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Aliases for NAA15 Gene

Aliases for NAA15 Gene

  • N(Alpha)-Acetyltransferase 15, NatA Auxiliary Subunit 2 3 5
  • NMDA Receptor-Regulated Protein 1 3 4
  • N-Terminal Acetyltransferase 3 4
  • Gastric Cancer Antigen Ga19 3 4
  • NMDA Receptor Regulated 1 2 3
  • Protein Tubedown-1 3 4
  • TBDN100 3 4
  • NARG1 3 4
  • Ga19 3 4
  • NATH 3 4
  • Transcriptional Coactivator Tubedown-100 3
  • Tubedown-1 3
  • NAT1P 3
  • TBDN 3

External Ids for NAA15 Gene

Previous HGNC Symbols for NAA15 Gene

  • NARG1

Previous GeneCards Identifiers for NAA15 Gene

  • GC04P140222
  • GC04P135952

Summaries for NAA15 Gene

Entrez Gene Summary for NAA15 Gene

  • This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species suggests that this protein may be an N-acetyltransferase. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAA15 Gene

NAA15 (N(Alpha)-Acetyltransferase 15, NatA Auxiliary Subunit) is a Protein Coding gene. Diseases associated with NAA15 include n-terminal acetyltransferase deficiency and gastric cancer. GO annotations related to this gene include poly(A) RNA binding and N-acetyltransferase activity. An important paralog of this gene is NAA16.

UniProtKB/Swiss-Prot for NAA15 Gene

  • Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Gene Wiki entry for NAA15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAA15 Gene

Genomics for NAA15 Gene

Regulatory Elements for NAA15 Gene

Promoters for NAA15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAA15 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAA15 Gene

Chromosome:
4
Start:
139,301,455 bp from pter
End:
139,420,033 bp from pter
Size:
118,579 bases
Orientation:
Plus strand

Genomic View for NAA15 Gene

Genes around NAA15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAA15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAA15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAA15 Gene

Proteins for NAA15 Gene

  • Protein details for NAA15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ9-NAA15_HUMAN
    Recommended name:
    N-alpha-acetyltransferase 15, NatA auxiliary subunit
    Protein Accession:
    Q9BXJ9
    Secondary Accessions:
    • D3DNY6
    • Q52LG9
    • Q8IWH4
    • Q8NEV2
    • Q9H8P6

    Protein attributes for NAA15 Gene

    Size:
    866 amino acids
    Molecular mass:
    101272 Da
    Quaternary structure:
    • Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15. Interacts with XRCC6, NAA50 and XRCC5. Associates with HYPK when in a complex with NAA10.
    SequenceCaution:
    • Sequence=AAH39818.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for NAA15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAA15 Gene

Proteomics data for NAA15 Gene at MOPED

Post-translational modifications for NAA15 Gene

  • Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.
  • Ubiquitination at Lys 34, Lys 41, Lys 262, Lys 266, Lys 286, Lys 305, Lys 312, Lys 454, Lys 496, Lys 543, Lys 659, Lys 756, and Lys 770
  • Modification sites at PhosphoSitePlus

Other Protein References for NAA15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NAA15 Gene

Domains & Families for NAA15 Gene

Gene Families for NAA15 Gene

Suggested Antigen Peptide Sequences for NAA15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXJ9

UniProtKB/Swiss-Prot:

NAA15_HUMAN :
  • Contains 8 TPR repeats.
Similarity:
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with NAA15: view

Function for NAA15 Gene

Molecular function for NAA15 Gene

UniProtKB/Swiss-Prot Function:
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.

Gene Ontology (GO) - Molecular Function for NAA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016407 contributes_to acetyltransferase activity IDA 15496142
genes like me logo Genes that share ontologies with NAA15: view
genes like me logo Genes that share phenotypes with NAA15: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAA15 Gene

Localization for NAA15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAA15 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAA15 Gene COMPARTMENTS Subcellular localization image for NAA15 gene
Compartment Confidence
nucleus 5
cytosol 4
chloroplast 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NAA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031415 NatA complex IDA 15496142
genes like me logo Genes that share ontologies with NAA15: view

Pathways & Interactions for NAA15 Gene

SuperPathways for NAA15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAA15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NAA15: view

No data available for Pathways by source and SIGNOR curated interactions for NAA15 Gene

Drugs & Compounds for NAA15 Gene

(1) Additional Compounds for NAA15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAA15: view

Transcripts for NAA15 Gene

Unigene Clusters for NAA15 Gene

N(alpha)-acetyltransferase 15, NatA auxiliary subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAA15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:

