Aliases for RMI1 Gene
External Ids for RMI1 Gene
Previous HGNC Symbols for RMI1 Gene
Previous GeneCards Identifiers for RMI1 Gene
RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM, Mar 2008]
GeneCards Summary for RMI1 Gene
RMI1 (RecQ Mediated Genome Instability 1) is a Protein Coding gene. Diseases associated with RMI1 include bloom syndrome. Among its related pathways are Fanconi anemia pathway and Cell Cycle, Mitotic. An important paralog of this gene is TDRD3.
UniProtKB/Swiss-Prot for RMI1 Gene
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.