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Aliases for ORAI2 Gene

Aliases for ORAI2 Gene

  • ORAI Calcium Release-Activated Calcium Modulator 2 2 3 5
  • Transmembrane Protein 142B 2 3 4
  • CAP-Binding Protein Complex Interacting Protein 2 2 3
  • CAP-Binding Protein Complex-Interacting Protein 2 3 4
  • TMEM142B 3 4
  • C7orf19 3 4
  • CBCIP2 3 4
  • Chromosome 7 Open Reading Frame 19 2
  • Putative Protein ORAI2-2 3
  • H_NH0514P08.8 3
  • MEM142B 3

External Ids for ORAI2 Gene

Previous HGNC Symbols for ORAI2 Gene

  • C7orf19
  • TMEM142B

Previous GeneCards Identifiers for ORAI2 Gene

  • GC07P101862
  • GC07P102074
  • GC07P096656

Summaries for ORAI2 Gene

GeneCards Summary for ORAI2 Gene

ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway. GO annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI1.

UniProtKB/Swiss-Prot for ORAI2 Gene

  • Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Tocris Summary for ORAI2 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

Gene Wiki entry for ORAI2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAI2 Gene

Genomics for ORAI2 Gene

Regulatory Elements for ORAI2 Gene

Promoters for ORAI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ORAI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ORAI2 Gene

Chromosome:
7
Start:
102,433,106 bp from pter
End:
102,456,821 bp from pter
Size:
23,716 bases
Orientation:
Plus strand

Genomic View for ORAI2 Gene

Genes around ORAI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAI2 Gene

Proteins for ORAI2 Gene

  • Protein details for ORAI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SN7-ORAI2_HUMAN
    Recommended name:
    Protein orai-2
    Protein Accession:
    Q96SN7
    Secondary Accessions:
    • Q6IA68
    • Q8WY94
    • Q9H9Y3

    Protein attributes for ORAI2 Gene

    Size:
    254 amino acids
    Molecular mass:
    28570 Da
    Quaternary structure:
    • Interacts with CRACR2A/EFCAB4B.
    SequenceCaution:
    • Sequence=AAG23755.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAP22352.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAG33568.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for ORAI2 Gene

Proteomics data for ORAI2 Gene at MOPED

Post-translational modifications for ORAI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ORAI2 Gene

Domains & Families for ORAI2 Gene

Gene Families for ORAI2 Gene

Protein Domains for ORAI2 Gene

Suggested Antigen Peptide Sequences for ORAI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SN7

UniProtKB/Swiss-Prot:

ORAI2_HUMAN :
  • Belongs to the Orai family.
Family:
  • Belongs to the Orai family.
genes like me logo Genes that share domains with ORAI2: view

Function for ORAI2 Gene

Molecular function for ORAI2 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Gene Ontology (GO) - Molecular Function for ORAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015279 store-operated calcium channel activity IBA --
genes like me logo Genes that share ontologies with ORAI2: view
genes like me logo Genes that share phenotypes with ORAI2: view

Animal Model Products

miRNA for ORAI2 Gene

miRTarBase miRNAs that target ORAI2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAI2 Gene

Localization for ORAI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORAI2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORAI2 Gene COMPARTMENTS Subcellular localization image for ORAI2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ORAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA --
genes like me logo Genes that share ontologies with ORAI2: view

Pathways & Interactions for ORAI2 Gene

SuperPathways for ORAI2 Gene

Superpath Contained pathways
1 Calcium signaling pathway
genes like me logo Genes that share pathways with ORAI2: view

Pathways by source for ORAI2 Gene

1 KEGG pathway for ORAI2 Gene

Interacting Proteins for ORAI2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000348752%0d%0a9606.ENSP00000300737%0d%0a9606.ENSP00000409382%0d%0a9606.ENSP00000368966%0d%0a9606.ENSP00000417569%0d%0a
Selected Interacting proteins: Q96SN7-ORAI2_HUMAN ENSP00000348752 for ORAI2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ORAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070588 calcium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with ORAI2: view

No data available for SIGNOR curated interactions for ORAI2 Gene

Drugs & Compounds for ORAI2 Gene

(1) Drugs for ORAI2 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-APB Pharma Antagonist, Pore Blocker IP3 receptor antagonist. Also TRP channel modulator 0

(4) Additional Compounds for ORAI2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5J 4
827001-82-1
ML 9 hydrochloride
105637-50-1
SKF 96365 hydrochloride
130495-35-1
YM 58483
223499-30-7

