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Aliases for AGMAT Gene

Aliases for AGMAT Gene

  • Agmatinase 2 3 5
  • Agmatine Ureohydrolase (Agmatinase) 2 3
  • EC 3.5.3.11 4 61
  • AUH 3 4
  • Agmatinase, Mitochondrial 3
  • Agmatine Ureohydrolase 4
  • EC 3.5.3 61

External Ids for AGMAT Gene

Previous GeneCards Identifiers for AGMAT Gene

  • GC01M015296
  • GC01M015078
  • GC01M015050
  • GC01M015262
  • GC01M015261
  • GC01M015644
  • GC01M015772
  • GC01M015898
  • GC01M014418

Summaries for AGMAT Gene

GeneCards Summary for AGMAT Gene

AGMAT (Agmatinase) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Arginine and proline metabolism. GO annotations related to this gene include agmatinase activity. An important paralog of this gene is ARG2.

Gene Wiki entry for AGMAT Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGMAT Gene

Genomics for AGMAT Gene

Regulatory Elements for AGMAT Gene

Enhancers for AGMAT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G015507 1.5 FANTOM5 ENCODE 20.8 +76.3 76331 2.1 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ENSG00000237938 AGMAT ZBTB17 CASP9 RPL22P3 RPS16P1 SPEN ENSG00000224621 FBXO42 GC01P015468
GH01G015522 1.4 ENCODE dbSUPER 21.1 +59.8 59791 5.9 MLX CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 AGMAT CASP9 SPEN ENSG00000237938 RPL22P3 FBXO42 ZBTB17 GC01P015468
GH01G015583 1.3 ENCODE dbSUPER 20.7 +0.3 326 1.9 HDGF HNRNPUL1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF121 ZNF143 AGMAT CASP9 PIR62159
GH01G015543 1.3 ENCODE dbSUPER 17.2 +41.3 41300 1.1 HDGF PKNOX1 CREB3L1 ARNT ZNF766 FOS JUNB REST SMARCB1 ZNF592 AGMAT FBLIM1 ENSG00000251866 GC01P015565 PIR45878
GH01G015488 0.9 ENCODE 21.8 +96.0 96008 1.5 ATF1 ARNT ARID4B RAD21 ZNF335 SLC30A9 ZNF121 GATA2 EGR1 CREM AGMAT CTRC LOC101927417 FHAD1 GC01P015468 CASP9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AGMAT on UCSC Golden Path with GeneCards custom track

Promoters for AGMAT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000001909 210 1001 HDGF HNRNPUL1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF121

Genomic Location for AGMAT Gene

Chromosome:
1
Start:
15,571,699 bp from pter
End:
15,585,110 bp from pter
Size:
13,412 bases
Orientation:
Minus strand

Genomic View for AGMAT Gene

Genes around AGMAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AGMAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AGMAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGMAT Gene

Proteins for AGMAT Gene

  • Protein details for AGMAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSE5-SPEB_HUMAN
    Recommended name:
    Agmatinase, mitochondrial
    Protein Accession:
    Q9BSE5
    Secondary Accessions:
    • Q5TDH1
    • Q9H5J3

    Protein attributes for AGMAT Gene

    Size:
    352 amino acids
    Molecular mass:
    37660 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for AGMAT Gene

Selected DME Specific Peptides for AGMAT Gene

Q9BSE5:
  • ANLLFEMLC
  • RVVQIGIRGSS
  • LDPAYAPGTGTPEIAGLTP
  • RPGARFGP
  • QALEIIRGC

Post-translational modifications for AGMAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AGMAT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for AGMAT Gene

Suggested Antigen Peptide Sequences for AGMAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSE5

UniProtKB/Swiss-Prot:

SPEB_HUMAN :
  • Belongs to the arginase family. Agmatinase subfamily.
Family:
  • Belongs to the arginase family. Agmatinase subfamily.
genes like me logo Genes that share domains with AGMAT: view

No data available for Gene Families for AGMAT Gene

Function for AGMAT Gene

Molecular function for AGMAT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Agmatine + H(2)O = putrescine + urea.

Enzyme Numbers (IUBMB) for AGMAT Gene

Gene Ontology (GO) - Molecular Function for AGMAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008783 agmatinase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AGMAT: view
genes like me logo Genes that share phenotypes with AGMAT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AGMAT

CRISPR Products

miRNA for AGMAT Gene

miRTarBase miRNAs that target AGMAT

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AGMAT Gene

Localization for AGMAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGMAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AGMAT gene
Compartment Confidence
extracellular 5
mitochondrion 5
peroxisome 2
cytosol 2

Gene Ontology (GO) - Cellular Components for AGMAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AGMAT: view

Pathways & Interactions for AGMAT Gene

genes like me logo Genes that share pathways with AGMAT: view

Pathways by source for AGMAT Gene

UniProtKB/Swiss-Prot Q9BSE5-SPEB_HUMAN

  • Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.

