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Aliases for FAM118B Gene

Aliases for FAM118B Gene

  • Family With Sequence Similarity 118 Member B 2 3 5
  • Family With Sequence Similarity 118, Member B 2

External Ids for FAM118B Gene

Previous GeneCards Identifiers for FAM118B Gene

  • GC11P125587
  • GC11P126081
  • GC11P122023

Summaries for FAM118B Gene

GeneCards Summary for FAM118B Gene

FAM118B (Family With Sequence Similarity 118 Member B) is a Protein Coding gene. An important paralog of this gene is FAM118A.

UniProtKB/Swiss-Prot for FAM118B Gene

  • May play a role in Cajal bodies formation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM118B Gene

Genomics for FAM118B Gene

Regulatory Elements for FAM118B Gene

Enhancers for FAM118B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G126280 1.1 ENCODE 42.3 +71.0 71033 4.2 HDGF PKNOX1 FOXA2 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 FEZF1 FOXRED1 FAM118B DCPS HP11014 ENSG00000254694 RPUSD4 RNU4-86P TIRAP ENSG00000254905
GH11G126188 1.2 ENCODE dbSUPER 35.3 -22.2 -22192 2.1 PKNOX1 MLX ARID4B ZNF48 SP5 NFYC JUNB PPARG TBX21 KAT8 FAM118B FOXRED1 RPUSD4 ENSG00000254833 ENSG00000254790 RNU4-86P DCPS ENSG00000254771 ENSG00000254694
GH11G126310 1.6 FANTOM5 Ensembl ENCODE dbSUPER 25.5 +100.4 100363 3.0 PKNOX1 RB1 BMI1 RAD21 ZBTB40 ZNF143 ZNF207 RELB IKZF2 CREM FOXRED1 FAM118B DCPS TIRAP SRPRA HP11014 PIR55528
GH11G126266 1.1 ENCODE 32.4 +57.1 57124 3.3 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 ZNF207 FOS SP3 FOXRED1 FAM118B RN7SL351P
GH11G126302 1.1 ENCODE 27.2 +92.6 92620 2.4 HNRNPUL1 PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 FAM118B DCPS HP11014
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM118B on UCSC Golden Path with GeneCards custom track

Promoters for FAM118B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000046612 286 1801 PKNOX1 FOXA2 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for FAM118B Gene

Chromosome:
11
Start:
126,211,414 bp from pter
End:
126,262,986 bp from pter
Size:
51,573 bases
Orientation:
Plus strand

Genomic View for FAM118B Gene

Genes around FAM118B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM118B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM118B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM118B Gene

Proteins for FAM118B Gene

  • Protein details for FAM118B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPY3-F118B_HUMAN
    Recommended name:
    Protein FAM118B
    Protein Accession:
    Q9BPY3
    Secondary Accessions:
    • Q9H7B0

    Protein attributes for FAM118B Gene

    Size:
    351 amino acids
    Molecular mass:
    39499 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Overexpression changes the morphology of Cajal bodies, while depletion disrupts the localization of components of Cajal bodies, reduces splicing capacity and inhibits cell proliferation.

neXtProt entry for FAM118B Gene

Post-translational modifications for FAM118B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM118B Gene

Domains & Families for FAM118B Gene

Protein Domains for FAM118B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM118B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPY3

UniProtKB/Swiss-Prot:

F118B_HUMAN :
  • Belongs to the FAM118 family.
Family:
  • Belongs to the FAM118 family.
genes like me logo Genes that share domains with FAM118B: view

No data available for Gene Families for FAM118B Gene

Function for FAM118B Gene

Molecular function for FAM118B Gene

UniProtKB/Swiss-Prot Function:
May play a role in Cajal bodies formation.

Gene Ontology (GO) - Molecular Function for FAM118B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM118B: view
genes like me logo Genes that share phenotypes with FAM118B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM118B Gene

Localization for FAM118B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM118B Gene

Nucleus, Cajal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM118B gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM118B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0015030 Cajal body IEA --
genes like me logo Genes that share ontologies with FAM118B: view

Pathways & Interactions for FAM118B Gene

SuperPathways for FAM118B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM118B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030576 Cajal body organization IEA --
genes like me logo Genes that share ontologies with FAM118B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM118B Gene

Transcripts for FAM118B Gene

Unigene Clusters for FAM118B Gene

Family with sequence similarity 118, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM118B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c
SP1: - - -
SP2: -
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - -
SP7: -
SP8:
SP9: -
SP10: - - - -

Relevant External Links for FAM118B Gene

GeneLoc Exon Structure for
FAM118B
ECgene alternative splicing isoforms for
FAM118B

Expression for FAM118B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM118B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM118B Gene

This gene is overexpressed in Bone (26.8) and Fetal ovary (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM118B Gene



Protein tissue co-expression partners for FAM118B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM118B Gene:

FAM118B

SOURCE GeneReport for Unigene cluster for FAM118B Gene:

Hs.276315

Evidence on tissue expression from TISSUES for FAM118B Gene

  • Lung(4.2)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with FAM118B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM118B Gene

Orthologs for FAM118B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM118B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM118B 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 97 (a)
OneToMany
FAM118B 34 35
  • 91.07 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM118B 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM118B 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM118B 34 35
  • 92.69 (n)
rat
(Rattus norvegicus)
Mammalia Fam118b 34
  • 91.71 (n)
mouse
(Mus musculus)
Mammalia Fam118b 34 16 35
  • 91.64 (n)
chicken
(Gallus gallus)
Aves FAM118B 34 35
  • 80.29 (n)
lizard
(Anolis carolinensis)
Reptilia FAM118B 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam118b 34
  • 75.29 (n)
Str.19476 34
zebrafish
(Danio rerio)
Actinopterygii fam118b 35
  • 73 (a)
OneToOne
LOC799102 34
  • 70.98 (n)
Species where no ortholog for FAM118B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM118B Gene

ENSEMBL:
Gene Tree for FAM118B (if available)
TreeFam:
Gene Tree for FAM118B (if available)

Paralogs for FAM118B Gene

Paralogs for FAM118B Gene

(1) SIMAP similar genes for FAM118B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM118B: view

Variants for FAM118B Gene

Sequence variations from dbSNP and Humsavar for FAM118B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000001988 -- 126,211,625(+) TCCAC(C/T)TGGGC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000037247 -- 126,231,419(+) TTTTT(C/T)CCTGA intron-variant
rs1000108868 -- 126,257,842(+) TACCT(A/C)CACAT intron-variant
rs1000176021 -- 126,239,425(+) TATGT(A/G)TGTGT intron-variant
rs1000207768 -- 126,246,573(+) TAACC(C/G)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM118B Gene

Variant ID Type Subtype PubMed ID
dgv715e59 CNV duplication 20981092
esv2447763 CNV deletion 19546169
esv3628000 CNV loss 21293372
nsv477761 CNV novel sequence insertion 20440878
nsv537 CNV insertion 18451855
nsv556529 CNV loss 21841781

Variation tolerance for FAM118B Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM118B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM118B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM118B Gene

Disorders for FAM118B Gene

Relevant External Links for FAM118B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM118B

No disorders were found for FAM118B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM118B Gene

Publications for FAM118B Gene

  1. Fam118B, a novel component in Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. (PMID: 24569877) Li Y. … Chen J. (J. Cell. Sci. 2014) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64

Products for FAM118B Gene

Sources for FAM118B Gene

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