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CALCA Gene(Protein Coding)

Calcitonin Related Polypeptide Alpha

GCID:
GC11M014945
GIFtS:
66
Genes Participants
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Aliases for CALCA Gene

Aliases for CALCA Gene

  • Calcitonin Related Polypeptide Alpha 2 3 5
  • Calcitonin Gene-Related Peptide I 3 4
  • Alpha-Type CGRP 3 4
  • Calcitonin 1 2 3
  • Calcitonin 2 3
  • CGRP-I 3 4
  • CALC1 3 4
  • Calcitonin/Calcitonin-Related Polypeptide, Alpha 3
  • Calcitonin Gene-Related Peptide 1 3
  • Katacalcin 3
  • CGRP1 3
  • CGRP 3
  • PCT 3
  • CT 3
  • KC 3

External Ids for CALCA Gene

Previous HGNC Symbols for CALCA Gene

  • CALC1

Previous GeneCards Identifiers for CALCA Gene

  • GC11M016170
  • GC11M015736
  • GC11M015027
  • GC11M014952
  • GC11M014671

Summaries for CALCA Gene

Entrez Gene Summary for CALCA Gene

  • This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

GeneCards Summary for CALCA Gene

CALCA (Calcitonin Related Polypeptide Alpha) is a Protein Coding gene. Diseases associated with CALCA include Reflex Sympathetic Dystrophy and Complex Regional Pain Syndrome. Among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Endothelin Pathways. GO annotations related to this gene include identical protein binding and protein complex binding. An important paralog of this gene is CALCB.

UniProtKB/Swiss-Prot for CALCA Gene

  • CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.

  • Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

  • Katacalcin is a potent plasma calcium-lowering peptide.

Tocris Summary for CALCA Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCA Gene

Genomics for CALCA Gene

Products:

  1. Regulatory Element

Regulatory Elements for CALCA Gene

Enhancers for CALCA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G015074 1.2 Ensembl ENCODE 11.1 -102.5 -102464 1.2 ZNF2 ZNF48 RAD21 GLIS2 ZNF366 SCRT2 ZNF143 ZNF654 OVOL3 TSHZ1 COPB1 CYP2R1 CALCA INSC GC11P015078 GC11P015027
GH11G015073 0.7 Ensembl 11.1 -101.5 -101547 0.2 MAZ RNF2 ZNF140 ZEB2 ZFHX2 KLF16 ZNF692 ZNF391 PRDM4 ZBTB20 CALCA INSC GC11P015078 GC11P015027
GH11G014976 0.7 ENCODE 0.7 -2.6 -2576 0.2 CTCF PKNOX1 RNF2 SUZ12 CBX2 RAD21 PBX2 SMC3 ZNF143 PRDM4 CALCA OR7E41P
GH11G014974 0.6 ENCODE 0.7 -2.3 -2336 0.1 CTCF PKNOX1 SUZ12 PBX2 RAD21 EZH2 CALCA OR7E41P
GH11G014975 0.5 ENCODE 0.7 -2.1 -2116 0.1 RNF2 SUZ12 EZH2 CALCA OR7E41P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CALCA on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CALCA gene promoter:

Genomic Location for CALCA Gene

Chromosome:
11
Start:
14,966,668 bp from pter
End:
14,972,354 bp from pter
Size:
5,687 bases
Orientation:
Minus strand

Genomic View for CALCA Gene

Genes around CALCA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CALCA Gene

Proteins for CALCA Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01258-CALC_HUMAN
    Recommended name:
    Calcitonin
    Protein Accession:
    P01258
    Secondary Accessions:
    • B7ZL39
    • Q13935
    • Q13937
    • Q52LX7

    Protein attributes for CALCA Gene

    Size:
    141 amino acids
    Molecular mass:
    15466 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:

  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06881-CALCA_HUMAN
    Recommended name:
    Calcitonin gene-related peptide 1
    Protein Accession:
    P06881
    Secondary Accessions:
    • Q93048
    • Q9UCP0

