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Aliases for CALD1 Gene

Aliases for CALD1 Gene

  • Caldesmon 1 2 3
  • CDM 3 4 6
  • Caldesmon 3
  • H-CAD 3
  • L-CAD 3
  • NAG22 3
  • HCAD 3
  • LCAD 3
  • CAD 4

External Ids for CALD1 Gene

Summaries for CALD1 Gene

Entrez Gene Summary for CALD1 Gene

  • This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALD1 Gene

CALD1 (Caldesmon 1) is a Protein Coding gene. Diseases associated with CALD1 include mixed endometrial stromal and smooth muscle tumor and breast leiomyosarcoma. Among its related pathways are Integrin Pathway and Cytoskeletal Signaling. GO annotations related to this gene include actin binding and myosin binding.

UniProtKB/Swiss-Prot for CALD1 Gene

  • Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).

Gene Wiki entry for CALD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALD1 Gene

Genomics for CALD1 Gene

Genomic Location for CALD1 Gene

Start:
134,744,252 bp from pter
End:
134,970,729 bp from pter
Size:
226,478 bases
Orientation:
Plus strand

Genomic View for CALD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALD1 Gene

Regulatory Elements for CALD1 Gene

Proteins for CALD1 Gene

  • Protein details for CALD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05682-CALD1_HUMAN
    Recommended name:
    Caldesmon
    Protein Accession:
    Q05682
    Secondary Accessions:
    • A8K0X1
    • Q13978
    • Q13979
    • Q14741
    • Q14742
    • Q9UD91

    Protein attributes for CALD1 Gene

    Size:
    793 amino acids
    Molecular mass:
    93231 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALD1 Gene

neXtProt entry for CALD1 Gene

Proteomics data for CALD1 Gene at MOPED

Post-translational modifications for CALD1 Gene

  • In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CALD1 Gene

Domains for CALD1 Gene

Protein Domains for CALD1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q05682

UniProtKB/Swiss-Prot:

CALD1_HUMAN
Domain:
  • The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form:
    • Q05682
Family:
  • Belongs to the caldesmon family.:
    • Q05682
genes like me logo Genes that share domains with CALD1: view

No data available for Gene Families for CALD1 Gene

Function for CALD1 Gene

Molecular function for CALD1 Gene

GENATLAS Biochemistry: F-actin cross linking protein,caldesmon,with two alternatively spliced forms,high molecular weight in smooth muscle,low molecular weight in non muscle tissues and cells
UniProtKB/Swiss-Prot Function: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).

Gene Ontology (GO) - Molecular Function for CALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0005523 tropomyosin binding TAS 1555769
GO:0017022 myosin binding IEA --
genes like me logo Genes that share ontologies with CALD1: view
genes like me logo Genes that share phenotypes with CALD1: view

Animal Models for CALD1 Gene

MGI Knock Outs for CALD1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CALD1 Gene

Localization for CALD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALD1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALD1 Gene COMPARTMENTS Subcellular localization image for CALD1 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
plasma membrane 4
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for CALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton TAS 16130169
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton IDA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CALD1: view

Pathways for CALD1 Gene

genes like me logo Genes that share pathways with CALD1: view

Gene Ontology (GO) - Biological Process for CALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0006936 muscle contraction TAS --
genes like me logo Genes that share ontologies with CALD1: view

Compounds for CALD1 Gene

(1) HMDB Compounds for CALD1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for CALD1 Gene

Compound -log(P) Hits PubMed IDs
actomyosin 59.7 1
genes like me logo Genes that share compounds with CALD1: view

Transcripts for CALD1 Gene

mRNA/cDNA for CALD1 Gene

(8) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALD1 Gene

Caldesmon 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1:
SP2: - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9:
SP10:
SP11: -
SP12:

ExUns: 18b ^ 19a · 19b ^ 20a · 20b · 20c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:

