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Aliases for CALCA Gene

Aliases for CALCA Gene

  • Calcitonin-Related Polypeptide Alpha 2 3
  • Calcitonin Gene-Related Peptide I 3 4
  • Alpha-Type CGRP 3 4
  • Calcitonin 1 2 3
  • CGRP-I 3 4
  • CALC1 3 4
  • Calcitonin/Calcitonin-Related Polypeptide, Alpha 3
  • Calcitonin 2
  • Katacalcin 3
  • CGRP1 3
  • CGRP 3
  • CT 3
  • KC 3

External Ids for CALCA Gene

Previous HGNC Symbols for CALCA Gene

  • CALC1

Previous GeneCards Identifiers for CALCA Gene

  • GC11M016170
  • GC11M015736
  • GC11M015027
  • GC11M014952
  • GC11M014671

Summaries for CALCA Gene

Entrez Gene Summary for CALCA Gene

  • This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

GeneCards Summary for CALCA Gene

CALCA (Calcitonin-Related Polypeptide Alpha) is a Protein Coding gene. Diseases associated with CALCA include glucocorticoid-induced osteoporosis and complex regional pain syndrome. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include identical protein binding and protein complex binding. An important paralog of this gene is CALCB.

UniProtKB/Swiss-Prot for CALCA Gene

  • CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.

  • Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones

  • Katacalcin is a potent plasma calcium-lowering peptide

Tocris Summary for CALCA Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCA Gene

Genomics for CALCA Gene

Regulatory Elements for CALCA Gene

Transcription factor binding sites by QIAGEN in the CALCA gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CALCA Gene

Chromosome:
11
Start:
14,966,668 bp from pter
End:
14,972,354 bp from pter
Size:
5,687 bases
Orientation:
Minus strand

Genomic View for CALCA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCA Gene

Proteins for CALCA Gene

  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01258-CALC_HUMAN
    Recommended name:
    Calcitonin
    Protein Accession:
    P01258
    Secondary Accessions:
    • B7ZL39
    • Q13935
    • Q13937
    • Q52LX7

    Protein attributes for CALCA Gene

    Size:
    141 amino acids
    Molecular mass:
    15466 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06881-CALCA_HUMAN
    Recommended name:
    Calcitonin gene-related peptide 1
    Protein Accession:
    P06881
    Secondary Accessions:
    • Q93048
    • Q9UCP0

    Protein attributes for CALCA Gene

    Size:
    128 amino acids
    Molecular mass:
    13898 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALCA Gene

Proteomics data for CALCA Gene at MOPED

Post-translational modifications for CALCA Gene

  • Glycosylation at Thr 105
  • Modification sites at PhosphoSitePlus

Other Protein References for CALCA Gene

Antibody Products

  • R&D Systems Antibodies for CALCA (Procalcitonin)
  • Cell Signaling Technology (CST) Antibodies for CALCA (CALCA iso3)

No data available for DME Specific Peptides for CALCA Gene

Domains & Families for CALCA Gene

Gene Families for CALCA Gene

Suggested Antigen Peptide Sequences for CALCA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06881

UniProtKB/Swiss-Prot:

CALCA_HUMAN :
  • Belongs to the calcitonin family.
Family:
  • Belongs to the calcitonin family.
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with CALCA: view

Function for CALCA Gene

Molecular function for CALCA Gene

GENATLAS Biochemistry:
calcitonin,3.4kDa and calcitonin related peptide,alpha,3.8kDa,formed by alternative splicing of the same gene,expressed in thyroid C cells,involved in calcium homeostasis,mediating the effects of Indian Hedgehog and PTH related peptide on chondrocyte differentiation,also expressed in parts of the nervous and endocrine system,potent vasodilatator and hypotensor
UniProtKB/Swiss-Prot Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
UniProtKB/Swiss-Prot Function:
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones
UniProtKB/Swiss-Prot Function:
Katacalcin is a potent plasma calcium-lowering peptide

Gene Ontology (GO) - Molecular Function for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA 16014619
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 9620797
GO:0031716 calcitonin receptor binding IPI 8078488
GO:0032403 protein complex binding IDA 14722252
genes like me logo Genes that share ontologies with CALCA: view
genes like me logo Genes that share phenotypes with CALCA: view

Animal Models for CALCA Gene

MGI Knock Outs for CALCA:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CALCA Gene

Localization for CALCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCA Gene COMPARTMENTS Subcellular localization image for CALCA gene
Compartment Confidence
extracellular 5
cytosol 4
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
vacuole 2
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 2408883
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 17267696
genes like me logo Genes that share ontologies with CALCA: view

Pathways & Interactions for CALCA Gene

genes like me logo Genes that share pathways with CALCA: view

Pathways by source for CALCA Gene

1 Cell Signaling Technology pathway for CALCA Gene
2 BioSystems pathways for CALCA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Endothelial Cell Biology in human,mouse,rat
    • Hypertension in human,mouse,rat