    Protein attributes for CALCA Gene

    Size:
    128 amino acids
    Molecular mass:
    13898 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALCA Gene

Post-translational modifications for CALCA Gene

  • Glycosylation at posLast=105105
  • Modification sites at PhosphoSitePlus

Other Protein References for CALCA Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

No data available for DME Specific Peptides for CALCA Gene

Domains & Families for CALCA Gene

Gene Families for CALCA Gene

HGNC:

Protein Domains for CALCA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CALCA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06881

UniProtKB/Swiss-Prot:

CALCA_HUMAN :
  • Belongs to the calcitonin family.
Family:
  • Belongs to the calcitonin family.
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with CALCA: view

Function for CALCA Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CALCA Gene

GENATLAS Biochemistry:
calcitonin,3.4kDa and calcitonin related peptide,alpha,3.8kDa,formed by alternative splicing of the same gene,expressed in thyroid C cells,involved in calcium homeostasis,mediating the effects of Indian Hedgehog and PTH related peptide on chondrocyte differentiation,also expressed in parts of the nervous and endocrine system,potent vasodilatator and hypotensor
UniProtKB/Swiss-Prot Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
UniProtKB/Swiss-Prot Function:
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
UniProtKB/Swiss-Prot Function:
Katacalcin is a potent plasma calcium-lowering peptide.

Gene Ontology (GO) - Molecular Function for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA --
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 17689535
GO:0031716 calcitonin receptor binding IPI 8078488
GO:0032403 protein complex binding IDA --
genes like me logo Genes that share ontologies with CALCA: view

Phenotypes for CALCA Gene

GenomeRNAi human phenotypes for CALCA:
genes like me logo Genes that share phenotypes with CALCA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CALCA

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CALCA Gene

Localization for CALCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALCA gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18057382
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA --
genes like me logo Genes that share ontologies with CALCA: view

Pathways & Interactions for CALCA Gene

genes like me logo Genes that share pathways with CALCA: view

Pathways by source for CALCA Gene

1 Cell Signaling Technology pathway for CALCA Gene
1 GeneGo (Thomson Reuters) pathway for CALCA Gene

Gene Ontology (GO) - Biological Process for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001944 vasculature development IDA --
GO:0001984 vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0002027 regulation of heart rate IEA --
GO:0002031 G-protein coupled receptor internalization IDA --
GO:0002548 monocyte chemotaxis IDA 15248232
genes like me logo Genes that share ontologies with CALCA: view

No data available for SIGNOR curated interactions for CALCA Gene

Drugs & Compounds for CALCA Gene

Products:

  1. Drug

(87) Drugs for CALCA Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
MK-0974 Investigational Pharma Target CGRP receptor antagonist 0
Olcegepant Investigational Pharma Target Non-peptide receptor of CGRP,first potent and selective 0
CGRP (rat) Pharma Potent vasodilator 0
CGRP 8-37 (rat) Pharma CGRP1 receptor antagonist 0

(50) Additional Compounds for CALCA Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
BIBN 4096
204697-65-4

(5) Tocris Compounds for CALCA Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist 151804-77-2
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
BIBN 4096 Potent and selective CGRP receptor antagonist 204697-65-4
CGRP (rat) Potent vasodilator 83651-90-5
CGRP 8-37 (rat) CGRP1 receptor antagonist 129121-73-9

(6) ApexBio Compounds for CALCA Gene

Compound Action Cas Number
BMS-927711 CGRP receptor antagonist 1289023-67-1
CGRP (rat) 83651-90-5
CGRP 8-37 (rat) 129121-73-9
MK-0974 CGRP receptor antagonist 781649-09-0
MK-3207 CGRP receptor antagonist 957118-49-9
Olcegepant Non-peptide receptor of CGRP,first potent and selective 204697-65-4
genes like me logo Genes that share compounds with CALCA: view

Drug Products

Transcripts for CALCA Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CALCA Gene

(5) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALCA Gene

Calcitonin-related polypeptide alpha:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for CALCA Gene

GeneLoc Exon Structure for
CALCA
ECgene alternative splicing isoforms for
CALCA

Expression for CALCA Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALCA Gene

mRNA expression in normal human tissues for CALCA Gene
mRNA expression by BioGPS for CALCA GenemRNA expression by GTEx for CALCA Gene

mRNA differential expression in normal tissues according to GTEx for CALCA Gene

This gene is overexpressed in Thyroid (x23.1) and Liver (x15.7).

