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Aliases for FAM118B Gene

Aliases for FAM118B Gene

  • Family With Sequence Similarity 118 Member B 2 3 5
  • Family With Sequence Similarity 118, Member B 2

External Ids for FAM118B Gene

Previous GeneCards Identifiers for FAM118B Gene

  • GC11P125587
  • GC11P126081
  • GC11P122023

Summaries for FAM118B Gene

GeneCards Summary for FAM118B Gene

FAM118B (Family With Sequence Similarity 118 Member B) is a Protein Coding gene. An important paralog of this gene is FAM118A.

UniProtKB/Swiss-Prot for FAM118B Gene

  • May play a role in Cajal bodies formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM118B Gene

Genomics for FAM118B Gene

Regulatory Elements for FAM118B Gene

Enhancers for FAM118B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM118B on UCSC Golden Path with GeneCards custom track

Promoters for FAM118B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM118B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM118B Gene

126,211,414 bp from pter
126,262,986 bp from pter
51,573 bases
Plus strand

Genomic View for FAM118B Gene

Genes around FAM118B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM118B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM118B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM118B Gene

Proteins for FAM118B Gene

  • Protein details for FAM118B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM118B
    Protein Accession:
    Secondary Accessions:
    • Q9H7B0

    Protein attributes for FAM118B Gene

    351 amino acids
    Molecular mass:
    39499 Da
    Quaternary structure:
    No Data Available
    • Overexpression changes the morphology of Cajal bodies, while depletion disrupts the localization of components of Cajal bodies, reduces splicing capacity and inhibits cell proliferation.

neXtProt entry for FAM118B Gene

Proteomics data for FAM118B Gene at MOPED

Post-translational modifications for FAM118B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM118B Gene

No data available for DME Specific Peptides for FAM118B Gene

Domains & Families for FAM118B Gene

Protein Domains for FAM118B Gene


Suggested Antigen Peptide Sequences for FAM118B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM118 family.
  • Belongs to the FAM118 family.
genes like me logo Genes that share domains with FAM118B: view

No data available for Gene Families for FAM118B Gene

Function for FAM118B Gene

Molecular function for FAM118B Gene

UniProtKB/Swiss-Prot Function:
May play a role in Cajal bodies formation.
genes like me logo Genes that share phenotypes with FAM118B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM118B Gene

Localization for FAM118B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM118B Gene

Nucleus, Cajal body.

Subcellular locations from

Jensen Localization Image for FAM118B Gene COMPARTMENTS Subcellular localization image for FAM118B gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for FAM118B Gene

Pathways & Interactions for FAM118B Gene

SuperPathways for FAM118B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM118B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM118B Gene

Drugs & Compounds for FAM118B Gene

No Compound Related Data Available

Transcripts for FAM118B Gene

Unigene Clusters for FAM118B Gene

Family with sequence similarity 118, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM118B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c
SP1: - - -
SP2: -
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - -
SP7: -
SP9: -
SP10: - - - -

Relevant External Links for FAM118B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM118B Gene

mRNA expression in normal human tissues for FAM118B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM118B Gene

This gene is overexpressed in Bone (26.8) and Fetal ovary (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM118B Gene

SOURCE GeneReport for Unigene cluster for FAM118B Gene Hs.276315

genes like me logo Genes that share expression patterns with FAM118B: view

Protein tissue co-expression partners for FAM118B Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM118B Gene

Orthologs for FAM118B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM118B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM118B 35
  • 91.07 (n)
  • 97.15 (a)
-- 36
  • 97 (a)
FAM118B 36
  • 99 (a)
(Canis familiaris)
Mammalia FAM118B 35
  • 92.69 (n)
  • 97.15 (a)
FAM118B 36
  • 97 (a)
(Mus musculus)
Mammalia Fam118b 35
  • 91.64 (n)
  • 98.01 (a)
Fam118b 16
Fam118b 36
  • 98 (a)
(Pan troglodytes)
Mammalia FAM118B 35
  • 99.81 (n)
  • 100 (a)
FAM118B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam118b 35
  • 91.71 (n)
  • 98.57 (a)
(Monodelphis domestica)
Mammalia FAM118B 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia FAM118B 36
  • 93 (a)
(Gallus gallus)
Aves FAM118B 35
  • 80.29 (n)
  • 91.59 (a)
FAM118B 36
  • 91 (a)
(Anolis carolinensis)
Reptilia FAM118B 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam118b 35
  • 75.29 (n)
  • 90.42 (a)
Str.19476 35
(Danio rerio)
Actinopterygii LOC799102 35
  • 70.98 (n)
  • 80.72 (a)
fam118b 36
  • 73 (a)
Species with no ortholog for FAM118B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM118B Gene

Gene Tree for FAM118B (if available)
Gene Tree for FAM118B (if available)

Paralogs for FAM118B Gene

Paralogs for FAM118B Gene

(1) SIMAP similar genes for FAM118B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM118B: view

Variants for FAM118B Gene

Sequence variations from dbSNP and Humsavar for FAM118B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs519586 -- 126,225,320(-) TAAGA(C/T)TGGAA intron-variant
rs527720 -- 126,228,063(+) CCAAA(A/G)TGCTG intron-variant
rs530925 -- 126,250,165(-) gcagt(G/T)agccg intron-variant
rs530952 -- 126,250,161(-) tgagc(C/T)gagat intron-variant
rs533058 -- 126,215,553(+) TTAGC(C/T)GGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM118B Gene

Variant ID Type Subtype PubMed ID
nsv537 CNV Insertion 18451855
esv2447763 CNV Deletion 19546169

Variation tolerance for FAM118B Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM118B Gene

Disorders for FAM118B Gene

Relevant External Links for FAM118B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM118B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM118B Gene

Publications for FAM118B Gene

  1. Fam118B, a novel component in Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. (PMID: 24569877) Li Y. … Chen J. (J. Cell. Sci. 2014) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for FAM118B Gene

Sources for FAM118B Gene