Aliases for NR4A3 Gene
External Ids for NR4A3 Gene
Previous GeneCards Identifiers for NR4A3 Gene
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
GeneCards Summary for NR4A3 Gene
NR4A3 (Nuclear Receptor Subfamily 4, Group A, Member 3) is a Protein Coding gene. Diseases associated with NR4A3 include chondrosarcoma, extraskeletal myxoid and chondrosarcoma. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include sequence-specific DNA binding and steroid hormone receptor activity. An important paralog of this gene is AR.
UniProtKB/Swiss-Prot for NR4A3 Gene
Binds to the B1A response-element