ExUns: 20b ^ 21 ^ 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:

Relevant External Links for NAA15 Gene

GeneLoc Exon Structure for
NAA15
ECgene alternative splicing isoforms for
NAA15

Expression for NAA15 Gene

mRNA expression in normal human tissues for NAA15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAA15 Gene

This gene is overexpressed in Lymph node (16.5) and Peripheral blood mononuclear cells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAA15 Gene



SOURCE GeneReport for Unigene cluster for NAA15 Gene Hs.745047

mRNA Expression by UniProt/SwissProt for NAA15 Gene

Q9BXJ9-NAA15_HUMAN
Tissue specificity: Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.
genes like me logo Genes that share expression patterns with NAA15: view

Protein tissue co-expression partners for NAA15 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NAA15 Gene

Orthologs for NAA15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAA15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAA15 35
  • 96.04 (n)
  • 99.19 (a)
NAA15 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAA15 35
  • 95.92 (n)
  • 99.14 (a)
NAA15 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naa15 35
  • 93.14 (n)
  • 98.5 (a)
Naa15 16
Naa15 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAA15 35
  • 99.85 (n)
  • 99.88 (a)
NAA15 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naa15 35
  • 92.52 (n)
  • 98.03 (a)
oppossum
(Monodelphis domestica)
Mammalia NAA15 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves NAA15 35
  • 85.67 (n)
  • 95.83 (a)
NAA15 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAA15 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia naa15 35
  • 80.52 (n)
  • 90.05 (a)
Str.7467 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4200 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15380 35
naa15a 35
  • 69.75 (n)
  • 80.23 (a)
naa15a 36
  • 80 (a)
OneToMany
naa15b 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nat1 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-29 36
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAT1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10581 36
  • 50 (a)
OneToMany
Species with no ortholog for NAA15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAA15 Gene

ENSEMBL:
Gene Tree for NAA15 (if available)
TreeFam:
Gene Tree for NAA15 (if available)

Paralogs for NAA15 Gene

Paralogs for NAA15 Gene

(10) SIMAP similar genes for NAA15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NAA15: view

Variants for NAA15 Gene

Sequence variations from dbSNP and Humsavar for NAA15 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2169 -- 139,312,195(-) TCTCA(C/G)TAAGA intron-variant
rs765620 -- 139,375,468(-) AAAAA(A/G)AAAAG intron-variant
rs998310 -- 139,387,830(-) TACTG(G/T)GAATT intron-variant
rs747004 -- 139,333,364(+) gtgca(C/T)tgcta intron-variant
rs1450735 -- 139,315,491(-) actca(A/G)gctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAA15 Gene

Variant ID Type Subtype PubMed ID
nsv880160 CNV Gain 21882294
dgv977e199 CNV Deletion 23128226
esv2728426 CNV Deletion 23290073
nsv822748 CNV Loss 20364138
nsv442922 CNV CNV 18776908
nsv514254 CNV Loss 21397061
nsv4529 CNV Insertion 18451855
nsv830084 CNV Loss 17160897

Variation tolerance for NAA15 Gene

Residual Variation Intolerance Score: 9.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAA15 Gene

HapMap Linkage Disequilibrium report
NAA15
Human Gene Mutation Database (HGMD)
NAA15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAA15 Gene

Disorders for NAA15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NAA15 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
n-terminal acetyltransferase deficiency
  • ogden syndrome
gastric cancer
  • stomach cancer
breast benign neoplasm
thoracic benign neoplasm
  • benign neoplasm of thorax
thyroid cancer, monmedullary, 1
  • papillary thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NAA15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAA15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAA15
genes like me logo Genes that share disorders with NAA15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAA15 Gene

Publications for NAA15 Gene

  1. NATH, a novel gene overexpressed in papillary thyroid carcinomas. (PMID: 12140756) Fluge O. … Lillehaug J.R. (Oncogene 2002) 2 3 4 23 67
  2. Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. (PMID: 19420222) Arnesen T. … Gevaert K. (Proc. Natl. Acad. Sci. U.S.A. 2009) 2 3 23
  3. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. (PMID: 19660095) Polevoda B. … Sherman F. (BMC Proc. 2009) 2 3
  4. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). (PMID: 19480662) Arnesen T. … Lillehaug J.R. (BMC Biochem. 2009) 3 23
  5. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. (PMID: 16638120) Arnesen T. … Lillehaug J.R. (BMC Biochem. 2006) 3 23

Products for NAA15 Gene

Sources for NAA15 Gene

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