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Aliases for NANOG Gene

Aliases for NANOG Gene

  • Nanog Homeobox 2 3 5
  • Homeobox Transcription Factor Nanog 4
  • HNanog 4

External Ids for NANOG Gene

Previous GeneCards Identifiers for NANOG Gene

  • GC12P007842
  • GC12P007833
  • GC12U900534
  • GC12P007941
  • GC12P007940

Summaries for NANOG Gene

Entrez Gene Summary for NANOG Gene

  • The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for NANOG Gene

NANOG (Nanog Homeobox) is a Protein Coding gene. Diseases associated with NANOG include Teratocarcinoma and Embryonal Carcinoma. Among its related pathways are Mesodermal Commitment Pathway and Innate Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is NANOGP8.

UniProtKB/Swiss-Prot for NANOG Gene

  • Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Gene Wiki entry for NANOG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOG Gene

Genomics for NANOG Gene

Regulatory Elements for NANOG Gene

Enhancers for NANOG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G006940 1.9 FANTOM5 ENCODE dbSUPER 10.7 -834.1 -834136 25.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SPSB2 ENSG00000219410 ENSG00000247853 NOP2 NCAPD2 SCARNA12 ENSG00000256967 ATN1 TNFRSF1A SCNN1A
GH12G008241 1 ENCODE 10.5 +455.2 455211 2.7 HDGF PKNOX1 ATF1 AGO1 ARID4B SIN3A YY1 GLIS2 ZNF143 ZNF207 PHC1 NANOG ENSG00000256552 FAM86FP LINC00612 GC12P008268
GH12G006880 0.9 ENCODE 10.7 -906.9 -906923 1.6 ZFP64 ARID4B DMAP1 ZNF202 REST ZNF623 ZNF518A ZNF292 MIER3 ZBTB21 SPSB2 ENSG00000219410 C12orf57 GNB3 PHB2 ENSG00000247853 ENO2 CDCA3 USP5 ATN1
GH12G007796 1.2 Ensembl ENCODE dbSUPER 5.8 +11.0 11044 4.6 BCOR ZNF792 ZNF10 ZNF781 RARA JUND ZNF316 ZNF34 POLR2A ZBTB33 FAM66C GNB3 NECAP1 ENO2 DPPA3 DEFB109F RPL13P5 DSTNP2 SLC2A3 NANOG
GH12G007786 0.9 Ensembl ENCODE dbSUPER 5.8 +0.2 177 2.1 ZBTB33 REST DPPA3 GDF3 NANOG SLC2A3 GC12M007800 ENSG00000199912
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NANOG on UCSC Golden Path with GeneCards custom track

Genomic Location for NANOG Gene

Chromosome:
12
Start:
7,787,794 bp from pter
End:
7,799,141 bp from pter
Size:
11,348 bases
Orientation:
Plus strand

Genomic View for NANOG Gene

Genes around NANOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOG Gene

Proteins for NANOG Gene

  • Protein details for NANOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9S0-NANOG_HUMAN
    Recommended name:
    Homeobox protein NANOG
    Protein Accession:
    Q9H9S0
    Secondary Accessions:
    • D3DUU4
    • Q2TTG0
    • Q6JZS5

    Protein attributes for NANOG Gene

    Size:
    305 amino acids
    Molecular mass:
    34620 Da
    Quaternary structure:
    • Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281 (By similarity). Interacts with PCGF1 (PubMed:26687479).
    Miscellaneous:
    • Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene.

    Three dimensional structures from OCA and Proteopedia for NANOG Gene

    Alternative splice isoforms for NANOG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NANOG Gene

Post-translational modifications for NANOG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOG Gene

Antibody Products

  • Abcam antibodies for NANOG
  • Cloud-Clone Corp. Antibodies for NANOG

No data available for DME Specific Peptides for NANOG Gene

Domains & Families for NANOG Gene

Gene Families for NANOG Gene

Protein Domains for NANOG Gene

Suggested Antigen Peptide Sequences for NANOG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9S0

UniProtKB/Swiss-Prot:

NANOG_HUMAN :
  • Belongs to the Nanog homeobox family.
Family:
  • Belongs to the Nanog homeobox family.
genes like me logo Genes that share domains with NANOG: view

Function for NANOG Gene

Molecular function for NANOG Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Gene Ontology (GO) - Molecular Function for NANOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16153702
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 16153702
GO:0003714 transcription corepressor activity ISS --
GO:0005515 protein binding IPI 26687479
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NANOG: view
genes like me logo Genes that share phenotypes with NANOG: view

Animal Models for NANOG Gene

MGI Knock Outs for NANOG:

Animal Model Products

CRISPR Products

Targeted motifs for NANOG Gene
HOMER Transcription Factor Regulatory Elements motif NANOG
  • Consensus sequence: GGCCATTAAC Submotif: canonical Cell Type: mES GEO ID: GSE11724

