Free for academic non-profit institutions. Other users need a Commercial license

CALCA Gene(Protein Coding)

Calcitonin Related Polypeptide Alpha

GCID:
GC11M014945
GIFtS:
51
Genes Participants
UDN Logo

Aliases for CALCA Gene

Aliases for CALCA Gene

  • Calcitonin Related Polypeptide Alpha 2 3 5
  • Calcitonin Gene-Related Peptide I 3 4
  • Alpha-Type CGRP 3 4
  • Calcitonin 1 2 3
  • Calcitonin 2 3
  • CGRP-I 3 4
  • CALC1 3 4
  • Calcitonin/Calcitonin-Related Polypeptide, Alpha 3
  • Calcitonin Gene-Related Peptide 1 3
  • Katacalcin 3
  • CGRP1 3
  • CGRP 3
  • PCT 3
  • CT 3
  • KC 3

External Ids for CALCA Gene

Previous HGNC Symbols for CALCA Gene

  • CALC1

Previous GeneCards Identifiers for CALCA Gene

  • GC11M016170
  • GC11M015736
  • GC11M015027
  • GC11M014952
  • GC11M014671

Summaries for CALCA Gene

Entrez Gene Summary for CALCA Gene

  • This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

GeneCards Summary for CALCA Gene

CALCA (Calcitonin Related Polypeptide Alpha) is a Protein Coding gene. Diseases associated with CALCA include Reflex Sympathetic Dystrophy and Complex Regional Pain Syndrome. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein complex binding. An important paralog of this gene is CALCB.

UniProtKB/Swiss-Prot for CALCA Gene

  • CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.

  • Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

  • Katacalcin is a potent plasma calcium-lowering peptide.

Tocris Summary for CALCA Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCA Gene

Additional gene information for CALCA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCA Gene

Genomics for CALCA Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CALCA Gene

Promoters and enhancers for CALCA Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11I014972 Promoter 0.7 EPDnew 550.8 0.0 -17 0.1 ATF4 CEBPG EZH2 CALCA OR7E41P CALCB
GH11I015074 Enhancer 1.1 Ensembl ENCODE 11.1 -102.5 -102463 1.2 SIN3A ZNF2 ZNF48 GLIS2 ZNF143 REST TSHZ1 ZNF610 GLIS1 SP7 COPB1 CYP2R1 CALCA INSC GC11P015078 GC11P015027 CALCB
GH11I015075 Promoter 1 EPDnew 11.1 -101.2 -101220 0.1 ZBTB21 ZNF449 ZNF140 MZF1 CEBPG ZNF335 GLIS2 POLR2A ZNF391 ZBTB20 CALCB CALCA INSC GC11P015078 GC11P015027
GH11I015073 Enhancer 0.7 Ensembl 11.1 -101.5 -101547 0.2 MAZ ZNF449 ZBTB11 ZNF140 MZF1 ZEB2 ZNF335 ZFHX2 KLF16 ZNF692 CALCA INSC GC11P015078 GC11P015027 CALCB
GH11I014976 Enhancer 0.6 ENCODE 0.8 -2.6 -2576 0.2 MEIS2 CTCF PKNOX1 SUZ12 RAD21 ZNF335 SP1 ZNF143 PRDM4 EZH2 CALCA OR7E41P CALCB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CALCA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALCA gene promoter:

Genomic Locations for CALCA Gene

Genomic Locations for CALCA Gene
chr11:14,966,668-14,972,354
(GRCh38/hg38)
Size:
5,687 bases
Orientation:
Minus strand
chr11:14,988,214-14,993,900
(GRCh37/hg19)

Genomic View for CALCA Gene

Genes around CALCA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CALCA Gene

Proteins for CALCA Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01258-CALC_HUMAN
    Recommended name:
    Calcitonin
    Protein Accession:
    P01258
    Secondary Accessions:
    • B7ZL39
    • Q13935
    • Q13937
    • Q52LX7