(5) Tocris Compounds for ORAI2 Gene

Compound Action Cas Number
2-APB IP3 receptor antagonist. Also TRP channel modulator 524-95-8
5J 4 CRAC channel blocker; anti-inflammatory 827001-82-1
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry 130495-35-1
YM 58483 Inhibitor of SOCE in non-excitable cells 223499-30-7
genes like me logo Genes that share compounds with ORAI2: view

Transcripts for ORAI2 Gene

Unigene Clusters for ORAI2 Gene

ORAI calcium release-activated calcium modulator 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORAI2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for ORAI2 Gene

GeneLoc Exon Structure for
ORAI2
ECgene alternative splicing isoforms for
ORAI2

Expression for ORAI2 Gene

mRNA expression in normal human tissues for ORAI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORAI2 Gene

This gene is overexpressed in Whole Blood (x10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORAI2 Gene



SOURCE GeneReport for Unigene cluster for ORAI2 Gene Hs.363308

genes like me logo Genes that share expression patterns with ORAI2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ORAI2 Gene

Orthologs for ORAI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ORAI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ORAI2 35
  • 92.91 (n)
  • 97.64 (a)
ORAI2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ORAI2 35
  • 91.34 (n)
  • 98.03 (a)
ORAI2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Orai2 35
  • 89.73 (n)
  • 96.8 (a)
Orai2 16
Orai2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ORAI2 35
  • 99.08 (n)
  • 100 (a)
ORAI2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Orai2 35
  • 89.2 (n)
  • 96.8 (a)
oppossum
(Monodelphis domestica)
Mammalia ORAI2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORAI2 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves ORAI2 35
  • 82.68 (n)
  • 89.76 (a)
ORAI2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia orai1 35
  • 71.26 (n)
  • 82.68 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14076 35
orai2 35
  • 78.74 (n)
  • 83.86 (a)
orai2 36
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8808 35
fruit fly
(Drosophila melanogaster)
Insecta olf186-F 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea orai-1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8521 36
  • 36 (a)
OneToMany
Species with no ortholog for ORAI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ORAI2 Gene

ENSEMBL:
Gene Tree for ORAI2 (if available)
TreeFam:
Gene Tree for ORAI2 (if available)

Paralogs for ORAI2 Gene

Paralogs for ORAI2 Gene

(2) SIMAP similar genes for ORAI2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ORAI2: view

Variants for ORAI2 Gene

Sequence variations from dbSNP and Humsavar for ORAI2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs34947403 - 102,438,999(+) CTCCT(C/G)CCTGC intron-variant, reference, missense
rs1129271 -- 102,446,755(-) ATGCC(A/G)AGCAC reference, synonymous-codon
rs1133471 -- 102,436,230(+) GGAAG(G/T)AACGT intron-variant, utr-variant-5-prime
rs1133472 -- 102,439,157(+) ACCTC(C/T)GCCCT intron-variant, reference, synonymous-codon
rs1138748 -- 102,450,975(+) GTGGG(C/G)GGATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ORAI2 Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
nsv464664 CNV Gain 19166990
nsv464665 CNV Loss 19166990
esv2656867 CNV Deletion 23128226
esv2672060 CNV Deletion 23128226
dgv7412n71 CNV Loss 21882294
esv259612 OTHER Complex 20981092
esv260065 OTHER Complex 20981092
nsv888832 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
nsv824248 CNV Gain 20364138

Variation tolerance for ORAI2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORAI2 Gene

HapMap Linkage Disequilibrium report
ORAI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAI2 Gene

Disorders for ORAI2 Gene

Relevant External Links for ORAI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORAI2

No disorders were found for ORAI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORAI2 Gene

Publications for ORAI2 Gene

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PMID: 16582901) Feske S. … Rao A. (Nature 2006) 2 3 4 67
  2. Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis. (PMID: 24603752) Dragoni S. … Moccia F. (PLoS ONE 2014) 3
  3. The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells. (PMID: 24040356) Ashmole I. … Bradding P. (PLoS ONE 2013) 3
  4. Capacitative and non-capacitative signaling complexes in human platelets. (PMID: 22640869) Berna-Erro A. … Rosado J.A. (Biochim. Biophys. Acta 2012) 3
  5. Expression of Orai genes and I(CRAC) activation in the human retinal pigment epithelium. (PMID: 20607548) Cordeiro S. … Strauss O. (Graefes Arch. Clin. Exp. Ophthalmol. 2011) 3

Products for ORAI2 Gene

Sources for ORAI2 Gene

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