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Aliases for NCOA4 Gene

Aliases for NCOA4 Gene

  • Nuclear Receptor Coactivator 4 2 3
  • ELE1 3 4 6
  • Androgen Receptor-Associated Protein Of 70 KDa 3 4
  • 70 KDa Androgen Receptor Coactivator 3 4
  • RET-Activating Gene ELE1 2 3
  • 70 KDa AR-Activator 3 4
  • NCoA-4 3 4
  • ARA70 3 4
  • PTC3 3 6
  • RFG 3 4
  • Androgen Receptor Coactivator 70 KDa Protein 4
  • Ret-Activating Protein ELE1 4
  • Ret Fused 3

External Ids for NCOA4 Gene

Previous GeneCards Identifiers for NCOA4 Gene

  • GC10P050408
  • GC10P051457
  • GC10P050916
  • GC10P051235
  • GC10P051565
  • GC10P045675

Summaries for NCOA4 Gene

Entrez Gene Summary for NCOA4 Gene

  • This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

GeneCards Summary for NCOA4 Gene

NCOA4 (Nuclear Receptor Coactivator 4) is a Protein Coding gene. Diseases associated with NCOA4 include thyroid carcinoma, papillary and prostate cancer. Among its related pathways are Pathways in cancer and Androgen Signaling. GO annotations related to this gene include transcription coactivator activity and androgen receptor binding.

UniProtKB/Swiss-Prot for NCOA4 Gene

  • Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.

Gene Wiki entry for NCOA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA4 Gene

Genomics for NCOA4 Gene

Regulatory Elements for NCOA4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCOA4 Gene

46,005,088 bp from pter
46,030,714 bp from pter
25,627 bases
Minus strand

Genomic View for NCOA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCOA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA4 Gene

Proteins for NCOA4 Gene

  • Protein details for NCOA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear receptor coactivator 4
    Protein Accession:
    Secondary Accessions:
    • A8K8W5
    • B4E260
    • E9PAV7
    • J3KQN8
    • Q14239

    Protein attributes for NCOA4 Gene

    614 amino acids
    Molecular mass:
    69726 Da
    Quaternary structure:
    • Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner

    Three dimensional structures from OCA and Proteopedia for NCOA4 Gene

    Alternative splice isoforms for NCOA4 Gene


neXtProt entry for NCOA4 Gene

Proteomics data for NCOA4 Gene at MOPED

Post-translational modifications for NCOA4 Gene

  • Ubiquitination at Lys181, Lys255, Lys271, Lys343, Lys356, Lys367, Lys377, Lys424, Lys465, Lys472, Lys490, Lys545, and Lys558
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NCOA4 Gene

Domains for NCOA4 Gene

Protein Domains for NCOA4 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NCOA4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NCOA4 Gene

Function for NCOA4 Gene

Molecular function for NCOA4 Gene

GENATLAS Biochemistry: nuclear receptor coactivator 4,in transcriptional activation of target genes upon specific induction by androgens,ligand dependent,70kDa,expressed in prostate cells,fused with RET in papillary thyroid carcinomas
UniProtKB/Swiss-Prot Function: Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.

Gene Ontology (GO) - Molecular Function for NCOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0050681 androgen receptor binding NAS 15572661
genes like me logo Genes that share ontologies with NCOA4: view

Phenotypes for NCOA4 Gene

GenomeRNAi human phenotypes for NCOA4:
genes like me logo Genes that share phenotypes with NCOA4: view

Animal Model Products

CRISPR Products

miRNA for NCOA4 Gene

miRTarBase miRNAs that target NCOA4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCOA4 Gene

Localization for NCOA4 Gene

Subcellular locations from

Jensen Localization Image for NCOA4 Gene COMPARTMENTS Subcellular localization image for NCOA4 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NCOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8643607
genes like me logo Genes that share ontologies with NCOA4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NCOA4 Gene

Pathways for NCOA4 Gene

genes like me logo Genes that share pathways with NCOA4: view

Pathways by source for NCOA4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NCOA4 Gene

Selected Interacting proteins: Q13772-NCOA4_HUMAN for NCOA4 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for NCOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008584 male gonad development TAS 8643607
GO:0009725 response to hormone IEA --
GO:0030521 androgen receptor signaling pathway NAS 15572661
GO:0045893 positive regulation of transcription, DNA-templated NAS 15572661
genes like me logo Genes that share ontologies with NCOA4: view