    Protein attributes for CALCA Gene

    Size:
    141 amino acids
    Molecular mass:
    15466 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:

  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06881-CALCA_HUMAN
    Recommended name:
    Calcitonin gene-related peptide 1
    Protein Accession:
    P06881
    Secondary Accessions:
    • Q93048
    • Q9UCP0

    Protein attributes for CALCA Gene

    Size:
    128 amino acids
    Molecular mass:
    13898 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALCA Gene

Post-translational modifications for CALCA Gene

Other Protein References for CALCA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CALCA (Procalcitonin)
  • Cell Signaling Technology (CST) Antibodies for CALCA (CALCA iso3)

No data available for DME Specific Peptides for CALCA Gene

Domains & Families for CALCA Gene

Gene Families for CALCA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for CALCA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CALCA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06881

UniProtKB/Swiss-Prot:

CALCA_HUMAN :
  • Belongs to the calcitonin family.
Family:
  • Belongs to the calcitonin family.
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with CALCA: view

Function for CALCA Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CALCA Gene

GENATLAS Biochemistry:
calcitonin,3.4kDa and calcitonin related peptide,alpha,3.8kDa,formed by alternative splicing of the same gene,expressed in thyroid C cells,involved in calcium homeostasis,mediating the effects of Indian Hedgehog and PTH related peptide on chondrocyte differentiation,also expressed in parts of the nervous and endocrine system,potent vasodilatator and hypotensor
UniProtKB/Swiss-Prot Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
UniProtKB/Swiss-Prot Function:
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
UniProtKB/Swiss-Prot Function:
Katacalcin is a potent plasma calcium-lowering peptide.

Gene Ontology (GO) - Molecular Function for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA --
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 17689535
GO:0031716 calcitonin receptor binding IPI 8078488
GO:0032403 protein complex binding IDA --
genes like me logo Genes that share ontologies with CALCA: view

Phenotypes for CALCA Gene

GenomeRNAi human phenotypes for CALCA:
genes like me logo Genes that share phenotypes with CALCA: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CALCA Gene

Localization for CALCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALCA gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18057382
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA --
genes like me logo Genes that share ontologies with CALCA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALCA Gene

Pathways & Interactions for CALCA Gene

genes like me logo Genes that share pathways with CALCA: view

Pathways by source for CALCA Gene

1 Cell Signaling Technology pathway for CALCA Gene
1 GeneGo (Thomson Reuters) pathway for CALCA Gene

Gene Ontology (GO) - Biological Process for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001944 vasculature development IDA --
GO:0001984 artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0002027 regulation of heart rate IEA --
GO:0002031 G-protein coupled receptor internalization IDA --
GO:0002548 monocyte chemotaxis IDA 15248232
genes like me logo Genes that share ontologies with CALCA: view

No data available for SIGNOR curated interactions for CALCA Gene

Drugs & Compounds for CALCA Gene

Products:

  1. Drug

(89) Drugs for CALCA Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
cyclic amp Experimental Pharma 0
Olcegepant Investigational Pharma Target Non-peptide receptor of CGRP,first potent and selective 0
Telcagepant Investigational Pharma Target CGRP receptor antagonist 0
MK-3207 Investigational Pharma CGRP receptor antagonist 0

(48) Additional Compounds for CALCA Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3

(5) Tocris Compounds for CALCA Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6

(6) ApexBio Compounds for CALCA Gene

Compound Action Cas Number
BMS-927711 CGRP receptor antagonist 1289023-67-1
CGRP (rat) 83651-90-5
CGRP 8-37 (rat) 129121-73-9
MK-0974 CGRP receptor antagonist 781649-09-0
MK-3207 CGRP receptor antagonist 957118-49-9
Olcegepant Non-peptide receptor of CGRP,first potent and selective 204697-65-4
genes like me logo Genes that share compounds with CALCA: view

Drug Products

Transcripts for CALCA Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CALCA Gene

(5) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALCA Gene

Calcitonin-related polypeptide alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for CALCA Gene

GeneLoc Exon Structure for
CALCA
ECgene alternative splicing isoforms for
CALCA

Expression for CALCA Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALCA Gene

mRNA expression in normal human tissues for CALCA Gene
mRNA expression by BioGPS for CALCA GenemRNA expression by GTEx for CALCA Gene

mRNA differential expression in normal tissues according to GTEx for CALCA Gene

This gene is overexpressed in Thyroid (x23.1) and Liver (x15.7).

