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Aliases for UXS1 Gene

Aliases for UXS1 Gene

  • UDP-Glucuronate Decarboxylase 1 2 3 4
  • UGD 3 4 6
  • EC 4 63
  • UXS-1 3 4
  • Short Chain Dehydrogenase/Reductase Family 6E, Member 12 3
  • Short Chain Dehydrogenase/Reductase Family 6E 2
  • UDP-Glucuronic Acid Decarboxylase 1 3
  • Member 12 2
  • SDR6E1 3

External Ids for UXS1 Gene

Previous GeneCards Identifiers for UXS1 Gene

  • GC02M104573
  • GC02M105162
  • GC02M106314
  • GC02M106331
  • GC02M106709
  • GC02M100479

Summaries for UXS1 Gene

Entrez Gene Summary for UXS1 Gene

  • This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for UXS1 Gene

UXS1 (UDP-Glucuronate Decarboxylase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glucuronidation. GO annotations related to this gene include coenzyme binding and UDP-glucuronate decarboxylase activity. An important paralog of this gene is TGDS.

UniProtKB/Swiss-Prot for UXS1 Gene

  • Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis

Gene Wiki entry for UXS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UXS1 Gene

Genomics for UXS1 Gene

Regulatory Elements for UXS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UXS1 Gene

106,093,303 bp from pter
106,194,339 bp from pter
101,037 bases
Minus strand

Genomic View for UXS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UXS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UXS1 Gene

Proteins for UXS1 Gene

  • Protein details for UXS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-glucuronic acid decarboxylase 1
    Protein Accession:
    Secondary Accessions:
    • Q8NBX3
    • Q9H5C2

    Protein attributes for UXS1 Gene

    420 amino acids
    Molecular mass:
    47577 Da
    Name=NAD(+); Xref=ChEBI:CHEBI:57540;
    Quaternary structure:
    • Interacts with AKT1.

    Three dimensional structures from OCA and Proteopedia for UXS1 Gene

    Alternative splice isoforms for UXS1 Gene


neXtProt entry for UXS1 Gene

Proteomics data for UXS1 Gene at MOPED

Post-translational modifications for UXS1 Gene

  • Glycosylation at Asn316
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for UXS1 Gene

Gene Families for UXS1 Gene

Protein Domains for UXS1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
genes like me logo Genes that share domains with UXS1: view

Function for UXS1 Gene

Molecular function for UXS1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-D-glucuronate = UDP-D-xylose + CO(2)
UniProtKB/Swiss-Prot Function:
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis

Enzyme Numbers (IUBMB) for UXS1 Gene

Gene Ontology (GO) - Molecular Function for UXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
GO:0042803 protein homodimerization activity IDA 23656592
GO:0048040 UDP-glucuronate decarboxylase activity IDA 23072385
genes like me logo Genes that share ontologies with UXS1: view

Phenotypes for UXS1 Gene

genes like me logo Genes that share phenotypes with UXS1: view

Animal Models for UXS1 Gene

MGI Knock Outs for UXS1:

Animal Model Products

miRNA for UXS1 Gene

miRTarBase miRNAs that target UXS1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UXS1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for UXS1 Gene

Localization for UXS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UXS1 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for UXS1 Gene COMPARTMENTS Subcellular localization image for UXS1 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with UXS1: view

Pathways for UXS1 Gene

genes like me logo Genes that share pathways with UXS1: view

Pathways by source for UXS1 Gene

UniProtKB/Swiss-Prot Q8NBZ7-UXS1_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1

Gene Ontology (GO) - Biological Process for UXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process --
GO:0008152 metabolic process --
GO:0009058 biosynthetic process --
GO:0033320 UDP-D-xylose biosynthetic process IEA --
GO:0051262 protein tetramerization IDA 23656592
genes like me logo Genes that share ontologies with UXS1: view

Drugs for UXS1 Gene

(5) HMDB Compounds for UXS1 Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
  • 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt
  • 1,4-Dihydronicotinamide adenine dinucleotide
  • alpha-D-Xylopyranosyl ester
Uridine diphosphate glucuronic acid
  • a-D-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
genes like me logo Genes that share compounds with UXS1: view