Compounds for NCOA4 Gene

(11) Novoseek inferred chemical compound relationships for NCOA4 Gene

Compound -log(P) Hits PubMed IDs
hydroxyflutamide 88.8 5
testosterone 70.9 35
dihydrotestosterone 64.7 3
bicalutamide 62.5 1
cyproteroneacetate 47.8 1
genes like me logo Genes that share compounds with NCOA4: view

Transcripts for NCOA4 Gene

Unigene Clusters for NCOA4 Gene

Nuclear receptor coactivator 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCOA4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA4 Gene

No ASD Table

Relevant External Links for NCOA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCOA4 Gene

mRNA expression in normal human tissues for NCOA4 Gene

mRNA differential expression in normal tissues according to GTEx for NCOA4 Gene

This gene is overexpressed in Whole Blood (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NCOA4 Gene

SOURCE GeneReport for Unigene cluster for NCOA4 Gene Hs.643658

mRNA Expression by UniProt/SwissProt for NCOA4 Gene

Tissue specificity: Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis
genes like me logo Genes that share expressions with NCOA4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NCOA4 Gene

Orthologs for NCOA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NCOA4 35
  • 99.38 (n)
  • 99.08 (a)
(Bos Taurus)
Mammalia NCOA4 35
  • 87.15 (n)
  • 84.48 (a)
(Canis familiaris)
Mammalia NCOA4 35
  • 87.55 (n)
  • 83.62 (a)
(Mus musculus)
Mammalia Ncoa4 35
  • 83.71 (n)
  • 80.72 (a)
Ncoa4 16
(Rattus norvegicus)
Mammalia Ncoa4 35
  • 82.79 (n)
  • 78.52 (a)
(Gallus gallus)
Aves NCOA4 35
  • 62.39 (n)
  • 55.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8113 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ncoa4 35
  • 57.26 (n)
  • 50.77 (a)
(Danio rerio)
Actinopterygii -- 35
ncoa4 35
  • 53.96 (n)
  • 46.42 (a)
Species with no ortholog for NCOA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA4 Gene

Gene Tree for NCOA4 (if available)
Gene Tree for NCOA4 (if available)

Paralogs for NCOA4 Gene

No data available for Paralogs for NCOA4 Gene

Variants for NCOA4 Gene

Sequence variations from dbSNP and Humsavar for NCOA4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs14818 -- 46,005,841(-) CGGGG(C/T)TTAAA utr-variant-3-prime
rs1132109 -- 46,013,560(-) CTCCA(C/T)GCCAG missense, reference
rs1132111 - 46,010,500(-) AGCAC(C/G)AAAGG reference, missense
rs3209583 -- 46,004,892(-) ACATC(C/T)ATTAA downstream-variant-500B
rs3813713 -- 46,024,691(-) AAATA(C/G)TGAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NCOA4 Gene

Variant ID Type Subtype PubMed ID
dgv273e1 CNV Complex 17122850
nsv428232 CNV Gain+Loss 18775914
dgv274e1 CNV Complex 17122850
nsv895383 CNV Loss 21882294
nsv508583 CNV Loss 20534489
dgv275e1 CNV Complex 17122850
nsv510992 CNV Complex 20534489
dgv702n71 CNV Gain 21882294
nsv895385 CNV Gain 21882294
nsv467192 CNV Gain 19166990
nsv470936 CNV Gain 18288195
nsv521269 CNV Gain 19592680
nsv895388 CNV Gain 21882294
nsv518071 CNV Gain 19592680

Relevant External Links for NCOA4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA4 Gene

Disorders for NCOA4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NCOA4 Gene including...

Search for NCOA4 Gene in MalaCards »

(1) OMIM Diseases for NCOA4 Gene (601984)


  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas.

(11) Novoseek inferred disease relationships for NCOA4 Gene

Disease -log(P) Hits PubMed IDs
thyroid papillary carcinoma 80.4 5
prostate cancer 55.6 17
withdrawal syndrome 53.8 1
carcinoma papillary 43.3 2
thyroid cancer 42.9 2

Relevant External Links for NCOA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NCOA4: view

Publications for NCOA4 Gene

  1. Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. (PMID: 8290261) Santoro M. … Fusco A. (Oncogene 1994) 2 3 4 23
  2. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. (PMID: 8643607) Yeh S. … Chang C. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  3. Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. (PMID: 9892017) Alen P. … Peeters B. (Mol. Endocrinol. 1999) 3 4 23
  4. Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. (PMID: 10347167) Heinlein C.A. … Chang C. (J. Biol. Chem. 1999) 3 4 23
  5. Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. (PMID: 8187085) Bongarzone I. … Pierotti M.A. (Cancer Res. 1994) 3 4 23

Products for NCOA4 Gene

Sources for NCOA4 Gene

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