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NANOG

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NANOG Gene

Localization for NANOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NANOG gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
cytosol 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NANOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18932205
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 20458727
genes like me logo Genes that share ontologies with NANOG: view

Pathways & Interactions for NANOG Gene

genes like me logo Genes that share pathways with NANOG: view

Gene Ontology (GO) - Biological Process for NANOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001714 endodermal cell fate specification IDA 20713518
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 16153702
GO:0007275 multicellular organism development IEA --
GO:0008283 cell proliferation IMP 16501172
genes like me logo Genes that share ontologies with NANOG: view

No data available for SIGNOR curated interactions for NANOG Gene

Transcripts for NANOG Gene

mRNA/cDNA for NANOG Gene

(4) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOG Gene

Nanog homeobox:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NANOG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANOG Gene

No ASD Table

Relevant External Links for NANOG Gene

GeneLoc Exon Structure for
NANOG
ECgene alternative splicing isoforms for
NANOG

Expression for NANOG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NANOG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOG Gene

This gene is overexpressed in Testis (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of NANOG Gene:

NANOG

SOURCE GeneReport for Unigene cluster for NANOG Gene:

Hs.635882

mRNA Expression by UniProt/SwissProt for NANOG Gene:

Q9H9S0-NANOG_HUMAN
Tissue specificity: Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes.

Evidence on tissue expression from TISSUES for NANOG Gene

  • Nervous system(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with NANOG: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NANOG Gene

Orthologs for NANOG Gene

This gene was present in the common ancestor of chordates.

Orthologs for NANOG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOG 34 35
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia NANOG 34 35
  • 79.59 (n)
cow
(Bos Taurus)
Mammalia NANOG 34 35
  • 78.93 (n)
rat
(Rattus norvegicus)
Mammalia Nanog 34
  • 73.97 (n)
mouse
(Mus musculus)
Mammalia Nanog 34 16 35
  • 73.33 (n)
oppossum
(Monodelphis domestica)
Mammalia NANOG 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 26 (a)
OneToMany
NANOG 35
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NANOG 35
  • 23 (a)
OneToOne
Species where no ortholog for NANOG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NANOG Gene

ENSEMBL:
Gene Tree for NANOG (if available)
TreeFam:
Gene Tree for NANOG (if available)

Paralogs for NANOG Gene

Variants for NANOG Gene

Sequence variations from dbSNP and Humsavar for NANOG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000041624 -- 7,794,284(+) GGCTA(A/G)CCTGT intron-variant
rs1000470220 -- 7,796,063(+) ATAAA(A/T)CTTTG downstream-variant-500B
rs1000831779 -- 7,796,402(+) TTGTA(C/G)ATGTG downstream-variant-500B
rs1001477808 -- 7,788,267(+) GGAAG(A/C)CTGGA upstream-variant-2KB
rs1001645432 -- 7,796,343(+) GTTTT(A/T)GAATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NANOG Gene

Variant ID Type Subtype PubMed ID
dgv57e55 CNV gain 17911159
dgv5e196 CNV duplication 17116639
dgv6e196 CNV duplication 17116639
esv2422393 CNV duplication 17116639
esv2745493 CNV deletion 23290073
esv2759877 CNV gain+loss 17122850
esv3628442 CNV gain 21293372
esv3892131 CNV gain 25118596
nsv1159953 CNV duplication 26073780
nsv428270 CNV gain 18775914
nsv596 CNV insertion 18451855
nsv7227 OTHER inversion 18451855
nsv973012 CNV duplication 23825009

Variation tolerance for NANOG Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NANOG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANOG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOG Gene

Disorders for NANOG Gene

MalaCards: The human disease database

(7) MalaCards diseases for NANOG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
ovarian embryonal carcinoma
  • embryonal carcinoma of ovary
venous hemangioma
germ cell and embryonal cancer
  • germ cell and embryonal neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search NANOG in MalaCards View complete list of genes associated with diseases

Relevant External Links for NANOG

Genetic Association Database (GAD)
NANOG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NANOG
genes like me logo Genes that share disorders with NANOG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANOG Gene

Publications for NANOG Gene

  1. Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. (PMID: 15983365) Hyslop L.A. … Lako M. (Stem Cells 2005) 3 4 22 64
  2. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (PMID: 14990856) Clark A.T. … Reijo Pera R.A. (Stem Cells 2004) 3 4 22 64
  3. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. (PMID: 15108323) Hart A.H. … Robb L. (Dev. Dyn. 2004) 3 4 22 64
  4. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (PMID: 12787504) Mitsui K. … Yamanaka S. (Cell 2003) 2 3 4 64
  5. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. (PMID: 12787505) Chambers I. … Smith A. (Cell 2003) 2 3 4 64

Products for NANOG Gene

  • Addgene plasmids for NANOG

Sources for NANOG Gene

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