10A Gene

  • Wingless-Type MMTV Integration Site Family, Member 10A 2 3
  • STHAG4 3 6
  • OODD 3 6
  • SSPS 3 6
  • Protein Wnt-10a 3

External Ids for WNT10A Gene

Previous GeneCards Identifiers for WNT10A Gene

  • GC02P217761
  • GC02P218466
  • GC02P219709
  • GC02P219947
  • GC02P219570
  • GC02P219453
  • GC02P219745
  • GC02P211599

Summaries for WNT10A Gene

Entrez Gene Summary for WNT10A Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT10A Gene

WNT10A (Wingless-Type MMTV Integration Site Family, Member 10A) is a Protein Coding gene. Diseases associated with WNT10A include odontoonychodermal dysplasia and schopf-schulz-passarge syndrome. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT10B.

UniProtKB/Swiss-Prot for WNT10A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters

Gene Wiki entry for WNT10A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT10A Gene

Genomics for WNT10A Gene

Regulatory Elements for WNT10A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WNT10A Gene

Start:
218,880,363 bp from pter
End:
218,899,581 bp from pter
Size:
19,219 bases
Orientation:
Plus strand

Genomic View for WNT10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT10A Gene

Proteins for WNT10A Gene

  • Protein details for WNT10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZT5-WN10A_HUMAN
    Recommended name:
    Protein Wnt-10a
    Protein Accession:
    Q9GZT5
    Secondary Accessions:
    • Q53S44
    • Q96TA7
    • Q9H7S8

    Protein attributes for WNT10A Gene

    Size:
    417 amino acids
    Molecular mass:
    46444 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT10A Gene

Proteomics data for WNT10A Gene at MOPED

Post-translational modifications for WNT10A Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn106 and Asn363
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT10A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WNT10A Gene

Domains for WNT10A Gene

Gene Families for WNT10A Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT10A Gene

Suggested Antigen Peptide Sequences for WNT10A Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZT5

UniProtKB/Swiss-Prot:

WN10A_HUMAN :
  • Q9GZT5
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT10A: view

Function for WNT10A Gene

Molecular function for WNT10A Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters

LifeMap Function Summary for WNT10A Gene

During embryonic development, WNT10A as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for WNT10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT10A: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT10A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WNT10A Gene

Localization for WNT10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT10A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT10A Gene COMPARTMENTS Subcellular localization image for WNT10A gene
Compartment Confidence
extracellular 5
plasma membrane 3
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with WNT10A: view

Pathways for WNT10A Gene

genes like me logo Genes that share pathways with WNT10A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for WNT10A Gene

Gene Ontology (GO) - Biological Process for WNT10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IMP 17847007
GO:0007275 multicellular organismal development --
GO:0010628 positive regulation of gene expression IEA --
GO:0014033 neural crest cell differentiation IEA --
GO:0016055 Wnt signaling pathway IBA --
genes like me logo Genes that share ontologies with WNT10A: view

Transcripts for WNT10A Gene

Unigene Clusters for WNT10A Gene

Wingless-type MMTV integration site family, member 10A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT10A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT10A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - - -
SP3:

Relevant External Links for WNT10A Gene

GeneLoc Exon Structure for
WNT10A
ECgene alternative splicing isoforms for
WNT10A

Expression for WNT10A Gene

mRNA expression in normal human tissues for WNT10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for WNT10A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.4) and Pancreas (24.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT10A Gene

SOURCE GeneReport for Unigene cluster for WNT10A Gene Hs.121540

genes like me logo Genes that share expressions with WNT10A: view

Expression partners for WNT10A Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WNT10A Gene

Orthologs for WNT10A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT10A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia WNT10A 35
  • 92.93 (n)
  • 98.43 (a)
WNT10A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt10a 35
  • 89.05 (n)
  • 95.2 (a)
Wnt10a 16
Wnt10a 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT10A 35
  • 99.68 (n)
  • 100 (a)
WNT10A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt10a 35
  • 88.73 (n)
  • 95.44 (a)
cow
(Bos Taurus)
Mammalia WNT10A 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT10A 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WNT10A 35
  • 79.82 (n)
  • 83.24 (a)
WNT10A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT10A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt10a 35
  • 74.46 (n)
  • 79.89 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt10a 35
  • 73.69 (n)
  • 76.76 (a)
wnt10a 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt10 37
  • 45 (a)
Wnt10 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egl-20 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for WNT10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT10A Gene

ENSEMBL:
Gene Tree for WNT10A (if available)
TreeFam:
Gene Tree for WNT10A (if available)

Paralogs for WNT10A Gene

Paralogs for WNT10A Gene

Selected SIMAP similar genes for WNT10A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WNT10A: view

Variants for WNT10A Gene

Sequence variations from dbSNP and Humsavar for WNT10A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1054630 -- 218,893,399(-) TTCCT(A/G)TAAGA utr-variant-3-prime
rs1057306 - 218,892,921(+) TCCGG(A/C)CGCAC missense, reference
rs2385199 -- 218,886,024(+) GTCAC(A/G)CAGCT intron-variant
rs3806557 -- 218,879,152(+) TGAGG(A/G)GGAAA upstream-variant-2KB
rs3840475 -- 218,879,068(+) CTGCT(-/C)CCCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WNT10A Gene

Variant ID Type Subtype PubMed ID
nsv875864 CNV Loss 21882294
nsv834542 CNV Gain 17160897
dgv4436n71 CNV Loss 21882294
nsv875867 CNV Loss 21882294

Relevant External Links for WNT10A Gene

HapMap Linkage Disequilibrium report
WNT10A
Human Gene Mutation Database (HGMD)
WNT10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT10A Gene

Disorders for WNT10A Gene

(3) OMIM Diseases for WNT10A Gene (606268)

UniProtKB/Swiss-Prot

WN10A_HUMAN
  • Note=Defects in WNT10A may be a cause of hypohidrotic/anhidrotic ectodermal dysplasia, a disorder characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Most patients carrying WNT10A mutations present with sweating anomalies. However, comparison with cases harboring mutations in the ectodysplasin pathway identifies some phenotypic differences. Dermatological features (anomalies of hair and sweat glands) are less severe in patients carrying WNT10A mutations and facial dysmorphism can be absent. The dental phenotype consists in microdontia, whereas teeth agenesis is more frequent in patients carrying mutations in the ectodysplasin pathway.
  • Odonto-onycho-dermal dysplasia (OODD) [MIM:257980]: A rare autosomal recessive ectodermal dysplasia characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin. {ECO:0000269 PubMed:17847007, ECO:0000269 PubMed:19559398}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Schopf-Schulz-Passarge syndrome (SSPS) [MIM:224750]: A rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms. {ECO:0000269 PubMed:19559398}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Tooth agenesis selective 4 (STHAG4) [MIM:150400]: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped. {ECO:0000269 PubMed:21484994, ECO:0000269 PubMed:22581971}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for WNT10A Gene

Relevant External Links for WNT10A

Genetic Association Database (GAD)
WNT10A
Human Genome Epidemiology (HuGE) Navigator
WNT10A
genes like me logo Genes that share disorders with WNT10A: view

No data available for Novoseek inferred disease relationships and Genatlas for WNT10A Gene

Publications for WNT10A Gene

  1. WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PMID: 11350055) Kirikoshi H. … Katoh M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  2. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. (PMID: 17847007) Adaimy L. … Megarbane A. (Am. J. Hum. Genet. 2007) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty T.H. … Scott A.F. (Hum. Genet. 2006) 3 48
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48

Products for WNT10A Gene

Sources for WNT10A Gene

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