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Aliases for PPCS Gene

Aliases for PPCS Gene

  • Phosphopantothenoylcysteine Synthetase 2 3 4
  • PPC Synthetase 4
  • EC 6.3.2.5 4
  • COAB 4

External Ids for PPCS Gene

Summaries for PPCS Gene

Entrez Gene Summary for PPCS Gene

  • Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PPCS Gene

PPCS (Phosphopantothenoylcysteine Synthetase) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include phosphopantothenate--cysteine ligase activity.

UniProtKB/Swiss-Prot for PPCS Gene

  • Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4-phosphopantothenate to form 4-phosphopantothenoylcysteine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPCS Gene

Genomics for PPCS Gene

Genomic Location for PPCS Gene

Start:
42,456,117 bp from pter
End:
42,473,385 bp from pter
Size:
17,269 bases
Orientation:
Plus strand

Genomic View for PPCS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPCS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPCS Gene

Regulatory Elements for PPCS Gene

Proteins for PPCS Gene

  • Protein details for PPCS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAB8-PPCS_HUMAN
    Recommended name:
    Phosphopantothenate--cysteine ligase
    Protein Accession:
    Q9HAB8
    Secondary Accessions:
    • Q3KQT2
    • Q5VVM0

    Protein attributes for PPCS Gene

    Size:
    311 amino acids
    Molecular mass:
    34005 Da
    Quaternary structure:
    • Homodimer
    Miscellaneous:
    • The mammalian enzyme has a preference for ATP over CTP, in contrast to the E.coli ortholog
    SequenceCaution:
    • Sequence=BAB13931.1; Type=Frameshift; Positions=282; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPCS Gene

    Alternative splice isoforms for PPCS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPCS Gene

Proteomics data for PPCS Gene at MOPED

Post-translational modifications for PPCS Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys224

No data available for DME Specific Peptides for PPCS Gene

Domains for PPCS Gene

Protein Domains for PPCS Gene

UniProtKB/Swiss-Prot:

PPCS_HUMAN
Family:
  • Belongs to the PPC synthetase family.:
    • Q9HAB8
genes like me logo Genes that share domains with PPCS: view

No data available for Gene Families for PPCS Gene

Function for PPCS Gene

Molecular function for PPCS Gene

UniProtKB/Swiss-Prot CatalyticActivity: CTP + (R)-4-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4-phosphopantothenoyl)-L-cysteine
UniProtKB/Swiss-Prot Function: Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4-phosphopantothenate to form 4-phosphopantothenoylcysteine.

Enzyme Numbers (IUBMB) for PPCS Gene

Gene Ontology (GO) - Molecular Function for PPCS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004632 phosphopantothenate--cysteine ligase activity TAS --
genes like me logo Genes that share ontologies with PPCS: view

Phenotypes for PPCS Gene

GenomeRNAi human phenotypes for PPCS:
genes like me logo Genes that share phenotypes with PPCS: view

miRNA for PPCS Gene

miRTarBase miRNAs that target PPCS

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PPCS Gene

Localization for PPCS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPCS Gene COMPARTMENTS Subcellular localization image for PPCS gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PPCS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PPCS: view

Pathways for PPCS Gene

SuperPathways for PPCS Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Metabolism
3 Disease
4 Pantothenate and CoA biosynthesis
genes like me logo Genes that share pathways with PPCS: view

UniProtKB/Swiss-Prot Q9HAB8-PPCS_HUMAN

  • Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5

Interacting Proteins for PPCS Gene

Gene Ontology (GO) - Biological Process for PPCS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0009108 coenzyme biosynthetic process TAS --
GO:0015937 coenzyme A biosynthetic process IEA --
GO:0015939 pantothenate metabolic process TAS --
genes like me logo Genes that share ontologies with PPCS: view

Compounds for PPCS Gene

(9) HMDB Compounds for PPCS Gene

Compound Synonyms Cas Number PubMed IDs
4-Phosphopantothenoylcysteine
  • Pantothenoylcysteine 4'-phosphate
7196-09-0
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Cytidine monophosphate
  • 5'-CMP
63-37-6
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4