Transcripts for UXS1 Gene

Unigene Clusters for UXS1 Gene

UDP-glucuronate decarboxylase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UXS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UXS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: -

Relevant External Links for UXS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UXS1 Gene

mRNA expression in normal human tissues for UXS1 Gene

Protein differential expression in normal tissues for UXS1 Gene

This gene is overexpressed in Pancreas (25.2), Lung (11.4), Fetal ovary (8.9), and Testis (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UXS1 Gene

SOURCE GeneReport for Unigene cluster for UXS1 Gene Hs.743389

genes like me logo Genes that share expressions with UXS1: view

Expression partners for UXS1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UXS1 Gene

Orthologs for UXS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UXS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UXS1 35
  • 88.41 (n)
  • 96.67 (a)
UXS1 36
  • 97 (a)
(Canis familiaris)
Mammalia UXS1 35
  • 90.71 (n)
  • 97.95 (a)
UXS1 36
  • 93 (a)
(Mus musculus)
Mammalia Uxs1 35
  • 89.13 (n)
  • 98.57 (a)
Uxs1 16
Uxs1 36
  • 99 (a)
(Pan troglodytes)
Mammalia UXS1 35
  • 99.44 (n)
  • 99.76 (a)
UXS1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Uxs1 35
  • 89.13 (n)
  • 97.14 (a)
(Monodelphis domestica)
Mammalia UXS1 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia UXS1 36
  • 93 (a)
(Gallus gallus)
Aves UXS1 35
  • 83.25 (n)
  • 94.52 (a)
UXS1 36
  • 94 (a)
(Anolis carolinensis)
Reptilia UXS1 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8401 35
uxs1 35
  • 77.91 (n)
  • 90.02 (a)
(Danio rerio)
Actinopterygii uxs1 35
  • 77.1 (n)
  • 88.11 (a)
uxs1 36
  • 88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7979 37
  • 67 (a)
CG7979 35
  • 62.46 (n)
  • 71.15 (a)
CG7979 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004268 35
  • 64.35 (n)
  • 70.75 (a)
(Caenorhabditis elegans)
Secernentea sqv-1 35
  • 62.02 (n)
  • 67.73 (a)
sqv-1 36
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GAL10 36
  • 10 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UXS5 35
  • 62.7 (n)
  • 63.99 (a)
(Glycine max)
eudicotyledons Gma.6843 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.729 35
(Hordeum vulgare)
Liliopsida Hv.942 35
(Oryza sativa)
Liliopsida Os03g0278000 35
  • 59.53 (n)
  • 63.26 (a)
(Triticum aestivum)
Liliopsida Ta.23697 35
(Zea mays)
Liliopsida Zm.730 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10399 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
Species with no ortholog for UXS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UXS1 Gene

Gene Tree for UXS1 (if available)
Gene Tree for UXS1 (if available)

Paralogs for UXS1 Gene

Paralogs for UXS1 Gene

(1) SIMAP similar genes for UXS1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with UXS1: view

Variants for UXS1 Gene

Sequence variations from dbSNP and Humsavar for UXS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1991 -- 106,094,084(-) TAATC(A/G)GTACA reference, missense, nc-transcript-variant, utr-variant-3-prime
rs716373 -- 106,179,030(+) TCATG(C/T)TACCT intron-variant
rs725216 -- 106,105,489(-) CAAGA(C/T)GGTCT intron-variant
rs725217 -- 106,105,676(-) ACCTC(A/G)CATCG intron-variant
rs737101 -- 106,116,089(+) TGAGA(C/T)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UXS1 Gene

Variant ID Type Subtype PubMed ID
nsv524810 CNV Loss 19592680

Relevant External Links for UXS1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UXS1 Gene

Disorders for UXS1 Gene

Relevant External Links for UXS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for UXS1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for UXS1 Gene

Publications for UXS1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide- sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development. (PMID: 12391314) Hwang H.-Y. … Horvitz H.R. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4

Products for UXS1 Gene

  • Addgene plasmids for UXS1

Sources for UXS1 Gene

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