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Aliases for NANOG Gene

Aliases for NANOG Gene

  • Nanog Homeobox 2 3 5
  • Homeobox Transcription Factor Nanog 4
  • HNanog 4

External Ids for NANOG Gene

Previous GeneCards Identifiers for NANOG Gene

  • GC12P007842
  • GC12P007833
  • GC12U900534
  • GC12P007941
  • GC12P007940

Summaries for NANOG Gene

Entrez Gene Summary for NANOG Gene

  • The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for NANOG Gene

NANOG (Nanog Homeobox) is a Protein Coding gene. Diseases associated with NANOG include teratocarcinoma and cystadenocarcinoma. Among its related pathways are Developmental Biology and SIDS Susceptibility Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is NANOGP8.

UniProtKB/Swiss-Prot for NANOG Gene

  • Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Gene Wiki entry for NANOG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOG Gene

Genomics for NANOG Gene

Regulatory Elements for NANOG Gene

Promoters for NANOG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NANOG on UCSC Golden Path with GeneCards custom track

Genomic Location for NANOG Gene

Chromosome:
12
Start:
7,787,794 bp from pter
End:
7,799,141 bp from pter
Size:
11,348 bases
Orientation:
Plus strand

Genomic View for NANOG Gene

Genes around NANOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOG Gene

Proteins for NANOG Gene

  • Protein details for NANOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9S0-NANOG_HUMAN
    Recommended name:
    Homeobox protein NANOG
    Protein Accession:
    Q9H9S0
    Secondary Accessions:
    • D3DUU4
    • Q2TTG0
    • Q6JZS5

    Protein attributes for NANOG Gene

    Size:
    305 amino acids
    Molecular mass:
    34620 Da
    Quaternary structure:
    • Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281 (By similarity). Interacts with PCGF1 (PubMed:26687479).
    Miscellaneous:
    • Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene.

    Three dimensional structures from OCA and Proteopedia for NANOG Gene

    Alternative splice isoforms for NANOG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NANOG Gene

Proteomics data for NANOG Gene at MOPED

Post-translational modifications for NANOG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOG Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for NANOG

No data available for DME Specific Peptides for NANOG Gene

Domains & Families for NANOG Gene

Gene Families for NANOG Gene

Protein Domains for NANOG Gene

Suggested Antigen Peptide Sequences for NANOG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9S0

UniProtKB/Swiss-Prot:

NANOG_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Nanog homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Nanog homeobox family.
genes like me logo Genes that share domains with NANOG: view

Function for NANOG Gene

Molecular function for NANOG Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Gene Ontology (GO) - Molecular Function for NANOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26687479
genes like me logo Genes that share ontologies with NANOG: view
genes like me logo Genes that share phenotypes with NANOG: view

Animal Models for NANOG Gene

MGI Knock Outs for NANOG:

Animal Model Products

Targeted motifs for NANOG Gene
HOMER Transcription Factor Regulatory Elements motif NANOG
  • Consensus sequence: GGCCATTAAC Submotif: canonical Cell Type: mES GEO ID: GSE11724

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NANOG Gene

Localization for NANOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NANOG Gene COMPARTMENTS Subcellular localization image for NANOG gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 2
chloroplast 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NANOG Gene

Pathways & Interactions for NANOG Gene

genes like me logo Genes that share pathways with NANOG: view

Gene Ontology (GO) - Biological Process for NANOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IMP 16501172
GO:0019827 stem cell population maintenance IEP 15108323
GO:0030154 cell differentiation IEP 16501172
GO:0045595 regulation of cell differentiation IMP 16501172
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 20713518
genes like me logo Genes that share ontologies with NANOG: view

No data available for SIGNOR curated interactions for NANOG Gene

Drugs & Compounds for NANOG Gene

No Compound Related Data Available

Transcripts for NANOG Gene

mRNA/cDNA for NANOG Gene

(5) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOG Gene

Nanog homeobox:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANOG Gene

No ASD Table

Relevant External Links for NANOG Gene

GeneLoc Exon Structure for
NANOG
ECgene alternative splicing isoforms for
NANOG

Expression for NANOG Gene

mRNA expression in normal human tissues for NANOG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOG Gene

This gene is overexpressed in Testis (x5.7).