(1) Novoseek inferred chemical compound relationships for PPCS Gene

Compound -log(P) Hits PubMed IDs
cysteine 50.6 4
genes like me logo Genes that share compounds with PPCS: view

Transcripts for PPCS Gene

Unigene Clusters for PPCS Gene

Phosphopantothenoylcysteine synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPCS Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6:
SP7: - -

Relevant External Links for PPCS Gene

GeneLoc Exon Structure for
PPCS
ECgene alternative splicing isoforms for
PPCS

Expression for PPCS Gene

mRNA expression in normal human tissues for PPCS Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPCS Gene

SOURCE GeneReport for Unigene cluster for PPCS Gene Hs.706662

genes like me logo Genes that share expressions with PPCS: view

Orthologs for PPCS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPCS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPCS 36
  • 90.87 (n)
  • 89 (a)
PPCS 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPCS 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPCS 36
  • 88 (n)
  • 86.17 (a)
PPCS 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppcs 36
  • 85.53 (n)
  • 87.46 (a)
Ppcs 16
Ppcs 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPCS 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPCS 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppcs 36
  • 85.32 (n)
  • 88.1 (a)
chicken
(Gallus gallus)
Aves PPCS 36
  • 67.64 (n)
  • 68.5 (a)
PPCS 37
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15423 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ppcs 36
  • 63.88 (n)
  • 64.81 (a)
zebrafish
(Danio rerio)
Actinopterygii ppcs 36
  • 59.33 (n)
  • 58.67 (a)
ppcs 37
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004311 36
  • 50.82 (n)
  • 42.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ppcs 36
  • 50.12 (n)
  • 41.96 (a)
Ppcs 37
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.6 36
  • 49.8 (n)
  • 46.96 (a)
Y71H2AM.6 37
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR391W 36
  • 50.86 (n)
  • 45.02 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB2 36
  • 46.54 (n)
  • 43.02 (a)
CAB2 37
  • 30 (a)
OneToOne
CAB2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08757g 36
  • 48.13 (n)
  • 44.03 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02080 36
  • 50.34 (n)
  • 47.77 (a)
rice
(Oryza sativa)
Liliopsida Os08g0176100 36
  • 51.23 (n)
  • 46.67 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09090 36
  • 52.32 (n)
  • 48.52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC4B3.18 36
  • 47.65 (n)
  • 44.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for PPCS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPCS Gene

ENSEMBL:
Gene Tree for PPCS (if available)
TreeFam:
Gene Tree for PPCS (if available)

Paralogs for PPCS Gene

Pseudogenes.org Pseudogenes for PPCS Gene

genes like me logo Genes that share paralogs with PPCS: view

No data available for Paralogs for PPCS Gene

Variants for PPCS Gene

Sequence variations from dbSNP and Humsavar for PPCS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs915328 -- 42,470,496(+) ATTCA(A/G)ATACT intron-variant
rs915329 -- 42,470,736(+) TCTAT(A/G)AGTTG intron-variant
rs2050449 -- 42,471,323(+) TTATG(C/T)TGTTG intron-variant
rs2275116 -- 42,463,308(+) TCCGT(A/C)GGCAC intron-variant
rs2275117 -- 42,463,459(+) GCATT(A/C)CGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPCS Gene

Variant ID Type Subtype PubMed ID
nsv870704 CNV Gain 21882294

Relevant External Links for PPCS Gene

HapMap Linkage Disequilibrium report
PPCS

Disorders for PPCS Gene

No disorders were found for PPCS Gene.

No data available for UniProtKB/Swiss-Prot for PPCS Gene

Publications for PPCS Gene

  1. Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. (PMID: 12906824) Manoj N. … Ealick S.E. (Structure 2003) 3 4 23
  2. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. (PMID: 11923312) Daugherty M. … Osterman A. (J. Biol. Chem. 2002) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Kinetic characterization of human phosphopantothenoylcysteine synthetase. (PMID: 19683078) Yao J. … Dotson G.D. (Biochim. Biophys. Acta 2009) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PPCS Gene

Sources for PPCS Gene

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