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Aliases for RPAP2 Gene

Aliases for RPAP2 Gene

  • RNA Polymerase II Associated Protein 2 2 3 5
  • C1orf82 3 4
  • Putative RNA Polymerase II Subunit B1 CTD Phosphatase RPAP2 3
  • RNA Polymerase II-Associated Protein 2 4
  • Chromosome 1 Open Reading Frame 82 2
  • EC 3.1.3.16 4
  • Rtr1 3

External Ids for RPAP2 Gene

Previous HGNC Symbols for RPAP2 Gene

  • C1orf82

Previous GeneCards Identifiers for RPAP2 Gene

  • GC01P092537
  • GC01P092764
  • GC01P090884

Summaries for RPAP2 Gene

GeneCards Summary for RPAP2 Gene

RPAP2 (RNA Polymerase II Associated Protein 2) is a Protein Coding gene. Among its related pathways are RNA polymerase II transcribes snRNA genes and Gene Expression. GO annotations related to this gene include CTD phosphatase activity.

UniProtKB/Swiss-Prot for RPAP2 Gene

  • Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated Ser-7 of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of Ser-5 of the CTD, thereby promoting transcription of snRNA genes.

Gene Wiki entry for RPAP2 Gene

Additional gene information for RPAP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPAP2 Gene

Genomics for RPAP2 Gene

Regulatory Elements for RPAP2 Gene

Enhancers for RPAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H091843 1.7 VISTA Ensembl ENCODE dbSUPER 16.4 -453.7 -453676 3 FOXA2 ARID4B FEZF1 BRCA1 RAD21 RFX5 YY1 ZNF366 SCRT2 RCOR1 RPAP2 GLMN HFM1 GC01P091842 GC01M091855
GH01H093078 1.2 ENCODE 20.5 +781.5 781471 4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 CCDC18-AS1 MTF2 SNORD21 SNORA66 TRR-TCT1-1 GLMN DNTTIP2 RPAP2 DR1 RPL5
GH01H092803 1.5 FANTOM5 Ensembl ENCODE 14 +506.1 506093 3 HDGF PKNOX1 ATF1 ARNT TCF12 GTF3C2 ZNF121 ZNF766 GATA2 FOS CCDC18-AS1 SNORA66 SNORD21 MTF2 GLMN RPAP2 EVI5 ENSG00000230439 RPL5 DR1
GH01H091863 1.5 Ensembl ENCODE dbSUPER 11.7 -434.4 -434447 1 FEZF1 ZNF2 ZNF121 ZNF302 KLF7 TSHZ1 ZNF623 ZNF610 ZSCAN16 GLIS1 HFM1 RPAP2 GC01M091855 GC01P091842
GH01H093177 1.4 ENCODE dbSUPER 11.7 +881.1 881059 4 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CCDC18-AS1 SNORA66 SNORD21 RPL5 ENSG00000230439 DNTTIP2 GLMN LOC100289500 ENSG00000233482 MTCO3P21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPAP2 on UCSC Golden Path with GeneCards custom track

Promoters for RPAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009821 -64 2200 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3

Genomic Location for RPAP2 Gene

Chromosome:
1
Start:
92,298,965 bp from pter
End:
92,402,056 bp from pter
Size:
103,092 bases
Orientation:
Plus strand

Genomic View for RPAP2 Gene

Genes around RPAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPAP2 Gene

Proteins for RPAP2 Gene

  • Protein details for RPAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXW5-RPAP2_HUMAN
    Recommended name:
    Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
    Protein Accession:
    Q8IXW5
    Secondary Accessions:
    • C9JKB5
    • Q49AS7
    • Q9H8Y2

    Protein attributes for RPAP2 Gene

    Size:
    612 amino acids
    Molecular mass:
    69509 Da
    Quaternary structure:
    • Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on Ser-7 on CTD.

    Alternative splice isoforms for RPAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPAP2 Gene

Post-translational modifications for RPAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPAP2 Gene

No data available for DME Specific Peptides for RPAP2 Gene

Domains & Families for RPAP2 Gene

Gene Families for RPAP2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for RPAP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXW5

UniProtKB/Swiss-Prot:

RPAP2_HUMAN :
  • The RTR1-type zinc finger mediates interactions with RNA polymerase II complex subunits.
  • Belongs to the RPAP2 family.
Domain:
  • The RTR1-type zinc finger mediates interactions with RNA polymerase II complex subunits.
Family:
  • Belongs to the RPAP2 family.
genes like me logo Genes that share domains with RPAP2: view

Function for RPAP2 Gene

Molecular function for RPAP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated Ser-7 of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of Ser-5 of the CTD, thereby promoting transcription of snRNA genes.