NURSA nuclear receptor signaling pathways regulating expression of CALCA Gene:

CALCA

SOURCE GeneReport for Unigene cluster for CALCA Gene:

Hs.37058

Evidence on tissue expression from TISSUES for CALCA Gene

  • Thyroid gland(4.2)
  • Bone(3.2)
  • Nervous system(3)
  • Kidney(2.9)
  • Blood(2.8)
  • Lung(2.3)
  • Lymph node(2.3)
  • Urine(2.2)
  • Intestine(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with CALCA: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCA Gene

Orthologs for CALCA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CALCA 34
  • 93 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia CALCA 33
  • 75.15 (n)
CT 34
  • 61 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CRSP-3 33 34
  • 75.07 (n)
CRSP-2 34
  • 72 (a)
 OneToMany
CRSP1 34
  • 43 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Calca 34
  • 75 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 45 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 42 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves CALCA 34
  • 48 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 44 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii calca 34
  • 45 (a)
 OneToMany
Species where no ortholog for CALCA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALCA Gene

ENSEMBL:
Gene Tree for CALCA (if available)
TreeFam:
Gene Tree for CALCA (if available)

Paralogs for CALCA Gene

Paralogs for CALCA Gene

(2) SIMAP similar genes for CALCA Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CALCA Gene

genes like me logo Genes that share paralogs with CALCA: view

Variants for CALCA Gene

Sequence variations from dbSNP and Humsavar for CALCA Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000133139 -- 14,970,798(-) G/T intron_variant
rs1001671419 -- 14,969,783(-) G/A intron_variant
rs1001807163 -- 14,969,381(-) C/T intron_variant
rs1002001767 -- 14,968,240(-) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1002137688 -- 14,967,942(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CALCA Gene

Variant ID Type Subtype PubMed ID
esv3578250 CNV gain 25503493
nsv832071 CNV loss 17160897

Variation tolerance for CALCA Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALCA Gene

Human Gene Mutation Database (HGMD)
CALCA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALCA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCA Gene

Disorders for CALCA Gene

MalaCards: The human disease database

(123) MalaCards diseases for CALCA Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
reflex sympathetic dystrophy
  • complex regional pain syndrome
complex regional pain syndrome
  • reflex sympathetic dystrophy
spinal stenosis
  • cervical spinal stenosis
thyroid carcinoma, familial medullary
  • mtc
giant cell reparative granuloma
  • central giant cell granuloma
- elite association - COSMIC cancer census association via MalaCards
Search CALCA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CALCA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CALCA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCA Gene

Publications for CALCA Gene

  1. The complete sequence of human preprocalcitonin. (PMID: 6546550) Le Moullec JM … Moukhtar MS (FEBS letters 1984) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. BDNF and CGRP interaction: implications in migraine susceptibility. (PMID: 20959432) Lemos C … Sousa A (Cephalalgia : an international journal of headache 2010) 3 44 58
  4. Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture. (PMID: 20173430) Herlyn P … Gradl G (The Clinical journal of pain 2010) 3 44 58
  5. Association of the calcitonin gene (CA) polymorphism with osteoarthritis of the knee in a Mexican mestizo population. (PMID: 19736013) Magaña JJ … Miranda-Duarte A (The Knee 2010) 3 44 58

Products for CALCA Gene

Sources for CALCA Gene

Content
Loading form....