Relevant External Links for CALD1 Gene

GeneLoc Exon Structure for
CALD1
ECgene alternative splicing isoforms for
CALD1

Expression for CALD1 Gene

mRNA expression in normal human tissues for CALD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALD1 Gene

This gene is overexpressed in Esophagus - Muscularis (5.4), Artery - Tibial (4.6), and Colon - Sigmoid (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALD1 Gene

SOURCE GeneReport for Unigene cluster for CALD1 Gene Hs.490203

mRNA Expression by UniProt/SwissProt for CALD1 Gene

Q05682-CALD1_HUMAN
Tissue specificity: High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart
genes like me logo Genes that share expressions with CALD1: view

Orthologs for CALD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALD1 35
  • 89.55 (n)
  • 91.59 (a)
CALD1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALD1 35
  • 85.19 (n)
  • 87.19 (a)
CALD1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cald1 16
Cald1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CALD1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALD1 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALD1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CALD1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100124848 35
  • 64.45 (n)
  • 63.57 (a)
Str.12979 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
cald1 36
  • 37 (a)
OneToMany
cald1l 36
  • 54 (a)
OneToMany
Species with no ortholog for CALD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALD1 Gene

ENSEMBL:
Gene Tree for CALD1 (if available)
TreeFam:
Gene Tree for CALD1 (if available)

Paralogs for CALD1 Gene

Pseudogenes.org Pseudogenes for CALD1 Gene

genes like me logo Genes that share paralogs with CALD1: view

No data available for Paralogs for CALD1 Gene

Variants for CALD1 Gene

Sequence variations from dbSNP and Humsavar for CALD1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs11204 -- 134,969,179(+) TATTT(C/T)ATATT utr-variant-3-prime
rs721364 -- 134,861,138(+) CAGGT(A/C)TACAG intron-variant
rs741688 -- 134,855,355(-) AAGCC(A/G)AAGAA intron-variant
rs741689 -- 134,855,106(-) TGGAT(C/T)ATGAT intron-variant
rs741690 -- 134,854,544(+) TAATG(A/T)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALD1 Gene

Variant ID Type Subtype PubMed ID
nsv889223 CNV Gain 21882294
nsv5959 CNV Insertion 18451855
esv2668646 CNV Deletion 23128226
esv29739 CNV Loss 19812545
nsv521781 CNV Loss 19592680
esv2677689 CNV Deletion 23128226
esv2735182 CNV Deletion 23290073
esv4039 CNV Deletion 18987735
nsv365920 CNV Loss 16902084
esv2735183 CNV Deletion 23290073
nsv516148 CNV Loss 19592680
nsv527174 CNV Loss 19592680

Relevant External Links for CALD1 Gene

HapMap Linkage Disequilibrium report
CALD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALD1 Gene

Disorders for CALD1 Gene

Relevant External Links for CALD1

Genetic Association Database (GAD)
CALD1
Human Genome Epidemiology (HuGE) Navigator
CALD1
genes like me logo Genes that share disorders with CALD1: view

No data available for UniProtKB/Swiss-Prot for CALD1 Gene

Publications for CALD1 Gene

  1. Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells. (PMID: 1885618) Novy R.E. … Lin J.J.-C. (J. Biol. Chem. 1991) 2 3 4
  2. Genomic structure of the human caldesmon gene. (PMID: 1465449) Hayashi K. … Sobue K. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  3. Cloning of cDNAs encoding human caldesmons. (PMID: 1555769) Humphrey M.B. … Bryan J. (Gene 1992) 3 4 23
  4. Differential expression of splicing variants of the human caldesmon gene (CALD1) in glioma neovascularization versus normal brain microvasculature. (PMID: 15161654) Zheng P.P. … Kros J.M. (Am. J. Pathol. 2004) 3 23
  5. The role of caldesmon in the regulation of endothelial cytoskeleton and migration. (PMID: 15521070) Mirzapoiazova T. … Verin A.D. (J. Cell. Physiol. 2005) 3 23

Products for CALD1 Gene

Sources for CALD1 Gene

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