Enzyme Numbers (IUBMB) for RPAP2 Gene

Phenotypes From GWAS Catalog for RPAP2 Gene

Gene Ontology (GO) - Molecular Function for RPAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity EXP 22137580
GO:0005515 protein binding IPI 24656813
GO:0008420 CTD phosphatase activity IMP 22137580
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPAP2: view
genes like me logo Genes that share phenotypes with RPAP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPAP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPAP2 Gene

Localization for RPAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPAP2 Gene

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPAP2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22137580
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA,IEA 22137580
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RPAP2: view

Pathways & Interactions for RPAP2 Gene

genes like me logo Genes that share pathways with RPAP2: view

Pathways by source for RPAP2 Gene

2 Reactome pathways for RPAP2 Gene

Interacting Proteins for RPAP2 Gene

Gene Ontology (GO) - Biological Process for RPAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009301 snRNA transcription IMP 22137580
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain IMP 22137580
genes like me logo Genes that share ontologies with RPAP2: view

No data available for SIGNOR curated interactions for RPAP2 Gene

Drugs & Compounds for RPAP2 Gene

(2) Drugs for RPAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with RPAP2: view

Transcripts for RPAP2 Gene

Unigene Clusters for RPAP2 Gene

RNA polymerase II associated protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPAP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPAP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for RPAP2 Gene

GeneLoc Exon Structure for
RPAP2
ECgene alternative splicing isoforms for
RPAP2

Expression for RPAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPAP2 Gene

This gene is overexpressed in Testis (25.8), CD8 Tcells (23.6), and Blymphocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPAP2 Gene



Protein tissue co-expression partners for RPAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPAP2 Gene:

RPAP2

SOURCE GeneReport for Unigene cluster for RPAP2 Gene:

Hs.444421

Evidence on tissue expression from TISSUES for RPAP2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RPAP2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPAP2 Gene

Orthologs for RPAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPAP2 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia RPAP2 33
  • 89.55 (n)
-- 34
  • 85 (a)
OneToMany
-- 34
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPAP2 33 34
  • 88.45 (n)
rat
(Rattus norvegicus)
Mammalia Rpap2 33
  • 77.83 (n)
mouse
(Mus musculus)
Mammalia Rpap2 33 16 34
  • 77.65 (n)
oppossum
(Monodelphis domestica)
Mammalia RPAP2 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPAP2 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPAP2 33 34
  • 64.34 (n)
lizard
(Anolis carolinensis)
Reptilia RPAP2 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpap2 33
  • 58.47 (n)
Str.16031 33
zebrafish
(Danio rerio)
Actinopterygii rpap2 33 34
  • 54.36 (n)
Dr.25701 33
fruit fly
(Drosophila melanogaster)
Insecta CG34183 34
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for RPAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPAP2 Gene

ENSEMBL:
Gene Tree for RPAP2 (if available)
TreeFam:
Gene Tree for RPAP2 (if available)

Paralogs for RPAP2 Gene

Pseudogenes.org Pseudogenes for RPAP2 Gene

genes like me logo Genes that share paralogs with RPAP2: view

No data available for Paralogs for RPAP2 Gene

Variants for RPAP2 Gene

Sequence variations from dbSNP and Humsavar for RPAP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs762515373 Pathogenic 92,297,408(+) CCTTA(-/TTCTT)TTCAT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs142032681 Likely benign 92,297,425(+) TGAAT(A/C)ATTTC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs145401012 Likely benign 92,298,948(+) CTCCC(A/C)GCCGC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs201467961 Likely benign 92,297,394(+) CAAGA(C/T)TGTAC intron-variant, upstream-variant-2KB
rs556956035 Likely benign 92,298,928(+) ACCGG(C/T)CAGAA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPAP2 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV deletion 23290073
esv3346260 CNV insertion 20981092
nsv1133878 CNV deletion 24896259
nsv477492 CNV novel sequence insertion 20440878
nsv830592 CNV gain 17160897

Variation tolerance for RPAP2 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPAP2 Gene

Disorders for RPAP2 Gene

Relevant External Links for RPAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPAP2

No disorders were found for RPAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPAP2 Gene

Publications for RPAP2 Gene

  1. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C … Coulombe B (Molecular cell 2007) 2 3 4 60
  2. RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. (PMID: 24997600) Ni Z … Greenblatt JF (Nature structural & molecular biology 2014) 3 4 60
  3. The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. (PMID: 22781759) Xiang K … Tong L (Nature communications 2012) 2 3 60
  4. Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes. (PMID: 22137580) Egloff S … Murphy S (Molecular cell 2012) 3 4 60
  5. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. (PMID: 22231121) Ni Z … Greenblatt JF (Transcription 2011) 3 4 60

Products for RPAP2 Gene

Sources for RPAP2 Gene

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