SOURCE GeneReport for Unigene cluster for NANOG Gene Hs.635882

mRNA Expression by UniProt/SwissProt for NANOG Gene

Q9H9S0-NANOG_HUMAN
Tissue specificity: Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes.
genes like me logo Genes that share expression patterns with NANOG: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NANOG Gene

Orthologs for NANOG Gene

This gene was present in the common ancestor of chordates.

Orthologs for NANOG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NANOG 35
  • 78.93 (n)
  • 70.9 (a)
NANOG 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NANOG 35
  • 79.59 (n)
  • 70.31 (a)
NANOG 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nanog 35
  • 73.33 (n)
  • 61.03 (a)
Nanog 16
Nanog 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NANOG 35
  • 99.23 (n)
  • 98.36 (a)
NANOG 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nanog 35
  • 73.97 (n)
  • 64.73 (a)
oppossum
(Monodelphis domestica)
Mammalia NANOG 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 26 (a)
OneToMany
NANOG 36
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NANOG 36
  • 23 (a)
OneToOne
Species with no ortholog for NANOG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NANOG Gene

ENSEMBL:
Gene Tree for NANOG (if available)
TreeFam:
Gene Tree for NANOG (if available)

Paralogs for NANOG Gene

Paralogs for NANOG Gene

(8) SIMAP similar genes for NANOG Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NANOG: view

Variants for NANOG Gene

Sequence variations from dbSNP and Humsavar for NANOG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2889551 - 7,793,044(-) ACACT(A/C)TTCTC reference, missense, utr-variant-5-prime
rs1108032 -- 7,794,152(+) CACTG(C/T)AGCCT intron-variant
rs877716 -- 7,794,263(+) GACAC(A/G)GTGTT intron-variant
rs877717 -- 7,794,154(+) CTGCA(A/G)CCTTC intron-variant
rs1860931 -- 7,794,421(-) TATTC(A/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NANOG Gene

Variant ID Type Subtype PubMed ID
dgv5e196 CNV Duplication 17116639
dgv6e196 CNV Duplication 17116639
esv2422393 CNV Duplication 17116639
dgv57e55 CNV Gain 17911159
dgv454e1 CNV Complex 17122850
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
dgv1354n71 CNV Gain 21882294
dgv456e1 CNV Complex 17122850
nsv7227 OTHER Inversion 18451855
esv2745493 CNV Deletion 23290073
dgv457e1 CNV Complex 17122850
nsv596 CNV Insertion 18451855

Variation tolerance for NANOG Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANOG Gene

HapMap Linkage Disequilibrium report
NANOG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOG Gene

Disorders for NANOG Gene

MalaCards: The human disease database

(7) MalaCards diseases for NANOG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
cystadenocarcinoma
  • cystadenocarcinoma nos
brain cancer
  • adult brain tumor
germ cell and embryonal cancer
  • germ cell and embryonal neoplasm
venous hemangioma
- elite association - COSMIC cancer census association via MalaCards
Search NANOG in MalaCards View complete list of genes associated with diseases

Relevant External Links for NANOG

Genetic Association Database (GAD)
NANOG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOG
genes like me logo Genes that share disorders with NANOG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANOG Gene

Publications for NANOG Gene

  1. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. (PMID: 12787505) Chambers I. … Smith A. (Cell 2003) 2 3 4 67
  2. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. (PMID: 18593985) Chiou S.H. … Lo J.F. (Clin. Cancer Res. 2008) 3 23
  3. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. (PMID: 15615706) Deb-Rinker P. … Walker P.R. (J. Biol. Chem. 2005) 3 23
  4. Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. (PMID: 15983365) Hyslop L.A. … Lako M. (Stem Cells 2005) 3 23
  5. Core transcriptional regulatory circuitry in human embryonic stem cells. (PMID: 16153702) Boyer L.A. … Young R.A. (Cell 2005) 3 23

Products for NANOG Gene

Sources for NANOG Gene

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