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Aliases for FAM118B Gene

Aliases for FAM118B Gene

  • Family With Sequence Similarity 118, Member B 2 3

External Ids for FAM118B Gene

Previous GeneCards Identifiers for FAM118B Gene

  • GC11P125587
  • GC11P126081
  • GC11P122023

Summaries for FAM118B Gene

GeneCards Summary for FAM118B Gene

FAM118B (Family With Sequence Similarity 118, Member B) is a Protein Coding gene. An important paralog of this gene is FAM118A.

UniProtKB/Swiss-Prot for FAM118B Gene

  • May play a role in Cajal bodies formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM118B Gene

Genomics for FAM118B Gene

Regulatory Elements for FAM118B Gene

Genomic Location for FAM118B Gene

Start:
126,211,414 bp from pter
End:
126,262,986 bp from pter
Size:
51,573 bases
Orientation:
Plus strand

Genomic View for FAM118B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM118B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM118B Gene

Proteins for FAM118B Gene

  • Protein details for FAM118B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPY3-F118B_HUMAN
    Recommended name:
    Protein FAM118B
    Protein Accession:
    Q9BPY3
    Secondary Accessions:
    • Q9H7B0

    Protein attributes for FAM118B Gene

    Size:
    351 amino acids
    Molecular mass:
    39499 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Overexpression changes the morphology of Cajal bodies, while depletion disrupts the localization of components of Cajal bodies, reduces splicing capacity and inhibits cell proliferation.

neXtProt entry for FAM118B Gene

Proteomics data for FAM118B Gene at MOPED

Post-translational modifications for FAM118B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM118B Gene

No data available for DME Specific Peptides for FAM118B Gene

Domains for FAM118B Gene

Protein Domains for FAM118B Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM118B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPY3

UniProtKB/Swiss-Prot:

F118B_HUMAN :
  • Q9BPY3
Family:
  • Belongs to the FAM118 family.
genes like me logo Genes that share domains with FAM118B: view

No data available for Gene Families for FAM118B Gene

Function for FAM118B Gene

Molecular function for FAM118B Gene

UniProtKB/Swiss-Prot Function: May play a role in Cajal bodies formation.

Gene Ontology (GO) - Molecular Function for FAM118B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM118B: view

Phenotypes for FAM118B Gene

GenomeRNAi human phenotypes for FAM118B:
genes like me logo Genes that share phenotypes with FAM118B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM118B Gene

Localization for FAM118B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM118B Gene

Nucleus, Cajal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM118B Gene COMPARTMENTS Subcellular localization image for FAM118B gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM118B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015030 Cajal body IEA --
genes like me logo Genes that share ontologies with FAM118B: view

Pathways for FAM118B Gene

SuperPathways for FAM118B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM118B Gene

None

No data available for Pathways by source for FAM118B Gene

Transcripts for FAM118B Gene

Unigene Clusters for FAM118B Gene

Family with sequence similarity 118, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM118B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c
SP1: - - -
SP2: -
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - -
SP7: -
SP8:
SP9: -
SP10: - - - -

Relevant External Links for FAM118B Gene

GeneLoc Exon Structure for
FAM118B
ECgene alternative splicing isoforms for
FAM118B

Expression for FAM118B Gene

mRNA expression in normal human tissues for FAM118B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM118B Gene

SOURCE GeneReport for Unigene cluster for FAM118B Gene Hs.276315

genes like me logo Genes that share expressions with FAM118B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM118B Gene

Orthologs for FAM118B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM118B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM118B 35
  • 99.81 (n)
  • 100 (a)
FAM118B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 97 (a)
OneToMany
FAM118B 35
  • 91.07 (n)
  • 97.15 (a)
FAM118B 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FAM118B 35
  • 92.69 (n)
  • 97.15 (a)
FAM118B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam118b 35
  • 91.64 (n)
  • 98.01 (a)
Fam118b 16
Fam118b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM118B 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM118B 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam118b 35
  • 91.71 (n)
  • 98.57 (a)
chicken
(Gallus gallus)
Aves FAM118B 35
  • 80.29 (n)
  • 91.59 (a)
FAM118B 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM118B 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam118b 35
  • 75.29 (n)
  • 90.42 (a)
Str.19476 35
zebrafish
(Danio rerio)
Actinopterygii fam118b 36
  • 73 (a)
OneToOne
LOC799102 35
  • 70.98 (n)
  • 80.72 (a)
Species with no ortholog for FAM118B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM118B Gene

ENSEMBL:
Gene Tree for FAM118B (if available)
TreeFam:
Gene Tree for FAM118B (if available)

Paralogs for FAM118B Gene

Paralogs for FAM118B Gene

Selected SIMAP similar genes for FAM118B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM118B: view

Variants for FAM118B Gene

Sequence variations from dbSNP and Humsavar for FAM118B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs487148 -- 126,228,047(+) TACCT(G/T)CCTGA intron-variant
rs507073 -- 126,260,333(-) TCCCA(A/G)ggcca intron-variant
rs507113 -- 126,222,669(-) TGTAG(G/T)ATTTT intron-variant
rs512577 -- 126,222,046(-) AAAAC(A/G)AACAA intron-variant
rs519586 -- 126,225,320(-) TAAGA(C/T)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM118B Gene

Variant ID Type Subtype PubMed ID
nsv537 CNV Insertion 18451855
esv2447763 CNV Deletion 19546169

Relevant External Links for FAM118B Gene

HapMap Linkage Disequilibrium report
FAM118B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM118B Gene

Disorders for FAM118B Gene

No disorders were found for FAM118B Gene.

No data available for UniProtKB/Swiss-Prot for FAM118B Gene

Publications for FAM118B Gene

  1. Fam118B, a novel component in Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. (PMID: 24569877) Li Y. … Chen J. (J. Cell. Sci. 2014) 2 3 4
  2. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for FAM118B Gene

Sources for FAM118B Gene

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