NURSA nuclear receptor signaling pathways regulating expression of CALCA Gene:

CALCA

SOURCE GeneReport for Unigene cluster for CALCA Gene:

Hs.37058

Evidence on tissue expression from TISSUES for CALCA Gene

  • Thyroid gland(4.2)
  • Bone(3.2)
  • Nervous system(3)
  • Kidney(2.9)
  • Blood(2.8)
  • Lung(2.3)
  • Lymph node(2.3)
  • Urine(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with CALCA: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCA Gene

Orthologs for CALCA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CALCA 35
  • 93 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia CALCA 34
  • 75.15 (n)
CT 35
  • 61 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CRSP-3 35 34
  • 75.07 (n)
 OneToMany
CRSP-2 35
  • 72 (a)
 OneToMany
CRSP1 35
  • 43 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Calca 35
  • 75 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 45 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 42 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves CALCA 35
  • 48 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 44 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii calca 35
  • 45 (a)
 OneToMany
Species where no ortholog for CALCA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALCA Gene

ENSEMBL:
Gene Tree for CALCA (if available)
TreeFam:
Gene Tree for CALCA (if available)

Paralogs for CALCA Gene

Paralogs for CALCA Gene

(2) SIMAP similar genes for CALCA Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CALCA Gene

genes like me logo Genes that share paralogs with CALCA: view

Variants for CALCA Gene

Sequence variations from dbSNP and Humsavar for CALCA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000133139 -- 14,970,798(+) GGGAG(G/T)CTGAG intron-variant
rs1001671419 -- 14,969,783(+) CCCTT(A/G)GAGGC intron-variant
rs1001807163 -- 14,969,381(+) CCTGG(C/T)CTCCT intron-variant
rs1002001767 -- 14,968,240(+) GTCAC(A/G)GGCAC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1002137688 -- 14,967,942(+) AAAGT(C/T)GCTGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CALCA Gene

Variant ID Type Subtype PubMed ID
esv3578250 CNV gain 25503493
nsv832071 CNV loss 17160897

Variation tolerance for CALCA Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALCA Gene

Human Gene Mutation Database (HGMD)
CALCA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALCA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCA Gene

Disorders for CALCA Gene

MalaCards: The human disease database

(127) MalaCards diseases for CALCA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
reflex sympathetic dystrophy
  • reflex sympathetic dystrophy syndrome
complex regional pain syndrome
  • reflex sympathetic dystrophy
spinal stenosis
  • cervical spinal stenosis
medullary thyroid carcinoma, familial
  • medullary thyroid carcinoma
giant cell reparative granuloma
  • central giant cell granuloma
- elite association - COSMIC cancer census association via MalaCards
Search CALCA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CALCA

Genetic Association Database (GAD)
CALCA
Human Genome Epidemiology (HuGE) Navigator
CALCA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALCA
genes like me logo Genes that share disorders with CALCA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCA Gene

Publications for CALCA Gene

  1. The complete sequence of human preprocalcitonin. (PMID: 6546550) le Moullec J.-M. … Moukhtar M.S. (FEBS Lett. 1984) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. BDNF and CGRP interaction: implications in migraine susceptibility. (PMID: 20959432) Lemos C. … Sousa A. (Cephalalgia 2010) 3 46 64
  4. Association of the calcitonin gene (CA) polymorphism with osteoarthritis of the knee in a Mexican mestizo population. (PMID: 19736013) MagaA+a J.J. … Miranda-Duarte A. (Knee 2010) 3 46 64
  5. Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture. (PMID: 20173430) Herlyn P. … Gradl G. (Clin J Pain 2010) 3 46 64

Products for CALCA Gene

Sources for CALCA Gene

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