Gene Ontology (GO) - Biological Process for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IDA 18603306
GO:0001935 endothelial cell proliferation IDA 17267696
GO:0001944 vasculature development IDA 17267696
GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure IDA 10642343
GO:0001984 vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure IEA --
genes like me logo Genes that share ontologies with CALCA: view

No data available for SIGNOR curated interactions for CALCA Gene

Drugs & Compounds for CALCA Gene

(82) Drugs for CALCA Gene - From: NovoSeek, HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alendronate Approved Pharma Inhibition, Inhibitor Bone resorption inhibitor, Osteoclast function modifiers (important in bone metastasis) 153
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Bretylium Approved Pharma 0
Buserelin Approved Pharma Full agonist, Agonist 30
Calcium carbonate Approved Pharma 185

(54) Additional Compounds for CALCA Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1
CGRP (rat)
83651-90-5
SUN-B 8155
345893-91-6
1,25 DIHYDROXY VITAMIN D3
genes like me logo Genes that share compounds with CALCA: view

Transcripts for CALCA Gene

Unigene Clusters for CALCA Gene

Calcitonin-related polypeptide alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALCA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for CALCA Gene

GeneLoc Exon Structure for
CALCA
ECgene alternative splicing isoforms for
CALCA

Expression for CALCA Gene

mRNA expression in normal human tissues for CALCA Gene

mRNA differential expression in normal tissues according to GTEx for CALCA Gene

This gene is overexpressed in Thyroid (x23.1) and Liver (x15.7).

SOURCE GeneReport for Unigene cluster for CALCA Gene Hs.37058

genes like me logo Genes that share expression patterns with CALCA: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CALCA Gene

Orthologs for CALCA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CALCA 35
  • 75.15 (n)
  • 64.04 (a)
CT 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRSP-3 35
  • 75.07 (n)
  • 59.06 (a)
CRSP-2 36
  • 72 (a)
OneToMany
CRSP-3 36
  • 68 (a)
OneToMany
CRSP1 36
  • 43 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Calca 16
Calca 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CALCA 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALCA 36
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii calca 36
  • 45 (a)
OneToMany
Species with no ortholog for CALCA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALCA Gene

ENSEMBL:
Gene Tree for CALCA (if available)
TreeFam:
Gene Tree for CALCA (if available)

Paralogs for CALCA Gene

Paralogs for CALCA Gene

(2) SIMAP similar genes for CALCA Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CALCA Gene

genes like me logo Genes that share paralogs with CALCA: view

Variants for CALCA Gene

Sequence variations from dbSNP and Humsavar for CALCA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2956 -- 14,967,575(-) TAAAA(A/T)ATCCA intron-variant
rs5239 -, - 14,969,993(-) TGCAG(A/G)ACTAT missense, reference, nc-transcript-variant
rs5242 -- 14,967,452(-) AAATA(C/T)AGATC intron-variant
rs5243 -- 14,967,167(-) GTGAG(A/G)TAATA intron-variant
rs924099 -- 14,973,064(+) CCGCA(C/T)AGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CALCA Gene

Variant ID Type Subtype PubMed ID
nsv832071 CNV Loss 17160897
nsv897006 CNV Gain 21882294
nsv897007 CNV Gain 21882294
nsv897008 CNV Loss 21882294

Variation tolerance for CALCA Gene

Residual Variation Intolerance Score: 78.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALCA Gene

HapMap Linkage Disequilibrium report
CALCA
Human Gene Mutation Database (HGMD)
CALCA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCA Gene

Disorders for CALCA Gene

MalaCards: The human disease database

(125) MalaCards diseases for CALCA Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
glucocorticoid-induced osteoporosis
  • steroid-induced osteoporosis
complex regional pain syndrome
  • complex regional pain syndromes
reflex sympathetic dystrophy
  • reflex sympathetic dystrophy syndrome
spinal stenosis
  • lumbar spinal stenosis
cerebral arteriosclerosis
- elite association
Search CALCA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CALCA

Genetic Association Database (GAD)
CALCA
Human Genome Epidemiology (HuGE) Navigator
CALCA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALCA
genes like me logo Genes that share disorders with CALCA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCA Gene

Publications for CALCA Gene

  1. Olcegepant, a non-peptide CGRP1 antagonist for migraine treatment. (PMID: 17665333) Recober A. … Russo A.F. (IDrugs 2007) 23 25 67
  2. Confounder summary scores when comparing the effects of multiple drug exposures. (PMID: 19757416) Cadarette S.M. … StA1rmer T. (Pharmacoepidemiol Drug Saf 2010) 23 67
  3. Prescription of anti-osteoporosis drugs during 2004-2007-a nationwide register study in Norway. (PMID: 19898839) Devold H.M. … Sogaard A.J. (Eur. J. Clin. Pharmacol. 2010) 23 67
  4. What have we learnt from triggering migraine? (PMID: 20173638) Schytz H.W. … Ashina M. (Curr. Opin. Neurol. 2010) 23 67
  5. Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. (PMID: 20203154) Bjerre Knudsen L. … Moerch U. (Endocrinology 2010) 23 67

Products for CALCA Gene

Sources for CALCA Gene

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