Gene Ontology (GO) - Biological Process for AGMAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008295 spermidine biosynthetic process IEA --
GO:0009446 putrescine biosynthetic process IEA --
GO:0033388 putrescine biosynthetic process from arginine IEA --
GO:0097055 agmatine biosynthetic process TAS --
genes like me logo Genes that share ontologies with AGMAT: view

No data available for SIGNOR curated interactions for AGMAT Gene

Drugs & Compounds for AGMAT Gene

(11) Drugs for AGMAT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34
spermine Approved Nutra Full agonist, Agonist 0
Guanidine Approved Pharma 0
Urea Approved Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for AGMAT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
Norspermidine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
56-18-8
genes like me logo Genes that share compounds with AGMAT: view

Transcripts for AGMAT Gene

mRNA/cDNA for AGMAT Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AGMAT Gene

Agmatine ureohydrolase (agmatinase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AGMAT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2: -

Relevant External Links for AGMAT Gene

GeneLoc Exon Structure for
AGMAT
ECgene alternative splicing isoforms for
AGMAT

Expression for AGMAT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AGMAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AGMAT Gene

This gene is overexpressed in Kidney - Cortex (x24.3) and Liver (x12.3).

Protein differential expression in normal tissues from HIPED for AGMAT Gene

This gene is overexpressed in Kidney (49.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AGMAT Gene



NURSA nuclear receptor signaling pathways regulating expression of AGMAT Gene:

AGMAT

SOURCE GeneReport for Unigene cluster for AGMAT Gene:

Hs.461532

mRNA Expression by UniProt/SwissProt for AGMAT Gene:

Q9BSE5-SPEB_HUMAN
Tissue specificity: Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord.

Evidence on tissue expression from TISSUES for AGMAT Gene

  • Kidney(4.6)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with AGMAT: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AGMAT Gene

Orthologs for AGMAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AGMAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGMAT 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia AGMAT 34 35
  • 87.88 (n)
cow
(Bos Taurus)
Mammalia AGMAT 34 35
  • 87.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AGMAT 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agmat 34 16 35
  • 82.48 (n)
rat
(Rattus norvegicus)
Mammalia Agmat 34
  • 81.53 (n)
oppossum
(Monodelphis domestica)
Mammalia AGMAT 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGMAT 34 35
  • 73.77 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia agmat 34
  • 70.99 (n)
zebrafish
(Danio rerio)
Actinopterygii agmat 34 35
  • 65.51 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6064 34
worm
(Caenorhabditis elegans)
Secernentea T21F4.1 35
  • 13 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04235g 34
  • 44.98 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAR1 35
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G08900 34
  • 45.93 (n)
rice
(Oryza sativa)
Liliopsida Os04g0106300 34
  • 46.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 65 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01348 34
  • 47.96 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC11D3.09 34
  • 46.94 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.395 34
Species where no ortholog for AGMAT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGMAT Gene

ENSEMBL:
Gene Tree for AGMAT (if available)
TreeFam:
Gene Tree for AGMAT (if available)

Paralogs for AGMAT Gene

Paralogs for AGMAT Gene

genes like me logo Genes that share paralogs with AGMAT: view

Variants for AGMAT Gene

Sequence variations from dbSNP and Humsavar for AGMAT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000035063 -- 15,572,210(+) GGTTT(-/TTTTGTTTTG)TTTTG intron-variant, utr-variant-3-prime
rs1000486626 -- 15,584,340(+) GAGAC(-/A)AGAGT intron-variant
rs1000558085 -- 15,581,527(+) ACACA(C/T)GTGAC intron-variant
rs1001036171 -- 15,573,362(+) ATCTT(C/G)AAAGA utr-variant-3-prime
rs1001043178 -- 15,581,326(+) CCTGG(G/T)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGMAT Gene

Variant ID Type Subtype PubMed ID
esv3577747 CNV loss 25503493

Variation tolerance for AGMAT Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.38; 81.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AGMAT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AGMAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AGMAT Gene

Disorders for AGMAT Gene

Relevant External Links for AGMAT

Genetic Association Database (GAD)
AGMAT
Human Genome Epidemiology (HuGE) Navigator
AGMAT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AGMAT

No disorders were found for AGMAT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AGMAT Gene

Publications for AGMAT Gene

  1. Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus. (PMID: 11804860) Mistry S.K. … Morris S.M. Jr. (Am. J. Physiol. 2002) 2 3 4 22 64
  2. Cloning and characterization of human agmatinase. (PMID: 11914032) Iyer R.K. … Cederbaum S.D. (Mol. Genet. Metab. 2002) 2 3 4 22 64
  3. Human agmatinase is diminished in the clear cell type of renal cell carcinoma. (PMID: 14648699) Dallmann K. … Walther R. (Int. J. Cancer 2004) 2 3 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X. … Kong X. (PLoS ONE 2010) 3 46 64

Products for AGMAT Gene

Sources for AGMAT Gene

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