Aliases for RIC3 Gene
External Ids for RIC3 Gene
Previous GeneCards Identifiers for RIC3 Gene
This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
GeneCards Summary for RIC3 Gene
RIC3 (RIC3 Acetylcholine Receptor Chaperone) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein binding involved in protein folding and acetylcholine receptor binding.
UniProtKB/Swiss-Prot for RIC3 Gene
Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.